Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SGPP1 | 81537 | sphingosine-1-phosphate phosphatase 1 | 14 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20372795 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 84 tissue specimens, 42 primary sporadic CRCs obtained from patients who underwent radical surgery, and its corresponding control tissues. Stage : - | Oligo GEArray(R) human extracellular matrix and adhesion molecules microarray,real time RT-PCR | Down-regulation | - | COL12A1, CSPG2, FN1, MMP-7 and SGCE were down-regulated in tumours with high microsatellite instability when compared to the stable group. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009] |
| Chromosome | 14 |
| Location | 14q23.1 |
| Start | 64150934 |
| End | 64194756 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 43823 |
| OMIM ID | 612826 |
| HGNC ID | HGNC:17720 |
| Unigene ID | Hs.24678 |
| Ensembl ID | ENSG00000126821 |
| PharmGKB ID | PA134884424 |
Protein Information
| Protein ID | NP_110418.1 |
|---|---|
| Protein Name | sphingosine-1-phosphate phosphatase 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 441 |
| Uniprot ID | Q969G2 |
| Ensembl Protein ID | ENSP00000263726 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 112;- |
| S | Phosphorylation | 101 |
| T | Phosphorylation | 114 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Sphingolipid metabolism | hsa00600 |
| Sphingolipid signaling pathway | hsa04071 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03388 | 126-275 | PAP2_SPPase1 |
| cl00474 | 126-275 | PAP2_like superfamily |
| PLN02525 | 143-435 | PLN02525 |
| cd01610 | 163-275 | PAP2_like |
| pfam01569 | 160-279 | PAP2 |
| smart00014 | 168-275 | acidPPc |
| cd03392 | 120-281 | PAP2_like_2 |
| cd03395 | 142-275 | PAP2_like_4 |
| cd03393 | 146-271 | PAP2_like_3 |
| cd03382 | 120-275 | PAP2_dolichyldiphosphatase |
| cd03391 | 145-269 | PAP2_containing_2_like |
| cd03385 | 150-276 | PAP2_BcrC_like |
| cd03383 | 204-274 | PAP2_diacylglycerolkinase |
| PRK09597 | 198-274 | PRK09597 |
| cd03386 | 204-278 | PAP2_Aur1_like |
| cd03381 | 142-274 | PAP2_glucose_6_phosphatase |
| COG0671 | 142-284 | PgpB |
Ontology Information
| HPRD ID | 6590 |
|---|---|
| Molecular Class | Lipid phosphatase |
| Molecular Function | Sulfotransferase activity (GO:0008146) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.