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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tissue and blood sample No. of Sample : - Stage : TNM Stage II | Biochemical isolation to nano-LC-MS/MS analysis | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008] |
| Chromosome | 15 |
| Location | 15q15-q21 |
| Start | 62390575 |
| End | 62844631 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 454057 |
| OMIM ID | 607349 |
| HGNC ID | HGNC:15447 |
| Unigene ID | Hs.569438 |
| Ensembl ID | ENSG00000171914 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005254714.2 |
|---|---|
| Exon | join(1..111,199113..199188,256701..256872,259510..259607, 261431..261560,262588..262740,265370..265512, 267197..267324,283253..283316,284643..284747, 296067..296222,302266..302367,303742..303818, 307114..307294,308180..308293,310532..310640, 311418..311626,312192..312290,316512..316679, 317928..318222,321337..321503,325757..325885, 327002..327115,329193..329306,331779..331913, 334402..334530,336513..336615,346304..346512, 347640..347759,348774..348971,350056..350195, 357777..357870,359828..359917,361731..361853, 363199..363342,364958..365119,371107..371247, 371698..371879,372989..373121,375747..375848, 380390..380560,386190..386336,390566..390667, 393197..393316,402067..402213,405553..405719, | mRNA Sequence | Download Select all |
| Length | 11914 |
CDS Information
| Location | join(256737..256872,259510..259607,261431..261560, 262588..262740,265370..265512,267197..267324, 283253..283316,284643..284747,296067..296222, 302266..302367,303742..303818,307114..307294, 308180..308293,310532..310640,311418..311626, 312192..312290,316512..316679,317928..318222, 321337..321503,325757..325885,327002..327115, 329193..329306,331779..33 |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_055874.2 |
|---|---|
| Protein Name | Talin 2 |
| Molecular Wt. (Da) | 271483 |
| Protein Sequence | Download Select all |
| Length | 2542 |
| Uniprot ID | P17948 |
| Ensembl Protein ID | ENSP00000282397 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 1843 |
| Y | Phosphorylation | 1665;- |
| S | Phosphorylation | 473 |
| S | Phosphorylation | 428 |
| S | Phosphorylation | 179 |
| T | Phosphorylation | 639 |
| S | Phosphorylation | 651 |
| T | Phosphorylation | 1793 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 23396 | PIP5K1C | 5834 | NP_036530.1 | in vitro | 12422219 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Focal adhesion | hsa04510 |
| HTLV-I infection | hsa05166 |
| Platelet activation | hsa04611 |
| Rap1 signaling pathway | hsa04015 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd12150 | 1656-1827 | talin-RS |
| cl17094 | 1656-1827 | talin-RS superfamily |
| cd10569 | 312-403 | FERM_C_Talin |
| cl17171 | 312-403 | PH-like superfamily |
| cd14473 | 213-308 | FERM_B-lobe |
| cl09511 | 213-308 | FERM_B-lobe superfamily |
| pfam09141 | 494-655 | Talin_middle |
| cl07673 | 494-655 | Talin_middle superfamily |
| smart00307 | 2337-2532 | ILWEQ |
| cl19756 | 2337-2532 | I_LWEQ superfamily |
| pfam08913 | 1850-1974 | VBS |
| cl07488 | 1850-1974 | VBS superfamily |
| pfam01608 | 2383-2532 | I_LWEQ |
| pfam00373 | 209-316 | FERM_M |
| pfam09379 | 92-201 | FERM_N |
| cl09630 | 92-201 | FERM_N superfamily |
| cd00836 | 312-403 | FERM_C-lobe |
| cd12150 | 1045-1174 | talin-RS |
| cl17094 | 1045-1174 | talin-RS superfamily |
| cd13205 | 311-399 | FERM_C_fermitin |
| pfam02174 | 332-399 | IRS |
| cd13164 | 332-393 | PTB_DOK4_DOK5_DOK6 |
| cd13199 | 312-407 | FERM_C2_MyoVII |
| smart00307 | 602-762 | ILWEQ |
| cl19756 | 602-762 | I_LWEQ superfamily |
| smart00307 | 706-796 | ILWEQ |
| smart00295 | 90-316 | B41 |
Ontology Information
| HPRD ID | 1275 |
|---|---|
| Molecular Class | Cytoskeletal associated protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.