Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADAMTS12 | 81792 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | 5 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21559743 | 2011 | Cell line : - Source : - Sample Type : Formalin-fixed paraffin-embedded specimens No. of Sample : 112 Stage : - | Immunohistochemistry | Methylation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | ADAM metallopeptidases with thrombospondin type 1 motif |
| Description | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5q35 |
| Start | 33523640 |
| End | 33892319 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 368680 |
| OMIM ID | 606184 |
| HGNC ID | HGNC:14605 |
| Unigene ID | Hs.12680 |
| Ensembl ID | ENSG00000151388 |
| PharmGKB ID | PA24538 |
Protein Information
| Protein ID | NP_112217.2 |
|---|---|
| Protein Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1594 |
| Uniprot ID | Q9Y3M8 |
| Ensembl Protein ID | ENSP00000255486 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 234;- |
| S | Phosphorylation | 236;- |
| S | Phosphorylation | 436 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04273 | 246-453 | ZnMc_ADAMTS_like |
| cl00064 | 246-453 | ZnMc superfamily |
| pfam05986 | 702-812 | ADAM_spacer1 |
| cl20316 | 702-812 | ADAM_spacer1 superfamily |
| cd04269 | 246-452 | ZnMc_adamalysin_II_like |
| cd04267 | 246-445 | ZnMc_ADAM_like |
| pfam01562 | 52-195 | Pep_M12B_propep |
| cl03265 | 52-195 | Pep_M12B_propep superfamily |
| cd04272 | 248-452 | ZnMc_salivary_gland_MPs |
| smart00209 | 545-596 | TSP1 |
| cl15278 | 545-596 | TSP_1 superfamily |
| cd00203 | 331-444 | ZnMc |
| pfam13688 | 244-420 | Reprolysin_5 |
| pfam00090 | 548-596 | TSP_1 |
| pfam13582 | 269-403 | Reprolysin_3 |
| pfam13574 | 339-420 | Reprolysin_2 |
| cd04270 | 251-451 | ZnMc_TACE_like |
| pfam13583 | 318-440 | Reprolysin_4 |
| smart00608 | 515-676 | ACR |
| cl15456 | 515-676 | ADAM_CR superfamily |
| smart00209 | 946-997 | TSP1 |
| cl15278 | 946-997 | TSP_1 superfamily |
| smart00209 | 1474-1531 | TSP1 |
| cl15278 | 1474-1531 | TSP_1 superfamily |
| pfam00090 | 946-979 | TSP_1 |
| smart00209 | 828-883 | TSP1 |
| cl15278 | 828-883 | TSP_1 superfamily |
| smart00209 | 1427-1472 | TSP1 |
| cl15278 | 1427-1472 | TSP_1 superfamily |
| pfam01421 | 246-456 | Reprolysin |
| pfam05109 | 1026-1297 | Herpes_BLLF1 |
Ontology Information
| HPRD ID | 16461 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.