CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
BAP1	8314	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	3	hucep-6, KIAA0272, UCHL2

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23526420	2013	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 8 cases of CRC tissues and matched adjacent non-cancerous tissues Stage : -	real time RT-PCR, Western Blotting, Immunohistochemistry	Down-regulation	-	reduced BAP1 expression is associated with poor prognosis of CRC and BAP1 may serve as a novel prognostic biomarker for CRC. mRNA and protein levels of BAP1 were down-regulated in 6 out of 8 cases of CRC tissues compared with their adjacent non-cancerous tissues.

Gene Details

Chromosome 3 - NC_000003.12 (52401004..52410105, complement)
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Gene Type	protein coding
Gene Family
Description	This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.
Chromosome	3
Location	3p21.31-p2
Start	52401004
End	52410105
Strand	-
Gene Sequence	>gi\|568815595:c52410105-52401004 Homo sapiens chromosome 3, GRCh38.p2 Primary Assembly GAGCGCATGCCCGCATCTGCTGTCCGACAGGCGGAAGACGAGCCCAGAGGCGGAGCAGGGCCGTCGCGCC TTGGTGACGTCTGCCGCCGGCGCGGGCGGGTGACGCGACTGGGCCCGTTGTCTGTGTGTGGGACTGAGGG GCCCCGGGGGCGGTGGGGGCTCCCGGTGGGGGCAGCGGTGGGGAGGGAGGGCCTGGACATGGCGCTGAGG GGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGTGAGGAGGGGACCGG GAGGGCCAGGGGCTGGGGAGGCCGGATGGGCCCGGGACGCGCCTGCCTGACCATCACCCCCTCCTCTTGT CGCCCCACCCAGGCCTCTTCACCCTGCTCGTGGAAGATTTCGGTAAGAGCCTTTTCTCCCTGCCGGACCG GGGCTGTGGCGGCCCACCCCTGCGCCCTCACTCATCAGGGGCTGTCCTTCCCTACTGCTTTCCTTTCCTC ATCGCAGGTGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGGTGAGTGG CTGTACACCAGGGCTGCCCCTTACACCCAGAGTGCTGGGGAAGGTCCCAGAGAACAGGGCCCCTTAGGGA AGACAGTGCCAGGAACCCTACGTTGTAAAATCTCACAGAAAGCAGCAGCCTTGCTCTCTGAGTGCCCGCT CCTGATCAAACTGATACTTTCTTTTCTCCCAAACTTTCCTTAGCGCTTCCCTTTTTGTAGCAGCCCCCTC CCCACCCCTAAGCATCCTTTGGTTCAGCTGCTTTCCTGGCCTTGCAGCGGGAAGACCCCGGTCACACAAT GTCTTTTGTGCAGTTGTGTAATGTATTAATTTTAGTGTGCCCATGTGTCCTTGGCTTTAATCCTGACACA AAGTCATCCTGTATTGATTGGTTGGGGTGACAAGGCCCCTCCTGGGTGCCCACACTTAGAGTCTTTTCCC AGTGGTCCTGCAGAATAGATGTGTAAGAGAGTAGCAACAGTAGCAACCGTGACTGAACCAAGAAGTCTAC TTTAATTTCCTGGAACAAAAGAGACTGGTGTGGGTGTTCATTTGCTTTCCTGACTGCATTGGGGCCCACA AGTGAGAAGGAGTGCCTCAGTTCCTCATCAGAGTTTTTGTTCTTGTCTTACTTTGTGTTCCTACCCTGTC CCATCCTTGGCCCTCAGTTCCAGCTTTTCTTCTCTTACCCAGAACTATAGACTTCATAAGGAGACTGGGT GGACTCCTGGAGCATCACAGTCAGAGGCTTATGCTTTGCTCTGCCTGTGGCAGGCCTTTGGTGTGTGAGG GCACAAGGCCACTTCAGACACAGTGTTGGGAAGAAGCCAGGGGAGAGGGGGGATCACAGCAAGGACACCT GAGTGATGACGCAGTGCAAAGGATTAATGGGAGAAAGAAGGGAATGCTGATTGTCTTCTCCCCTTTGGCT GATCTGGCTCTGCCCCTTACTTCCCCCAGCCCTGTATATGGATTTATCTTCCTGTTCAAATGGATCGAAG AGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAA TAACATGTTCTTTGCCCACCAGGTCTGCTGGACTCTGTGCTTTGTTTGGAGGGTGGGATGCTGCCATGTT TTTGCTTGGGAAGTGGAAATGGAGGAAGACAGGAGGAGGAGATAGGCAGATTCTAGGGGTGGTAGCTACA GAAATCCTCTGGCAGAACGAACTGAACTCTTAATTCATTAAAGGGAACAGCTTTAGAGTAGGAGGGTGTC TGAGTCCACTCTCTGTGTCCTCAGATATCCAGTGGGTATTTGGTAGGTGCTTGTTAAATGAATAAACATT AGGCAAAGATGAAAGGAGCTGAGAAGGGGAGTTGTCCAGATATGACTGACCTGCTCTGGATCCCCATTCT TGATGTATATGGGCTTGGGGCTTGCAGTGAGGGGTGCTGTGTATGGGTGACTATTCTTGGTTTCACAGCT GATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTGGGA CCCACCCTGAGTCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGGTAGGCTGCAGTGCCTTCATCC TGGCTCACAGCCAACTGGGCAGATCTGACCCTGAGGGCCACTGGGAATGCTACCACATGATATTGGGTAC TATTAGGCTGTTTCTTTTTCAAATGATTGTTTATGTTACATTTGACTCTTAAATAAATTGTGTAAGGCCA TTGTTTTTAGATGCAGTTGCGGGGAAAGGACACAGGCCTAGGGAGGGAGGAGAGTTTCCTTAAGTCAGAC CATGTCAGAACCTTCTCTGTCAGGACTTTTCCTCTCAGGCCATGTTGCTTCCTAGTGTCCACTAATTACC ATGCAAGGCCAGCACAGTCCATCTCTTTGGGGCTCCAGAGCTCTTTTCTGCCCCCACCAGCCTTTTAAGA AAGTTCGTCTGTGTTCCTTCCGATTCCTGGAATGCCTCCAGGCTGCTCTCTGAAGCTTTGCCTTCCACCC ATAGTCCTACCTGAGGAGAAATTATTCTGATACGGCCTTATTTTCTTCCCCGTAGAGCAAAGGATATGCG ATTGGCAATGCCCCGGAGTTGGCCAAGGCCCATAATAGCCATGCCAGGTGTGTGGGAGCTGTGGGAGCTG ATGTGGGGTGGGAGTAGGGGGAGTATCATTTTTTGGGCCCTGACTCTGTTTTTCCCCAGGCCCGAGCCAC GCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTCCACTTTGTCAGCTA TGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGTAGGCAC CATGAGCTGGAGGCCTGTTGGGTGTCTCTGCCTACCTCCTAGGGAGCTGGGGCTCAGGGCCCTCTGGTAT GTGGTACCCAGTGGCAGGGGTTGTCGGTACCGACACCCGGCTCTGGCTGGGGTTTCACCCTACACCATAT TGCCCGACCAGCTCCTGATTCCCTGGCTCAACTGCTCTTCTCTGTCTTCCTTCCCACTCCTGGCCTGCCC AAACTCAGGGTTTCCTTCTCGCTGATTCCTTGTCTTGGTCTCCACTAGGGCCCTGGGGGGAGGACGAGGA GTGGACAGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGTAAGGGCCCTGT GCCTGCCCTGTTCTACTCTCTGGAGCTGTACCTACTTTGGGAGGGACAGAGAGTATCCAGGTGATTTGTA AATTGCAAGGCCATATGGTGAATCTGGCAAGATCAGGCTTAGATCATGGGTTCTCAACTTGTTGTCTTAT TTCCTGCCTGGGCTGCCTGTGGCCTGCTCCTGGGTGGGCTGGGGGAGGGGCAGGCCTCAGTGGAGCCTTA GGCAGCCCAGGTCTGCTGGTTCACTTCCAGATAGGCCCCTCATACAGCTTGTTGGAAGGTACCAGCTCAG GTGCCTGGCATGTATGGCTAGTCGCTGCCTGCCTGTTGGGGTGGGGCCTATACCTACAGCTGCAGGTGTG ACTGCAGGGAGCCCTGCCAGGATATCTGCCTCAACCTGATGGCGGGGCCGGGGCGGGAGCTGCTCTCACG GCTGCGGCTGTGACTGCAGGGAGCCCTACCACGACATCCGCTTCAACCTGATGGCAGTGGTGCCCGACCG CAGGATCAAGTATGAGGCCAGGCTGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAG CAGGTAGGTGCCCTTTCTTCCTGGCCTCTGCCCAGCCCAACCCTCCCTGCATTCCTCCTCCCTTCCCCCA CAGCATTTGTCTCTGATTCGTGAACATACTCTCTTGTAGATCTGGGCTTCAGCTAACCACATCTTTTCTT TGCCCCCATTGTGGGAAAGGTGGGACTTGGAGTGGGGAGGGAGAATAGCTTCTAAAAGGAAGTTTGGGTT TGGGTGTTTTATTTCCCTGTGAGTGAATGGGTAGAGCCAAGGCCATTATTCCTTTAGGTCCTCAGCCCTT AGCTATTTAAGGTAGAAGCCCGGGTCTACCCTTTCTCCTCTGAGCCCTGGATTCTGTTGTTAGCTGATAA GAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCTCAAGAGTCACAGCTGCCTGAGGAGTCCAAGTC AGCCAGCAACAAGTCCCCGCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAGGGCAACCACACA GGTACTGGGGGGTTTGGGACCTCTTGTGGACCTCAGAGCCACCCGCTAATGTCTGACATGGGAGGCCTAA ACAGGGAAAGTCTTTTTCTGGGGATGTCCTTGGGCAGTGTTCTTCCCCCGTCAGAAGGTAGAGGGAGAGC AGTCCTTCCCTAAAGAAAGGCACCTGTAAAGGGCCGCTGTTACCACAGGCCCCTGGGCCCTTCTCTGTAA TGTACACTCCCTTTCTTGTTTTCTCTAGAGGCGGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCTTCCTG CTTCTTTTTTCCCATCTCATTCTTTGCCCTGTCTCATTGCGGGATCATGACTTAGAGCTTGCTGACTCCC ATTGCACCAGCTGGCTGGGCTGTTCTTCTCTGGGAAGTGCTGGTTCACAGGGCCGGGGAGACTGTGAGCT TTTCTTGGAGATCCTACTGGAGGTCCTGCCTGTGTTCTTGCCCTGTCTCAGATGGTGCAGAGGAGGCGGC TGGTTCATGCGCACAAGCCCCATCCCACAGCCCTCCCAACAAACCCAAGCTAGTGGTGAAGCCTCCAGGC AGCAGCCTCAATGGGGTTCACCCCAACCCCACTCCCATTGTCCAGCGGCTGCCGGCCTTTCTAGACAATC ACAATTATGCCAAGTCCCCCATGCAGGTAAGCTGGGAGCACCCTTGCAGGATTCTCTACTTGATTCTCTT GAGAGGCTGCAACAGGCAATTTTCCCATGTGGTTCCTTGGTGTTCATCCTTGGCATGGCTGGGTCAAGCT GCCTGGGCCTGGGTTGCTAGGTTCCTCTGCCTGATATGAAAAGGCCCCCACAACAGCAGGAGCTTAGGGA GGCAGGGAGAGCTCCTTTGAATTTAATCTAGTTACGTGGCTGTGGGATTAAATGTTTAGGTCACGCTCCT TGGTACAACTTCATGGGTTGGGTTTTACTGGCAAAATAAAGGCATGTGTTTCAGGGCACTCTGTTTCTCT TAAAACCCCTCCGTGGGGTTCTATCCAGTGTAAGTGGGTGGCAGCCTCCCCACAAGCCAAGGACAGGCCA TGGAACAGCTGGAGGGGTTCCGCTGACTCAGTCTGGAAAACCATGTTGGCTTTCTCTCTGGCTGTGAGTG TCTAGGCTCAGCCTGGGCCGAGCAGCACTTGTTTGTAACTGCCCTGGTCTTTGTCCCAGGAGGAAGAAGA CCTGGCGGCAGGTGTGGGCCGCAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGATGATGAGGAT GACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAACTCTGCCCTTAGGTCAGCCCAGCTTTCTA AGGCTACCAGGTTCTAGGTGCTTCGGATCCCATCCTGAATATCTCAGTCTGTGTCTGAGAATGCCCTGCA GCAGATAATGTTGAGCACCTGCGGAGTTTGGGGCCCTGGGGGAGGCTGGCATGATGGGGCTGACCCCAGG TCCCCAGGAAGTTTTTGGTGGGCTGGGGGGTAAGGCTGAGCACGTAAGCTTATATCATGTCCTATTGGAA GTGGCCTTTTAGCCAGGCCTTGAAGGATTGGTTGGGGCAGGGATGGAGGAGATGTGGGTGGTGGGGAGGC AGCTTTGCTGGAACACAGGGCATTGGCAAAAGGCCAGGAGTGGGATGGCTGGAATAGAGGAAGTGTCTTT TGAGGACACTTGGCTGCAGCTGTCAGAACTTGATGCCAGGCTTAGCATGGCTAGTTCAAGTTGCTTGGAC CAAGTATAAGGAGTTTTAGGGTCAGCCCCTGGAGGTCGGGATGTATTTAAGCCATTCTGGGTACTGCTGG GTATGGTCACCTGGCCCGTTCCCTTGCTTCACATCTTCTCGGGCCCCACAGGTATAAGGGGAAGGGAACA GGGAAGCCAGGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAACACCATCAACG TCTTGGCTGAGAAGCTCAAAGAGTCCCAGAAGGACCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGG GGCTGGGAGTCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCCACCCCCAGCAATGAGAGTACA GACACGGCCTCTGAGATCGGCAGTGCTTTCAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCGA CGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGGAGAGGATGACAGCCTGCTGCG TGTTGACTGCATACGCTACAACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCAC CTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACAGGTGGGCCTTGGACTGGCTCACTGGCCACTT GGTGCACCCAGGAGGGAGGAGGGAAGTGGCCAAGTGACCACAAAGTGTCCTGCACTCTGATGATTTTCTT GTGACCTCTCTTCCCAGAGGGTGGGAAGGGTTCCTCGCCCTCCATCAGACCAATCCAAGGCAGCCAGGGG TCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCCACGGACAGCAGAGAGAAGACGGGGATGGTGAGGC CTGGCGAGCCCTTGAGTGGGGAGAAATACTCACCCAAGGTGAGCCTCCGTTGTGGTTTTCTCCTTTAATC CTGGCAGAGGGTAAGGCCTGAGCTCCTCCTGCCCAGGTGCCAAGTTCTTGATTGGAACTTTGGTGTGAAG ATTGGTGGCTGGAGCCATGTGCCAGAAGACTTTCTGGGTTGGGTGGTGGCAGGGGCCTTGATAGGCATGG ACTCGCTGCTCATCCTTGCCTCTAGCTGCCTATTGCTCGTGGGGCTTTGTTGCTGGCCCGCCCCGATCAG AGGTGCAATGCTGGGTTTTGGCAGGAGCTGCTGGCACTGCTGAAGTGTGTGGAGGCTGAGATTGCAAACT ATGAGGCGTGCCTCAAGGAGGAGGTAGAGAAGAGGAAGAAGTTCAAGGTGGGTGATTTCTCCAGTTGCCT GATCTGGCCTCTCCCGAGGTCCACTGGTGGCTGCTCTGGCAAGATTGGCTCCAGTGCTCTCAGTCTTCTT CTCTCCTACAGATTGATGACCAGAGAAGGACCCACAACTACGATGAGTTCATCTGCACCTTTATCTCCAT GCTGGCTCAGGAAGGTGAGGGGATGCGCTGCTGTCTTAACTGGAATGCCCTGCTGAGGGCCGTGTCCTTC AGCTCCCCTCCCCTGGCCTCTCCTGAGGCTTGAGCAGACCTTGGGGCACAGGGAGGGCCATGAGAGCCTC AGCTCCTGGCCTGAGGCAGCCAGCACCTGCTCAAGGGTCTCTACCTCTTCGCAGGCATGCTGGCCAACCT AGTGGAGCAGAACATCTCCGTGCGGCGGCGCCAAGGGGTCAGCATCGGCCGGCTCCACAAGCAGCGGAAG CCTGACCGGCGGAAACGCTCTCGCCCCTACAAGGCCAAGCGCCAGTGAGGACTGCTGGCCCTGACTCTGC AGCCCACTCTTGCCGTGTGGCCCTCACCAGGGTCCTTCCCTGCCCCACTTCCCCTTTTCCCAGTATTACT GAATAGTCCCAGCTGGAGAGTCCAGGCCCTGGGAATGGGAGGAACCAGGCCACATTCCTTCCATCGTGCC CTGAGGCCTGACACGGCAGATCAGCCCCATAGTGCTCAGGAGGCAGCATCTGGAGTTGGGGCACAGCGAG GTACTGCAGCTTCCTCCACAGCCGGCTGTGGAGCAGCAGGACCTGGCCCTTCTGCCTGGGCAGCAGAATA TATATTTTACCTATCAGAGACATCTATTTTTCTGGGCTCCAACCCAACATGCCACCATGTTGACATAAGT TCCTACCTGACTATGCTTTCTCTCCTAGGAGCTGTCCTGGTGGGCCCAGGTCCTTGTATCATGCCACGGT CCCAACTACAGGGTCCTAGCTGGGGGCCTGGGTGGGCCCTGGGCTCTGGGCCCTGCTGCTCTAGCCCCAG CCACCAGCCTGTCCCTGTTGTAAGGAAGCCAGGTCTTCTCTCTTCATTCCTCTTAGGAGAGTGCCAAACT CAGGGACCCAGCACTGGGCTGGGTTGGGAGTAGGGTGTCCCAGTGGGGTTGGGGTGAGCAGGCTGCTGGG ATCCCATGGCCTGAGCAGAGCATGTGGGAACTGTTCAGTGGCCTGTGAACTGTCTTCCTTGTTCTAGCCA GGCTGTTCAAGACTGCTCTCCATAGCAAGGTTCTAGGGCTCTTCGCCTTCAGTGTTGTGGCCCTAGCTAT GGGCCTAAATTGGGCTCTAGGTCTCTGTCCCTGGCGCTTGAGGCTCAGAAGAGCCTCTGTCCAGCCCCTC AGTATTACCATGTCTCCCTCTCAGGGGTAGCAGAGACAGGGTTGCTTATAGGAAGCTGGCACCACTCAGC TCTTCCTGCTACTCCAGTTTCCTCAGCCTCTGCAAGGCACTCAGGGTGGGGGACAGCAGGATCAAGACAA CCCGTTGGAGCCCCTGTGTTCCAGAGGACCTGATGCCAAGGGGTAATGGGCCCAGCAGTGCCTCTGGAGC CCAGGCCCCAACACAGCCCCATGGCCTCTGCCAGATGGCTTTGAAAAAGGTGATCCAAGCAGGCCCCTTT ATCTGTACATAGTGACTGAGTGGGGGGTGCTGGCAAGTGTGGCAGCTGCCTCTGGGCTGAGCACAGCTTG ACCCCTCTAGCCCCTGTAAATACTGGATCAATGAATGAATAAAACTCTCCTAAGAATCTCCTGAGAAATG AA Download Select all
Length	9102
OMIM ID	603089
HGNC ID	HGNC:950
Unigene ID	Hs.106674
Ensembl ID	ENSG00000163930
PharmGKB ID	-

mRNA Information

mRNA ID	NM_004656.3
Exon	join(1..264,363..392,498..552,1500..1632,2029..2148, 2646..2707,2790..2932,3199..3277,3730..3853,4194..4341, 4812..4996,5520..5653,6212..6690,6808..6968,7235..7327, 7432..7504,7685..9102)
mRNA Sequence	>8314 GAGCGCATGCCCGCATCTGCTGTCCGACAGGCGGAAGACGAGCCCAGAGGCGGAGCAGGGCCGT CGCGCCTTGGTGACGTCTGCCGCCGGCGCGGGCGGGTGACGCGACTGGGCCCGTTGTCTGTGTG TGGGACTGAGGGGCCCCGGGGGCGGTGGGGGCTCCCGGTGGGGGCAGCGGTGGGGAGGGAGGGC CTGGACATGGCGCTGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAG CGACCCAGGCCTCTTCACCCTGCTCGTGGAAGATTTCGGTGTCAAGGGGGTGCAAGTGGAGGAG ATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTCCTGTTCAAATGGA TCGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGA TGATATTGTGAATAACATGTTCTTTGCCCACCAGCTGATACCCAACTCTTGTGCAACTCATGCC TTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTGGGACCCACCCTGAGTCGCATGAAGG ACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGC CAAGGCCCATAATAGCCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTT AGTGCAGTGCGGACCATGGAGGCGTTCCACTTTGTCAGCTATGTGCCTATCACAGGCCGGCTCT TTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAGGACGAGGAGTG GACAGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGGAGCCCTAC CACGACATCCGCTTCAACCTGATGGCAGTGGTGCCCGACCGCAGGATCAAGTATGAGGCCAGGC TGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGCTGATAAGAGTAAC ACAGCCAGAGCTGATTCAGACCCACAAGTCTCAAGAGTCACAGCTGCCTGAGGAGTCCAAGTCA GCCAGCAACAAGTCCCCGCTGGTGCTGGAAGCAAACAGGGCCCCTGCAGCCTCTGAGGGCAACC ACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGCCCCATCCCACAGCCCTCCCAA CAAACCCAAGCTAGTGGTGAAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCCACT CCCATTGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTATGCCAAGTCCCCCATGCAGG AGGAAGAAGACCTGGCGGCAGGTGTGGGCCGCAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTA CTCAGATGATGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAACTCTGCC CTTAGGTATAAGGGGAAGGGAACAGGGAAGCCAGGGGCATTGAGCGGTTCTGCTGATGGGCAAC TGTCAGTGCTGCAGCCCAACACCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAGAAGGA CCTCTCAATTCCTCTGTCCATCAAGACTAGCAGCGGGGCTGGGAGTCCGGCTGTGGCAGTGCCC ACACACTCGCAGCCCTCACCCACCCCCAGCAATGAGAGTACAGACACGGCCTCTGAGATCGGCA GTGCTTTCAACTCGCCACTGCGCTCGCCTATCCGCTCAGCCAACCCGACGCGGCCCTCCAGCCC TGTCACCTCCCACATCTCCAAGGTGCTTTTTGGAGAGGATGACAGCCTGCTGCGTGTTGACTGC ATACGCTACAACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGCCTGCTGCACCTGG CTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACAGAGGGTGGGAAGGGTTCCTCGCCCTCCAT CAGACCAATCCAAGGCAGCCAGGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCCACG GACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAGTGGGGAGAAATACTCAC CCAAGGAGCTGCTGGCACTGCTGAAGTGTGTGGAGGCTGAGATTGCAAACTATGAGGCGTGCCT CAAGGAGGAGGTAGAGAAGAGGAAGAAGTTCAAGATTGATGACCAGAGAAGGACCCACAACTAC GATGAGTTCATCTGCACCTTTATCTCCATGCTGGCTCAGGAAGGCATGCTGGCCAACCTAGTGG AGCAGAACATCTCCGTGCGGCGGCGCCAAGGGGTCAGCATCGGCCGGCTCCACAAGCAGCGGAA GCCTGACCGGCGGAAACGCTCTCGCCCCTACAAGGCCAAGCGCCAGTGAGGACTGCTGGCCCTG ACTCTGCAGCCCACTCTTGCCGTGTGGCCCTCACCAGGGTCCTTCCCTGCCCCACTTCCCCTTT TCCCAGTATTACTGAATAGTCCCAGCTGGAGAGTCCAGGCCCTGGGAATGGGAGGAACCAGGCC ACATTCCTTCCATCGTGCCCTGAGGCCTGACACGGCAGATCAGCCCCATAGTGCTCAGGAGGCA GCATCTGGAGTTGGGGCACAGCGAGGTACTGCAGCTTCCTCCACAGCCGGCTGTGGAGCAGCAG GACCTGGCCCTTCTGCCTGGGCAGCAGAATATATATTTTACCTATCAGAGACATCTATTTTTCT GGGCTCCAACCCAACATGCCACCATGTTGACATAAGTTCCTACCTGACTATGCTTTCTCTCCTA GGAGCTGTCCTGGTGGGCCCAGGTCCTTGTATCATGCCACGGTCCCAACTACAGGGTCCTAGCT GGGGGCCTGGGTGGGCCCTGGGCTCTGGGCCCTGCTGCTCTAGCCCCAGCCACCAGCCTGTCCC TGTTGTAAGGAAGCCAGGTCTTCTCTCTTCATTCCTCTTAGGAGAGTGCCAAACTCAGGGACCC AGCACTGGGCTGGGTTGGGAGTAGGGTGTCCCAGTGGGGTTGGGGTGAGCAGGCTGCTGGGATC CCATGGCCTGAGCAGAGCATGTGGGAACTGTTCAGTGGCCTGTGAACTGTCTTCCTTGTTCTAG CCAGGCTGTTCAAGACTGCTCTCCATAGCAAGGTTCTAGGGCTCTTCGCCTTCAGTGTTGTGGC CCTAGCTATGGGCCTAAATTGGGCTCTAGGTCTCTGTCCCTGGCGCTTGAGGCTCAGAAGAGCC TCTGTCCAGCCCCTCAGTATTACCATGTCTCCCTCTCAGGGGTAGCAGAGACAGGGTTGCTTAT AGGAAGCTGGCACCACTCAGCTCTTCCTGCTACTCCAGTTTCCTCAGCCTCTGCAAGGCACTCA GGGTGGGGGACAGCAGGATCAAGACAACCCGTTGGAGCCCCTGTGTTCCAGAGGACCTGATGCC AAGGGGTAATGGGCCCAGCAGTGCCTCTGGAGCCCAGGCCCCAACACAGCCCCATGGCCTCTGC CAGATGGCTTTGAAAAAGGTGATCCAAGCAGGCCCCTTTATCTGTACATAGTGACTGAGTGGGG GGTGCTGGCAAGTGTGGCAGCTGCCTCTGGGCTGAGCACAGCTTGACCCCTCTAGCCCCTGTAA ATACTGGATCAATGAATGAATAAAACTCTCCTAAGAATCTCCTGAGAAATGAAAAAAAAAAAAA AAAAA Download Select all
Length	3717

CDS Information

Location	join(228..264,363..392,498..552,1500..1632,2029..2148, 2646..2707,2790..2932,3199..3277,3784..3853,4194..4341, 4812..4996,5520..5653,6212..6690,6808..6968,7166..7327, 7432..7504,7685..7818)
CDS Sequence	>lcl\|NM_004656.3_cds_NP_004647.1_1 [gene=BAP1] [protein=ubiquitin carboxyl-terminal hydrolase BAP1] [protein_id=NP_004647.1] [location=228..2417] ATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTCGTGGAAGATTTCGGTG TCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTAT CTTCCTGTTCAAATGGATCGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCC GTGATTGATGATGATATTGTGAATAACATGTTCTTTGCCCACCAGCTGATACCCAACTCTTGTGCAACTC ATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTGGGACCCACCCTGAGTCGCATGAAGGA CTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCCAAGGCC CATAATAGCCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGA CCATGGAGGCGTTCCACTTTGTCAGCTATGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAA GGTCTACCCCATTGACCATGGGCCCTGGGGGGAGGACGAGGAGTGGACAGACAAGGCCCGGCGGGTCATC ATGGAGCGTATCGGCCTCGCCACTGCAGGGGAGCCCTACCACGACATCCGCTTCAACCTGATGGCAGTGG TGCCCGACCGCAGGATCAAGTATGAGGCCAGGCTGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGA GGCTCTGCAGCAGCTGATAAGAGTAACACAGCCAGAGCTGATTCAGACCCACAAGTCTCAAGAGTCACAG CTGCCTGAGGAGTCCAAGTCAGCCAGCAACAAGTCCCCGCTGGTGCTGGAAGCAAACAGGGCCCCTGCAG CCTCTGAGGGCAACCACACAGATGGTGCAGAGGAGGCGGCTGGTTCATGCGCACAAGCCCCATCCCACAG CCCTCCCAACAAACCCAAGCTAGTGGTGAAGCCTCCAGGCAGCAGCCTCAATGGGGTTCACCCCAACCCC ACTCCCATTGTCCAGCGGCTGCCGGCCTTTCTAGACAATCACAATTATGCCAAGTCCCCCATGCAGGAGG AAGAAGACCTGGCGGCAGGTGTGGGCCGCAGCCGAGTTCCAGTCCGCCCACCCCAGCAGTACTCAGATGA TGAGGATGACTATGAGGATGACGAGGAGGATGACGTGCAGAACACCAACTCTGCCCTTAGGTATAAGGGG AAGGGAACAGGGAAGCCAGGGGCATTGAGCGGTTCTGCTGATGGGCAACTGTCAGTGCTGCAGCCCAACA CCATCAACGTCTTGGCTGAGAAGCTCAAAGAGTCCCAGAAGGACCTCTCAATTCCTCTGTCCATCAAGAC TAGCAGCGGGGCTGGGAGTCCGGCTGTGGCAGTGCCCACACACTCGCAGCCCTCACCCACCCCCAGCAAT GAGAGTACAGACACGGCCTCTGAGATCGGCAGTGCTTTCAACTCGCCACTGCGCTCGCCTATCCGCTCAG CCAACCCGACGCGGCCCTCCAGCCCTGTCACCTCCCACATCTCCAAGGTGCTTTTTGGAGAGGATGACAG CCTGCTGCGTGTTGACTGCATACGCTACAACCGTGCTGTCCGTGATCTGGGTCCTGTCATCAGCACAGGC CTGCTGCACCTGGCTGAGGATGGGGTGCTGAGTCCCCTGGCGCTGACAGAGGGTGGGAAGGGTTCCTCGC CCTCCATCAGACCAATCCAAGGCAGCCAGGGGTCCAGCAGCCCAGTGGAGAAGGAGGTCGTGGAAGCCAC GGACAGCAGAGAGAAGACGGGGATGGTGAGGCCTGGCGAGCCCTTGAGTGGGGAGAAATACTCACCCAAG GAGCTGCTGGCACTGCTGAAGTGTGTGGAGGCTGAGATTGCAAACTATGAGGCGTGCCTCAAGGAGGAGG TAGAGAAGAGGAAGAAGTTCAAGATTGATGACCAGAGAAGGACCCACAACTACGATGAGTTCATCTGCAC CTTTATCTCCATGCTGGCTCAGGAAGGCATGCTGGCCAACCTAGTGGAGCAGAACATCTCCGTGCGGCGG CGCCAAGGGGTCAGCATCGGCCGGCTCCACAAGCAGCGGAAGCCTGACCGGCGGAAACGCTCTCGCCCCT ACAAGGCCAAGCGCCAGTGA Download Select all
CCDS ID	-

Protein Information

Protein ID	NP_004647.1
Protein Name	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Molecular Wt. (Da)	80231
Protein Sequence	>8314 MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVST LVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKG YAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPID HGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVL EALQQLIRVTQPELIQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSC AQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRS RVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVL AEKLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIR SANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALT EGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKELLALLKCVE AEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGV SIGRLHKQRKPDRRKRSRPYKAKRQ Download Select all
Length	729
Uniprot ID	P35225
Ensembl Protein ID	ENSP00000304915

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
T	Phosphorylation	487
S	Phosphorylation	489
S	Phosphorylation	592;-
S	Phosphorylation	597;-
S	Phosphorylation	583;-
S	Phosphorylation	384;-
Y	Phosphorylation	394;-
S	Phosphorylation	395
S	Phosphorylation	582
S	Phosphorylation	595
S	Phosphorylation	585
S	Phosphorylation	596
S	Phosphorylation	327
S	Phosphorylation	521
S	Phosphorylation	292
S	Phosphorylation	369
S	Phosphorylation	464

Enzyme Information

EC	3.4.19.12
Name	ubiquitinyl hydrolase 1 ubiquitin C-terminal hydrolase yeast ubiquitin hydrolase
Class	Hydrolases; Acting on peptide bonds (peptidases); Omega peptidases
Sysname
Substrate
Product
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
672	BRCA1	218	NP_009231.2	in vitro;in vivo;yeast 2-hybrid	9528852

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd09617	5-233	Peptidase_C12_UCH37_BAP1
cl08306	5-233	Peptidase_C12 superfamily
pfam01088	4-214	Peptidase_C12
cd02255	5-233	Peptidase_C12
cd09616	5-232	Peptidase_C12_UCH_L1_L3

Ontology Information

HPRD ID	4329
Molecular Class	Ubiquitin proteasome system protein
Molecular Function	Cytokine activity (GO:0005125)
Biological Process	Immune response (GO:0006955)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO