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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TFPI2 | 7980 | tissue factor pathway inhibitor 2 | 7 | PP5, TFPI-2, REF1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19435926 | 2009 | Cell line : - Source : Department of Pathology, Johns Hopkins University Sample Type : - No. of Sample : - Stage : TNM Stage I-III | Methylation-specific PCR, Chromatin Immunoprecipitation | Methylation | - | Detection of TFPI2 methylation in stool DNA may act as a useful adjunct to the noninvasive strategies for screening of CRCs in the future. TFPI2 methylation was detected in stool DNA from stage I to III CRC patients with a sensitivity of 76% to 89% and a specificity of 79% to 93%. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. |
| Chromosome | 7 |
| Location | 7q |
| Start | 93885397 |
| End | 93890991 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5595 |
| OMIM ID | 600033 |
| HGNC ID | HGNC:11761 |
| Unigene ID | Hs.438231 |
| Ensembl ID | ENSG00000105825 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001271003.1 |
|---|---|
| Exon | join(1..401,706..855,1769..1957,3561..3731,4096..5595) | mRNA Sequence | Download Select all |
| Length | 2368 |
CDS Information
| Location | join(314..401,706..855,1769..1957,3561..3731,4096..4172) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001257932.1 |
|---|---|
| Protein Name | tissue factor pathway inhibitor 2 |
| Molecular Wt. (Da) | 23502 |
| Protein Sequence | Download Select all |
| Length | 224 |
| Uniprot ID | Q14626 |
| Ensembl Protein ID | ENSP00000326500 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2160 | F11 | 7524 | NP_000119.1 | in vitro | 8555184 |
| 3818 | KLKB1 | 1971 | NP_000883.2 | in vitro | 8555184 |
| 5340 | PLG | 1417 | NP_000292.1 | in vitro | 8555184 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1ZR0 |
|---|---|
| Resolution | 1.8 |
| Method | X-RAY DIFFRACTION |
| Chains | B, D |
| Molecule | Tissue factor pathway inhibitor 2 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00109 | 34-86 | KU |
| cl00101 | 34-86 | KU superfamily |
| cd00109 | 156-204 | KU |
| cl00101 | 156-204 | KU superfamily |
| smart00131 | 34-86 | KU |
| pfam00014 | 35-86 | Kunitz_BPTI |
| smart00131 | 156-204 | KU |
| pfam00014 | 157-204 | Kunitz_BPTI |
| pfam00014 | 95-149 | Kunitz_BPTI |
| cl00101 | 95-149 | KU superfamily |
| cd00109 | 105-149 | KU |
| smart00131 | 106-149 | KU |
Ontology Information
| HPRD ID | 1194 |
|---|---|
| Molecular Class | Protease inhibitor |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.