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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ACTN4 81 actinin, alpha 4  19 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15633123   2005Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 26

Stage : -

immunohistochemistryUp-regulation-Actinin-4 actively increases cell motility and promotes lymph node metastasis of colorectal cancer


Gene Details



Chromosome 19 - NC_000019.10 (38647616..38730531)

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Gene Type protein coding
Gene Family EF-hand domain containing
Description Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.  
Chromosome 19
Location 19q13
Start 38647616  
End 38730531  
Strand +  
Gene Sequence

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Length 82916  
OMIM ID 604638   
HGNC ID HGNC:166   
Unigene ID Hs.270291   
Ensembl ID ENSG00000130402   
PharmGKB ID -   

mRNA Information


mRNA ID XM_005259281.3
Exon join(1..292,52985..53099,53387..53506,57319..57405, 58429..58516,60502..60580,61780..61861,62642..62727, 66854..66946,69471..69701,70312..70459,73923..74073, 75999..76107,76322..76462,76542..76724,76816..76950, 78109..78288,79342..79488,80701..80766,81381..81539, 81659..82913)  
mRNA Sequence

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Length 3966  



CDS Information


   
Location join(131..292,52985..53099,53387..53506,57319..57405, 58429..58516,60502..60580,61780..61861,62642..62727, 66854..66946,69471..69701,70312..70459,73923..74073, 75999..76107,76322..76462,76542..76724,76816..76950, 78109..78288,79342..79488,80331..80411,81381..81539, 81659..81817)
CDS Sequence

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CCDS ID CCDS12518.1



Protein Information


      
Protein IDNP_004915.2
Protein Nameactinin, alpha 4
Molecular Wt. (Da)104723
Protein Sequence

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Length 911  
Uniprot IDP23769
Ensembl Protein ID ENSP00000345681  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation265;-
KAcetylation625
KAcetylation592
KAcetylation114
KAcetylation417
KAcetylation214
SPhosphorylation159

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
70ACTC115NP_005150.1in vivo12042308   
89ACTN32148NP_001095.1in vivo10656685   
135ADORA2A43NP_000666.2in vitro;yeast 2-hybrid12837758   
525ATP6V1B11887NP_001683.2in vivo10915794   
815CAMK2A6532NP_057065.2in vitro;yeast 2-hybrid11160423   
816CAMK2B12127NP_001211.3in vitro;yeast 2-hybrid11160423   
818CAMK2G3672NP_751911.1in vitro;in vivo;yeast 2-hybrid11160423   
1308COL17A1223NP_000485.3in vivo;yeast 2-hybrid11739652   
2934GSN674NP_000168.1in vitro11733011   
3688ITGB1628NP_391987.1in vitro2116421   
4703NEB1196NP_004534.2in vitro11882289   
4843NOS21225NP_000616.3in vitro12960352   
5054SERPINE11418NP_000593.1in vitro;in vivo;yeast 2-hybrid15493875   
5781PTPN111470NP_002825.3in vitro;in vivo11382784   
7082TJP13002NP_003248.3in vitro;in vivo16944923   
8161COIL2605NP_004636.1yeast 2-hybrid16713569   
9223MAGI14020NP_001028229.1in vitro12042308   
26278SACS5135NP_055178.3yeast 2-hybrid16713569   
51778MYOZ25724NP_057683.1yeast 2-hybrid16189514   
57554LRRC79930NP_065845.1in vitro;yeast 2-hybrid11160423   
58529MYOZ15725NP_067068.1yeast 2-hybrid16189514   


Pathway Information


                                                      
Pathway Name Pathway ID
Adherens junction hsa04520
Amoebiasis hsa05146
Arrhythmogenic right ventricular cardiomyopathy (ARVC) hsa05412
Focal adhesion hsa04510
Leukocyte transendothelial migration hsa04670
Regulation of actin cytoskeleton hsa04810
Systemic lupus erythematosus hsa05322
Tight junction hsa04530
Viral carcinogenesis hsa05203


Structure Information


PDB ID1WLX
Resolution
MethodSOLUTION NMR
Chains A  
Molecule Alpha-actinin 4  
Model View



Domain Information




ID Location Description
cd00176414-640  SPEC
cl02488414-640  SPEC superfamily
cd00014164-268  CH
cl00030164-268  CH superfamily
cd0001452-154  CH
cl0003052-154  CH superfamily
cd00176532-754  SPEC
cl02488532-754  SPEC superfamily
cd00176296-517  SPEC
cl02488296-517  SPEC superfamily
cd00051769-836  EFh
cl08302769-836  EFh superfamily
pfam00307166-269  CH
pfam0030753-153  CH
smart0003354-152  CH
pfam00435413-517  Spectrin
smart00033167-264  CH
smart00150416-517  SPEC
pfam00435528-639  Spectrin
pfam00435293-403  Spectrin
pfam11971173-247  CAMSAP_CH
pfam00435649-752  Spectrin
smart00150532-637  SPEC
smart00054810-837  EFh
cl23347810-837  EFh superfamily
pfam08726841-907  EFhand_Ca_insen
pfam13499777-835  EF-hand_7
COG506948-311  SAC6
PTZ00184759-868  PTZ00184
COG5126762-871  FRQ1
PTZ00183761-869  PTZ00183
COG5126768-841  FRQ1
COG0497446-570  RecN
TIGR03185442-771  DNA_S_dndD
COG506954-217  SAC6
COG1196401-718  Smc


Ontology Information


   
HPRD ID2906
Molecular ClassCytoskeletal protein
Molecular FunctionGrowth factor activity (GO:0008083)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO