Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18844453 | 2008 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 96 Stage : - | real-time PCR | Up-regulation | - | BCL2L12 gene expression may represent a potential new biomarker for colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| Chromosome | 19 |
| Location | 19q13.3 |
| Start | 50168399 |
| End | 50177173 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8775 |
| OMIM ID | 610837 |
| HGNC ID | HGNC:13787 |
| Unigene ID | Hs.289052 |
| Ensembl ID | ENSG00000126453 |
| PharmGKB ID | PA25306 |
Protein Information
| Protein ID | NP_001035758.1 |
|---|---|
| Protein Name | BCL2-like 12 (proline rich) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 334 |
| Uniprot ID | Q96QR1 |
| Ensembl Protein ID | ENSP00000292641 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 242;- |
| S | Phosphorylation | 241;- |
| S | Phosphorylation | 113 |
| T | Phosphorylation | 117 |
| S | Phosphorylation | 121 |
| S | Phosphorylation | 273 |
| S | Phosphorylation | 272 |
| S | Phosphorylation | 243 |
| S | Phosphorylation | 242 |
| S | Phosphorylation | 245 |
| S | Phosphorylation | 244 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 13983 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.