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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15633123    | 2005 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 26 Stage : - | immunohistochemistry | Up-regulation | - | Actinin-4 actively increases cell motility and promotes lymph node metastasis of colorectal cancer |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | EF-hand domain containing |
| Description | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.   |
| Chromosome | 19 |
| Location | 19q13 |
| Start | 38647616   |
| End | 38730531   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 82916   |
| OMIM ID | 604638    |
| HGNC ID | HGNC:166    |
| Unigene ID | Hs.270291    |
| Ensembl ID | ENSG00000130402    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_005259281.3 |
|---|---|
| Exon | join(1..292,52985..53099,53387..53506,57319..57405, 58429..58516,60502..60580,61780..61861,62642..62727, 66854..66946,69471..69701,70312..70459,73923..74073, 75999..76107,76322..76462,76542..76724,76816..76950, 78109..78288,79342..79488,80701..80766,81381..81539, 81659..82913)   | mRNA Sequence |    Download   Select all |
| Length | 3966   |
CDS Information
| Location | join(131..292,52985..53099,53387..53506,57319..57405, 58429..58516,60502..60580,61780..61861,62642..62727, 66854..66946,69471..69701,70312..70459,73923..74073, 75999..76107,76322..76462,76542..76724,76816..76950, 78109..78288,79342..79488,80331..80411,81381..81539, 81659..81817) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS12518.1 |    
Protein Information
| Protein ID | NP_004915.2 |
|---|---|
| Protein Name | actinin, alpha 4 |
| Molecular Wt. (Da) | 104723 |
| Protein Sequence |    Download   Select all |
| Length | 911   |
| Uniprot ID | P23769 |    
| Ensembl Protein ID | ENSP00000345681   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 265;- |
| K | Acetylation | 625 |
| K | Acetylation | 592 |
| K | Acetylation | 114 |
| K | Acetylation | 417 |
| K | Acetylation | 214 |
| S | Phosphorylation | 159 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 70 |    ACTC1 |    15 |    NP_005150.1 |    in vivo |    12042308    |
| 89 |    ACTN3 |    2148 |    NP_001095.1 |    in vivo |    10656685    |
| 135 |    ADORA2A |    43 |    NP_000666.2 |    in vitro;yeast 2-hybrid |    12837758    |
| 525 |    ATP6V1B1 |    1887 |    NP_001683.2 |    in vivo |    10915794    |
| 815 |    CAMK2A |    6532 |    NP_057065.2 |    in vitro;yeast 2-hybrid |    11160423    |
| 816 |    CAMK2B |    12127 |    NP_001211.3 |    in vitro;yeast 2-hybrid |    11160423    |
| 818 |    CAMK2G |    3672 |    NP_751911.1 |    in vitro;in vivo;yeast 2-hybrid |    11160423    |
| 1308 |    COL17A1 |    223 |    NP_000485.3 |    in vivo;yeast 2-hybrid |    11739652    |
| 2934 |    GSN |    674 |    NP_000168.1 |    in vitro |    11733011    |
| 3688 |    ITGB1 |    628 |    NP_391987.1 |    in vitro |    2116421    |
| 4703 |    NEB |    1196 |    NP_004534.2 |    in vitro |    11882289    |
| 4843 |    NOS2 |    1225 |    NP_000616.3 |    in vitro |    12960352    |
| 5054 |    SERPINE1 |    1418 |    NP_000593.1 |    in vitro;in vivo;yeast 2-hybrid |    15493875    |
| 5781 |    PTPN11 |    1470 |    NP_002825.3 |    in vitro;in vivo |    11382784    |
| 7082 |    TJP1 |    3002 |    NP_003248.3 |    in vitro;in vivo |    16944923    |
| 8161 |    COIL |    2605 |    NP_004636.1 |    yeast 2-hybrid |    16713569    |
| 9223 |    MAGI1 |    4020 |    NP_001028229.1 |    in vitro |    12042308    |
| 26278 |    SACS |    5135 |    NP_055178.3 |    yeast 2-hybrid |    16713569    |
| 51778 |    MYOZ2 |    5724 |    NP_057683.1 |    yeast 2-hybrid |    16189514    |
| 57554 |    LRRC7 |    9930 |    NP_065845.1 |    in vitro;yeast 2-hybrid |    11160423    |
| 58529 |    MYOZ1 |    5725 |    NP_067068.1 |    yeast 2-hybrid |    16189514    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction |    hsa04520 |    
| Amoebiasis |    hsa05146 |    
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) |    hsa05412 |    
| Focal adhesion |    hsa04510 |    
| Leukocyte transendothelial migration |    hsa04670 |    
| Regulation of actin cytoskeleton |    hsa04810 |    
| Systemic lupus erythematosus |    hsa05322 |    
| Tight junction |    hsa04530 |    
| Viral carcinogenesis |    hsa05203 |    
Structure Information
| PDB ID | 1WLX |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A   |
| Molecule | Alpha-actinin 4   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00176 | 414-640  | SPEC |
| cl02488 | 414-640  | SPEC superfamily |
| cd00014 | 164-268  | CH |
| cl00030 | 164-268  | CH superfamily |
| cd00014 | 52-154  | CH |
| cl00030 | 52-154  | CH superfamily |
| cd00176 | 532-754  | SPEC |
| cl02488 | 532-754  | SPEC superfamily |
| cd00176 | 296-517  | SPEC |
| cl02488 | 296-517  | SPEC superfamily |
| cd00051 | 769-836  | EFh |
| cl08302 | 769-836  | EFh superfamily |
| pfam00307 | 166-269  | CH |
| pfam00307 | 53-153  | CH |
| smart00033 | 54-152  | CH |
| pfam00435 | 413-517  | Spectrin |
| smart00033 | 167-264  | CH |
| smart00150 | 416-517  | SPEC |
| pfam00435 | 528-639  | Spectrin |
| pfam00435 | 293-403  | Spectrin |
| pfam11971 | 173-247  | CAMSAP_CH |
| pfam00435 | 649-752  | Spectrin |
| smart00150 | 532-637  | SPEC |
| smart00054 | 810-837  | EFh |
| cl23347 | 810-837  | EFh superfamily |
| pfam08726 | 841-907  | EFhand_Ca_insen |
| pfam13499 | 777-835  | EF-hand_7 |
| COG5069 | 48-311  | SAC6 |
| PTZ00184 | 759-868  | PTZ00184 |
| COG5126 | 762-871  | FRQ1 |
| PTZ00183 | 761-869  | PTZ00183 |
| COG5126 | 768-841  | FRQ1 |
| COG0497 | 446-570  | RecN |
| TIGR03185 | 442-771  | DNA_S_dndD |
| COG5069 | 54-217  | SAC6 |
| COG1196 | 401-718  | Smc |
Ontology Information
| HPRD ID | 2906 |    
|---|---|
| Molecular Class | Cytoskeletal protein |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
