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General Information
- Evidence
- Gene
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23393166 | 2013 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 1 Stage : TNM stage IV | Immunohistochemistry, Molecular genetic analyses. | Up-regulation | - | Plasma levels of FGF23 were highly elevated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013] |
| Chromosome | 12 |
| Location | 12p13 |
| Start | 4477393 |
| End | 4488894 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11502 |
| OMIM ID | 605380 |
| HGNC ID | HGNC:3680 |
| Unigene ID | Hs.287370 |
| Ensembl ID | ENSG00000118972 |
| PharmGKB ID | PA28119 |
mRNA Information
| mRNA ID | ?NM_020638.2 |
|---|---|
| Exon | join(1..357,7032..7135,8946..11502) | mRNA Sequence | Download Select all |
| Length | 3018 |
Protein Information
| Protein ID | NP_065689.1 |
|---|---|
| Protein Name | fibroblast growth factor 23 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 251 |
| Uniprot ID | O15205 |
| Ensembl Protein ID | ENSP00000366249 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 175 |
| R | Proteolytic Cleavage | 179 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5251 | PHEX | 2387 | NP_000435.3 | in vitro | 11409890 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00058 | 40-160 | FGF |
| cl00060 | 40-160 | FGF superfamily |
| smart00442 | 39-143 | FGF |
| pfam00167 | 39-158 | FGF |
Ontology Information
| HPRD ID | 9288 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.