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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDK2AP1 | 8099 | cyclin-dependent kinase 2 associated protein 1 | 12 | DORC1, doc-1, DOC1, ST19, p12DOC-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15806176 | 2005 | Cell line : 24 human colorectal cancer cell lines, 12 MSI and 12
microsatellite stable (MSS) Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | Mutations in the microsatellite-like sequence of the CDK2-AP1 gene in MSI CRC are associated with decreased CDK2-AP1 expression. In addition, modulation of CDK2-AP1 expression in human CRC alters cell proliferation and apoptosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] |
| Chromosome | 12 |
| Location | 12q24 |
| Start | 123745517 |
| End | 123756863 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11347 |
| OMIM ID | 602198 |
| HGNC ID | HGNC:14002 |
| Unigene ID | Hs.433201 |
| Ensembl ID | ENSG00000111328 |
| PharmGKB ID | PA26308 |
mRNA Information
| mRNA ID | ?NM_001270433.1 |
|---|---|
| Exon | join(177..753,5035..5132,6995..7121,10514..11347) | mRNA Sequence | Download Select all |
| Length | 1655 |
Protein Information
| Protein ID | NP_001257362.1 |
|---|---|
| Protein Name | cyclin-dependent kinase 2 associated protein 1 |
| Molecular Wt. (Da) | 28454 |
| Protein Sequence | Download Select all |
| Length | 115 |
| Uniprot ID | Q9BUP3 |
| Ensembl Protein ID | ENSP00000392985 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 24 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1017 | CDK2 | 310 | NP_001789.2 | in vitro;in vivo | 10938106 |
| 5422 | POLA1 | 2416 | NP_058633.2 | in vitro;in vivo | 10877824 |
| 10263 | CDK2AP2 | 13242 | NP_005842.1 | in vitro;in vivo;yeast 2-hybrid | 14985111 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam09806 | 18-115 | CDK2AP |
| cl10779 | 18-115 | CDK2AP superfamily |
| PRK09196 | 54-97 | PRK09196 |
| cl21457 | 54-97 | TIM_phosphate_binding superfamily |
Ontology Information
| HPRD ID | 6895 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Chaperone activity (GO:0003754) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.