Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WNT10A | 80326 | wingless-type MMTV integration site family, member 10A | 2 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11350055 | 2001 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR,Northern blotting | Up-regulation | - | Overexpression WNT10A and WNT6 might play key roles in human carcinogenesis through activation of WNT-beta-catenin-TCF signaling pathway, just like Wnt10b and Wnt1. |
| 11605000 | 2001 | Cell line : TE2, TE3, TE4, A-172, MCF7 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR | Up-regulation | - | Up-regulation of WNT10A mRNA might play key roles in some cases of esophageal, gastric, and colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Wingless-type MMTV integration sites |
| Description | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008] |
| Chromosome | 2 |
| Location | 2q35 |
| Start | 219745255 |
| End | 219758651 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 13397 |
| OMIM ID | 606268 |
| HGNC ID | HGNC:13829 |
| Unigene ID | Hs.121540 |
| Ensembl ID | ENSG00000135925 |
| PharmGKB ID | PA37817 |
Protein Information
| Protein ID | NP_079492.2 |
|---|---|
| Protein Name | wingless-type MMTV integration site family, member 10A |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 417 |
| Uniprot ID | Q5T3U5 |
| Ensembl Protein ID | ENSP00000244533 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00110 | 60-417 | wnt |
| cl19568 | 60-417 | wnt superfamily |
| smart00097 | 63-417 | WNT1 |
Ontology Information
| HPRD ID | 3686 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.