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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26209639 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Results reveal a novel function of intracellular IL1R2 that acts with c-Fos to enhance the transcription of IL-6 and VEGF-A, which promotes angiogenesis in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors, "CD molecules", "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] |
| Chromosome | 2 |
| Location | 2q12 |
| Start | 102608306 |
| End | 102644885 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 36580 |
| OMIM ID | 147811 |
| HGNC ID | HGNC:5994 |
| Unigene ID | Hs.25333 |
| Ensembl ID | ENSG00000115590 |
| PharmGKB ID | PA29810 |
mRNA Information
| mRNA ID | ?NM_001261419.1 |
|---|---|
| Exon | join(1..218,16700..16827,17747..18011,24056..24236, 27823..27997,30372..30434,32718..32853,34296..34438, 36411..36729) | mRNA Sequence | Download Select all |
| Length | 1628 |
Protein Information
| Protein ID | NP_001248348.1 |
|---|---|
| Protein Name | interleukin 1 receptor, type II |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 398 |
| Uniprot ID | Q92826 |
| Ensembl Protein ID | ENSP00000290295 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3552 | IL1A | 988 | NP_000566.3 | in vitro | 7878046 |
| 3553 | IL1B | 985 | NP_000567.1 | in vitro | 7878046 |
| 3557 | IL1RN | 978 | NP_776213.1 | in vivo | 1834644 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis | hsa05146 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Hematopoietic cell lineage | hsa04640 |
| HTLV-I infection | hsa05166 |
| MAPK signaling pathway | hsa04010 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05897 | 136-230 | Ig2_IL1R2_like |
| cl11960 | 136-230 | Ig superfamily |
| cd05756 | 30-125 | Ig1_IL1R_like |
| cl11960 | 30-125 | Ig superfamily |
| cd05757 | 136-230 | Ig2_IL1R_like |
| cd05896 | 35-125 | Ig1_IL1RAPL-1_like |
| pfam13895 | 134-228 | Ig_2 |
| cd00096 | 46-122 | Ig |
| pfam13895 | 42-125 | Ig_2 |
| cd04976 | 167-221 | Ig2_VEGFR |
| cd00096 | 149-221 | Ig |
| pfam13927 | 236-330 | Ig_3 |
| cl11960 | 236-330 | Ig superfamily |
| cd05729 | 40-113 | Ig2_FGFR_like |
| cd05724 | 41-112 | Ig2_Robo |
| pfam00047 | 43-110 | ig |
| cd05856 | 43-113 | Ig2_FGFRL1-like |
| PHA02633 | 95-125 | PHA02633 |
| cl19653 | 95-125 | PHA02633 superfamily |
| PHA02785 | 6-327 | PHA02785 |
| PHA02826 | 27-228 | PHA02826 |
| smart00410 | 42-125 | IG_like |
| smart00409 | 42-125 | IG |
| smart00408 | 42-113 | IGc2 |
| smart00408 | 167-208 | IGc2 |
| smart00410 | 149-228 | IG_like |
| smart00409 | 149-228 | IG |
| pfam07679 | 237-330 | I-set |
| pfam07679 | 42-125 | I-set |
| pfam07679 | 166-210 | I-set |
| smart00410 | 244-341 | IG_like |
| smart00409 | 244-341 | IG |
Ontology Information
| HPRD ID | 3520 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.