Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ATG10 | 83734 | autophagy related 10 | 5 | DKFZP586I0418, FLJ13954 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23285162 | 2012 | Cell line : HCT116, HT29, KM12C, WiDr, LoVo, SW480, SW48, HCT15, DLD1, RKO, CaCo2 Source : ATCC, Asan Medical Center (Seoul, Korea). Sample Type : CRC tumor and normal tissue No. of Sample : 37 Stage : AJCC stageb, I/II/III/IV. | Western Blottimg, Immunohistochemistry,Cell Proliferation Assay | Up-regulation | - | Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis indicating that ATG10 may be a potential prognostic maker in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008] |
| Chromosome | 5 |
| Location | 5q14.1 |
| Start | 81267844 |
| End | 81551958 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 284115 |
| OMIM ID | 610800 |
| HGNC ID | HGNC:20315 |
| Unigene ID | Hs.713698 |
| Ensembl ID | ENSG00000152348 |
| PharmGKB ID | PA134872167 |
Protein Information
| Protein ID | NP_001124500.1 |
|---|---|
| Protein Name | autophagy related 10 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 220 |
| Uniprot ID | Q9BSA4 |
| Ensembl Protein ID | ENSP00000269346 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9140 | ATG12 | 8496 | NP_004698.2 | in vitro;in vivo | 12482611 |
| 9474 | ATG5 | 16051 | NP_004840.1 | yeast 2-hybrid | 12482611 |
| 10533 | ATG7 | 12293 | NP_006386.1 | yeast 2-hybrid | 12482611 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Regulation of autophagy | hsa04140 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03987 | 99-167 | Autophagy_act_C |
| cl08411 | 99-167 | Autophagy_act_C superfamily |
Ontology Information
| HPRD ID | 8821 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Serine-type peptidase activity (GO:0008236) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.