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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
USP7 7874 ubiquitin specific peptidase 7 (herpes virus-associated)  16- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22750444   2012Cell line : SW480 CRC cells.

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : Matched tumor/normal tissue specimens from 104 patients.

Stage : -

Luciferase reporter and ChIP assay,real-time PCR analysis.Down-regulation--


Gene Details



NC_000016.9 (8985951..9057341, complement)

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Gene Type protein coding
Gene Family Ubiquitin-specific peptidases
Description -  
Chromosome 16
Location 16p13.3
Start 8985951  
End 9057341  
Strand -  
Gene Sequence

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Length 71391  
OMIM ID 602519   
HGNC ID HGNC:12630   
Unigene ID Hs.386939   
Ensembl ID -   
PharmGKB ID PA37255   

mRNA Information


mRNA ID ?NM_003470.2
Exon join(1..278,33088..33192,40072..40270,42190..42328, 43038..43126,44346..44454,46329..46459,46929..46983, 47960..48040,48141..48231,52658..52740,55035..55144, 56903..57059,58154..58298,58920..59050,60083..60217, 61003..61104,61298..61403,62251..62343,62428..62495, 62855..62955,63728..63881,64297..64364,64846..64954, 65048..65125,66386..66486,67744..67843,68335..68454, 68630..68701,68845..68935,69381..71391)  
mRNA Sequence

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Length 5412  



CDS Information


   
Location 200..3508
CDS Sequence

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CCDS ID CCDS32385.1



Protein Information


      
Protein IDNP_003461.2
Protein Nameubiquitin specific peptidase 7 (herpes virus-associated)
Molecular Wt. (Da)35218
Protein Sequence

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Length 1102  
Uniprot IDQ15596
Ensembl Protein ID ENSP00000399968  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation18
SPhosphorylation963
KAcetylation869
KAcetylation1096
KAcetylation595
KAcetylation1084

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6310ATXN13333NP_000323.2in vivo;yeast 2-hybrid12093161   
7157TP531859NP_000537.3in vitro;in vivo1   192   387   216   474   400   
7185TRAF13418NP_005649.1in vitro11279055   
7186TRAF23538NP_066961.2in vitro11279055   
7187TRAF33539NP_663777.1in vitro11279055   
7188TRAF53834NP_004610.1in vitro11279055   
7189TRAF63833NP_665802.1in vitro11279055   
9093DNAJA39758NP_005138.3yeast 2-hybrid16713569   
9463PICK116176NP_036539.1yeast 2-hybrid16713569   
9618TRAF43915NP_004286.2in vitro11279055   
9709HERPUD17456NP_055500.1yeast 2-hybrid16713569   
9915ARNT26915NP_055677.3yeast 2-hybrid16713569   
10346TRIM225951NP_006065.2yeast 2-hybrid16713569   
11060WWP23812NP_008945.2yeast 2-hybrid16713569   
23072HECW111385NP_055867.3yeast 2-hybrid16713569   
23090ZNF4235189NP_055884.2yeast 2-hybrid16713569   
23613ZMYND810166NP_898868.1yeast 2-hybrid16713569   
27429HTRA25919NP_037379.1yeast 2-hybrid16713569   
51177PLEKHO112217NP_057358.2yeast 2-hybrid16713569   
54550NECAB213263NP_061938.2yeast 2-hybrid16713569   
54880BCOR6458NP_001116857.1yeast 2-hybrid16713569   
55182RNF22013336NP_060620.2yeast 2-hybrid16713569   
55698RADIL7663NP_060529.4yeast 2-hybrid16713569   
57563KLHL813928NP_065854.3yeast 2-hybrid16713569   
57692MAGEE16583NP_065983.1yeast 2-hybrid16713569   
648447-Mar9817NP_073737.1yeast 2-hybrid16713569   
65057ACD12417NP_001075955.1yeast 2-hybrid16713569   
79656BEND57756AAH07932.2yeast 2-hybrid16713569   
84447SYVN17618NP_757385.1yeast 2-hybrid16713569   
84699CREB3L316752NP_115996.1yeast 2-hybrid16713569   


Pathway Information


                        
Pathway Name Pathway ID
Epstein-Barr virus infection hsa05169
FoxO signaling pathway hsa04068
Herpes simplex infection hsa05168
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd02659212-523  peptidase_C19C
cl02553212-523  Peptidase_C19 superfamily
cd0377267-202  MATH_HAUSP
cl0244667-202  MATH superfamily
pfam12436619-865  USP7_ICP0_bdg
cl13823619-865  USP7_ICP0_bdg superfamily
pfam14533874-1088  USP7_C2
cl20557874-1088  USP7_C2 superfamily
cd02257215-519  Peptidase_C19
cd02668215-518  Peptidase_C19L
cd02663215-518  Peptidase_C19G
cd02661215-519  Peptidase_C19E
cd02657215-518  Peptidase_C19A
cd02674215-519  Peptidase_C19R
cd02664215-518  Peptidase_C19H
cd02667215-530  Peptidase_C19K
cd02660215-519  Peptidase_C19D
cd02671208-518  Peptidase_C19O
cd0012170-196  MATH
cd02658215-518  Peptidase_C19B
cd02662215-518  Peptidase_C19F
cd02665215-519  Peptidase_C19I
smart0006174-171  MATH
pfam0091778-195  MATH
cd02666214-519  Peptidase_C19J
cd0377571-195  MATH_Ubp21p
cd02670395-482  Peptidase_C19N
cd02669377-491  Peptidase_C19M
COG507755-1100  COG5077
pfam00443213-518  UCH
pfam13423214-485  UCH_1
COG5533214-489  COG5533
COG5560371-522  UBP12
COG5560207-305  UBP12
COG5207213-444  UBP14
COG5207421-498  UBP14


Ontology Information


   
HPRD ID9280
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionTransporter activity (GO:0005215)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO