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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FXR1 8087 FMR1 autosomal homolog 1  3FXR1P 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17086209   2007Cell line : -

Source : American Type Culture Collection repository.

Sample Type : -

No. of Sample : -

Stage : -

RNA isolation and Northern blot,Affymetrix oligonucleotide array data analysis,Sequencing analysis,Analysis of frameshift mutations in DNA from primary colon tumors.Mutation-Bi-allelic inactivating mutations were found in the FXR1, SEC31L1, NCOR1, BAT3, PHF14, ZNF294, C19ORF5 genes as well as genes coding for proteins with yet unknown functions.


Gene Details



NC_000003.11 (180630096..180700541)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3q28
Start 180630096  
End 180700541  
Strand +  
Gene Sequence

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Length 70446  
OMIM ID 600819   
HGNC ID HGNC:4023   
Unigene ID Hs.478407   
Ensembl ID ENSG00000114416   
PharmGKB ID PA28439   

mRNA Information


mRNA ID ?NM_001013438.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS3238.1



Protein Information


      
Protein IDNP_001013456.1
Protein NameFMR1 autosomal homolog 1
Molecular Wt. (Da)26368
Protein Sequence

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Length 621  
Uniprot IDQ13162
Ensembl Protein ID ENSP00000368646  



Post-translational Modification Information (Source : HPRD)


Residue Type site
RMethylation445
RMethylation453
RMethylation445
RMethylation453
RMethylation360
RMethylation368
TPhosphorylation488;-
YPhosphorylation477;-
TPhosphorylation488;-
YPhosphorylation477;-
YPhosphorylation392;-
TPhosphorylation403;-
SPhosphorylation485;-
SPhosphorylation485;-
SPhosphorylation400;-
SPhosphorylation494;-
SPhosphorylation494;-
SPhosphorylation409;-
TPhosphorylation401;-
SPhosphorylation403;-
TPhosphorylation401;-
SPhosphorylation403;-
TPhosphorylation316;-
SPhosphorylation318;-
SPhosphorylation413;-
SPhosphorylation413;-
SPhosphorylation328;-
TPhosphorylation411;-
SPhosphorylation406;-
TPhosphorylation411;-
SPhosphorylation406;-
SPhosphorylation321;-
TPhosphorylation326;-
SPhosphorylation409;-
SPhosphorylation409;-
SPhosphorylation324;-
TPhosphorylation483
TPhosphorylation491
TPhosphorylation500
TPhosphorylation483
TPhosphorylation491
TPhosphorylation500
TPhosphorylation398
TPhosphorylation406
TPhosphorylation415
SPhosphorylation587
SPhosphorylation502
SPhosphorylation420
SPhosphorylation432
SPhosphorylation420
SPhosphorylation432
SPhosphorylation335
SPhosphorylation347
SPhosphorylation423
SPhosphorylation423
SPhosphorylation338
TPhosphorylation597
TPhosphorylation512

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2332FMR12398NP_002015.1in vitro;in vivo;yeast 2-hybrid7   489   725   866   820   010   000   000   
11098PRSS237149NP_009104.1yeast 2-hybrid16169070   
11161C14orf15201NP_009107.1yeast 2-hybrid16169070   
51631LUC7L217456NP_057103.2yeast 2-hybrid16169070   
55791C1orf10317975NP_060842.3yeast 2-hybrid16169070   
57562KIAA137717212NP_065853.2yeast 2-hybrid16169070   


Pathway Information


      
Pathway Name Pathway ID
RNA transport hsa03013


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00105286-352  KH-I
cl00098286-352  KH-I superfamily
cd00105220-280  KH-I
cl00098220-280  KH-I superfamily
pfam12235361-486  FXR1P_C
cl13645361-486  FXR1P_C superfamily
pfam0564159-115  Agenet
cl2295859-115  Agenet superfamily
pfam00013286-351  KH_1
smart00322286-324  KH
cd02396288-318  PCBP_like_KH
smart00322221-280  KH
pfam00013221-276  KH_1
pfam13014292-329  KH_3
cd02393286-344  PNPase_KH
smart0074358-115  Agenet
cd02394286-325  vigilin_like_KH
cd02393221-280  PNPase_KH
PRK11824286-344  PRK11824
PRK13764286-336  PRK13764
TIGR01952223-309  nusA_arch
PRK08406223-304  PRK08406
TIGR03591286-344  polynuc_phos
PRK11824228-309  PRK11824
COG1185228-376  Pnp
COG0195223-304  NusA
COG1185286-362  Pnp
TIGR03591225-309  polynuc_phos
TIGR03665225-313  arCOG04150


Ontology Information


   
HPRD ID6580
Molecular ClassNot Available
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO