Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RASSF5 | 83593 | Ras association (RalGDS/AF-6) domain family member 5 | 1 | Maxp1, NORE1, RAPL |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20969767 | 2010 | Cell line : Caco2, Colo320, HCT116, SW403, SW620, DLD 1, WiDr, SNU C1, SNU C4, SNU C5 Source : Kyung Hee University Medical Center (Seoul, Korea). Sample Type : - No. of Sample : - Stage : - | realtime RT-PCR , DNA PCR,Immunoblotting, Nonisotopic PCR-SSCP,Bisulfite DNA sequencing | Methylation | - | - |
| 22733432 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Methylation | - | RASSF1A, RASSF2 and RASSF5 methylation has been associated with CRC development. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q31 |
| Start | 206680866 |
| End | 206762616 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 81751 |
| OMIM ID | 607020 |
| HGNC ID | HGNC:17609 |
| Unigene ID | Hs.497579 |
| Ensembl ID | ENSG00000136653 |
| PharmGKB ID | PA134958571 |
Protein Information
| Protein ID | NP_872604.1 |
|---|---|
| Protein Name | Ras association (RalGDS/AF-6) domain family member 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 418 |
| Uniprot ID | Q8TDN4 |
| Ensembl Protein ID | ENSP00000256925 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 180 |
| S | Phosphorylation | 182 |
| S | Phosphorylation | 182 |
| T | Phosphorylation | 350 |
| T | Phosphorylation | 352 |
| T | Phosphorylation | 199 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3265 | HRAS | 1813 | NP_005334.1 | in vitro | 9488663 |
| 3845 | KRAS | 1817 | NP_203524.1 | in vitro | 11857081 |
| 4893 | NRAS | 1273 | NP_002515.1 | in vitro;yeast 2-hybrid | 9488663 |
| 5898 | RALA | 1549 | NP_005393.2 | yeast 2-hybrid | 9488663 |
| 5908 | RAP1B | 1546 | NP_056461.1 | in vitro;in vivo | 9488663 |
| 5911 | RAP2A | 1547 | NP_066361.1 | in vitro;yeast 2-hybrid | 11857081 |
| 6237 | RRAS | 1299 | NP_006261.1 | in vitro;in vivo | 11857081 |
| 6789 | STK4 | 5395 | NP_006273.1 | in vivo | 1 186 456 516 892 060 |
| 11186 | RASSF1 | 5470 | NP_733832.1 | in vitro;in vivo | 11857081 |
| 22800 | RRAS2 | 2518 | NP_036382.2 | in vitro | 11857081 |
| 54386 | TERF2IP | 5452 | NP_061848.2 | in vitro | 12845325 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Leukocyte transendothelial migration | hsa04670 |
| Non-small cell lung cancer | hsa05223 |
| Pathways in cancer | hsa05200 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00029 | 133-170 | C1 |
| cl00040 | 133-170 | C1 superfamily |
| cd01778 | 272-365 | RASSF1_RA |
| cl00155 | 272-365 | UBQ superfamily |
| cd01768 | 277-362 | RA |
| smart00314 | 272-363 | RA |
| pfam00788 | 288-363 | RA |
| cd01784 | 275-363 | rasfadin_RA |
| pfam00130 | 133-170 | C1_1 |
| smart00109 | 133-170 | C1 |
| cd01782 | 286-360 | AF6_RA_repeat1 |
| pfam03107 | 136-162 | C1_2 |
| cl03893 | 136-162 | C1_2 superfamily |
Ontology Information
| HPRD ID | 5932 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.