Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ITIH5 | 80760 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 10 | MGC10848 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25093535 | 2014 | Cell line : HCT116, CaCo2, SW480 Source : ATCC, Ttumor bank of Euregional comprehensive Cancer Center Aachen (ECCA), now being part of the RWTH centralized biomaterial bank Sample Type : CRC tumor and normal tissue No. of Sample : 30 CRC tumor and 30 adjacent normal tissue Stage : - | Methylation-specific PCR,Western blotting,immunohistochemistry | Hypermethylation | - | ITIH5 may serve as a novel epigenetic-based diagnostic biomarker with further clinical impact for risk stratification of CIMP-positive colon cancer patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| Chromosome | 10 |
| Location | 10p14 |
| Start | 7601232 |
| End | 7708961 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 107730 |
| OMIM ID | 609783 |
| HGNC ID | HGNC:21449 |
| Unigene ID | Hs.498586 |
| Ensembl ID | ENSG00000123243 |
| PharmGKB ID | PA134899668 |
Protein Information
| Protein ID | NP_001001851.1 |
|---|---|
| Protein Name | inter-alpha-trypsin inhibitor heavy chain family, member 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 942 |
| Uniprot ID | Q9C019 |
| Ensembl Protein ID | ENSP00000259930 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01461 | 292-473 | vWA_interalpha_trypsin_inhibitor |
| cl00057 | 292-473 | vWFA superfamily |
| pfam06668 | 715-909 | ITI_HC_C |
| cl05947 | 715-909 | ITI_HC_C superfamily |
| pfam08487 | 47-161 | VIT |
| cl02699 | 47-161 | VIT superfamily |
| smart00327 | 295-467 | VWA |
| cd00198 | 295-451 | vWFA |
| cd01465 | 295-450 | vWA_subgroup |
| pfam00092 | 295-472 | VWA |
| smart00609 | 55-161 | VIT |
| pfam13768 | 294-451 | VWA_3 |
| pfam13519 | 295-441 | VWA_2 |
| cd01463 | 293-456 | vWA_VGCC_like |
| cd01466 | 296-451 | vWA_C3HC4_type |
| cd01450 | 295-451 | vWFA_subfamily_ECM |
| cd01464 | 292-451 | vWA_subfamily |
| COG4245 | 289-451 | TerY |
| cd01451 | 296-412 | vWA_Magnesium_chelatase |
| cd01454 | 296-442 | vWA_norD_type |
| cd01472 | 294-442 | vWA_collagen |
| cd01456 | 290-443 | vWA_ywmD_type |
| cd01474 | 298-438 | vWA_ATR |
| pfam10138 | 296-450 | vWA-TerF-like |
| cd01480 | 292-446 | vWA_collagen_alpha_1-VI-type |
| cd01462 | 294-441 | VWA_YIEM_type |
| pfam05762 | 293-407 | VWA_CoxE |
| TIGR03788 | 291-620 | marine_srt_targ |
| COG1240 | 296-427 | ChlD |
| COG2304 | 292-486 | YfbK |
| TIGR03436 | 292-446 | acidobact_VWFA |
| COG2425 | 296-408 | ViaA |
| TIGR02442 | 296-416 | Cob-chelat-sub |
Ontology Information
| HPRD ID | 12943 |
|---|---|
| Molecular Class | Protease inhibitor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.