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General Information
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17386109 | 2007 | Cell line : HCT116,Colo205 Source : 1Division of Hematology/Oncology, University of California, Irvine, USA and 2Incell Corporation, San Antonio, Texas, USA. Sample Type : CRC Tumor and normal tissue No. of Sample : - Stage : - | real time RT-PCR, norrin binding assay, luciferase activity | Up-regulation | - | Fz4 expression may play a critical role in responses to Wnt signaling in the tumor microenvironment. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class F : Frizzled receptors, "CD molecules" |
| Description | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008 |
| Chromosome | 11 |
| Location | 11q14-q21 |
| Start | 86656717 |
| End | 86666440 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9724 |
| OMIM ID | 604579 |
| HGNC ID | HGNC:4042 |
| Unigene ID | Hs.591968 |
| Ensembl ID | - |
| PharmGKB ID | PA28459 |
mRNA Information
| mRNA ID | ?NM_012193.3 |
|---|---|
| Exon | join(1..598,2929..9724) | mRNA Sequence | Download Select all |
| Length | 7394 |
Protein Information
| Protein ID | NP_036325.2 |
|---|---|
| Protein Name | frizzled class receptor 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 537 |
| Uniprot ID | Q15063 |
| Ensembl Protein ID | ENSP00000369066 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1740 | DLG2 | 4663 | NP_001136171.1 | yeast 2-hybrid | 12067714 |
| 1742 | DLG4 | 4199 | NP_001356.1 | in vivo;yeast 2-hybrid | 12067714 |
| 260425 | MAGI3 | 11290 | NP_001136254.1 | in vivo;yeast 2-hybrid | 15195140 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07448 | 42-167 | CRD_FZ4 |
| cl02447 | 42-167 | CRD_FZ superfamily |
| pfam01534 | 209-514 | Frizzled |
| cl21587 | 209-514 | 7tm_2 superfamily |
| cd07457 | 44-162 | CRD_FZ9_like |
| cd07462 | 42-164 | CRD_FZ10 |
| cd07463 | 44-162 | CRD_FZ9 |
| smart00063 | 45-161 | FRI |
| pfam01392 | 45-159 | Fz |
| cd07458 | 43-160 | CRD_FZ1_like |
| cd07066 | 44-163 | CRD_FZ |
| cd07456 | 44-163 | CRD_FZ5_like |
| cd07461 | 41-160 | CRD_FZ8 |
| cd07460 | 45-160 | CRD_FZ5 |
| cd07888 | 44-159 | CRD_corin_2 |
| cd07464 | 45-149 | CRD_FZ2 |
| cd07465 | 45-149 | CRD_FZ1 |
| cd07466 | 45-149 | CRD_FZ7 |
| cd07441 | 45-149 | CRD_SFRP3 |
| cd07442 | 45-149 | CRD_SFRP4 |
| cd07449 | 45-149 | CRD_FZ3 |
| cd07446 | 45-153 | CRD_SFRP2 |
| cd07454 | 44-160 | CRD_LIN_17 |
| cd07444 | 47-153 | CRD_SFRP5 |
| cd07452 | 44-159 | CRD_sizzled |
| cd07453 | 47-181 | CRD_crescent |
| cd07443 | 47-149 | CRD_SFRP1 |
| cd07450 | 45-153 | CRD_FZ6 |
| cd07447 | 44-148 | CRD_Carboxypeptidase_Z |
| cd07445 | 42-155 | CRD_corin_1 |
| cd07455 | 44-153 | CRD_Collagen_XVIII |
| cd07451 | 90-155 | CRD_SMO |
Ontology Information
| HPRD ID | 5520 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.