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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19930159 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : Paired tumor and normal mucosa samples from 120 consecutive CRC patients, 20 adenomas, and eight synchronous hepatic metastases of CRC. Stage : TNM Stage I-IV | Linear quadrupole ion trap fourier transform mass spectrometry (LTQ-FTMS), Western blotting | Up-regulation | - | Over-expression of TAGLN2 may serve as a new biomarker for predicting progression and prognosis of CRC. |
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | - |
| 22766685 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 64 paired tissue samples (CRC tumor and adjacent normal mucosa) Stage : - | Stem-loopRT-PCR. | Up-regulation | - | Expression of the miR-1-133a cluster inversely correlated with TAGLN2 in the tumor specimens. Epigenetic repression of the miR-1-133a cluster may play a critical role in colorectal cancer metastasis by silencing TAGLN2. |
| 22943952 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 120 colorectal cancer patients. Stage : TNM Stage IV | Tissue microarray and immunohistochemistry | Up-regulation | - | The expression of transgelin-2 is correlated with clinicopathological features and prognosis in colorectal cancer, may be the potential marker of metastasis and the prognosis of colorectal cancer patients |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013] |
| Chromosome | 1 |
| Location | 1q21-q25 |
| Start | 159918107 |
| End | 159925542 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7436 |
| OMIM ID | 604634 |
| HGNC ID | HGNC:11554 |
| Unigene ID | Hs.517168 |
| Ensembl ID | ENSG00000158710 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_003564.2 |
|---|---|
| Exon | join(1..93,5006..5213,5708..5882,6167..6269,6602..7436) | mRNA Sequence | Download Select all |
| Length | 1419 |
CDS Information
| Location | join(2073..2107,5006..5213,5708..5882,6167..6269, 6602..6743) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS60314.1 |
Protein Information
| Protein ID | NP_001264152.1 |
|---|---|
| Protein Name | Transgelin 2 |
| Molecular Wt. (Da) | 22260 |
| Protein Sequence | Download Select all |
| Length | 199 |
| Uniprot ID | P19971 |
| Ensembl Protein ID | ENSP00000252029 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 163 |
| S | Phosphorylation | 185 |
| K | Acetylation | 20 |
| K | Acetylation | 17 |
| T | Phosphorylation | 180 |
| Y | Phosphorylation | 192 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1WYM |
|---|---|
| Resolution | - |
| Method | solution NMR |
| Chains | A |
| Molecule | Transgelin-2 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00014 | 25-136 | CH |
| cl00030 | 25-136 | CH superfamily |
| smart00033 | 29-132 | CH |
| pfam00307 | 27-132 | CH |
| pfam00402 | 174-198 | Calponin |
| cl02859 | 174-198 | Calponin superfamily |
| COG5199 | 14-188 | SCP1 |
| COG5261 | 48-132 | IQG1 |
Ontology Information
| HPRD ID | 3790 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Signal transduction (GO:0007165); Cell communication (GO:0007154) |
Drug Information
No matching records could be found.