Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ARID1A | 8289 | AT rich interactive domain 1A (SWI-like)  | 1 | ELD; B120; OSA1; P270; hELD; BM029; MRD14; hOSA1; BAF250; C1orf4; BAF250a; SMARCF1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22009941    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : 759 malignant neoplasms including pancreas, breast, colon, stomach, lung, prostate, brain, and blood (leukemias) Stage : - | RT-PCR | Mutation | - | Aberrant chromatin remoDeletionng consequent to ARID1A inactivation contributes to a variety of different types of neoplasms. |
| 22810696    | 2012 | Cell line : - Source : Biospecimen Core Resource Sample Type : - No. of Sample : 276 CRC samples Stage : - | Whole-genome sequencing, Affymetrix SNP6.0 arrays. | Mutation | - | To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples.
|
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]   |
| Chromosome | 1 |
| Location | 1p35.3 |
| Start | 26696031   |
| End | 26782110   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 86080   |
| OMIM ID | 603024    |
| HGNC ID | HGNC:11110    |
| Unigene ID | Hs.468972     |
| Ensembl ID | ENSG00000117713    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011542542.1 |
|---|---|
| Exon | complement(331..375)   | mRNA Sequence |    Download   Select all |
| Length | 3948   |
CDS Information
| Location | complement(331..375) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_006006.3 |
|---|---|
| Protein Name | AT rich interactive domain 1A (SWI-like) |
| Molecular Wt. (Da) | 241915 |
| Protein Sequence |    Download   Select all |
| Length | 2285   |
| Uniprot ID | O00716 |    
| Ensembl Protein ID | ENSP00000262904   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1755 |
| S | Phosphorylation | 696 |
| S | Phosphorylation | 772 |
| S | Phosphorylation | 1538 |
| S | Phosphorylation | 698 |
| S | Phosphorylation | 772 |
| S | Phosphorylation | 363;- |
| S | Phosphorylation | 363;- |
| S | Phosphorylation | 363;- |
| S | Phosphorylation | 604;- |
| S | Phosphorylation | 604;- |
| S | Phosphorylation | 604;- |
| S | Phosphorylation | 1944 |
| S | Phosphorylation | 1727 |
| T | Phosphorylation | 286 |
| S | Phosphorylation | 301 |
| T | Phosphorylation | 286 |
| S | Phosphorylation | 301 |
| T | Phosphorylation | 286 |
| S | Phosphorylation | 301 |
| S | Phosphorylation | 698 |
| S | Phosphorylation | 702 |
| S | Phosphorylation | 696 |
| S | Phosphorylation | 702 |
| S | Phosphorylation | 696 |
| S | Phosphorylation | 698 |
| S | Phosphorylation | 702 |
| S | Phosphorylation | 764 |
| S | Phosphorylation | 764 |
| S | Phosphorylation | 764 |
| S | Phosphorylation | 772 |
| S | Phosphorylation | 1182 |
| S | Phosphorylation | 1182 |
| S | Phosphorylation | 1182 |
| S | Phosphorylation | 1184 |
| S | Phosphorylation | 1184 |
| S | Phosphorylation | 1184 |
| K | Acetylation | 1905 |
| K | Acetylation | 1688 |
| K | Acetylation | 1612 |
| K | Acetylation | 1395 |
| S | Phosphorylation | 233 |
| S | Phosphorylation | 233 |
| S | Phosphorylation | 233 |
| S | Phosphorylation | 1751 |
| S | Phosphorylation | 1534 |
| S | Phosphorylation | 1754 |
| S | Phosphorylation | 1537 |
| S | Phosphorylation | 367 |
| S | Phosphorylation | 367 |
| S | Phosphorylation | 367 |
| S | Phosphorylation | 382 |
| S | Phosphorylation | 382 |
| S | Phosphorylation | 382 |
| S | Phosphorylation | 1087 |
| S | Phosphorylation | 1087 |
| S | Phosphorylation | 1087 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1RYU |
|---|---|
| Resolution | - |
| Method | solution NMR |
| Chains | A   |
| Molecule | SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam12031 | 1975-2231  | DUF3518 |
| cl13467 | 1975-2231  | DUF3518 superfamily |
| pfam01388 | 1014-1104  | ARID |
| cl02633 | 1014-1104  | ARID superfamily |
| smart00501 | 1018-1109  | BRIGHT |
| smart01014 | 1018-1104  | ARID |
| TIGR01628 | 372-469  | PABP-1234 |
| pfam04094 | 304-468  | DUF390 |
| pfam09770 | 609-856  | PAT1 |
| pfam09770 | 652-947  | PAT1 |
| PRK07764 | 598-729  | PRK07764 |
| pfam03153 | 674-793  | TFIIA |
| pfam09770 | 604-780  | PAT1 |
| pfam09770 | 354-552  | PAT1 |
| PHA03307 | 598-774  | PHA03307 |
Ontology Information
| HPRD ID | 3799 |    
|---|---|
| Molecular Class | RNA binding protein |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
