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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ITCH 83737 itchy E3 ubiquitin protein ligase  20AIP4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26110611   2015Cell line : HCT116, SW480

Source : Cell Bank of Type Culture Collection of the Chinese Academy of Sciences, Shanghai Institute of Cell Biology. Tissue sample from The First Affiliated Hospital of Wenzhou Medical College (Wenzhou).

Sample Type : CRC tumor and normal tissue

No. of Sample : 45

Stage : TNM Stage I-III

real time RT-PCR,Western blotting,Cell viability assayDown-regulation-cir-ITCH expression was typically down-regulated in CRC compared to the peritumoral tissue.


Gene Details



NC_000020.10 (32951041..33099198)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]  
Chromosome 20
Location 20q11.22
Start 32951041  
End 33099198  
Strand +  
Gene Sequence

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Length 148158  
OMIM ID 606409   
HGNC ID HGNC:13890   
Unigene ID Hs.632272   
Ensembl ID ENSG00000078747   
PharmGKB ID PA29934   

mRNA Information


mRNA ID ?NM_001257137.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS13234.1



Protein Information


      
Protein IDNP_001244066.1
Protein Nameitchy E3 ubiquitin protein ligase
Molecular Wt. (Da)0
Protein Sequence

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Length 903  
Uniprot IDQ8WXI7
Ensembl Protein ID  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SAcetylation2
SAcetylation2
SPhosphorylation2
SPhosphorylation10
SPhosphorylation13
TPhosphorylation15
SPhosphorylation2
SPhosphorylation10
SPhosphorylation13
TPhosphorylation15
SPhosphorylation4
SPhosphorylation4

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                   
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1822ATN16311NP_001931.2in vitro;yeast 2-hybrid9647693   
1840DTX13991NP_004407.2in vivo17028573   
3725JUN1302NP_002219.1in vivo17110928   
4851NOTCH11827NP_060087.3in vitro;in vivo12682059   
4950OCLN4191NP_002529.1in vitro;in vivo;yeast 2-hybrid11782481   
5430POLR2A8916NP_000928.1in vitro;in vivo16055720   
6456SH3GL25125NP_003017.1in vitro;in vivo14684745   
7223TRPC49154NP_003297.1in vivo17110928   
7442TRPV13648NP_542437.2in vivo17110928   
8650NUMB4767NP_001005743.1in vitro;in vivo12682059   
8737RIPK14583NP_003795.2in vivo19131965   
11052CPSF65401AAH00714.1in vitro;in vivo16055720   
26994RNF119955NP_055187.1in vitro;in vivo1   455   911   719   131   960   


Pathway Information


                        
Pathway Name Pathway ID
Endocytosis hsa04144
Non-alcoholic fatty liver disease (NAFLD) hsa04932
TNF signaling pathway hsa04668
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00078548-901  HECTc
cl00077548-901  HECTc superfamily
cd0402117-140  C2_E3_ubiquitin_ligase
cl1460317-140  C2 superfamily
cd00201441-470  WW
cl00157441-470  WW superfamily
cd00201361-391  WW
cl00157361-391  WW superfamily
cd00201329-359  WW
cl00157329-359  WW superfamily
cd00201481-510  WW
cl00157481-510  WW superfamily
pfam00632599-901  HECT
cd0003020-110  C2
smart0023919-109  C2
smart00456439-471  WW
pfam0016820-98  C2
pfam00397440-469  WW
smart00456327-359  WW
pfam00397360-389  WW
smart00456359-391  WW
pfam00397328-357  WW
cd0405039-115  C2B_Synaptotagmin-like
smart00456479-510  WW
cd0838220-115  C2_Smurf-like
cd0404420-114  C2A_Tricalbin-like
cd0405120-122  C2_SRC2_like
cd0403841-102  C2_ArfGAP
cd0839120-108  C2A_C2C_Synaptotagmin_like
cd0837323-115  C2A_Ferlin
cd0401119-102  C2B_Ferlin
cd0404621-136  C2_Calpain
cd0027517-100  C2_PLC_like
pfam00397480-509  WW
cd0403218-97  C2_Perforin
cd0403117-101  C2A_RIM1alpha
cd0401816-102  C2C_Ferlin
cd0402420-122  C2A_Synaptotagmin-like
cd0405239-83  C2B_Tricalbin-like
cd0404839-126  C2A_Copine
smart00119572-900  HECTc
COG5021359-903  HUL4
COG5104332-409  PRP40
COG5104444-509  PRP40


Ontology Information


   
HPRD ID6446
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionGTPase activator activity (GO:0005096)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO