Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SMC1A 8243 structural maintenance of chromosomes 1A  XDXS423E, KIAA0178, SB1.8, Smcb 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25884313   2015Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 427

Stage : TNM stage III, IV

Tissue microarrays, MTT assay,colony formation and flow cytometry assays, western blotting Up-regulation-SMC1A plays an essential role in the development of CRC and may be a predictive factor in patients with CRC.


Gene Details



NC_000023.10 (53401070..53449677, complement)

View Larger Image
   
Gene Type protein coding
Gene Family Structural maintenance of chromosomes proteins
Description Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]  
Chromosome X
Location Xp11.22-p1
Start 53401070  
End 53449677  
Strand -  
Gene Sequence

   Download   Select all

Length 48608  
OMIM ID 300040   
HGNC ID HGNC:11111   
Unigene ID Hs.211602   
Ensembl ID ENSG00000072501   
PharmGKB ID PA35961   

mRNA Information


mRNA ID ?NM_006306.3
Exon join(1..237,7560..7748,7859..7971,9294..9497,9591..9829, 10476..10734,10828..10968,13226..13308,13460..13667, 16773..16958,17057..17236,17338..17484,17580..17717, 18836..18952,19057..19163,22999..23140,26112..26257, 26349..26502,27841..27951,39476..39632,40069..40223, 40346..40497,41642..41711,41999..42109,42543..48580)  
mRNA Sequence

   Download   Select all

Length 9784  



CDS Information


   
Location129..3830
CDS Sequence

   Download   Select all

CCDS ID CCDS14352.1



Protein Information


      
Protein IDNP_006297.2
Protein Namestructural maintenance of chromosomes 1A
Molecular Wt. (Da)437472
Protein Sequence

   Download   Select all

Length 1233  
Uniprot IDP78371
Ensembl Protein ID ENSP00000299300  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation360
SPhosphorylation962
SPhosphorylation957
SPhosphorylation966
SPhosphorylation957
SPhosphorylation951;-
SPhosphorylation358;-
SPhosphorylation964
SPhosphorylation970
SPhosphorylation971
SPhosphorylation956
KAcetylation713
KAcetylation437
KAcetylation648
KAcetylation282
KAcetylation536
TPhosphorylation841
TPhosphorylation28
TPhosphorylation722
YPhosphorylation973

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
672BRCA1218NP_009231.2in vivo11877377   
4175MCM63485NP_005906.2in vivo16438930   
4176MCM71154NP_005907.3in vitro;in vivo16438930   
4436MSH2389NP_000242.1in vitro14657349   
4926NUMA11236CAA77669.1in vitro;in vivo11590136   
5422POLA12416NP_058633.2in vivo16438930   
5981RFC124NP_002904.3in vivo16438930   


Pathway Information


            
Pathway Name Pathway ID
Cell cycle hsa04110
Oocyte meiosis hsa04114


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd032754-148  ABC_SMC1_euk
cl214554-148  P-loop_NTPase superfamily
cd032751117-1220  ABC_SMC1_euk
cl214551117-1220  P-loop_NTPase superfamily
smart00968513-628  SMC_hinge
cl05797513-628  SMC_hinge superfamily
pfam06470514-628  SMC_hinge
cd032781117-1203  ABC_SMC_barmotin
cd032741118-1204  ABC_SMC4_euk
cd032391128-1208  ABC_SMC_head
cd032743-145  ABC_SMC4_euk
cd032784-100  ABC_SMC_barmotin
cd032733-140  ABC_SMC2_euk
cd03239Apr-84  ABC_SMC_head
cd032271128-1208  ABC_Class2
cd032724-145  ABC_SMC3_euk
cd032731128-1213  ABC_SMC2_euk
cd032721125-1203  ABC_SMC3_euk
cd03227Jul-84  ABC_Class2
pfam134767-206  AAA_23
cd03240Apr-65  ABC_Rad50
cd03279Jan-99  ABC_sbcCD
cd032401122-1203  ABC_Rad50
cd032761119-1188  ABC_SMC6_euk
pfam13555Apr-49  AAA_29
cd002671128-1188  ABC_ATPase
pfam1330427-158  AAA_21
cd00267Aug-65  ABC_ATPase
cd0324124-124  ABC_RecN
cd03276Jul-65  ABC_SMC6_euk
cd03277Feb-67  ABC_SMC5_euk
cd032771121-1174  ABC_SMC5_euk
cd032381110-1208  ABC_UvrA
cd03214Aug-46  ABC_Iron-Siderophores_B12_Hemin
cd03242Apr-75  ABC_RecF
cd03221Jul-46  ABCF_EF-3
pfam135581123-1176  SbcCD_C
cd0323527-45  ABC_Metallic_Cations
cd0321927-46  ABC_Mj1267_LivG_branched
cd03213Aug-46  ABCG_EPDR
pfam133041119-1188  AAA_21
cd032791123-1198  ABC_sbcCD
cd03256Jul-64  ABC_PhnC_transporter
cd032411118-1188  ABC_RecN
cd0322527-59  ABC_cobalt_CbiO_domain1
pfam024633-1210  SMC_N
COG11963-1223  Smc
TIGR021693-1203  SMC_prok_A
TIGR021683-1220  SMC_prok_B
COG04197-483  SbcC
PTZ00121156-509  PTZ00121
PTZ00121156-509  PTZ00121
PTZ00121144-508  PTZ00121
PTZ00121144-505  PTZ00121
COG0419659-1215  SbcC
PTZ00121156-775  PTZ00121
PRK03918236-854  PRK03918
TIGR006187-880  sbcc
PTZ00121145-509  PTZ00121
PRK03918156-508  PRK03918
PTZ00121287-923  PTZ00121
PTZ00121188-1041  PTZ00121
COG0419149-487  SbcC
PTZ00121156-477  PTZ00121
PRK000643-137  recF
PRK011564-505  PRK01156
PRK039184-510  PRK03918
TIGR00606281-503  rad50
PTZ00121156-476  PTZ00121
COG0419187-475  SbcC
COG11953-110  RecF
COG1106Apr-50  AAA15
PRK03918156-510  PRK03918
pfam12128278-510  DUF3584
PTZ00121141-926  PTZ00121
TIGR03319235-404  RNase_Y
PRK12704273-395  PRK12704
COG4372215-453  COG4372
COG4913363-904  COG4913
TIGR00611Mar-90  recf
pfam131754-254  AAA_15
PRK12704377-509  PRK12704
pfam09726285-519  Macoilin
COG4372139-361  COG4372
PTZ00108150-500  PTZ00108
COG4942231-472  EnvC
PRK00409378-508  PRK00409
pfam12128297-924  DUF3584
COG4637Jul-58  COG4637
PRK01156647-1213  PRK01156
PRK02224279-510  PRK02224
COG4942732-932  EnvC
pfam10186379-512  Atg14
PLN03229118-462  PLN03229
pfam05483166-475  SCP-1
TIGR0063425-218  recN
pfam07888210-510  CALCOCO1
COG4604Jun-59  CeuD
PRK03918672-931  PRK03918
COG1121May-45  ZnuC
COG1120May-46  FepC
TIGR04523195-477  Mplasa_alph_rch
COG2433385-510  COG2433
TIGR031854-521  DNA_S_dndD
COG0488May-51  Uup
pfam05483666-931  SCP-1
COG049724-449  RecN
TIGR0060616-498  rad50
pfam09731648-920  Mitofilin
pfam05557240-480  MAD
TIGR04523227-509  Mplasa_alph_rch
PRK03918668-923  PRK03918
pfam05557708-936  MAD
COG041028-99  LivF
PRK1354828-46  hmuV
pfam09726661-772  Macoilin
pfam05483676-1048  SCP-1
COG3593Apr-68  YbjD
COG3638Jul-64  PhnC
PRK05771213-467  PRK05771
pfam07888662-874  CALCOCO1
COG1116Jun-80  TauB
PRK00106282-404  PRK00106
TIGR00606282-1065  rad50
pfam05557659-1046  MAD
PRK02224185-510  PRK02224
TIGR03319663-779  RNase_Y
COG4988Nov-64  CydD
pfam12128194-900  DUF3584
COG0419659-1096  SbcC
TIGR04523672-921  Mplasa_alph_rch
pfam05483214-509  SCP-1
PRK022244-488  PRK02224


Ontology Information


   
HPRD ID16398
Molecular ClassCell cycle control protein
Molecular FunctionWater channel activity (GO:0015250)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO