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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22997602 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | Mutationm due to inactivation of DNA mismatch repair syste,results MSI |
| 11809809 | 2002 | Cell line : - Source : ATCC, J. P. Johnson, University of Munich. Sample Type : Mouse model No. of Sample : - Stage : - | Western blotting,northern blotting, cancer profiling arrays, mouse experiments | Up-regulation | - | Conductin expression in tumors, we found significant upregulation of the conductin mRNA in those carcinomas that are known to be induced by Wnt/Beta-catenin signaling, i.e., in colorectal and liver tumors. Conducting may therefore be an early marker for colorectal tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q23-q24 |
| Start | 65528563 |
| End | 65561622 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 33060 |
| OMIM ID | 604025 |
| HGNC ID | HGNC:904 |
| Unigene ID | Hs.156527 |
| Ensembl ID | ENSG00000168646 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004655.3 |
|---|---|
| Exon | join(1..173,2887..3817,11963..12103,20066..20168, 23280..23420,23788..24299,24560..24754,25070..25303, 25902..25997,27544..27711,31521..33060) | mRNA Sequence | Download Select all |
| Length | 4241 |
CDS Information
| Location | join(3003..3817,11963..12103,20066..20168,23280..23420, 23788..24299,25070..25303,25902..25997,27544..27711, 31521..31647) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_004646.3 |
|---|---|
| Protein Name | Axin 2 (conductin, axil) |
| Molecular Wt. (Da) | 93437 |
| Protein Sequence | Download Select all |
| Length | 843 |
| Uniprot ID | Q16254 |
| Ensembl Protein ID | ENSP00000368686 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 640 |
| S | Phosphorylation | 630 |
| S | Phosphorylation | 639 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 324 | APC | 1439 | NP_000029.2 | in vitro;in vivo;yeast 2-hybrid | 10966653 |
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vitro;in vivo;yeast 2-hybrid | 109 666 539 566 905 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Colorectal cancer | hsa05210 |
| Endometrial cancer | hsa05213 |
| Hippo signaling pathway | hsa04390 |
| Pathways in cancer | hsa05200 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08707 | 82-198 | RGS_Axin |
| cl02565 | 82-198 | RGS superfamily |
| cd11582 | Dec-73 | Axin_TNKS_binding |
| cl16934 | Dec-73 | Axin_TNKS_binding superfamily |
| pfam00615 | 81-199 | RGS |
| smart00315 | 81-199 | RGS |
| smart00021 | 761-843 | DAX |
| cl02426 | 761-843 | DIX superfamily |
| pfam00778 | 764-843 | DIX |
| cd07440 | 86-198 | RGS |
| cd08713 | 82-198 | RGS_RGS3 |
| cd08712 | 85-198 | RGS_RGS18 |
| pfam08833 | 432-468 | Axin_b-cat_bind |
| cl07441 | 432-468 | Axin_b-cat_bind superfamily |
| cd08709 | 85-198 | RGS_RGS2 |
| cd08714 | 82-198 | RGS_RGS4 |
| cd08715 | 82-197 | RGS_RGS1 |
| cd08705 | 75-196 | RGS_R7-like |
| cd08711 | 76-198 | RGS_RGS8 |
| cd08745 | 78-196 | RGS_RGS19 |
| cd08723 | 85-198 | RGS_RGS21 |
| cd08741 | 82-198 | RGS_RGS10 |
| cd08710 | 85-196 | RGS_RGS16 |
| cd08746 | 50-196 | RGS_RGS20 |
| cd08718 | 78-196 | RGS_RZ-like |
| cd08743 | 72-202 | RGS_RGS14 |
| cd08739 | 77-198 | RGS_RGS9 |
| cd08744 | 78-196 | RGS_RGS17 |
| cd08740 | 77-196 | RGS_RGS11 |
| cd08717 | 82-198 | RGS_RGS5 |
| cd08706 | 82-198 | RGS_R12-like |
| cd08716 | 91-196 | RGS_RGS13 |
| cd08737 | 77-196 | RGS_RGS6 |
| cd08742 | 85-198 | RGS_RGS12 |
| cd08738 | 77-198 | RGS_RGS7 |
| cd08722 | 86-198 | RGS_SNX14 |
| cd08719 | 95-196 | RGS_SNX13 |
| cd08734 | 88-191 | RGS-like_1 |
| PRK14965 | 332-435 | PRK14965 |
Ontology Information
| HPRD ID | 11860 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Guanyl-nucleotide exchange factor activity (GO:0005085) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.