CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
TKTL1	8277	transketolase-like 1	X	TKR, TKT2

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21980427	2011	Cell line : - Source : Gastroenterology Department of the Hospital Clinic of Barcelona Sample Type : - No. of Sample : 63 CRC patients. Stage : TNM Stage III	Immunohistochemistry, Western blotting	Down-regulation	-	Reported, downregulation of enzyme expression when metastasis appears, and a correlation between enzyme expression and regional lymph-node involvement in colon cancer.

Gene Details

Chromosome X - NC_000023.11 (154295674..154330363)
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Gene Type	protein coding
Gene Family
Description	The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene.
Chromosome	X
Location	Xq28
Start	154295674
End	154330363
Strand	+
Gene Sequence	>gi\|568815575:154295674-154330363 Homo sapiens chromosome X, GRCh38.p2 Primary Assembly TCCCTTGACTTGCTTGCGGAGGGAGCGGCCGGCGGAGGGAGCGGCAGGTGGAGGGAGTGGCACGAGGCAT GCGGAGGGAGCTGCACCGACATCACATAAACGCACTGGGCAGCTCGCAGGCGCCATTCGCTCTTCAGACG CCGGAGACGTAGGAGTGGGTCTTCAGACTCCAAAGGGGTTGGACTAATGGCGGATGCTGAGGCGAGGGCT GAGTTCCCGGAGGAGGCCAGACCTGACAGGGGCACCTTGCAGGTGTTGCAAGATATGGCCAGCCGCTTGC GAATCCATTCCATCAGGGCCACATGCTCCACGAGCTCCGGGTAAGTTCTCCTCATTGAAGTCTGGGTCAT GCAGGGCCACGGGCCCGGTGGCTTCAGGCCTGGTGGCCATGAGGCCGTGTGGTGAAGGGAGAGCCTTCAG AGGCACAATGGGCTGTGTCGTAATGCCCTGTCTTGGGCTGTTGGGGCCCGGTCGAGCACCCTAGATGGCA GCGAGGCACTATTCCCGCCAACCCAAGGGTCGGTCGGTTGGTTGGTCAGCCGCGGGTTCTGGAGCCCGCC CCTCAATTTACCCACGGCCAAAGTTCTGGAGGTCGCCAAGATCTCCAGTTGGGAGACAAAGGATCCAGAC TGGACTGAGGTGGCGGGAGAATGTCACTGGGATCAGATTGGGCTAGCTGTGGTTTTCATTTTAGCGGGGA GCAGGGCTTCCCTGGTAAGCAGTTGTACTGGATCCCCGAGGGTGAATGAGCGACTCTAACCCAGGATGTG AGGATAAAAAGCAATTAAAATTCCAGCCTGGGCAACATGGCGAAACCCCGTCTCTTACCAAAAAATAAAA ATAAAAAATGAGTCGGGCATGGGGGCGCACACCTGCACTCCCAGCTATTCGGGAGGCTTGCTTGTGCTGT TGGGTTTGCTGGTATGCAGTTGATGGTTTTTGCATCAGTTTGAGGGATATTGGTCTCTAGTTGTATTGTA GTATTTGGTTTTGGTATCAAAGTGTAATGCTGGCTTCATAGGATGTTTCAAAGTGTTCCATCTTAAATTT TTTGGAGTGGCTGGGTGTAGTGGCTGCCACCTGTAATCCCAAGCACTTTGGGAGGCCGAGGCAGACGGAT CGTGTGAGCCTAGAAACTAGTTCGAGATCAGCCTGGGCAAGATGGCGAACCTCTGTACAAAATGTTACAA AAATTAGCTGGGCGTGGTGGCACGTGCCTGTAGTCCCAGCTACGCGGGAGGCTGAGAGGCTCAGGTTACA GTGAACTGAGATTGCGCCACCGCACTCCAGCCTGGGCAAGAGCGAGACCGTGCCTCAAAGAAAAAAAAGT TAAACCCAGCTGAGGGCGGTGGCTCACGCCTGCAGTCTCAGTACGTGGGGCCTGAGGAGGGAGGATCGCT TGAGCCCAGGAGTTCGCATTCAGCTTGGCAAACAGTGAGACCCTGTCTCTAAAAAAATAAAGTAAAAGAA ACCGGGAATTGAGTACGAATTGGAACAAAAATGAGCTGTTGAATTTGCTAGTATGCGGTTGATGGTTTTT GCATCAGTATAAGGGATATTGGTCTACAGGTTTTTTTTGTTTTTTTTTTCTTTTTTTGTTTTGAGACGAA GTATCACTGTCGCCCAGGCTGGAGTGCAGTGGCACGATTTTGGCTCACTACAAGCTCCGCCTCCTGGGTT CACGCCATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTGCAGGCGCCCGCCACCACGCCTGGCTAAT TTTTTCTGTTTTTTAGTGGAGACGGGGTTTCCCCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGT GATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCTGGTCTAT AGTTTTGTTGTAGTATTTGCTTTTGGTATCAAAAGTGTAATGCTGGCTTCATAGGATGAGTTTCAAAGTG TTCCACCTTAAATTTTTTGGAGAGGTCGGGCGTGGTGGCTCCAACCTGTAATCCCAGGACTTTGAGAGGC CAAAGCAGGCGGATCGTGTGAGCCTAGAAAGTTCGAGATCAGCCTGGGCAAGATGGCAATCCCCTGTGCA GAATGTTACAAAAATTAGCTGGGCGTGGTGGCACGTGCCTGTAGTCCCAGCTACGCGGGGGACAGAGTTT GCAGTGAACTAAGATTGTGCCACTACGGCCTGGGGAACAGAGGAAGCGAGACCTTGTAGAGAAAAAAAAA TTTTTTTTTGAGGAGTTTGAAGAAGACTGTTGTTAATTTTTCTTTAAATGTTTGGCAGTAATTACGAATG AGGCTTTTATTTATTGGGCGTTTTTTTTATTACTGCTTTAGTCTCCTTACTAGTTAGTTGTAGGTCTATT CAGATTTTCTTGTCCTGATTAAGTTTTGTGAGGCTTTCTGTTTCTAGGAATTTATCCATTTCTTGTAGGT TAGTCCATTTGTTGGCATGCAGTTATTCATAGTACACTGTCACTCTTTTTATTTCTGTAGAAGCGGTATT AATGACTCCACTTTAACTTGATTGTACTTTTTTTTTTTAAGCAGGGTCTTGCTCTTTCACCCAGGCTGGA GTGCAGTGGTGCAATCATAGTTCACTGCAGCCTCGAACTCTCGTGGGCTCAAGCGACTCTCCTTCCTCTC AGCCTCTTGAGTAGCTGGAACTACAGGTGCACACCACCATGCCCTGCCCATCTATTAATAGCTAGTTTTG TTGACCTTTTATAAAGAACCAGCTTTGGCTAGGGGAGGTGGCTCACGCCTGTAACCTCAGCACTTTAGGA GGCCGAGGCAGCTGGATCACTTGAGCTCAAGAGTTCAGGACAAGCCTGGGCAACATGGGGAAACCCCGTC TCTGCCAAAAATACAACAATTAGCTAGACATGGCGAGCACCTGTAGTCTCAGCTACTCGGAAGGCTGAGG CGGAAGGATTGCTTGAGGCTGCAGTGAGCCATGTTTGTGCCCTACACTCCAGCCTGGGTGACAAACTGAG ACCCTGTCTCAAAAAGAAAAAAAAATTGGTTTCATTAAATTTTTTCTATTTTCTTAGTCTCTGTTTTATT TGTGCTTTGATCTTTTTTATTTCCTTTCTCCTGCTAGCTTTGGGTTTAGTCCTTACGTTGTAAAGTTAGG TTGTTGATTTGAAGGGTTATTTATTTATTATTATTTTTTGAGACAGAGTCTTGCTGTGTCGCCCAGGCTA GAGATGGGGTTTCTCCTTGTTGGCCAGGTTGGTTTCAGACCCCTGGCCTCAAGTGATCTGCCCGCTTCGG CTCCCAAAGTGCTGGGATTACAAGTGTGAGCCACCGCACCCGGCCAGATGTGAGGGGTTTTAAAAAATGT GTTTACAGCTAGAAATGTCCCACTTGGCACTGCTTTTGCTACATCACATAGGTTTTGGTATTTTGTACTT CTGTTTTCATTTGTCTCTAAGGGATTTTTCATTTTCTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTG AGACGGAGTTTTGCTTTTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTAGGCTTACCACAACCTCTGC CTCCCAGGTTCAAGCAATTCTCCTGCCTCGGCCTCCCAAGTAGCTGGGATTACACGCATGCACCTCCACG CCCAGCTAATTTTGTGTTTTTAGTAGAGACGGTGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCCG ACCTCAGGTGATCCGCCCACCTCGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCACCCAGC CTCTCATTTTCTTTTTTTAATTTTAATAGTGTTAGGGGTATAAGTTGTTTTTGCTTATGTGAATAAATTC TATATTGGTGAATTCTGAGATTTTAGTGTACCCATCACCCAAGCAGTGTACATTGTCCCCAATATGTAGT CTTTTATCCCTCACCTCCTTCCTACCTTCCCCCTTCATTCTCCTCCCCAAAGTCCGTTATATCACTCCAA AACTTAGCTCCACTTACAAGTGAAAACATACAGTATTTGGTTTTCTATTCCTGAGTTACTTCGCTTAAAA TAATGACCTCCAGCTCCACCCAAGTTGCTGCAAAATACATTGTTTTTTATGGCTGAGCAGTATTCCATGT TGTATATACACCACCTTCTTTATCCACTCATTGGTTGATGGACACTTAGGTTGGTTCCTTATCTTTGCAA TTGTGAATTGTGCTGCCTATAAACATGTGTGTGCATGTACCTTTTTCATATAATGACTTTTTTTCCTTTG GGTAGATAGCCAGTAGTGGAATTTCTGGATTGAATGGTAGATAGATGGTAATCTACTACTTTTAGTATTT TTTTTTTTTTTTTTTGTCTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGGGCAGTGGCGCAATGT TGGCTCACTGCAACCTCTGCTGTCCGGGTTCAAGCGATTCTCGTGCCTTAGCCTCCCGAGTAGCTGGGAC TACAGGCACACGCCACCACTGCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGC CAGGCTGATCTCGGTCTCTTGACCTGGTGATCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCG TGAGCCACCGTGCCCAGCCCGATGGTGTATTTTGATGGGAATTGCATTGAATCTGTAGATTGCTTTGGGC AGTATGGCCATTTTCACAATATTGATTCTTCCTATCCATGAGCATGAGATATCTTTGTTTGTGTCATCTG TGATGTCTTTCAGTAGTGTTTTGTAGTTTTTCTTGTAGCTGTCTTTCACCTCCTTGGTTAAGTATATTCC TAGGGTGGGTTTTATTTGTTGTTTTTGCTGTTTACAGCTGTTGTAAAAGGGATTGAGTTCTTGATTCTCA AGCTTGGTCGTTGTTGGTGTAGTGCTACTGATTTGTGTGCATTTATTTTGTAACCTGAGACTACTGAATT TGTTCATCAGATCTAAGAGTCTTTTGGATGAGTCTTTAGGATTTTGTTTGTTTGTGTTTGTTTGTTTGCT TGTTTTTGATGGAGTTTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCGCTGCAACCTCCA CCTCCCGGGTTCAAGCGATTCTCCTGCCTTACCCGAGTAGCTGGGACTACAGGTGTGTGCCACCGCACCC GGCAAATTTTTGTATTTTTGGTAGAGACAAAGTTTCACCAGACCATGGCCAGGCTGGTCTTGAACTCCTA ACCTCAGGTGATCTGCCCATCTCGGCCTCCCAAAGTGCTGGAATTACAGATGTGAGCCAACCGCGCCTGG CCTAGGGTTTTCTAGCTGTATGATCGTATCATCAGTGTTACAGCACTAGTTTGACTTCCTCTTCTCCAAT TTGGATGCCCTTTATTTATTTCGCCATTGGCTTTTGGTTGTGTAAGAGTGTGTTGCTTAATTTTCACAAA TTTGTGAATTTTCCAGTTTTCCATCTATTATTGATTTCTAACCTCATCCCATTGTGGTTAGAGAAAATAC TTAGTGCAATATGTTTTTTTAAATCTTGTTGGCCAGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTT GGGAGGCTGAGGTGGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCTTGGCCAACATGGTGAAACC CTGTCTCTACTAAAAATGCAAAAATTAGCCGGGCGTGGTGGTGCACCTCTGTAATCCCAGATACTTGGGA GGCCGAGGCAGGAAAATCACTTGAACCCGGAAGGTGGAGGTTGCAGTGAGCCGAGAGAGTGCCACTGTAC TCCAGCCTGGGCAACAGAGTGAGACTGTGTCTCAAAAAATAAATAAATAAATCTTGCTCCAGAGCCTGGG CTAGATAGTAAGAGGACAGTGTGGATGCAGTTAAGAACCATATATGTCTGAATTTTTTGTACATGTTCAT TTTGTTCCCTTCACCTTCAAAATTAGTAACAGATGGCTGCATTTTCTCAAGGGATCTGTGTGGCTTTTAA ATCTAAATCATCCACTTACAGGACATTTGCAAAGCAAGAGGTTTTAGTCCCCATTTTCTTTCTTTTTTTT TTTTTTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTTTCGAACTCCCGACCTCAGGTGAT CCGCCCACCTCGGCCTCCCAAGATGCTGGGATTACAGGCATGAGCCACTGTGCCCGGCCTAAGTCCCCAT TTTCTTTTTTCTTTTTTTTTTTTAAATGAGACAATTATTTATTTTAGGCAGATAGTCAACTTAAAAATCA TTCAGCGTGGGCACTCCTGAAACTGTCAGGATCATGTTGGTTTCCTCGCTGTTTGCCGGCTATTGGCATT TGTGTCATCACACACAGTCCGATGAGGTGACAACAGAAAAGCATATCTCACTTCTATCGTAGGTTTCCAT TCACTTTCGGGTTCTCAATCGCCCTGTGTTTCCTCAGTGATACTCCAGACTTTCCAGATGTTCTGGTTGA CCCATTCCTCTTTCTTTTTTTTTTGCAAAACAAAGCAAAAAGCAAGAAGAGAACTTTACATTTTGTCCAA TAGTCCTAAGAAATTTTCCCTGTAGAGAATGTCATCTAAGTCAAAACAAGGGTTGAATAGGGGCACCCAA ATCAGTTATCACTTAGGGCTGTTATAAGAAATGCCAAGACTGGGTGGCTTAAACAGCAGATATTCGTCTC TCACTGTCTGGAGGCTACAAATCCAAGATCAAGGTGCTAGCATGGTCAGTTCTGGCGAGGACCTGCTACT GGGCTCAAGAGCACTACCTTCCCCCCCGTATCCTCACATGGTCGGTCTCCAGCCTCTTCTCATAAAGGCG CTGATCCCATTCATGAGGGCTCCACTCTCACAGCGTAATCACCTCCCAAAGGCCCTGCCTCCAAATACTG TCACACTGGCATTAGGATTTCAGCATAGGAATTCTGGGGGGACACATTCAGTCCATGGCCTCCCGTACCT GTGAATGTGATCTTATTTGGAAATAGGGTTTTGTAGGTGAAATTAAGTTAAGGATCTTGAGATAAGATCA TCCTGGACTTAGGGTGGACCCTAAATCCAGTGACTAGTGTCCTTATAAGAGAAAGAAAAGAGAGATTGGA GACACACAGACACCGTGGAGAAACGCAGGAGAAAAGGTCCTGTGAAGGCAGAGAGGCAGGGACGGGAGTG ACCCAGCTGCAAGACGAAGAACACCTAGGGCCAGCAGTAGCTGGAGAGGCAGGGGCGAGGGCGATCCTCC CCTAGGACCTAGGGAGAGAGCGTGGCCCTGCTGCCACCTGGATTCTGGATTTCTGTTTTGAGCCATCACG TTTGTGGCAACTCACCCTGGCAGGCTTAGGAAACGAATGCGTTAACCCATTGCATTAGCGCACAAAATAA CACCCTGACTCGTTTCCTGCGCCAGCCTCCTACCTTGCCTTCTACTTATTAGACCCTACCTCTCATTCCC CATTTTTTAAAATTTTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTTGAGG CAGGGTTTCACTCTGTTGCTCAGCCTAGAGGTGCAGTGGCGTGATCATGGCTCACTACAGCCTTGACCTC CTGGGCTTAAGCAACCCTCCCACCTCAGCCTCCCAAGTAGCTTGAACTGCAGGTGCATGCCACCCTGCCC AGCTAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGAAAGACGAGGTTTCACCATGTTGCCCATGC TGGTCTCAAACTCCTGGGCTCAAGCAATCCTCCTGCATCATCCTCCAGAAGAGCCGGGATTACAGGTGTG AGCCCCCACGCCTGGCCTCTCCCTCCTTTTTATCATTCCCTCTTCCCTCGTCTTCCTTGGCTTTCCTCCT CACACCTCCTGCGTTTGGCCCCCTTCCATTTTCTTTTCTGCTTCTCTTTCCCAACTTCCCCCTCATCATG CCAGGGGGACTCCTGGGCTGCGTGCCACCCCCCTGGAAGTCCCCCATAATGAAGCAGGATTTATGCCTCA CACTTCACCATGGGAGAGCAGAAACCTCTCACTTGAAGCAAAAGGCACTGAAAATAAGCAAATAGTTATG CATTTGTCACTACCGAGTCCTAGCTGGCTTCCACCCTACCCCCCGCCCCCCACCATCTTCTTGCTCATTC AGGTCATCGTGTTCTCTGATACCCAGTAACTTCCATCATTTTCTACATGCATTTCTGTTGGTCTTCTGAG AATTGTGATTTTCCAAAGTAGAAAGGGCACATCGTCTTTTTGGAGCCTCAAAGGTGCAGACACTGATGCG TTGGGGGAGATCACAGTGTGACAAGGATGGGGTGGGAGTGTGTCACCCCCCTTTCTACCGACCCTCAGCA GTGGGGAGAGAGCAGAGGAGATGGAACCTGAGAGGAAGAAGAGATTTCCAATTACTTCCTTCTCGGTCCC TTCTCCACTGAAGCCTGTTACTCCTCTGCTGCCGGGGCCTCTTGAGTTTTCTCTCACTGAGCCAGGAAAG AGCTTAGTGAATAAAGAACAAGGTATCCCAGCAATGCAGGGAAGATGTCCAGGACAGTGAGTGTGAACGA GGGGTCCTGGAGAATGTGCACGCCAGCCCTGCAGGAGAATGTCCACGCCAGCCCTGCAGCCTGGTGGGCT CTGCCATCAGCACCCCAAAACCATTCATCAGTCACCTTCGACAATTGCACGTGCAAAAGCCCTCTTTTTG TGTCCTTTGAAGCTTTTTTTTTATCAGGCTGGGTGCGTGGCTCATGCCTGTAATCCCAGCACCTTGGGAG GCCGAGGCGGGAGAATCACTTGAGCCCAGGAGGTCGAGGCTGCAATGAGCTATGATCATGCCACTGCACT CCAGCCTGGGTGACAGAGTGAGGGCCCATCCCTTCGCGGGTCCCCATTAAGAAAATGGGGGAGGGACAGT CCCCATTTTCTTAATGGGGACTTTCTTAGTGAAATTTGAAATGAGAGATTATTAATATGAGCTGGGCCTA ACATCTTTTTTTACTTGCAGTTGGGGCAGAGCTCCAGGGAGTTGGTTTTGTCCCCTGCTGTCTTGTCCCC TCCCCCTTTTTAATTAATTAGGGCCTGGCTGGACTCACATGCAGGCCGCTTTCTAAGAGCAGCAGTTACT TTGGCAGCATTCAGAAAGGGCCTCAGTTACTCTACCATGACAAATTTCTCAGTCTGTCACCGTTCACTTC CTAAAAGAAATTCATTGTAGAAGGTAGAATGGGATCTTCATGGCATTTCTGATTCACAATGCTCCTGAAA GTTCCTCGGCATGTGGAAAGGCCACAGATGAATTTAAGCATGTGAAAGAATACTCATGTCAGAGGCACAA AGGAAACTTGCCCCGAGTCCACGGTGCTCTGCGGTTAGGAGCTGGCCTCACTGTGCACAGGGGGAGGGGT GGTGAGCTTACCGGGCTTTAAAGCGCCCTTCCAACCTGTGAGCCCTGCATTCCTTACCCTTGGTTGGATT CTTCCCGGGCTGGGAGAAATGACCGCTTCTATGAGGAGACCATGTGCCGAGGTCGTGTGCTAGGAAGCCA GTTGCTGTGAGAAATGACCAGTGTCATGTCTGTCTTTCAGCCACCCTACATCATGTAGCAGTTCTTCTGA GATCATGTCTGTGCTGTTCTTCTACATCATGAGGTACAAGCAGTCAGATCCAGAGAATCCGGACAACGAC CGATTTGTCCTCGCAAAGGTATGCCGGTGGGGAGCCCAGGGCTGCTGTGGCGCCTGCTGGTTAAGCCCAG TTTGAACAGCCACCGTGTGGGAACAAGGCCTGAAATGGGCCTCGTTTATTATTTTGGTTCTTCTTTCTTT GCATCTTAAAGCTCGAGTGTTCTAGTGAGGGCCACTTGGAGCCCTGTGATGGCATGGTAGGAAGGGTGGC TTGGGAGAGCTGACTGTCCTTCCTTTCCTTTGGTCACACCCTGCCTCGCCCCACTTAGCACGAACGCTTC CCCCATGGCAGGGTTATGCTGCTCCCACCCTCTGTGCTGCCTGAGGAGAGGCAGGCAGCCTCAGTGAATC CCACTCACTGAGCCTGGGGGAACTTGAGTGTAACCGGGAGGGACATCCCACCCCTGTCAGTTAGCTTCCT CTTCTATGTTTCTGCACATCTGACCTGAAACTGATGGGCACTTCTCATGAGATTGGGCAAAATACCAGCC ACTTCATGAAGTATCATGGGTGATAGGAAAGAAAAAGAACCTTAAAAACAAGGTCAGTTTGAGAATGTGT GGCTGGTTTGATGCCATCTCAAAGTACACTGTGTCCCGAAGCAAATTAAAACCTGGCTAGGGGCCGGGTG CAGTGGCTCACGCCTGTACTCCCAGCACTTTGGGAGACTGAGGTGGGTGGATCACTGGAGGCCAGGAGTC CGAGACCAGCCTGGTCAACATAGCAAAACTCCGTCTCCACTTAAAAAAAAAAAAAATTAGCTAGGCATGG TAGCACATGCCTCTAATCCCAGCTTTTCGGGAGGCTGAGGCACAAGAATTGTTTGAAGCTGGGAGGCAGA GGTTACAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGCGATAGAGCAAGACTCCATCTCAAAAG AAAAATCTGGCTGGGTAGAGTACTGTGTCCAAATAGAAATGCCAGATTAGCACAGTGGGAAGTGAAGACA AAAACTGGGCATAGCTGAAGTAAGTGCCTAAAGGTCATAATTGTGACCCTTGTCTTGGTGTCTGAACCAT AACATCAAATGGTTTGGCAAAAAATAAATAGAATTTACATGTGTACGCGCATGTGTGGAGAGAGGGATGA AGTAAATGCCTTCCATTGCTTTCAGTTGGTTATTGGAGGTAAGCAGTATACAGGAAGGAAATCATTGTGC TAGGCTTTAAACATGTCTATAAACTTGAACTTTTTTTACATCTTTTTTTGTTCTTTTTTTGGGGAGGTAG AGTCTCGCTCTTGCCCAGGCTTGAGTGCAGTGGCTCGGTCTCAGCTCAATGCACCCCTGACCTCCTGGCC TCAAGCGATCTTCCCATTTCAGCCTCTTGAGTAGATGGCATTACAGGCATGTGCCACTACGACCGGCTAA TTTTTGTATTTTTTGTAGAGACATGGTCTCACTATGTTGCCCAGGCTGGCCTCAAACTCCTGGGCCCAAG CGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCAACAAGCCACCGCTTCCAGCCCTCTTTACAAT GAAAATTGAAAAAAAAATAGATATATAAACGCAATATGGGTGTTTAGATTTCTGGTTTAAAATAAGGAAA GGCTGGGTACAGTGGCTCACACCAGTGCTTTGGGGGCTCCAGCAGGAGGATCTCTTGAGACCAGCCTGGG CAACATAGCAAGACCCCAGTGTCTACAAAAAATACGAAAATTAGCTGGGCGTGGTGGTGCGTGCCTGCAG CTACTCAGGAGGCTAAGGTGGGAGGATCACTTGAGCCTTGGGAGATAGAGCAAGACCCTGTCTCAAAAAA AAAGAAAAATCTAGACTGTCATATAACAGCTGCTATCAGAGCCATTGGCCTTAGGGGATGAAGAGGCTTT CTATCGGGCAGCAGCACACCAGGCCCTGTTCGGCTGCCAGAATTTGTGTGTTCATCAGATTTAGCTGGCT GATGAAATTGGAACAAAAGAGAAAACACATGAAGCATAGTCCATTGTGGTTTGCCTGGGAACGGGGTAAA CAGCTATACTCCAGGCAGAGCAGATCTTTATTCTAGCCTTTCACCTCCCTGAATCGTCTGCCCCGCAGCA TAAGGGTTCTTGAGAAAGACAGCACCCATGTGGGAGCACTTCTGCCATAACGGGCATCATACTGATGCCT CACCATTTTCTCAATCTATCCTCACTTTATCCTTGACCTCCTGTCACCTAAGGGGGCTCTGGTCTCCATT GCACCCATAAAGTCTTTGAGATGGGCCCACTGGCCTCACACTTCACAGCCAGAGGGAAGCAGAGTTGGTC TGACTGCTGAGCCCAGGCTCGGTCCATTATGTTATAGGACTTCCAAGGGCATGCAAGGCGACTGGGAGCC AGAGCTTGTTACGTGAGTGTGGTGGGTGCCATAGGGAGGGAGATGTGGCTAGAGGCATAGTCAAAAGAGA CTTGAGTTGAGTGGGGCAGTTCTGCTGGGCTGGAAATGCAGAACCAAAAGGGAGTCTCTGGGGGGCACAA AGCATGCAGAGAATTCCGGGGAAGGTCAAGAGCAACCAGAGAGTAGCAGAGGGTAGGAAGCAAGAAGCAG GAGATCAGAGAATCGTAAATACCATCCATCCATCTACAGTAGTGATGACCTCGCTCATCTCTGCTCGAAT GGCGCTGACGTTTGAGCAGAGGAGGGTGACAGGCAGGAAACAAACTTTTAAGTCAATAGATGGAGTGTCA GGTGGGGCCAAGCATCTGGAATCAAGTAAAAGTGGAGGAGGTAGGAGGCACTGGTTGAAAAAGAGTGGTC CAGAAAGACCTCAGTGCTGACGCTTGAGCAGGGATTTGGAAGAGGCAGGAGAGTGAGCTGTGCCCACATC CACGCACAAGCACTCCGGTAGTGGGTGCCATGAGTGCTAAGGCCCTGAGGCAGGTGTATGCCCACTGTGT TCAAGGAGCAGCAAGGAGGCCAGGGTGCCAGAGCAGTGGAAGGGAGAAATGGAGGTGATGGGGGCTGGGG TGGGCAGACAGGTGCAAACAGTTGAGCTCTACTTGGTGGGAGGTCGGAAGACCTTAGAAAGTTGAGCGAT GTGATCAGTCAACTTCAGTTTTAACAGGCTCCCCCTTGTGGCTAGATTGAGAATGGCTGTGGGGGAGGCT GGGAGGCCACTGCAGTGACAGAGGCAAGGGATGTTTAAGACCAGGTCGAAATGGTGGCTGCAGAAGCTGT TGGGTAAATTCAGTATGCTTGCAAGTTGGGCCTCTCCAGTCAGTGCAGCAGCTCTTTGGCATGACCTTGT GGCCCACAGAGGGCCACATTTTCTGCTTGGGATAGTGATGACCCTGTGCCTGCAAACAGGATGTTGGGGG TGGGGTAGATGCTAGTAGAAAGGGATTCATTTCTAGCGTGGGCACTTCTAGATGAGCACGTGTAAGATCT CAGTTGACCTGAGTTTTATAAACCAGGGAACCAGAGTATTCTCTTTCTGGTTTCTGTTTTAAGAATCCAT ATCCTCCATAGGATTGAACATGTGATTTGTGCATGACCGGGAAGGGCCATGGGAAAATGTCAAGAATCAT ACTTTACGTTTTCTGCTTTGTACTTGGGCTCCCCGTCTCTATTCCCAAAGCTCCAGCCACCCTTGCCATA CTGTATGGATTACCTATGACTCCCTGGGCAGGGACAGTGGATGTCTTCGTCACCTTAGTCACCTGAGTTT CCAGCCCAGGCTGAGCCCTGGGCTTGACCCATTTTCCACTTGTAACGTTGATCGGAAGCTTGGGGTGCAT ATGGGTGTGGGGAAGAGGAATTCACCCAGCAGGGCGGGAGGGGCTGTTCGGATGGGACGCTGCTACAGAG CTGACAGGAGCAGCCTGCACTCAGTGCGTGAGTCCACCTGATACCATGTCCTGCAGCTGCGTCTGGGCTC ACTGGGTCCCTTCTCTTACAGAGACTGTCGTTTGTGGATGTGGCAACAGGATGGCTCGGACAAGGACTGG GAGTTGCATGTGGAATGGCATATACTGGCAAGTACTTCGACAGGGCCAGGTGAGGTTCTTCCCCAGAAGC CATTTAACTGCCCTACATCTACATCCCCTTCCTAGAGTCTCGGGGGGCAGCCACCTATCTCCGTGATGTG GAGAGCCCTGAAGGGCCAGTCCCCATCACATCCCGTGGTGACCCCTCTGGAAGGCCTTCCCTGTGCCTTT TCCCCACCTCGGGCGGCTGCCCCACTTTCTCTCCCACAGGTCTGTTGAAAGGTTTCAGCTGCTGTTGCCT TTCCATTCTTATCCTAGGGTTGATAGCTTTTTTAAAACTTCCAGCACTTTAGTGGGGTCTGGGATGTGTG GTTTGTTTTTGAGACTGAGTCTCACTCTGTGGCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGC AACCTCTGCCTCCCAGTTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGC ACCACCATGCCCAGCTAATTTTTGTATTTTTGGTAGAGATGGGGTTTCGCCATGTTGGCCAGGCTGGTTT CAAACTCCTGACCTCAGGTGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGATGTGAGCCAC TGTGCCTGGCCAGATGTGTTTTCTTGATGCGAACACTCACGTCGTTGGTTGTGGAGGAATTTACTTCACA GCAGAACACGTTTCCAAGGTGGGGTGTTTTGATTGTTGTGATTATTGTAAATAAGTTGTAAGAACAGAAC TAGCAGGTGGCGGCGGGAGGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGG ATCGCCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCGAAACCGCCTCTCTACTAAAAAATAC AAAAACTAGCTGGGCATGGTGGCGTGGGCCTGTAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGGTT GCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCTGGGTGATGGAAACTCTGCCTCAAACAAACAAACA AAAAAATTAGAAGGTGGCAATGCTTTAAAAGGGAACTTACCAGAAAAATGAATGTGTAAATGTTTGGGGA ACTTAAGGATGCTGCTTTCTTCCCCTTCCCCTCTGGCCCTGTTTGCTTATTGATAAGGAAATGTGGCAGA AGAACCTAAAAGTTGCTTTACAGCTAGAACAGAAAACTAGCCAGAGGTAAAGCCTGCTTGTGAGCCCCCA GGCTTTTCAAGCTCGGCTTTCTTAGCTGCTGGGCTGGGGCAGAGTTGATGAGGGAGATTGTGGGAAGCGA ATGGTCTGGAGCAGCAGCTCCAGTTGCGTCCGTTTCTCCTCCTGAAATGCATTTGTTTGGTTGGCCCAGA TGATCCCCCACAGGGTCCTAAACCTCTCTTGTCTTGCTCCAGCTACCGGGTGTTCTGCCTCATGAGTGAT GGCGAGTCCTCAGAAGGCTCTGTCTGGGAGGCAATGGCCTTTGCTTCCTACTACAGTCTGGACAATCTTG TGGCAATCTTTGATGTGAACCGCCTGGGACACAGTGGTGCATTGCCCGCCGAGCACTGCATAAACATCTA TCAGAGGCGCTGCGAAGCCTTTGGGTAACTGTATTCTCTTGTGCTTGATTTCCATTCTGTCCTGCCCCCT TCATCTCTTGTAACCCAGCCTGCTCCTCTGTTGGCAGGTGGAACACTTATGTGGTGGACGGCCGGGACGT GGAGGCACTGTGCCAGGTATTCTGGCAGGCTTCTCAGGTGAAGCACAAGCCCACTGCTGTGGTGGCCAAG ACCTTCAAGGGCCGGGGCACCCCAAGTAAGCAAGCACTTTCCTCCTGCTCCTGGTTGTTAAAAGCATCTG TCCGCTCAGCAGCAGAGGCGGGAGAGGCTTAGAGGGGCCTAGGCAGATGACTCATTTAGTGAATAGCAGT TCTGCCTGGAGTATATGTTGGAGGCTCCTGCTCTCTTATTTTCACTAGCTAGTGTCTGCTTAGGATAGGA GATATCAAAAGCCCTAGCAGGTGAACAGTGATGTGCTGCCTGCACAAGGGAGTGGCTAGGAGTACAGCCC ATCGGAGGACTGACAGGGAACAATCTCTACGGTTAGTAGAATCAGAAAGCGTGCTGTGTGTATGAGCAGG TGCAAGAAATAAGAGTGCATACCTACACACGTGCCTAGGCCCACACTCTTCTGGAAGAACCCTGGGAATT GGGGAAGACGGGAGCTTGGAATCACCAACTATCACATTTCAAGGCTGACAGCTGAAATTGTTTATCTCAG GTTTAACTCATCACAAAGAGTGCGGCTCCTGGATTTTTTTAAAAGACTATAGACATTTTAGAATAAAACT GTTCTGTGACTCCTACCGAAAATATAGTTTTACTCTGGTACCCTCCGTTCAGTAAATTATTTTACCAGTG TGCTCCTGGCAGGACCCTGGGTGTTGTCCTTGCCTCTGCCTCCCCCTCATATGCCCACACATAGACCCAG TCCCCTAGATTACATCTTGGACCCATTCACTCCTCCCCATCTCTACTACCATGACTGTTGCCACACCCAT CATCTCTCCCAAAGTTCCAGCTGGCCTCCCTCCACACCAGTCTCTACACTGCTGCCACAGTGATCTTTCT ACAGTGGATCTGATCAGTCACTTTCCCCACTCCAAACCCTTCAATGGTTTCCAATCTTGCTTTGGATAAA ACTCAAACTTCTCATACCCACAAGACCCACCCTCCATGGTCTGCCCTACCTGTCTCTCCAGCCTTATTCT CATTCTCCCTTCCACTCACCAGTGGCCCTCAGGGGCATAGCTAGGTGCAATGGCTTGCACCTGTAATCCC AGCTACTTAGGAGGCGGAGGCGGGAGGATCACTCGAGCCCGAGGAGTTGGAAGCTGTGGTGAGTTATGAT CACCCACTGCACTCCAGCTTGGGGAGGAGTCATAGCGTGAGACCCCTGTCTCAAAACAAAAAGCCTCAGG GCCTTTGTCCAAGCTGTTCTCTCTGGCTGCAGCAGCGTCCCAGGCCCTCTGTGCCAGGTGTTCCTCCTGT GAGTCCTAGGGTGACATCTTTTTCATCGGGGTCTGTTTTTCAGGTGACCTCATAGGCACTCACTAAATAT TTATGGAATGGATGTCTTTTGTTTGTTTCATTACAGGTATTGAGGATGCAGAAAGTTGGCATGCAAAGCC AATGCCGAGAGAAAGAGCAGATGCCATTATCAAATTAATTGAGAGCCAGATACAGACCAGCAGGAATCTT GACCCACAGCCCCCCATTGAGGACTCACCTGAAGTCAACATCACAGATGTAAGGATGACCTCTCCACCTG ATTACAGAGTTGGTGACAAGGTAGGCAGAAAGGTGGATAATTGAATAAATCAGATACGTCAACTGCTTTG TTCTCTAATGTTGTTCGTATGTACACAGGATTCTTCATTTATTCTGGTCTCCATGGACGAACCAATTACT AGAGTGACATGTAACTAACAGTTCGTAGGCAATAAAGAGAGGTTTGCCATTTTTAAAAAATACATTTAGG GGTCCAAAGTGCAGCTGTGTCACGTGGATAGATACTGTGTAGTGGTGAGGTCTGGGCTTTCAGTGCACCC AGCATCGGAGTAGTGGACATTGCACCCAGTAGGTACTTGATCTTTCACCACTCCTGGCTCCCCTTCTCTT TTATTAGGTCTGATTTTTATTTTTGGCTTTCACATGTGTGTCTGAATTTTCTGATTGGTCAATTGCTATT TATTAGCTCCTGGTGTGGTGTGCCTTTTTCTAGCTTCCTAACTTTGGTTTGTGCATGAAACTGCCACGAC TCTGTGTCTCCGCTAAGAAGACTGGCCCCAGGCGGGCTGACCTTTTGAACTTACTCTCTGAATTACACAG AGGAGCAGGCCAATTCATCAGAAACCTCAAAAAGGAATCAAATGATGCACAAAACTCTTGAGTATCAAGT CCTTTTGGTTTTTAGCACCTTTACATCCTGCCTTCTGGTATATCATAGCAGACCTGACATAGGCAAGTTC TTTATGGCCTAGAGGAAGTAAGGCGGCGAGCCTAGGGAGGAAGGACACACTTTCTGATCCTTCTTTATTT GGAGAAATTTTGAGTGTTGCTCATGTTTTCTTAGCCTGGTAATGAGGGTTAAAAATAAATGAATTTTGAA TACTTGAGAAATCAAAAGACAAAAACCAGAAGAAAGGAGACGGTATATCAACAAAGGGTGGGCCAGGCAC AGTGGCTCACTCCTGTAATCCCAGCACTATCAGGAGGCCAAGACAGGAAGACCACTTGAGCCCAGGAGTT CAACACTAGCCTGGGCAAAGTAGTGAGACCCCATCTCTACATAGAATTTAAAAATTATCCAGGCATGGTG CCATAATATGGTTCCAGGTACTCTGGAGGCTGAGGCAGGAGAATCACCTGAGTCCAGGAGTTTGAGGGGA TAGTGAGCTATGATTGGGCCACTGCACTCCAGCCTGGGCAACGGAGCGAGACTCTGTCTCAAAAAAAAAA AAAAAGTTTGAGAAAACTATATAACTCCATAGTTGCATAATTGGTATGAAAATGTGTAAAAAGCGGGGGG ACCATTTTTAGGAATACATAAAATATCAAAATTGACTAAAAGAGGTATAAAAACCTTAAATGGATCAATA GCCCTAGAAAAAAATGGAGAAAATTATCCAAGTGCTATACCCCCAAAGCACCAGGCTCACCAGGTTATAT AAGACTGACTCATTTTTAACCTTTATGAAAAGAGTAATTTCTAAACTGTTTCAAATTTTTCCAAATACGG AGGAAGATGAAAATGTCATCCCGATTTACTTATGAAGCGAAAATGTGACAAAGCTAGCCTAAAGAAAACT GCAGAGCAACTTTCTTTATGAATACCAATATAAAAATTCTAAATAGAACATTAGCCCATCTCAACTTCAT TAGTACATTAAAAAAATTAAATGAATCAGTGAGCTCAAATTAGTAATGCAGATGACTCATGCCAGGAGAT GTAGGAATAGAATTCAGTGTTCTAGTGTTAGGTTAAAGGAAGGAGGGAAGTGTGATCATCATCATACACA CTAAACAAAAGCAATTCATAAAACTCAACATTTTTTTTTTGAGATGGAGTCTCGCTCAGTCACCCAGGCT GGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCTGCCCCCGGATTCAAGCGATTCTCCTGCCTCAG CCTCCCAAGTAGCTAGGATTACAGGCTCCCGCCATCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGAC GGGGTTTCACCTTGTTAGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGGTCCACCTGCCTCAGCCTCC CAAAATGCTGGGATTACAGATGTGAGCCAGCACACCTGGCCAAGTAATTTGAAAAATATAATGAGAACCA TTAATGTCGGAAATCTCACTCTTGAGCTGTGGAGTGTTTACCTGCTTAGGAAGTGGGGGTTGGGGGAGCG GGGGATGTTAACTAAAAAGAGCACAATTTGAGAAAAACTTGGGTGCCACATCAGCCATTTAGTATGGATT TAAGATTGGCTAGCAGTCCATGTTTATGACATTAAAGGAAATTTTTGGTGAGTCACGAATTTACTTTCTT CAAGATAGATGATAATTTGTCATTCTACAATATGGTACCTTCCTTCTGTAGTCGTTCCTTCTAAATGCAT TTGAAGAAACTCTACCACCTGATTGTCTCTGTCTTCTAGATAGCTACTCGGAAAGCATGCGGTCTGGCTC TGGCTAAGCTGGGCTACGCGAACAACAGAGTCGTTGTGCTGGATGGTGACACCAGGTACTCTACTTTCTC TGAGATATTCAACAAGGAGTACCCTGAGCGCTTCATCGAGTGCTTTATGGCTGAACAAAACATGGTGAGT GTGTAGTGTCTCTCAGGGCTTCTTAGAATCAATGGCCCACTGGACACAGGAGGCCCAGCCTGTGCTAGTT TTTCTTTCCATTTATGAAAGCAAAAGGACTGGAAAAAAATTTCCTGGGAAGCAGGAGGCAAGTAGCCAGG TGGAGTCTGAGAGGTGGCTTCTAGGTCTGCTAGGAGGGCCGTAATAGACTACTCGGCACTTGGAGTCTCC AAGTTGGCTGAGGGCAGCAGGCCCAAGGCCACAGACAGTGGGTCCTCTGAGCCTCGAACCATCTGAACCC AGGGCTCTGGGCCTGAAGCATCCCAGGCTCCCTAGTAGCTCCTTCTGCCCAATTCTGCAACCACCCAGAG GCACACTGGCTGAGGAGTCACAGGGAATGCAGAGTTTCCTTCTCTCCACTGTAGAGGGGCCTAATATAGC ACAGAAATGCAAATGTTGCACTTACTTCAATCACAAGAATATCAATGCTTAGAGCTGGTGCCTTAGGCAA AGCCATTCTGCTTATCTATGCCTCAGTCTCTCCCCAGAGTGATATTAATGCAGGGAGTATCTCAAGCACA TGCACACAAGCGCACCCCTCTGGAGAGGAAGGAGTTATGGCCAGTAAACCCTTTGAACTCTAAAGCTCTG CGCGTCATAGAAGATGATGCCCAGCTCCTGTCATTAGGCCAGAAAACCACAGGCCAGCAGGTCTTATGTG ACCACCAGTGACTTTATTTATAACAAGTAGTATTTTTAAAAAAAATTTTTTTAGACGAAGTCTCGCTCTG TCGCCCAGGCTGGAGTGGAGTGCTCAGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGACATTCTCCTGC CTCAGCCTCCCAAGTAGCTAGGACTACAGGTGCCCACCACCACACCCGGCTAATTTTTTGTATTTTTTAG TAGAGACGGGGTTTCACTGTGTTAGCCAGAGTGGTCTCAATCTCCTGACCTCGTGATCCGTCCGCCTCGG CCTCCCAAAGTGCTGGGATTACAGACATGAGCCACCGCGCCCAGCCAGTATTTTAAATTTTTTAAAAATT AGTTGCCAGCATTTAAAAATCAGATTATAGGTGTAGTGGCACCAGCCTGCAGTCCCAGCTACTCGGGACT CTAAGGCAGGAGGATGCTTGATCCCAGGACTTAAACGCTGCAATGTACCACTGCATTCCAGCCTGTGAAA CAGCGAGACCCCATCTCAAAAAAGAAAAAGAATCAGGAGGTCTTATATAGAATACATATTTCTGGATTCT TTTGAAAAATGGGAAGAACTACTACCATAGGGTGGCATTCCCTCCTGACGCCAGTTGACTGAAGCCAAAC AGCACCCCTGTTGAGATGGGTGTCCCCACAGCTCCCCATGCTCTGCTGGGCCATTTGGGTTTTTTGTTGT TTTGTGGTTTTTGGTTTTTTTTTGGGGGTTTTTTTTTTTTGAGATGGAGTCTCTCTCTCTCTCTCACCGA GGCTGGAGTGCAGTGGCACGATCACAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCCCTTGC CTCAGCCTCGCAGGTAGCTGGGATTACAGACATGCGCCACCATGCCTGGCTAATTTTTGTGTTTTTAGTG GAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCCAACTCCTGACCTCAGGTGATCTGCCTGCCTCAG CCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCCCCGAGCCTGGCTCATTAAGCTGTTTTCATTTTGAAT AGAAAACAATGCGATCCGTAATTTTCTGGATTAATGCTCCTGTCAAAAATTTTGCTCCCCACCTCACTGA TTGCCTCAGCACGCAGCCATGTAGTCTACTCCGTCCCTGCTGATATGTTCTCACAGTTGGAAAAAAGTTG TAAAGAAAAGGCGAGCAGGTGGTATTTAGTGCCATGTTGAAAGAGGTGGCTACAATGTAGAGCTTGACCA GGGGCAGTCAGGGACAACCTCTCAGAAAAGGTGATACTTAAGCTGAGTCTCAGGTGACGAGGGGTCAGCC GTGTGCAGATGTGGGAGACAGCATTTCAAGCAAGGGGCATGGCCAACTGTAGGCAGGCCCAGGCTTGGAA TGTTTGGAGAGCAGAGGAAGGGCCAAGTGGTAGGAGCATGGTGAACGCAGAAAACTCTCCAGGGCCCAGG TCATACGGGGTCTTATAGGCGCCCTTTTCAGTATCTCTGGTTCTCTTGCAGTTTGCTGGGAAGCCACTGG AGGGCTTTAAGCAGGAAAGCAACAGCCTGCGTTTTCCAAAACTCTGAAGACTGGAGAATGGCTTCACGTA GGAAAGGGAGGAGAAGGAGAGGGTGACTTGGACCAGGGCAGTAGCTGTGGAGTCGGAGGGAAGCAGACTT GTCACATATTGCCTTGGCAGGAGAGCCAGCAGGATGCCAACGGCAGGTGTCAGGACAGGACCCAAGGCTG GTGCTTGAGTGTGGGTGGCAGCACCTGGGGGAAGGTGGTGTCACCTCTTGAGATTGACAAGACTGGGGGA GAAGTGGACTGGAGGGCACCATCAGGAGCTCTGTGTGGGCCTGGGGGGTTGGGGCACCTGTTAGATGTAC AGAGGGGAGACAGTGGTATCAGATGGCTGGGCAGTAGATCAGTCAGTCATTTTCACATGTGGCCGCTCCA CACCACTAAATGCAGTTTTCTAAACTACATATTCGTTGGCCTAGTTTTAAGCTAACATCTTTTTTTTATT TTTATTTTTTGTAGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAATGCAGTGGCACAATCATGGCTCC CTGCAGCCTCAAACTCCTGGGCTCAAGGGGTCCTCTGGCCTCGGCCTCTTGAGGAGCTGGGAGCCGCCAT GCTTGGCCACATCTACATTTTTAATCATAAATTTAAGTCGTTGCAAAGGATGTAGTTGTTCATATATTGA CATTTTTGATACTTTAATACTCAAATCATGCCATTAATGATGACACTGGCTGGGCATAGTGGCTCACACC TGTAATCCCGGCACTTTGGGAGGCTGAAGCTGGAGGATTGCTGGAGTTCAAGAGTTCGAGACCAGGCCGG GTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGACGGATCACGAGGTCAGGAGA TGGAGACCATCCTGGCTAACATGGTGAAACCCCTTCTCTACTAAAAATACAAAAAAAAAAAAAAATTAGC CGGGCGTGGTGGTGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCG GGAGGCAGAGCTTGCAGTGAGCTGAGATTGCGCCACTGCAGTCCAGCCTGGGCGACAGAGCGAGCCTCCG TCTCAAAAAAAAAAAAAAAAAAAAAAGTTCAAGACCAGCCTGAACAACATAGTGAGACCTGGTCTGTAAT TAAAAAAAAAAAATTCATGCCAAGCCACTTTTCTTTGTCAGAAATTAAAACCCTTTTTCTACTTGATTTC CAATTTCCATTCCATTCATTTCCCCAATATATCTTTATGCATGAAAGCCTTTTATTGATTGTCCTATCAT TTTTCTCTGCAACAAAAATATGCATATAAATTGATAGGTTTTTAAAAAATTATAATATAGGCTTCTGAGC ATTAGGTTTTTTTTTCTGGACTGAGATAGAATTTTGATTATTATTAGCTGGTATGTTAGTGGATGAGTAT ACTTGTAGTTTGAATGTGATAGCATTGAGAACAGATTCTATTCCTGTTTTTCATCTTCATGATGTGCTAT GAAACCTTACTTACATGAATAAGTAGATGGGAAGGGAAGTTTTGTTAGAGGAATGTCACTCAGTTCTTTG AATTCCTTCCCAGTTGTAAGTCAAAAAATCACATAGTGATCTTTCATGTAAAGTTGTTTATAAAAGTTAT TTACAGAGTTGACAGTTTCATTAATTAAGTTCTTCACTTTCTCTCCACCAGCATAGTTATTTCAAATTGT CCTCTTTACTTGGGTCTGGAGGTTCTGCACTCCAGGATGATCCCCCTGTAAGAGTCAGGTGGCTGAGAGC ATGCCCTTTGGGGATCAGGTTGCTAGAAGGTGATTGTTAAAAGAGACAGTGGGAGACCCAGGGGCAGTGG CTCACGCCCGTAATCCCAGAACTTTGGGAGGCCGGCCGAGGTGGGTGGATCACCTGTCAGTTCGAGACCA GCCTGACCAATATGGTGAAACCTCGTCCCTACTAAAAATACAAAAATTAGCCAGACGTGGTGGCGGGTGC CTGTAATCCCAGCTACTCGGGAGGCAGAGACAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTG AGCCAAGATTGCACCAGTGCACCCCAGCCTGGGCAACAGAGCAAGACCCTGTCTAAAAAAAAAAAAAAAG ACCATGAGGGGAGCACAGACCCTCCTTTTGGCAGATGAATGTAGACAGAGTTGATCTGGAGTTTGGGATC TTGAGTGTAACACCCACAGCCACATCCCCTTTGGAAAGCCTGTGTGTATCCGCAGAGAGGTTTGTATTCT AGTTTGAAGCCTTCTGGGGTATTTGAGCCCGGACTTCTGGGGAAGGGGGGTAAGGAATGGCAATGTAAAG TGGGGATCATTACCAGAATGCACATCAGGGGAGCATTGGGCCAGATGCGACTTCCCGAGGGTGCACAGGG CCCTGAGGACTTGCCCCAGCAGCGCCCATGAGGCGACAGCAGTGGGCCACTGCCACACTGCAGAAACCGA GAGGAGGAAATGCCTTGAGATCAGGGGCCAAGTCAAGTCACAGGCCACCCAAGGTCAGGCAGCCTCTTGG TTTTGTGGCTTCGAGGTCCCTTGTGGGGATGGTGGCCTAGATGAAGTAGGCTGGGAAGAGCGTGGAAAAT GAGAAAGCAGGGGCAATGACTATAGGCAAGTTTTGAGAAGTTTGCTGCGAAGGAGAACACAGATGTAAAA GCAGGACAAGGCGGAGATGGGGCTGTGAAGATAAAAGGTGCTGGCGCACACCTGAATGGAAATAGAATGA TCCAAGAGAAAGGGAAGTAGCACAAGAGGGGAGGAGGAGCTGCATGGCTGGAGACCCCTGTGAGAAAGCA GGAACAGGACAGATTCAGGATGTCCTGTCGGGGCATGGACCCTGGAAAGCTGCGGACACCAGGAGGGCAG GCAAGAGAGTCTCATCTCTTGCTCCCTAGGAGCTATGAGTTGAGGGCGCCGTCTGAGCAGGAGGGACGGA CGGGTGCCCAGGGTTTGAGGAAAGAGGGGTGTGGGAAGGACGCATGCTAGAACTTCAGAGCAGTTCAGCA GGTGCAGAATGGGAGTTATCATGGGGACTGTGGGAGAAGGGGCGGTGGGGGCAATGCCCAGGGATGTTCT GATTCATGTTCTCTGTGCTGCAGGTGAGCGTGGCTCTGGGCTGTGCCTCCCGTGGACGGACCATTGCTTT TGCTAGCACCTTTGCTGCCTTTCTGACTCGAGCATTTGATCACATCCGGATAGGAGGCCTCGCTGAGAGC AACATCAACATTATTGGTTCCCACTGTGGGGTATCTGTTGGTAAGGGTTCTAAATGCCATCATCTTGGTA GCCTTCCTCCTTCACAGAGAAAGATTAGCATGTGATTGGTTAAACCACGAATTTCCTTATGGTTCCATGA AGTTTGATTATTCAAGCCTTTTTCTTGAAAAAGCCATATTGTACTTTAAAAGTGTCAGACTCTCAGGGCA ACTTTTGAAGTGCATCTCTCGGTGGTACTGTTGTTTCAGACAGTGAGAAACAGTTGCTTATCCCGAGTGC CCCTTGTGTGTTGAGCTGCGTGCAGGTTATGGACAGGACTGGCAGAGTCATGGAGCCTTTTCTGCCCTCG CTGTGGTTGCAGTCTAACTGAGGGTGAACAGCATCACAGAGGACGAGGAGCATTCTGGCTGGCTGCACAG CCTGCTCAGGTGGGAGGGGGGCTGGGACCACCATCACCACCTTCCTGCCTGGGGCAGCGAGAACCCTGGA GCGTGACACGAGGCAGGAACTCTTACAAACACACCCTTCTCAGAGTAGTAGTCACCTGGCAGGTGGGCTA GAAGGAAACCACAGGAAACGGGAAGCCAGAGAGGGGATTGAAACAAGGTGTGCAAGGTGGTGGGGGAGAA AACCAGGGGGGTGGGGGGGGACCTGAGAGTGAAGAAAGAGGTGAGTGTGCCTAACAGATGGAGCACTCTG CAATGGCGTGAAGAGCAAAACACACGAGTCTCCGGGATTCCTCACTTGGGAAACGTCAGAGAGTCATTTT CGTGAATGACAGAAATGACATGGGAAAGATGAGCCAGCTGGCGTGCCTGTGGCAGGCAGATGGGCTTACT AGATGTGGCTGCACACACTTGCTTCTAGAATGCCAGAGATGCACGCTGGAAAGCCATCTCAGGGACTCCC TGGGAGAATGAGGCTGGACGAGATGGCTCTAGATGGAGCTAGAGTCACGGCTGTCTGGGTGAAGCTGGAG GCACAGGTGGTGGCCAGAGAGAGGAGGCGCGGCAGTGTTGCAGGGGCAGAGGGGCCTAGGAAAGGGTCCT TGAGCCCACCTGTGGCTGTGCTCAGTTTCAGTTTTGAAATAGTCACATGGAGAAAGTGACTCTAGGTTCC ATCCAAAGAAGAACTGGAAGGCTGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTGGTGAAACCCCA TCTCTACTGAAAATAGAAAAATTAGCCAGGTGTGGTGGCACGCACCTGTATTCCAGCTACTCAGGACGCT GAGACAGGAGAATTGCTTGAACCCAGGAGGCAGAGGCTGCAGTGAGCCAAGATCACACCACTGCACTCCA GCCTGGCGACAGAGAGAGGCTTTGTCAAAAAAAAAAAAAAAAAAAAAAGCCAGAGCGGTGGCTCACACCT GTAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCATCTGTGGTCAGGAGTTTGAGACCAGCCTGAC CAATATGGTGAAACCCCATCTCTACTAAAAATACAAAACTTAGCCAGACATGTTGGCACATGACTGTAAT CCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTAGAGGCTGCGGTGAGCCAAG ATGACCTAGTGCGCTCAAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAATAATAATAGTTAATTTTTT TAAAAAAAGAGCTGGGCTGTTGAGGTTAGACAGTGGTCCTAGGCAAGGCAGTGTGCATGGTGACAATCCC CTTCCTAGCTGAGAAAAGCTAAGCTGCCCAGTGCACATTAAGATTTCTCTTTCACATTTCTGGTGAGAAA CTACGTTCCCAGATACACCCTAAAGTACCCTGTAGCACCCTCAGCATGCTTTGAAGGTGTGTTAACTACT TGGAAGGCCTGGAGAAATGAAAAAGACCACTTTGGTATGCAAAACCCGGTCTCTGGATATAGAAAAGATA GAGCAGAAAAGGGAGAACAAAGCCTGAGGACCTTCCTAAAGAGAACGGGTTCAGAGACTTAGCAGGCCAA ACTCAGGCCACCAATGCTCAGCCATCGTGGACAGTAACTTGGAGTGATCCATCTGAAAAGTCAGCTGAGA CTTTTCAGTTGACTAACCCGAGGTGTCACAGTGTGATCTCAAGGGAGACAGGCGTGCAAGAACACAATGT AAATGAGTTGTGAGGATGCAGCGGGACCATTTATGGGGCTCTGCTACAGCTCGGGACACCCCGTGGCAAT AGGAATAATTGCTTCTTCAGAGCTAGAAGTGGGTGGAGGGCAGGTTCCTAATGGGGTTATGCTCCTGTTT TCATCGGGCTCTGGTTCTCTCAGGTGACGATGGTGCTTCCCAGATGGCCCTGGAGGATATAGCCATGTTC CGAACCATTCCCAAGTGCACGATCTTCTACCCAACTGATGCCGTCTCCACGGAGCATGCTGTTGCTCTGG CAGCCAATGCCAAGGTATTTTTAAGGGGACACTAGTTTCAGACAGAAAATGCTTCTGGACTCTGCTAGTT TCATACTGATGATTGGACTTTTTTTTCTCAACATAAAAGTGATATTCATTATAGAAAATTTGGTGATAGA ATTCTTTACAAAAAAAACAGGAGATTATGCACACAAACACATTTGCCTTGTAAAAGAGTCCAACAGTACA GGATACTGAACAAAACCTGACAGCCTGTCTCAGTCAGGGTTTAGCAGAAGAAACAGGGACCATTCTGGGT GTTGTAAACAGGAGAAGGTGTTTAACAAAGGGTGCTTAAGAAGCCGCAGGAGCAAGCTTCAGGCAGAGTC CCAGACTATAGTGTTAGTCTCCAGTGGCTGCAGCCAGAGGCCAAGAAGCTCCTGCTGTGTCCTGACATCC AGGAAGCTGGAGAGCGGGTGGTAGGCTACCACTACAAACGAACCCGGGTTCCCTGGCCCTGGCTTGCCTT TGGAACAGCTTAGGGCGCCAAGAGTGTGTGGGACCTCATGCAAGGGCATCAGATGGACAGAATCAAATTC CTGTTCAGAACCTAGCTGCACGGGAGACGAGGCAGTGTGGTCTTGATCTTTCCAGCCTTTCCCACTAACG TTCAGCAGGTTTCCCTTGCCACCCTGGACCTCGCCCATGCGCCACACAGGTAACCCCTGGCACAGTCGGG ATGGGGACTGTATGTTCCCTTTCCAAGCACTCATGGGCGTTTCTTTGATTTTTTTTTTTATAAGTGGGCT CCCGCTTTACATATTATTAGGTACTTTTTTGTGTGGTTTTTGTGTTTTGTTTTTTGGGTTTTTTTTCTTT GGAGACAGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAGCCTCCG CCTCCCAGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGCGACTAGAGGTGCACTCCACCACGGCCGGCTA ATTTTTGTATTTTTGGGGAGAGACAGGGTTTCGCCATGTTGGCCAGGCTAGTCGCAAAACTCCTGGCCTC AAGTGATCCACCCACCTTGGCCTCCCAAAGTGCAGGGATTATAGGCATGAGCCACCGCACCTGGCCAATT GTGTACTTTTAAAATTAGTTTATCTTGGAGATTGTTCTGTGATTTCACACGTTATAGGGTTTCATTTCTA GAAAGGTCAAGAGAGGCGCAAAACAAGATTAGGTGATAGAAATTAGAGTAGAGGTTGCTTCATAGTGGGG GGAGACTGACTGGAAGGAGGCACAAGGGAACTCTGCTGGCGGAAGCGCTGCTGGGCTTGGATGAGGGCTC CACGGCGGATGCAGCATTCAGGAAGGGCTGAACTTAGGATGTATGCATTTCACTGCAGCTGAGTTATGCC TCGGTGAAGACACTGAATAAAGATGGATCATAGCGTATGAACGAACAGTAGCGACGTTTCTTGCTATATT CGTTTATAATGCATCCATTAATATGTATGTAAATTAACAAATACTTTAGACATACAAGTGTTCATTTATA CTGGTAAATGTTTATGTGCTCAAATTGGTCATAAAAATGTATTTACATTTTATTGGGAAAGGGGCCAGTC GTCTTGTATTCAGATAGATGTTTATGGTCTTTCTAAGGATGAAGCATTACAAGTTATTGTGGCAAAAGTT AATGTTTTAACATTCTATTCGGGCTTTCTAGTCAATGTGAGTCAGTGCTCCTGCCGTGAGTTAATGTTCT GTCTGCACAGAACAAGTCAGTGAGTATTGGGGAATCTTCCAAGGGGATTGGTGTGATGGCATGGGGGAGC TTGTCCTTCAGGGCAGCCCCAAGGTCCTGCTGGGACCTGTCGTCCACTGGTTGTAGATGCTCACCCCTTT CTCCAAAGCCTGTGTTTTTAGTAGAAAGAGCTGTCCTCTTCACACCCCTCCTTCACTTCTTTCAACGTCT GTTGTTGGAAATTCATTGTTTGCTTTTCTAAACCATGGCTCCATTTATGCCCTAGGGGATGTGCTTCATT CGGACCACCCGACCAGAAACTATGGTTATTTACACCCCACAAGAACGCTTTGAGATCGGACAGGCCAAGG TAAGGGCTTACGCGCTCCTGCGTTATTCAGTATCATCTCCTGTAAAAAGAACACTTCTGAATCTATCACC AGCTATCTTCAGAGTTGAGACATCATCCTTTCTTTGCTCTCATTTTTTTAAAAAACAGTTGTGACCTTTA CCTGCTTTTCCTTGGGAAGGAACATTCTATGAATTTCAGCTTAGCCTGAACTTTTCTGCTTTCCAAATGG AGTCTTTTGTTGTTGTTGAGTTCAAAGATAGTAACATGAAGCCACTTGAGCGGTCGTGGCTATAATTTAT CTTGGCCGCAAGCTAAACAAAACAGAAGCCAGCGCTTTGGGAGGCCAAGGCGGGAAGATTGCTTGAGGCC AGGAATTCCAGAGCAGCCTGGGAAACATAGCGAGATTCCCATCTTTACAAAAATTTTTTAAACTAGCCGG GTGTGGTGGCATCCACCTGTGGTCTCAGCTACTCAGGAGGCTGAGGAAGGAGGATAGAGGAGCGCAGGAA TTCAAGGCAGCAGTGAGCTATGATGGATCACACCACTGTACTCCAGCCTGGGTGACAAGAGTAAGACCCT ATCTCTAAAAACAAGACAAAAAATAATAGAAATCACTTGAAATGAATAATCTGTTAGGTTCAGATTTTAC AGATCTAAGGCCAGGAATAAAAGGGAACATGATCTCTGGTATTCTCACAAAAGCCCTGAGAAGTTCAGAT TATCAGTCCTATCTGTAGATGAGGATTGGAGAAAGTAAGTGTCTTACTTAAGGGTTTACAGCTTGTGAGT ACCAAGACCAGAATCCAGGCCTGAGTAGTGAGCCCAGTCTCCCCAGGTCTGCCCACCACGCTGACCATCC CCTGCTCAGCCTGCCTGTCAGGGCCATGCATAGAGAAAAGCAGAAACGTCTATGGAGAAAATAAGTGACT CTGCTCATCACCTAGGGAGTGGGGCTTGTAGACATTTTGGCATGCTTCCTTCCTGTCTTTGTTCTAGGCA TACATGTATATTTTACACAGTTGAGATCATACTGAATAGAAAGGTTTGCCCATAGCCACTCTTGAAAGAG CAGCAGGTAACATCCAATTTGGTTGCTAAGGACTAGGCTGCTCCAGAATTCACAGTTGCAAGTACTCAGA ATGGCCAGAGTGCTGCCATAAAGCAGGTGTTTCCAGAACTGTCCACTGTGTGCCATAACGTAGCTGGAAA ACGCCACCAAATGGAAAAGTTAGTGTTCACCTTTGGTGTTAACTACAGGTTCTGTTTCTATGGGGAGGGT CTCTTGACATTCACATGGTTTGCAGAGCTTGCTTATTTCTGTCGTCTCTTTTCTAATAATTTTCCTGTCC TGACAAAAGCAAGTAAATTTACTGATAGTAAAGGATGTGAGATAAATGTGTGTGATAACATGCATGGCAT GGATCGTTAAAGGGCTGGGCTTTGAAAAGAGGACATGGATATGTGTGCATGCGTGTATAAGTATTTTAAG AGGCCAGGACATCCTTAAAGAATGGGGTGGCTCAGAAACCCTTTCTGTACTATCAGCAATGGTTCTTAAG CTACAGGGAAACCTATACAGAGGGGAAGTGGAGAATAATTCCAGATGCCTCCGATGGGTAGCTTTGGAGG CAACAATCTATGAAAGAAGCCCAGGAACTCTGTCTTTGCTTGCAGAATAGTACGTTGTCGAGAGCGAGGG CTTTGATGTCAGCCCCGCCTGGCTGTGGGTCCCAGCCCTGCCCTGGGCCACTTCCTCCTGCTCTGAGATT TGCTTTCCTCAGCTGCAGAACGGTTGTGCCACTGAACAGATCTTACAGGGAGGCTGTGAGGGTTCTCAGA GTTCAGGCACACAAGATCTTAGCACTCAGCGTGTTGCCAATGCCCAGAATGTTCTCATTAACATGTTAGT CACTGGAGTCCAATCTTTGCATGCCATAGTGAGCTCTCAAACCAGACTCCTGATGGGTATGTGGCGTATC CATGCTCCAGGACAGCTGGAGCAGTGTAATTTCCTATCAAAAAGTATGTGTCCTGGCTTGTAAATGCATC TGATTTTTTTAGTAGTGAGTTATTAAGGAGTGAAATTGTTAGAATTGGGGGATAGCGGCATAGCAAAGTG CCTTCCACTTTGACATGCATTCTGTGTGTAGTAACCACGGCATTCTGTTTTGCTGGCACTATACCAGGTC CTCCGCCACTGTGTCAGTGACAAGGTCACAGTTATTGGAGCTGGAATTACTGTGTATGAAGCCTTAGCAG CTGCTGATGAGCTTTCGAAACAAGGTCAGTTGGTTGAGTATGAGCATTGAAGTTCAAGCTGGGAAGAGGT AGGACTTCAGCTACCTCCTGTGCCCTGAGTGCTCTTTTTATTTTTATCCCTGCATGTTATTCTGAGTCTC TTTCTTGTACCAAGCTGGTTTTTGCTGTTCTGCAGATATTTTTATCCGTGTCATCGACCTGTTTACCATT AAACCTCTGGATGTCGCCACCATCGTCTCCAGTGCAAAAGCCACAGAGGGCCGGATCATTACAGTGGAGG ATCACTACCCGCAAGGTGTGTGTGGGCATTGAGAATGCTTTGGAAGGTTTTGGTGTTTTTGTTTCCTTGA TTGGCCACATGGCATGCTCTCAGGCATCACCTATAGTCTACCTCTCACCCAGCATGGCTTTGTTATTTGA TGTTCACTAAGCGTGGGGCCATACTCATACACATCTGTGTGTCCCCAACAGAGTGCACAGTGCCCAGTCA CCAGGGCGGGTCAGTGGCAACACAGAGGAGTGGCTATTGCAGGCAAGCGAGGTGTCATGAAAAGCATCGC AGTTTCTTTGGGTTTGGAATGATGAATAGTATGCCCCAGGCCAGGCGTGGTGGCTTACACCTGTCATCCC AGCACTTTGGGAGGCCGAGGCAGGTAGAGATCACTTGAGGCCAGAAGCTCAAGACCAGCCTGGTCAACAT GGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAGTCCCAGC TACTTGGGAGGTTGAGGCAGGAGAATCACTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCAGGATCATA CCATTGCACTCCAGCTTGGGAAACAGAGTGAGACTCTGCCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAGTGTGCCCCGACGAAAGCAGGTATAGCAGAGAACACAGCAAATGCAGAAAA CAGTGTGTCAGGGAGAATGGGCTGGGCAGTGTTTGCGCCTGGAAAGGTTAGGTGGGACAGATGATGTGAT ACAAGGAGCATTGAGTGTTCATGCGGCAGGGGCCCTCTGAGCCTGCACAAGCGGTGCCTGATCTCTCGAA GGACTCCTGGGACCCAGCACACAGTTGCTCTCACACCTGAGGTTGATGACAGGGAAAGGGTGCAGGGGGG GATCCACCAGGGCAGGAACCATGGGCCAGGTGGAGTTGAAAGAAGTCCTGCCCCAGCCTCCCCTTGGCCC CACAAGGGGCATACTGAGAAGTGCCTCCCACGCAGGCTGTGTTCCTGCCTAAGGGATGCCTGCTAGAGAC TTGGCACCTCAAGTGTGTACTGGGGGCAGGTCCTGTTGGCACCCTCTGCCAGGCAGGTACCCAAATCCCT GGCTCCCAGCAGGAAAGCAGGTGCTCATGTCAACCACATTGTTCCTACAGACAGTCCAGGTGCATGACCG CCCTGTCTAGTGGGGAAAGTGTTAGAGTAGCAAGGGAACCTTCACGAGCCAAGAGCTAACCTTGCCAACC AACAGCCTCAAGCCAGCTAGTCACTTTTCTGCACTGTTAATTCATTAGTTCTAACCATTTTCAGGTCCCC AACAGCTTTGAGAATCAGAGTGCCACAGACCCCCACACTCAGGCAGCCCTTACTGTAGGTTGAGGCAGAG CAGTTTGGAAACTGGCAGTTTAGAATGAGAACTCCGCAGGCCCATCGGAGTGGCTGTTCACATGAATCAG ATTTTCCCCTGGGAAGCTGCAGATTCAAAGGCCTCTATGTGGTGAGGCTTTAAGGCTGACGAGCTGCTTT CACAAAAGGGCCTAACATCCTTGTTTCCCCAGGTGGCATCGGGGAAGCTGTCTGCGCAGCCGTCTCCATG GATCCTGACATTCAGGTTCATTCGCTGGCAGTGTCGGGAGTGCCCCAGAGTGGGAAGTCCGAGGAATTGC TGGATATGTATGGAATTAGTGCCAGACATATCATAGTGGCCGTGAAATGCATGTTGCTGAACTAAAATAG CTGTTAGCTTTGGTCTTTTGGCCTCTTTACCCTGTGTTTATGTTTGTTCCAAAACCATCATTTAAATCTC TACTGTCACATTTTGTTTCTTAAAAGCAAAGCCAGCTAACACCTTCATTCATCCCTAGTTCGGAAATTCA AGCTAACTACTTACCCTTTAAACTGTCACTGCATATGCAAGTACCGCTCTAATTTTTGGATCATTAAAGG GAGTTACACAACTTTTAAGTGAAAAAAATAGGTAACAAAACAACCACCTGATAGTAAGTTTTCTGATAAG ACTATAGATAAGTGGTAGAGGTAATCAATTCTTCCGAAGTGTTTCCTTCGTGAATAACTGGTAGAGGTAA TAGTTTTTTCAATGTATTTCCTTCATGAGTAAAGAAAATGTGGATTGAAGTATAGATTCCAGTAGCCTAG TTTCCACAGCACGATAACACCATGACGCCTACTGCTGTTCCCACCTTGGGATTCTGTGTGCTGCCATCCC ACCTGCAGCTGCCCTGGAATTCCCTTCGCTGTTTGCCTTCATCTCCCTCCACGTTTGAGAGGCTGTCAGG CAGCAGCGAAAGCTTGTTAGGATGTCCTGTGCTGCTTGTGATGAGAGCCTCCACACTGTACTGTTCAAGT CAATGTTAATAAAGCATTTCAAAACCAGCTGCTTTATTCA Download Select all
Length	34690
OMIM ID	300044
HGNC ID	HGNC:11835
Unigene ID	Hs.102866
Ensembl ID	ENSG00000007350
PharmGKB ID	-

mRNA Information

mRNA ID	NM_012253.3
Exon	join(1..320,9631..9748,13672..13769,15163..15354, 15438..15565,16907..17100,19500..19664,25084..25240, 27534..27664,29666..29749,31918..32014,32166..32285, 33843..34690)
mRNA Sequence	>8277 TCCCTTGACTTGCTTGCGGAGGGAGCGGCCGGCGGAGGGAGCGGCAGGTGGAGGGAGTGGCACG AGGCATGCGGAGGGAGCTGCACCGACATCACATAAACGCACTGGGCAGCTCGCAGGCGCCATTC GCTCTTCAGACGCCGGAGACGTAGGAGTGGGTCTTCAGACTCCAAAGGGGTTGGACTAATGGCG GATGCTGAGGCGAGGGCTGAGTTCCCGGAGGAGGCCAGACCTGACAGGGGCACCTTGCAGGTGT TGCAAGATATGGCCAGCCGCTTGCGAATCCATTCCATCAGGGCCACATGCTCCACGAGCTCCGG CAGTTCTTCTGAGATCATGTCTGTGCTGTTCTTCTACATCATGAGGTACAAGCAGTCAGATCCA GAGAATCCGGACAACGACCGATTTGTCCTCGCAAAGAGACTGTCGTTTGTGGATGTGGCAACAG GATGGCTCGGACAAGGACTGGGAGTTGCATGTGGAATGGCATATACTGGCAAGTACTTCGACAG GGCCAGCTACCGGGTGTTCTGCCTCATGAGTGATGGCGAGTCCTCAGAAGGCTCTGTCTGGGAG GCAATGGCCTTTGCTTCCTACTACAGTCTGGACAATCTTGTGGCAATCTTTGATGTGAACCGCC TGGGACACAGTGGTGCATTGCCCGCCGAGCACTGCATAAACATCTATCAGAGGCGCTGCGAAGC CTTTGGGTGGAACACTTATGTGGTGGACGGCCGGGACGTGGAGGCACTGTGCCAGGTATTCTGG CAGGCTTCTCAGGTGAAGCACAAGCCCACTGCTGTGGTGGCCAAGACCTTCAAGGGCCGGGGCA CCCCAAGTATTGAGGATGCAGAAAGTTGGCATGCAAAGCCAATGCCGAGAGAAAGAGCAGATGC CATTATCAAATTAATTGAGAGCCAGATACAGACCAGCAGGAATCTTGACCCACAGCCCCCCATT GAGGACTCACCTGAAGTCAACATCACAGATGTAAGGATGACCTCTCCACCTGATTACAGAGTTG GTGACAAGATAGCTACTCGGAAAGCATGCGGTCTGGCTCTGGCTAAGCTGGGCTACGCGAACAA CAGAGTCGTTGTGCTGGATGGTGACACCAGGTACTCTACTTTCTCTGAGATATTCAACAAGGAG TACCCTGAGCGCTTCATCGAGTGCTTTATGGCTGAACAAAACATGGTGAGCGTGGCTCTGGGCT GTGCCTCCCGTGGACGGACCATTGCTTTTGCTAGCACCTTTGCTGCCTTTCTGACTCGAGCATT TGATCACATCCGGATAGGAGGCCTCGCTGAGAGCAACATCAACATTATTGGTTCCCACTGTGGG GTATCTGTTGGTGACGATGGTGCTTCCCAGATGGCCCTGGAGGATATAGCCATGTTCCGAACCA TTCCCAAGTGCACGATCTTCTACCCAACTGATGCCGTCTCCACGGAGCATGCTGTTGCTCTGGC AGCCAATGCCAAGGGGATGTGCTTCATTCGGACCACCCGACCAGAAACTATGGTTATTTACACC CCACAAGAACGCTTTGAGATCGGACAGGCCAAGGTCCTCCGCCACTGTGTCAGTGACAAGGTCA CAGTTATTGGAGCTGGAATTACTGTGTATGAAGCCTTAGCAGCTGCTGATGAGCTTTCGAAACA AGATATTTTTATCCGTGTCATCGACCTGTTTACCATTAAACCTCTGGATGTCGCCACCATCGTC TCCAGTGCAAAAGCCACAGAGGGCCGGATCATTACAGTGGAGGATCACTACCCGCAAGGTGGCA TCGGGGAAGCTGTCTGCGCAGCCGTCTCCATGGATCCTGACATTCAGGTTCATTCGCTGGCAGT GTCGGGAGTGCCCCAGAGTGGGAAGTCCGAGGAATTGCTGGATATGTATGGAATTAGTGCCAGA CATATCATAGTGGCCGTGAAATGCATGTTGCTGAACTAAAATAGCTGTTAGCTTTGGTCTTTTG GCCTCTTTACCCTGTGTTTATGTTTGTTCCAAAACCATCATTTAAATCTCTACTGTCACATTTT GTTTCTTAAAAGCAAAGCCAGCTAACACCTTCATTCATCCCTAGTTCGGAAATTCAAGCTAACT ACTTACCCTTTAAACTGTCACTGCATATGCAAGTACCGCTCTAATTTTTGGATCATTAAAGGGA GTTACACAACTTTTAAGTGAAAAAAATAGGTAACAAAACAACCACCTGATAGTAAGTTTTCTGA TAAGACTATAGATAAGTGGTAGAGGTAATCAATTCTTCCGAAGTGTTTCCTTCGTGAATAACTG GTAGAGGTAATAGTTTTTTCAATGTATTTCCTTCATGAGTAAAGAAAATGTGGATTGAAGTATA GATTCCAGTAGCCTAGTTTCCACAGCACGATAACACCATGACGCCTACTGCTGTTCCCACCTTG GGATTCTGTGTGCTGCCATCCCACCTGCAGCTGCCCTGGAATTCCCTTCGCTGTTTGCCTTCAT CTCCCTCCACGTTTGAGAGGCTGTCAGGCAGCAGCGAAAGCTTGTTAGGATGTCCTGTGCTGCT TGTGATGAGAGCCTCCACACTGTACTGTTCAAGTCAATGTTAATAAAGCATTTCAAAACCAGCT GCTTTATTCA Download Select all
Length	2634

CDS Information

Location	join(187..320,9631..9748,13672..13769,15163..15354, 15438..15565,16907..17100,19500..19664,25084..25240, 27534..27664,29666..29749,31918..32014,32166..32285, 33843..34015)
CDS Sequence	>lcl\|NM_001145933.1_cds_NP_001139405.1_1 [gene=TKTL1] [protein=transketolase-like protein 1 isoform b] [protein_id=NP_001139405.1] [location=187..1959] ATGGCGGATGCTGAGGCGAGGGCTGAGTTCCCGGAGGAGGCCAGACCTGACAGGGGCACCTTGCAGGTGT TGCAAGATATGGCCAGCCGCTTGCGAATCCATTCCATCAGGGCCACATGCTCCACGAGCTCCGGCAGTTC TTCTGAGATCATGTCTGTGCTGTTCTTCTACATCATGAGGTACAAGCAGTCAGATCCAGAGAATCCGGAC AACGACCGATTTGTCCTCGCAAAGAGACTGTCGTTTGTGGATGTGGCAACAGGATGGCTCGGACAAGGAC TGGGAGTTGCATGTGGAATGGCATATACTGGCAAGTACTTCGACAGGGCCAGCTACCGGGTGTTCTGCCT CATGAGTGATGGCGAGTCCTCAGAAGGCTCTGTCTGGGAGGCAATGGCCTTTGCTTCCTACTACAGTCTG GACAATCTTGTGGCAATCTTTGATGTGAACCGCCTGGGACACAGTGGTGCATTGCCCGCCGAGCACTGCA TAAACATCTATCAGAGGCGCTGCGAAGCCTTTGGGTGGAACACTTATGTGGTGGACGGCCGGGACGTGGA GGCACTGTGCCAGGTATTCTGGCAGGCTTCTCAGGTGAAGCACAAGCCCACTGCTGTGGTGGCCAAGACC TTCAAGGGCCGGGGCACCCCAAGTATTGAGGATGCAGAAAGTTGGCATGCAAAGCCAATGCCGAGAGAAA GAGCAGATGCCATTATCAAATTAATTGAGAGCCAGATACAGACCAGCAGGAATCTTGACCCACAGCCCCC CATTGAGGACTCACCTGAAGTCAACATCACAGATGTAAGGATGACCTCTCCACCTGATTACAGAGTTGGT GACAAGATAGCTACTCGGAAAGCATGCGGTCTGGCTCTGGCTAAGCTGGGCTACGCGAACAACAGAGTCG TTGTGCTGGATGGTGACACCAGGTACTCTACTTTCTCTGAGATATTCAACAAGGAGTACCCTGAGCGCTT CATCGAGTGCTTTATGGCTGAACAAAACATGGTGAGCGTGGCTCTGGGCTGTGCCTCCCGTGGACGGACC ATTGCTTTTGCTAGCACCTTTGCTGCCTTTCTGACTCGAGCATTTGATCACATCCGGATAGGAGGCCTCG CTGAGAGCAACATCAACATTATTGGTTCCCACTGTGGGGTATCTGTTGGTGACGATGGTGCTTCCCAGAT GGCCCTGGAGGATATAGCCATGTTCCGAACCATTCCCAAGTGCACGATCTTCTACCCAACTGATGCCGTC TCCACGGAGCATGCTGTTGCTCTGGCAGCCAATGCCAAGGGGATGTGCTTCATTCGGACCACCCGACCAG AAACTATGGTTATTTACACCCCACAAGAACGCTTTGAGATCGGACAGGCCAAGGTCCTCCGCCACTGTGT CAGTGACAAGGTCACAGTTATTGGAGCTGGAATTACTGTGTATGAAGCCTTAGCAGCTGCTGATGAGCTT TCGAAACAAGATATTTTTATCCGTGTCATCGACCTGTTTACCATTAAACCTCTGGATGTCGCCACCATCG TCTCCAGTGCAAAAGCCACAGAGGGCCGGATCATTACAGTGGAGGATCACTACCCGCAAGGTGGCATCGG GGAAGCTGTCTGCGCAGCCGTCTCCATGGATCCTGACATTCAGGTTCATTCGCTGGCAGTGTCGGGAGTG CCCCAGAGTGGGAAGTCCGAGGAATTGCTGGATATGTATGGAATTAGTGCCAGACATATCATAGTGGCCG TGAAATGCATGTTGCTGAACTAA Download Select all
CCDS ID	CCDS35448.1

Protein Information

Protein ID	NP_001139406.1
Protein Name	transketolase-like 1
Molecular Wt. (Da)	59172
Protein Sequence	>8277 MSVLFFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRV FCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAFGWNT YVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRERADAIIKLI ESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALAKLGYANNRVVVL DGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFASTFAAFLTRAFDHIRI GGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEHAVALAANAKG MCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAAADELSKQDIFIR VIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQVHSLAVSGVPQ SGKSEELLDMYGISARHIIVAVKCMLLN Download Select all
Length	540
Uniprot ID	P29460
Ensembl Protein ID	ENSP00000231228

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

EC	2.2.1.1
Name	transketolase glycolaldehydetransferase
Class	Transferases; Transferring aldehyde or ketonic groups; Transketolases and transaldolases
Sysname	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase
Substrate	sedoheptulose 7-phosphate [CPD:C05382]; D-glyceraldehyde 3-phosphate [CPD:C00118]
Product	D-ribose 5-phosphate [CPD:C00117]; D-xylulose 5-phosphate [CPD:C00231]
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

No matching records from HPRD source could be found.

Pathway Information

Pathway Name	Pathway ID
Biosynthesis of amino acids	hsa01230
Carbon metabolism	hsa01200
Metabolic pathways	hsa01100
Pentose phosphate pathway	hsa00030

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd07033	293-448	TPP_PYR_DXS_TK_like
cl11410	293-448	TPP_enzyme_PYR superfamily
cd02012	30-245	TPP_TK
cl01629	30-245	TPP_enzymes superfamily
pfam00456	23-239	Transketolase_N
COG3959	24-219	TktA1
pfam02779	287-451	Transket_pyr
pfam02780	464-586	Transketolase_C
cl08363	464-586	Transketolase_C superfamily
smart00861	320-448	Transket_pyr
COG1071	96-266	AcoA
cd02000	92-217	TPP_E1_PDC_ADC_BCADC
cd02007	93-221	TPP_DXS
cd02017	88-195	TPP_E1_EcPDC_like
TIGR03182	94-266	PDH_E1_alph_y
cd00568	80-216	TPP_enzymes
CHL00149	95-276	odpA
TIGR03181	98-202	PDH_E1_alph_x
pfam00676	80-221	E1_dh
PRK05899	17-594	PRK05899
COG3958	286-591	TktA2
COG0021	20-594	TktA
TIGR00232	26-515	tktlase_bact
COG1154	178-591	Dxs
PRK05444	178-594	PRK05444
PTZ00089	43-594	PTZ00089
TIGR00204	178-594	dxs
PLN02790	32-508	PLN02790
PRK12754	25-594	PRK12754
COG0022	327-551	AcoB
PRK12571	184-594	PRK12571
PRK12753	25-508	PRK12753
PTZ00182	330-550	PTZ00182
PLN02234	96-553	PLN02234
PRK11892	435-550	PRK11892
PRK09212	330-550	PRK09212
PLN02582	324-553	PLN02582
PRK12315	185-546	PRK12315
PLN02683	324-553	PLN02683
PLN02225	325-594	PLN02225
COG2609	88-305	AceE
CHL00144	409-596	odpB

Ontology Information

HPRD ID	2776
Molecular Class	Enzyme: Transketolase
Molecular Function	Cytokine activity (GO:0005125)
Biological Process	Immune response (GO:0006955)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO