Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TET1 | 80312 | tet methylcytosine dioxygenase 1 | 10 | LCX, KIAA1676, bA119F7.1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25557833 | 2015 | Cell line : - Source : Department of General and Colorectal Surgery, Pozna? University of Medical Sciences, Poland. Sample Type : CRC tumor No. of Sample : 113 Stage : TNM Stage I-III | real time RT-PCR,bisulfite DNA sequencing, high-resolution melting analysis | Methylation | - | TET2 mRNA expression may be an independent prognostic factor for disease recurrence and outcome. Additionally, findings initially indicate the importance of DNA methylation in regulating TET1 expression. |
| 26063725 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | DNA methylation profiling, | Methylation | - | TET1 methylation may contribute to the establishment of a unique pathway in respect to CIMP-mediated tumorigenesis, which may be incidental to hMLH1 methylation and evidence also indicate that TET1 methylation may be a good biomarker for the prediction of metastasis in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015] |
| Chromosome | 10 |
| Location | 10q21 |
| Start | 70320117 |
| End | 70454239 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 134123 |
| OMIM ID | 607790 |
| HGNC ID | HGNC:29484 |
| Unigene ID | Hs.258855 |
| Ensembl ID | ENSG00000138336 |
| PharmGKB ID | PA162405605 |
Protein Information
| Protein ID | NP_085128.2 |
|---|---|
| Protein Name | tet methylcytosine dioxygenase 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 2136 |
| Uniprot ID | P56704 |
| Ensembl Protein ID | ENSP00000284523 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 871 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam12851 | 1580-1714 | Tet_JBP |
| cl21496 | 1580-1714 | 2OG-FeII_Oxy superfamily |
| pfam02008 | 585-624 | zf-CXXC |
| cl03401 | 585-624 | zf-CXXC superfamily |
| pfam12851 | 2007-2052 | Tet_JBP |
| cl21496 | 2007-2052 | 2OG-FeII_Oxy superfamily |
| cd09827 | 1035-1057 | PET_Prickle |
| cl05674 | 1035-1057 | PET superfamily |
| PHA03321 | 1846-1998 | PHA03321 |
| PHA03247 | 1786-1966 | PHA03247 |
Ontology Information
| HPRD ID | 7623 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.