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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23216165 | 2013 | Cell line : - Source : - Sample Type : GC,CRC,PCA tumor No. of Sample : 45 GC, 45 CRC and 45 PCA Stage : - | SSCP,immunohistochemistry | Mutation | - | Loss of SPOP expression was common in GC, CRC and PCA, |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | BTB/POZ domain containing |
| Description | This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q21.33 |
| Start | 47676246 |
| End | 47755525 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 79280 |
| OMIM ID | 602650 |
| HGNC ID | HGNC:11254 |
| Unigene ID | Hs.463382 |
| Ensembl ID | ENSG00000121067 |
| PharmGKB ID | PA36084 |
mRNA Information
| mRNA ID | ?NM_001007226.1 |
|---|---|
| Exon | join(1..231,55288..55431,56097..56218,58779..58930, 59056..59183,66707..66884,70235..70290,70792..70914, 76157..76299,77642..79280) | mRNA Sequence | Download Select all |
| Length | 2931 |
Protein Information
| Protein ID | NP_001007227.1 |
|---|---|
| Protein Name | speckle-type POZ protein |
| Molecular Wt. (Da) | 38233 |
| Protein Sequence | Download Select all |
| Length | 374 |
| Uniprot ID | O14775 |
| Ensembl Protein ID | ENSP00000261837 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3651 | PDX1 | 2843 | NP_000200.1 | in vivo;yeast 2-hybrid | 15121856 |
| 7185 | TRAF1 | 3418 | NP_005649.1 | in vitro | 11279055 |
| 9555 | H2AFY | 13624 | NP_613258.2 | yeast 2-hybrid | 12183056 |
| 10313 | RTN3 | 18516 | NP_958831.1 | yeast 2-hybrid | 16189514 |
| 10870 | HCST | 4971 | NP_055081.1 | in vitro;in vivo | 12 740 575 104 269 900 000 000 000 000 000 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03774 | 28-166 | MATH_SPOP |
| cl02446 | 28-166 | MATH superfamily |
| cd14734 | 297-359 | SPOP_C |
| cl06652 | 297-359 | BACK_like superfamily |
| pfam00651 | 190-297 | BTB |
| cl02518 | 190-297 | BTB superfamily |
| smart00225 | 201-297 | BTB |
| cd14733 | 297-358 | BACK_like |
| cd00121 | 32-161 | MATH |
| cd14821 | 297-358 | SPOP_C_like |
| cd14736 | 297-357 | SPOP_C_like_plant |
| pfam00917 | 38-163 | MATH |
| smart00061 | 36-137 | MATH |
| cd03772 | 130-166 | MATH_HAUSP |
| cd14735 | 297-335 | BACK_Kelch |
| PHA03098 | 195-325 | PHA03098 |
| PHA02713 | 185-290 | PHA02713 |
Ontology Information
| HPRD ID | 5226 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.