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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ARID1A 8289 AT rich interactive domain 1A (SWI-like)  1ELD; B120; OSA1; P270; hELD; BM029; MRD14; hOSA1; BAF250; C1orf4; BAF250a; SMARCF1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22009941   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : 759 malignant neoplasms including pancreas, breast, colon, stomach, lung, prostate, brain, and blood (leukemias)

Stage : -

RT-PCRMutation-Aberrant chromatin remoDeletionng consequent to ARID1A inactivation contributes to a variety of different types of neoplasms.

22810696   2012Cell line : -

Source : Biospecimen Core Resource

Sample Type : -

No. of Sample : 276 CRC samples

Stage : -

Whole-genome sequencing, Affymetrix SNP6.0 arrays.Mutation-To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples.


Gene Details



Chromosome: 1; NC_000001.10 (27022522..27108601)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 1
Location 1p35.3
Start 26696031  
End 26782110  
Strand -  
Gene Sequence

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Length 86080  
OMIM ID 603024   
HGNC ID HGNC:11110   
Unigene ID Hs.468972    
Ensembl ID ENSG00000117713   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011542542.1
Exon complement(331..375)  
mRNA Sequence

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Length 3948  



CDS Information


   
Location complement(331..375)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_006006.3
Protein NameAT rich interactive domain 1A (SWI-like)
Molecular Wt. (Da)241915
Protein Sequence

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Length 2285  
Uniprot IDO00716
Ensembl Protein ID ENSP00000262904  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1755
SPhosphorylation696
SPhosphorylation772
SPhosphorylation1538
SPhosphorylation698
SPhosphorylation772
SPhosphorylation363;-
SPhosphorylation363;-
SPhosphorylation363;-
SPhosphorylation604;-
SPhosphorylation604;-
SPhosphorylation604;-
SPhosphorylation1944
SPhosphorylation1727
TPhosphorylation286
SPhosphorylation301
TPhosphorylation286
SPhosphorylation301
TPhosphorylation286
SPhosphorylation301
SPhosphorylation698
SPhosphorylation702
SPhosphorylation696
SPhosphorylation702
SPhosphorylation696
SPhosphorylation698
SPhosphorylation702
SPhosphorylation764
SPhosphorylation764
SPhosphorylation764
SPhosphorylation772
SPhosphorylation1182
SPhosphorylation1182
SPhosphorylation1182
SPhosphorylation1184
SPhosphorylation1184
SPhosphorylation1184
KAcetylation1905
KAcetylation1688
KAcetylation1612
KAcetylation1395
SPhosphorylation233
SPhosphorylation233
SPhosphorylation233
SPhosphorylation1751
SPhosphorylation1534
SPhosphorylation1754
SPhosphorylation1537
SPhosphorylation367
SPhosphorylation367
SPhosphorylation367
SPhosphorylation382
SPhosphorylation382
SPhosphorylation382
SPhosphorylation1087
SPhosphorylation1087
SPhosphorylation1087

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


PDB ID1RYU
Resolution-
Methodsolution NMR
Chains A  
Molecule SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1  
Model View



Domain Information




ID Location Description
pfam120311975-2231  DUF3518
cl134671975-2231  DUF3518 superfamily
pfam013881014-1104  ARID
cl026331014-1104  ARID superfamily
smart005011018-1109  BRIGHT
smart010141018-1104  ARID
TIGR01628372-469  PABP-1234
pfam04094304-468  DUF390
pfam09770609-856  PAT1
pfam09770652-947  PAT1
PRK07764598-729  PRK07764
pfam03153674-793  TFIIA
pfam09770604-780  PAT1
pfam09770354-552  PAT1
PHA03307598-774  PHA03307


Ontology Information


   
HPRD ID3799
Molecular ClassRNA binding protein
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO