CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
10403737	1999	Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 49 patients undergoing colonic resection for colon adenocarcinoma Stage : -	ELISA, in situ hybridisation,real time RT-PCR, immunoblotting	Down-regulation	-	Caspase 1 was not expressed in colon cancer (primary colonic adenocarcinomas and cancer cell lines).

Gene Details

NC_000011.9 (104896235..104905884, complement)
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Gene Type	protein coding
Gene Family	Caspases
Description	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Chromosome	11
Location	11q23
Start	104896235
End	104905884
Strand	-
Gene Sequence	>gi\|568815587:c105036662-105025508 Homo sapiens chromosome 11, GRCh38.p2 Primary Assembly GAGGCCTCAGAATCATAGCAAAAGGCAAAAGAGGAGCAAGGACACGTCTTACATGGGTGCAGGCAAGAGG GTATGAGCAGAGGAATTCCCTTTTATAAAACCATCGGATCTCATGAGACATTCATTATCAAGAGAACAGC ATGGAAAAAAAACAGCACCCATGATTCAATTACATCCCACCAGATACCTCCCATAACACATGAGGATTAT TACAATTCAAGGTGAGATTTGAGTAGGGAAACAGAGACAGACCATATCACCAGCCTTCATGTTTGTCTTT CCCTCTTGAATGTGAGACCAAAGGGGAAAGGACCATGATATGTTTTGACTGAACCTCTGGCACCTAGAGC AATGTCGTCCGTATATGTTTGCTAAATGAATGACTAGATGCACTGCTTGAGGATTCTAACAAAAGATAAA CTTAGCTAAATAATCTGCAAATAATCATCCTTGATTATTTTTCTAACCTTAAACATTTGTATTAATTATA ATAATATCACTCATTATTTGCTTACCATTTGCCAGGCTATGTTCCATGCATTTTCCACATTTTCTCTCAC TTAATGCTCAAAACTGTGTAGGTACATACTATTAATAAAATTATTTCACATACAGAGGAACCAATGCATA GGGAAGTTCATTATCTTGCCAAGGAAGGGAAGTTTAAAATGCTAAGTTCGACATTCTCATTCCAGAGCCT ATGCTCTGGGCCTCTACAATGCAATTTCCCTCAAAAATAAACCCTCCAGGATGGGTGGGTGGCTCATGCC TGTAATCCTAGCAATTTGGGAGACCAAGGTGGGCACATTGCTTGAGCCTGGGAGCTGAAGACAAGCCTAG GAAACACAAGGAGACCCTGTCTTTACAAGAGATACAAATATTAGCTGGCCATGGTGGCATGTGCCAGTAA TTGCAGCTACTCGGGAGGCTGAGTTGGAAGAATCATCTGAGCCTGGGAAGTGGAGGCTGCAGTGAGCCAA GGTCAAATAACTGCATTCCGGCCTGCACGACAGAATGATACCCTGTATCAGAAAAAAAAAAAAACAGAAA GAAAAAAGCAATGTGAAAAGAAGGACATTAAATAAGAAAAGCTTTAATTCTGGTGAAAAATGTTTCTATT TCTTAAAGCAAAAATGTTTCACAGGGACATACATTACCCACAACTTTCCCAAGAGCTATGAGGTGGGGTC AGGGGAACAGTGGTTCACATACTCCAAAGGTTGTGTTACTTTTCTCCGTCAAGCTTTCTAATGATTGAGA AACTCTTCACTGTGTGAATTTAATTGTACACATACTTTTTCAATCCTGTCTTACTCTCCAAGCCCCATTC CCCTCCTACCCTGATCTATCCAAGGGCTGGTGAAGAAAATTTCCCATGGATACACTACCTGATGCAGGCT ACAGTTCTGATTCTTTAATGGGAAGAAAAATAAAGACATGCATATGCATGCACAGTGAGTATTTCCCAAT ACATGTACAGGCCCTGCCAAAAAGGAAGGCGAAGCATACTTTCAGTTTCAGTCACACAAGAAGGGAGGAG AGAAAAGCCATGGCCGGTGAGTCTTTTACTGTTCCAAGAACAGGTCCCTGGGAAGAAAGAGTTTTGGAAG GGGCTGGCTCTTCTGGAAGCCATAATTAGCATCTGTGGAAGTTTACTTGAGTAGAAGCAAGGAAAAGGGG GGAGAGGGAGGAGAGAAGGAACTAGAAGATTCTTGCAGACTTTAGAAAGGAAAGGCAAGCCCAGAAAGGA ACTGAGGCTTTAGGGGAAGCCTGATGTCATTTTGCAATCTTAATTAAACTCTTACTTACATGTTGAAAGT CTGACAGAGGGTACAGAATTGGCACAGGAGGAGTACTAGCAGCAGTGGTTCCTAAATGAAATGGGCTATT TCTGCTTCATTACTTTATTAACCAGAGTTAAATAAACATGCGACATAAGAGGATGATCTCTGCTTTCCAG GGACTGATGTGGAAATGGTAAACTCAGTCTTCAGGTCACTCCATGCACATGTATGGAGACTATTGAGGGA AACAAGTAGGACAGCAATACAGTAAGAAGAGGGATTACCCAACTGTGAGGAGGGGGACATTTCACTGATG AAATCTAAATGAGGTCACTTTCTGTTGATTACATGAGAGGAATATGAGGCTGTTTTCATGATGTGAGAAA TCCTTGTGCTCTAAACAGACAAGGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCGTTCCATGGGTGAAGG TACAATAAATGGCTTACTGGATGAATTATTACAGACAAGGGTGCTGAACAAGGAAGAGATGGAGAAAGTA AAACGTGAAAATGCTACAGTTATGGATAAGACCCGAGCTTTGATTGACTCCGTTATTCCGAAAGGGGCAC AGGCATGCCAAATTTGCATCACATACATTTGTGAAGAAGACAGTTACCTGGCAGGGACGCTGGGACTCTC AGCAGGTAAGGGTCAGTGACTTACACTCAAGTTCACCTAGGGCCTGTCTTCGTGCCTAACATTTGATTTC TTTACTAGTCATGTTAATTGGAAGAAAACTTTCTTATTTCTGGCTTCAGGGCCATATTTCTGTAGCAGGG TCCCTATTGCATGTCCCTTGACTCTCCTTTGATTCTTTTCCTTAATCCTCAGTGGCACTCTTCTGATTAA AGCTCATTTCCTGTTCTGAGTATGTGGTAGCTCCTTTACTGAAGCTCTTGAGAACCATCTGAAAAGCTTC ATGCTGTGTTTTCCAGTGTTCCTGGCAAGGCAAAATATTTACCTGTGGATTTATTTTTGCTGAGTGCAAG GGGTCTGTAGGCACTTATGTAGTTGTAAAGTCACATGAAGCTTTAAGGTTTATAATCAAATACTTTTTAT AACTTTTCTCCAAAATTTTACCCTCCCAAAAGAATAAAATATATTTCAATGATGGCGATACACTCAGAGA ACACATTGAACGTATAGAAAAGTGAAGATTTCTAATGGGCTCATTCCTCCAGTTGCCTCCTTGTATTTTC TTTGAGTAAGATCACCTGGTTGCCTGTTACCAGGCTGTGGGTCATGCTGTGAGGCCTGGAAATCCTCCAC TTGCAACCCTCCTCAGGCCCAATACAGGGCTCAGGAACTGAGCTGGCCAAATCTCATGACCACTTGGACC TACCACGTGGTGAGGATGAGAGTTCTGGTGGATTCCCAGTCATTGATGTCTGTGGCACTTCCTAAAGCCA CTTCAGAGGGAGATGTTCTTTGAAAGCAAAAGCCTTCTGTTCTAAGGGTTAGGGAAAGCTTATGCCTGTC TAAGCAGACATTGCAGATGTTTCTGTTTTCATCTATGTGTAATAAACACGTATTTTTCTACCAATGCCTC TTTCATTTTCTACCTCCCACCACTCTCTAAATTAAAGAACATCTTTAACATTATTTAATGTCAGTCAGTC AGTCAGTGTTATGGGAGAAATTTTTAGTGGGGAGTGTTTTACAGATTGGGGTAAAGTTTTCCAGAGATGA TAAGTGACTACTTCAATACCCTTTATCTTTTCATAGATCAAACATCTGGAAATTACCTTAATATGCAAGA CTCTCAAGGAGTACTTTCTTCCTTTCCAGGTAATGCTGTTTTTAAAGGAAGAGCATTCTTTGACCCACAT CTTCCTTGACATTAATTTTGTAGGATCAAACGTGGGTAAATGGGCTATGGAGAATTCTCATAGATTGGTC ATATAATTTTCTTTTTGTAATCTATTCTGCTTTTGTAGAAACTGTTTCCACAGCTTCATTATCCACATTT ATATTAAAAATTCTGAATCTGTGTCTCAAATCCTGATTACCCAAATAAGTACCAAACTTCATTATTTAAG CCTACTGAAATATTCACTCCCATCTCCCAGAGACACCTTATTCTAAACTTTCCCAGAGCTGAAAATGCTA TACTTCCACACCCTGCTTCTCTTCCGGTTTTGTGTAACTTGGTTATTGGTGCCACCGTCACCAGTTGTTC AAACCAGGAACTTGAAACTCATATGGGACCCTTCCTTCTCATGCACCTCTAACATTCAACCCATGGCCAA GTTTTATGCAGGCTTTTCTCAAATTTGGAACCATCTCTCTATTTCTACTTCTATTATTTTATTAAAGAAC CCCTATTCCCATAGTGCACTCTTAAACTTATATCTGAAAGCAATGTAGAGGCTAGGAATGCAAATTATTT ATCAAGTTCAGATATTACTCTACTGAATTTATTAAGGTTGGGTATCATGAATATTTTCTTAAATGTTTCA CAGCATGGGATATTCAATATATAAAGAAATACTGTATTCTCTACTATGAAAAAATAGCTCAAAAATAACC TAACTACTTCTAGTTTTTTTCTATTGTTTTCACACTTCTTTATGAAGAAATCCAACATTTTATCCAACAA ATGATTATTCTATAATTTTTTCCAATATATCTATTCTAATTCGTTCTTCTCCACATCAGCACATTTCATG CTGCCTTTGTTTATCTAACTGATTGTATAACAATTTTTCAAATTTGTTTTTAAAATTAAATATTATTTTT TGCCTTAATAGCTTCTAAAAGATCCTCCACACATCTAGAAAACTTATTTCTATTTTAAAACAAAGGTTAC ATTAATTTCTTTAACAAGGACATCACATTGTTGGATTGTGTTGAACCTGTGATGAAATAAAAGGCTCAAG GATTTTCTCACATAAACTCTGTGAAAACATTTCCTCAAGTGTCTGTGCAATGAATGTTTAGTGCTATAAA TCCATCTAGTGTGTACCTTGATTTTAGCATTTATCATTATATCTTCATTCTACTTCATATATTCAATATT CATGTCCTTTCATATGTATACATAGAAGGAAGAGATCCTGAAGGACAGGACAAAGATTCATTAAAAAATA TTCCTAGTGCTTACTACCATGTATATTAAGTAAATAAATAAAAAGATAAACATGTATTTTAAAAAATATT TTAGTAGATTAAATTAAGACCTGATCCCATTAAATTTTATCCTAGGGTTTGAATATTTTGAAAAAAGTTT ATATTCTTAACTATTTTATCTCACACATTTTTTGTTTTCTGAGTGTTTTATCAGGCATAGACTTTAAATT TTCCCTTTCTATGTTAGTATCTAAAATGCTTGTAGAAAGGCTGATCCTGAAATATGAAAGAAGATACTTG TAATGCATACCTGGAAATCTCTTGCTTGAAATGTGCTCCATTAGGAGCAAACTCACTCAGCTGTGTTAAT GATGTAGATCAGGATTGTCCTCCTCAGAGTGCATTTCCTCTTCTGTGGCTTCATCCATAGGTGAGGCTGT AACAAACACAAAGTGGAACAAACAGGGATGCCACTGTTCATGATGTTCTTTGTCTCTTGCAGCTCCTCAG GCAGTGCAGGACAACCCAGCTATGCCCACATCCTCAGGCTCAGAAGGGAATGTCAAGCTTTGCTCCCTAG AAGAAGCTCAAAGGATATGGAAACAAAAGTCGGCAGAGGTGCCATGCTCAGAACCCAAGGATAGAGTGGG GTGAAAGAAACACTTCAGGCAGTTCTGAAATGCAGTGGCTTATTCTTAGAGCCAACCTCATTGAGCAGTT CTGGAGAATCATACTTCTGCTCCCCTTACATAAAGGATTTCTATATCCTAGAATCCCAGGTTTATAGAAA GAGGTCCAAATTGGATCCACTTCCGGGGTAAATAACATCAGTGATGACAGCTATTGAATGCTTATTAAGA ATGGGCATTGTTCTAAGCATTTTGCACATGATAATATATAATTTTTAACCTTAAACACAACCCATTTTAG AGATCAAGAAGCTGAGACGGGATTGTTAAATATTTTTCCCAAAGAAAAACAATCAGAAATTGGAACAATC AGTTTTAGAATTCAGTCATTTTTGCTTCAAAGCTTGTGCATCTTTCAAAATCCTACCTATCAAGAACAAC GAAGTCAGAAGCTCAGCTGCCATCTGGGCATTTGCAATGTCCATGCATACTCTTGAAGCAGCATTCAATT CTGTTCCCCCTTTTCAATGTATGGTTCATGGGGTTTGGTATCTTGATAGGACTAAGGAAGGGGAAGCTGT CATAAACCAGGAAGGGAAATATTTAATTGGAAAGAACAAGGCTGTTCATTCAAATTGCATTTCCTACAGA TTTATCCAATAATGGACAAGTCAAGCCGCACACGTCTTGCTCTCATTATCTGCAATGAAGAATTTGACAG TATTCCTAGAAGAACTGGAGCTGAGGTTGACATCACAGGCATGACAATGCTGCTACAAAATCTGGGGTAC AGCGTAGATGTGAAAAAAAATCTCACTGCTTCGGTAAGTTCTATTATACAACAGAAACAATGGTTATGCC CTTCGTATAACTGAATAATATTAGAAAGCTTGGTTGTAAGACCAAGAAATGTAATCTCTTGATAATCTAA AATACAAACTTGCCATGAGAGAGTGCTGGATACTACATGGTCCTTTGTAACATAAGAGTCATGCAGCACA AGCCTGGTATAACTGAATTGGGAAATGTTTTATTGACTCAGTAATGCCACTGTCTCTCTACAAGATAACT CTGGATGACTTCCTATAACACTTTCCTTCACCTTTCTTGAAACTAAGACTAAATTTTTTTTTGGCACCCT GTTGTTTGTCACGGAATTCCTTAAGAAACTCCTTAAGTATTTATTTATTGACTTTCCAAGGTACCATGAT AGTTAATTACATAGTCGAAAATCAGTGATATGGTGTCTTTCAGGACATGACTACAGAGCTGGAGGCATTT GCACACCGCCCAGAGCACAAGACCTCTGACAGCACGTTCCTGGTGTTCATGTCTCATGGTATTCGGGAAG GCATTTGTGGGAAGAAACACTCTGAGCAAGTCCCAGATATACTACAACTCAATGCAATCTTTAACATGTT GAATACCAAGAACTGCCCAAGTTTGAAGGACAAACCGAAGGTGATCATCATCCAGGCCTGCCGTGGTGGT GAGTGCTGATGCCTTTGAGAACACCAGACAATCAAATACTATCCTACTCTGTATGCATCCAAGAATTTTT GGTTTCTTTTGGTTTGTCTTTTAATGTCAAAGAACACATACTGTCAGTATTCAAGAATGCAGCTTCTGTG AATTGAATGGCTGGTTGGTAGATATTTATTCCATATTTAAGCTTGAGATTTTGATGTTTGGAAATTTTTA CAATTTGTTTGATGGTTAGAAAAGATAAACATTGTTGAAAAGATTGTAACTGAAATGCATGTGTCTATTT GCATGTGAATTAATGATAGAGCAAACACATTAATAAATATCATTGAACAGAGGCTAGGAGGAAAACATCT TCTCAGCCATTGGTAGTAGTAACAAATCAAACTGTGTCTTTCCAGACAGCCCTGGTGTGGTGTGGTTTAA AGATTCAGTAGGAGTTTCTGGAAACCTATCTTTACCAACTACAGAAGAGTTTGAGGATGATGCTATTAAG AAAGCCCACATAGAGAAGGATTTTATCGCTTTCTGCTCTTCCACACCAGGTAACAGGTTTCTACACAGGA CATCTTTGTTGGGGCTATCAATAGAAAAAGTGACAATAACCCACTAGAGGTGGTGATTAACAACTCAAGA CCAACTCAAGCTTTGTTCCAAGTTATACACAGAATTCCCTTTATCCAAGAGAGCAATTTTGCATATCTGT TCAATGCATTACTAATTAAAGAATTCATCTATGTTTCAAAATATTTTTGGAACTTTGAGCGATAGCAGAG AATTAAATGGAAGACGGTATGTGCTGTAGTACATTAGAATCTGACTCTGCATAGAAAATTCTGCCATGTT GAGATCATTCATTAGTCCAATTTGCCCAGACATCAAATATTTATAGGAGAAGAGTAAGAGCAAGATTCTG AAAAGCAGAACAGCAAGCGAGACACTTTGGGGCCCTAAATTAAAGTGGGTTTTACCTAGAAGCATGAAGT GTGTGAGACAGAATATATTTGAATTTTTCTAAACGTATGCTTTGGAGTAAGAATCTTGCTATTATTGACT GACCCAGACATTTAGTATTTTGTAAAACAGTTCCACTAGTTCCTCCTCGGGCTTTCCTTGAATTGCTGAC TAATATGTGAATATAAATATTATTTTTCTAAGGATTTAATAAATTAATATATTTGAAATATTGGGCACGA CACAAAATAAAGCACACATTAAAAAACTGCTATTATTTAAAATGTATATATTTGATAACTTAATTCAGTT ACTTTTCTAAGCAAGGTTTAAATAAAAATTATTTAAATCCTTTCATTCACCACCTTTGGCAGTTTCCTGA GAGGACTTGCATTCTCTTGGTCACCTCTGGCCCAAAGGCCCTGTCTCTGCTCAAATAGTTAAGTTTTCTA AAATATTTTCTAAAATGAGATATCTTCTTTCAGAAGAAGCTTGGTTCTACATTGGGTTGAACATGCCCTG ATGTAGAACTCAATAATTTTTTTTTCCCAATGATCAGAAACAATGACACTACCCAAAAACACCATATATT TTCAGCCTGAGTACGTATAGCAGAGTTTAATATTAGACAGAACTGTTCGTTAGTATCCTTTGATCCCAGC CTTCCACATGACATTCACCGCTCTCTAAGTAGCTCTTTGTAGGCCTCTGGCTTCTCATTATCAATCTGGC TGATTTATGTGTCTTTCTTTTCTTTCACTTTCCTTACTCCTACCTTCTAGATGACTGTCAGAAACTCCAA TTCAGTTATCTATAACTTCCATGTTAAACCTATCTCCACATTCTGCTGTGCCAATCCCAACCACATCATA GTGATCTCCTGAAGAAAAATAATTATCTACTTCCTTAATTTCACAAAACATTTGCAAAGATATCTGTCTC CACGATATCTTTCACTTACTTCCTTTTACTAGAACAAGTCTCAGTTAAAGGCTTCATTTAGCTGAGATAG CTGGGTTTCTAAATAGAATTTTATTATCAATATATACTTTATGACCATTAGAACTGGCTAAAATGTGTCA TTAAAGAATGTGTCTGTCATTACATACAGAGCTATTGCTGCTGCTTTTCTCTTATGACTTCCTTTGCATA ATTTTATGCCTTCATTACTTCTGTGTCTACTATGTAATAAATTAATATTTTTCTTTAATATTTCTCTTCT TCATAAGAACTTTTTTCCTCCAATATACTGTGCTTATTTCCTTATCTACTCCTCCTAGATTTCTACTTTT GTTCTGTTTTATGATTTTTATAGTTAACTTTTTGTGTGTAAATATCTTACTGTCAATGTTATTTAATTTC GATTAATCTTTTATGAAGTACATAAATTGAGAATTTGATAATATAATTACCCCATGTAGACTGAGTATTG CATATCCTGGGTTATCTCAAACACTTGCGTGACCTCAGATACCTCTTGTGTATGGAGTTATTACCATCCC CTGTATAGCTAGCTGAGTCTATTAAATATCAGAATGCATAATTAACTTAAATCACAGTCAGTAATACCAC TTTGGGAATGCACATTTAGATATTTCATTTCCAAATCCCAATCACTCCCCTCTACCCCATTCCGCCTTTT CCTTATTTGCTACTAAATTTATGATTTCAAACATCCCTCAGCTGGAGTATAAATACTAGGGTTTCTTCTC TTTCTTCAGGCAAGAGCCAGTCTTGAGATTTGAAATGTGCTTTATCCATAGATAATGTTTCTTGGAGACA TCCCACAATGGGCTCTGTTTTTATTGGAAGACTCATTGAACATATGCAAGAATATGCCTGTTCCTGTGAT GTGGAGGAAATTTTCCGCAAGGTAAGATGCTAGTGGATGCTATTTTCACTCTACTTCCCTGAATGCTTGG CTATTGCAATTGGAAGCATAGAAAGCAGATCCAGACAAGTTTATCTTCCAATAATGCTCTTCTTTCCAAA AGAGTTTTGGAGTTCTTTGGAGAGTGGACAAACCCAGGAGCCTAATCCAATCTATTAAGACCCACAGCCT TGAGAAAACAATCATTTAGTTTCACCCCGCTCCTGCCCTGCAGAGACAAATGAATGGACTCTAATTTACC TGTGTCTCTCATGGCTATTAGATCCAGCAGCAGATTTAAAATGCCCTGAGGAGGGTCATTCAATGCTTAC ATACATATATGGTTATACTTGTTGCAGATGGAAGTACTTTTTGTTTTTGTCACTTATTTTGCTATATTTG TTGTAGTTTTTTGGCATAACTCAAGAAATTCTTGAAAAAAAAAACTCAGCAAAAAAAAGGGCTACAGACT TTCCTTACTCTTTTAGGTTCGATTTTCATTTGAGCAGCCAGATGGTAGAGCGCAGATGCCCACCACTGAA AGAGTGACTTTGACAAGATGTTTCTACCTCTTCCCAGGACATTAAAATAAGGAAACTGTATGAATGTCTG TGGGCAGGTACATGTGTATGGTCGGGAGTGTGGGAAGGTTGAGGAAAGGGTACTGAAAGTCCATTTGAGT CAAGAACTCTAGGTTTACAGGCTGAGAATCCTTAATCCAAAAATTTGAATTTTGAAATGCTCTAAAATCC AACACTGTGTGAGCGCCCACATGATATTCAAAGGAAATGTTTATTGAAACATTTCAAATTATAGGTTTTT GGATTAGGGATGCTAAACCAGTAAGTATACAGCTGAATTCCAATATACAAAAATATCTGAAATTTGAAAT ACTTCTGGTAGCATGCATTTTGGATAAGGGATAATCAAGCCATATACAGAAAATACTGAAGTAATGCCTT TCTTCTGGTCAGTGCAGAGCACGTTGCTCTTCTCCCAAAGTTTTTCATTTAGACCCCTTTTGAGATTCAT CTGATATTGGCCTAGAAGTGGCCGTAAGACTACAAACCCTCACTTTTGGATGTTTCTCTCCTTCACCTCA GCAGGGTATATTTAAACATAGCATGTGGTCTTTCCTTTTAAAATTGTGTATGTTCCCATTGGTGGTATAA CTTTATAACTTGCATGTCTTTAACAAAATTCTTTCCTATGTTTTTTTTTTTAATTATTTCTTTTTCTCAT AGGAAGTGAAGAGATCCTTCTGTAAAGGTTTTTGGAATTATGTCTGCTGAATAATAAACTTTTTTGAAAT AATAAATCTGGTAGAAAAATGAAAA Download Select all
Length	9650
OMIM ID	147678
HGNC ID	HGNC:1499
Unigene ID	Hs.2490
Ensembl ID	ENSG00000137752
PharmGKB ID	PA26083

mRNA Information

mRNA ID	XM_011543018.1
Exon	join(1..221,1481..1556,2275..2455,5383..5498,6160..6333, 6764..6998,7396..7539,9712..9821,10307..11155)
mRNA Sequence	>gi\|767970649\|ref\|XM_011543018.1\| PREDICTED: Homo sapiens caspase 1, apoptosis-related cysteine peptidase (CASP1), transcript variant X3, mRNA GAGGCCTCAGAATCATAGCAAAAGGCAAAAGAGGAGCAAGGACACGTCTTACATGGGTGCAGGCAAGAGG GTATGAGCAGAGGAATTCCCTTTTATAAAACCATCGGATCTCATGAGACATTCATTATCAAGAGAACAGC ATGGAAAAAAAACAGCACCCATGATTCAATTACATCCCACCAGATACCTCCCATAACACATGAGGATTAT TACAATTCAAGGCCCTGCCAAAAAGGAAGGCGAAGCATACTTTCAGTTTCAGTCACACAAGAAGGGAGGA GAGAAAAGCCATGGCCGACAAGGGTGCTGAACAAGGAAGAGATGGAGAAAGTAAAACGTGAAAATGCTAC AGTTATGGATAAGACCCGAGCTTTGATTGACTCCGTTATTCCGAAAGGGGCACAGGCATGCCAAATTTGC ATCACATACATTTGTGAAGAAGACAGTTACCTGGCAGGGACGCTGGGACTCTCAGCAGCTCCTCAGGCAG TGCAGGACAACCCAGCTATGCCCACATCCTCAGGCTCAGAAGGGAATGTCAAGCTTTGCTCCCTAGAAGA AGCTCAAAGGATATGGAAACAAAAGTCGGCAGAGATTTATCCAATAATGGACAAGTCAAGCCGCACACGT CTTGCTCTCATTATCTGCAATGAAGAATTTGACAGTATTCCTAGAAGAACTGGAGCTGAGGTTGACATCA CAGGCATGACAATGCTGCTACAAAATCTGGGGTACAGCGTAGATGTGAAAAAAAATCTCACTGCTTCGGA CATGACTACAGAGCTGGAGGCATTTGCACACCGCCCAGAGCACAAGACCTCTGACAGCACGTTCCTGGTG TTCATGTCTCATGGTATTCGGGAAGGCATTTGTGGGAAGAAACACTCTGAGCAAGTCCCAGATATACTAC AACTCAATGCAATCTTTAACATGTTGAATACCAAGAACTGCCCAAGTTTGAAGGACAAACCGAAGGTGAT CATCATCCAGGCCTGCCGTGGTGACAGCCCTGGTGTGGTGTGGTTTAAAGATTCAGTAGGAGTTTCTGGA AACCTATCTTTACCAACTACAGAAGAGTTTGAGGATGATGCTATTAAGAAAGCCCACATAGAGAAGGATT TTATCGCTTTCTGCTCTTCCACACCAGATAATGTTTCTTGGAGACATCCCACAATGGGCTCTGTTTTTAT TGGAAGACTCATTGAACATATGCAAGAATATGCCTGTTCCTGTGATGTGGAGGAAATTTTCCGCAAGGTT CGATTTTCATTTGAGCAGCCAGATGGTAGAGCGCAGATGCCCACCACTGAAAGAGTGACTTTGACAAGAT GTTTCTACCTCTTCCCAGGACATTAAAATAAGGAAACTGTATGAATGTCTGTGGGCAGGTACATGTGTAT GGTCGGGAGTGTGGGAAGGTTGAGGAAAGGGTACTGAAAGTCCATTTGAGTCAAGAACTCTAGGTTTACA GGCTGAGAATCCTTAATCCAAAAATTTGAATTTTGAAATGCTCTAAAATCCAACACTGTGTGAGCGCCCA CATGATATTCAAAGGAAATGTTTATTGAAACATTTCAAATTATAGGTTTTTGGATTAGGGATGCTAAACC AGTAAGTATACAGCTGAATTCCAATATACAAAAATATCTGAAATTTGAAATACTTCTGGTAGCATGCATT TTGGATAAGGGATAATCAAGCCATATACAGAAAATACTGAAGTAATGCCTTTCTTCTGGTCAGTGCAGAG CACGTTGCTCTTCTCCCAAAGTTTTTCATTTAGACCCCTTTTGAGATTCATCTGATATTGGCCTAGAAGT GGCCGTAAGACTACAAACCCTCACTTTTGGATGTTTCTCTCCTTCACCTCAGCAGGGTATATTTAAACAT AGCATGTGGTCTTTCCTTTTAAAATTGTGTATGTTCCCATTGGTGGTATAACTTTATAACTTGCATGTCT TTAACAAAATTCTTTCCTATGTTTTTTTTTTTAATTATTTCTTTTTCTCATAGGAAGTGAAGAGATCCTT CTGTAAAGGTTTTTGGAATTATGTCTGCTGAATAATAAACTTTTTTGAAATAATAAATCTGGTAGAAAAA TGAAAA Download Select all
Length	2106

CDS Information

Location	73..1356
CDS Sequence	>lcl\|XM_011543018.1_cds_XP_011541320.1_1 [gene=CASP1] [protein=caspase-1 isoform X2] [protein_id=XP_011541320.1] [location=73..1356] ATGAGCAGAGGAATTCCCTTTTATAAAACCATCGGATCTCATGAGACATTCATTATCAAGAGAACAGCAT GGAAAAAAAACAGCACCCATGATTCAATTACATCCCACCAGATACCTCCCATAACACATGAGGATTATTA CAATTCAAGGCCCTGCCAAAAAGGAAGGCGAAGCATACTTTCAGTTTCAGTCACACAAGAAGGGAGGAGA GAAAAGCCATGGCCGACAAGGGTGCTGAACAAGGAAGAGATGGAGAAAGTAAAACGTGAAAATGCTACAG TTATGGATAAGACCCGAGCTTTGATTGACTCCGTTATTCCGAAAGGGGCACAGGCATGCCAAATTTGCAT CACATACATTTGTGAAGAAGACAGTTACCTGGCAGGGACGCTGGGACTCTCAGCAGCTCCTCAGGCAGTG CAGGACAACCCAGCTATGCCCACATCCTCAGGCTCAGAAGGGAATGTCAAGCTTTGCTCCCTAGAAGAAG CTCAAAGGATATGGAAACAAAAGTCGGCAGAGATTTATCCAATAATGGACAAGTCAAGCCGCACACGTCT TGCTCTCATTATCTGCAATGAAGAATTTGACAGTATTCCTAGAAGAACTGGAGCTGAGGTTGACATCACA GGCATGACAATGCTGCTACAAAATCTGGGGTACAGCGTAGATGTGAAAAAAAATCTCACTGCTTCGGACA TGACTACAGAGCTGGAGGCATTTGCACACCGCCCAGAGCACAAGACCTCTGACAGCACGTTCCTGGTGTT CATGTCTCATGGTATTCGGGAAGGCATTTGTGGGAAGAAACACTCTGAGCAAGTCCCAGATATACTACAA CTCAATGCAATCTTTAACATGTTGAATACCAAGAACTGCCCAAGTTTGAAGGACAAACCGAAGGTGATCA TCATCCAGGCCTGCCGTGGTGACAGCCCTGGTGTGGTGTGGTTTAAAGATTCAGTAGGAGTTTCTGGAAA CCTATCTTTACCAACTACAGAAGAGTTTGAGGATGATGCTATTAAGAAAGCCCACATAGAGAAGGATTTT ATCGCTTTCTGCTCTTCCACACCAGATAATGTTTCTTGGAGACATCCCACAATGGGCTCTGTTTTTATTG GAAGACTCATTGAACATATGCAAGAATATGCCTGTTCCTGTGATGTGGAGGAAATTTTCCGCAAGGTTCG ATTTTCATTTGAGCAGCCAGATGGTAGAGCGCAGATGCCCACCACTGAAAGAGTGACTTTGACAAGATGT TTCTACCTCTTCCCAGGACATTAA Download Select all
CCDS ID	CCDS53704.1

Protein Information

Protein ID	XP_011541320.1
Protein Name	caspase 1, apoptosis-related cysteine peptidase
Molecular Wt. (Da)	47979
Protein Sequence	>lcl\|XM_011543018.1_prot_XP_011541320.1_1 [gene=CASP1] [protein=caspase-1 isoform X2] [protein_id=XP_011541320.1] [location=73..1356] MSRGIPFYKTIGSHETFIIKRTAWKKNSTHDSITSHQIPPITHEDYYNSRPCQKGRRSILSVSVTQEGRR EKPWPTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAV QDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDIT GMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQ LNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRC FYLFPGH Download Select all
Length	427
Uniprot ID	P10242
Ensembl Protein ID	ENSP00000339992

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
D	Proteolytic Cleavage	103
D	Proteolytic Cleavage	119
D	Proteolytic Cleavage	297
D	Proteolytic Cleavage	316
D	Proteolytic Cleavage	276
D	Proteolytic Cleavage	295
D	Proteolytic Cleavage	98
D	Proteolytic Cleavage	204
D	Proteolytic Cleavage	223
D	Proteolytic Cleavage	26
D	Proteolytic Cleavage	26
S	Phosphorylation	376

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
142	PARP1	1435	NP_001609.2	in vitro;in vivo	7642516
367	AR	2437	NP_000035.2	in vitro	9535906
598	BCL2L1	2497	NP_612815.1	in vitro	9435230
637	BID	3590	NP_932070.1	in vivo	972 749 111 085 743
831	CAST	233	NP_001741.4	in vitro	9705209
984	CDK11B	8909	NP_001778.1	in vitro	9632733
985	CDC2L2	308	NP_277073.1	in vitro;in vivo	9115219
1822	ATN1	6311	NP_001931.2	in vitro	9535906
1956	EGFR	579	NP_005219.2	in vitro;in vivo	11226410
2247	FGF2	622	NP_001997.5	in vivo	18329368
3064	HTT	883	NP_002102.4	in vitro	9535906
3552	IL1A	988	NP_000566.3	in vivo	18329368
3553	IL1B	985	NP_000567.1	in vitro;in vivo	77 975 101 919 001
3606	IL18	2976	NP_001553.1	in vitro;in vivo	9334240
4000	LMNA	1035	CAA27173.1	in vitro;in vivo	897 881 411 953 316
4137	MAPT	1142	NP_001116538.1	in vitro;in vivo	12888622
4734	NEDD4	3786	NP_940682.2	in vitro;in vivo	9593687
5321	PLA2G4A	8986	NP_077734.1	in vitro	9875225
5663	PSEN1	87	NP_000012.1	in vitro;in vivo	10069390
5664	PSEN2	2860	NP_000438.2	in vitro;in vivo	9 990 034 921 969 510 000 000
7020	TFAP2A	128	NP_003211.1	in vitro;in vivo	11438643

Pathway Information

Pathway Name	Pathway ID
Amyotrophic lateral sclerosis (ALS)	hsa05014
Cytosolic DNA-sensing pathway	hsa04623
Influenza A	hsa05164
Legionellosis	hsa05134
NOD-like receptor signaling pathway	hsa04621
Pertussis	hsa05133
Salmonella infection	hsa05132

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00032	152-401	CASc
cl00042	152-401	CASc superfamily
cd08325	May-87	CARD_CASP1-like
cl14633	May-87	DD superfamily
smart00115	153-402	CASc
pfam00656	163-400	Peptidase_C14
pfam00619	Mar-90	CARD
smart00114	Aug-89	CARD
cd01671	Jun-73	CARD
cd08786	Apr-74	CARD_RIP2_CARD3
cd08329	25-83	CARD_BIRC2_BIRC3

Ontology Information

HPRD ID	1818
Molecular Class	Cysteine protease
Molecular Function	Transcription factor activity (GO:0003700)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219); Apoptosis (GO:0006915); Regulation of cell proliferation (GO:0042127)

SNP Information

View SNP Geneview Report