Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MUS81 | 80198 | MUS81 structure-specific endonuclease subunit | 11 | FLJ44872, SLX3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 2553790 | 2014 | Cell line : - Source : Chinese Han patients. Sample Type : CRC tumor and normal tissue No. of Sample : 43 Stage : - | real time RT-PCR | Down-regulation | - | Down-regulation of Mus81 in colorectal cancer is correlated with tumor metastasis and progression, suggesting the value of Mus81 as a potential marker for colorectal cancer in Chinese Han patients. |
| 21175991 | 2011 | Cell line : - Source : Gastroenterological Surgery, Showa University Fujikaoka Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 92 Stage : TNM Stage I-IV | real time RT-PCR | Down-regulation | - | Reduced expression of Mus81 is closely related to hepatic metastasis and poor prognosis of colorectal carcinoma, indicating Mus81 as a novel prognostic marker for colorectal carcinoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - |
| Chromosome | 11 |
| Location | 11q13 |
| Start | 65627872 |
| End | 65633914 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6043 |
| OMIM ID | 606591 |
| HGNC ID | HGNC:29814 |
| Unigene ID | Hs.288798 |
| Ensembl ID | - |
| PharmGKB ID | PA134881809 |
Protein Information
| Protein ID | NP_079404.3 |
|---|---|
| Protein Name | MUS81 structure-specific endonuclease subunit |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 551 |
| Uniprot ID | Q8IZW8 |
| Ensembl Protein ID | ENSP00000254051 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 95 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 11200 | CHEK2 | 5084 | NP_001005735.1 | in vitro;in vivo;yeast 2-hybrid | 1 174 154 611 073 970 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Fanconi anemia pathway | hsa03460 |
| Homologous recombination | hsa03440 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02732 | 273-415 | ERCC4 |
| cl10594 | 273-415 | ERCC4 superfamily |
| smart00891 | 270-369 | ERCC4 |
| COG1948 | 261-515 | MUS81 |
| PRK13766 | 289-417 | PRK13766 |
Ontology Information
| HPRD ID | 8482 |
|---|---|
| Molecular Class | Deoxyribonuclease |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.