Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CASP5 | 838 | Caspase 5, apoptosis-related cysteine peptidase | 11 | ICH-3; ICEREL-III; ICE(rel)III |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22997602 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | Mutation due to inactivation of DNA mismatch repair |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Caspases |
| Description | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010] |
| Chromosome | 11 |
| Location | 11q22.2-q2 |
| Start | 104992633 |
| End | 105023221 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 30589 |
| OMIM ID | 602665 |
| HGNC ID | HGNC:1506 |
| Unigene ID | Hs.213327 |
| Ensembl ID | ENSG00000137757 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011543020.1 |
|---|---|
| Exon | join(2..92,14242..14415,19839..19948,21021..21194, 22727..22961,24194..24337,25730..25839,27380..27482, 28875..30589) | mRNA Sequence | Download Select all |
| Length | 1023 |
CDS Information
| Location | join(86..92,19839..19948,21021..21194,22727..22961, 24194..24337,25730..25839,27380..27478) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS44718.1 |
Protein Information
| Protein ID | NP_001129581.1 |
|---|---|
| Protein Name | Caspase 5, apoptosis-related cysteine peptidase |
| Molecular Wt. (Da) | 43130 |
| Protein Sequence | Download Select all |
| Length | 376 |
| Uniprot ID | P12235 |
| Ensembl Protein ID | ENSP00000281456 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4149 | MAX | 1113 | NP_002373.3 | in vitro;in vivo | 11535131 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| NOD-like receptor signaling pathway | hsa04621 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00032 | 182-431 | CASc |
| cl00042 | 182-431 | CASc superfamily |
| smart00115 | 183-432 | CASc |
| pfam00656 | 193-430 | Peptidase_C14 |
| cd08325 | 63-142 | CARD_CASP1-like |
| cl14633 | 63-142 | DD superfamily |
| smart00114 | 56-146 | CARD |
| pfam00619 | 61-147 | CARD |
Ontology Information
| HPRD ID | 58 |
|---|---|
| Molecular Class | Cysteine protease |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.