Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EEA1 | 8411 | Early endosome antigen 1  | 12 | MST105; ZFYVE2; MSTP105  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22968445    | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FF E-FASP,SAX fractionation,LC MSMS,Label-free quantitation. | Up-regulation | 3.7 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, FYVE domain containing |
| Description | -   |
| Chromosome | 12 |
| Location | 12q22 |
| Start | 92772509   |
| End | 92929331   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 156823   |
| OMIM ID | 605070    |
| HGNC ID | HGNC:3185    |
| Unigene ID | Hs.567367     |
| Ensembl ID | ENSG00000102189    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011538360.1 |
|---|---|
| Exon | complement(<156587..>156823)   | mRNA Sequence |    Download   Select all |
| Length | 8019   |
CDS Information
| Location | join(266..289,37611..37703,64345..64472,71847..71901, 71992..72057,75378..75417,76307..76420,77036..77157, 78066..78221,86751..86867,96482..96820,101271..101420, 103047..103166,109821..110024,112932..113132, 116239..116352,117898..118053,120176..120315, 126598..126928,127631..127732,130246..130440, 141283..141465,147197..147382,148921..149052, 150032 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS31874.1 |    
Protein Information
| Protein ID | NP_003557.2 |
|---|---|
| Protein Name | Early endosome antigen 1 |
| Molecular Wt. (Da) | 162335 |
| Protein Sequence |    Download   Select all |
| Length | 1411   |
| Uniprot ID | P30084 |    
| Ensembl Protein ID | ENSP00000357535   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 1392 |
| S | Phosphorylation | 15 |
| S | Phosphorylation | 70 |
| T | Phosphorylation | 761 |
| T | Phosphorylation | 836 |
| T | Phosphorylation | 837 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5868 |    RAB5A |    1542 |    NP_004153.2 |    in vitro;in vivo;yeast 2-hybrid |    14   600   265   104   911   900   000   000    |
| 5869 |    RAB5B |    1544 |    NP_002859.1 |    in vitro;in vivo;yeast 2-hybrid |    1   249   373   610   491   190    |
| 5878 |    RAB5C |    4947 |    NP_004574.2 |    in vitro |    12493736    |
| 10043 |    TOM1 |    5265 |    NP_001129204.1 |    in vitro |    14613930    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Endocytosis |    hsa04144 |    
| Phagosome |    hsa04145 |    
| Tuberculosis |    hsa05152 |    
Structure Information
| PDB ID | 1HYI |
|---|---|
| Resolution | - |
| Method | solution NMR |
| Chains | A   |
| Molecule | ENDOSOME-ASSOCIATED PROTEIN   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd15730 | 1347-1409  | FYVE_EEA1 |
| cl22851 | 1347-1409  | PHD_SF superfamily |
| pfam01363 | 1348-1411  | FYVE |
| smart00064 | 1346-1411  | FYVE |
| cd15721 | 1349-1406  | FYVE_RUFY1_like |
| cd15717 | 1349-1406  | FYVE_PKHF |
| cd15731 | 1349-1407  | FYVE_LST2 |
| cd00065 | 1357-1406  | FYVE_like_SF |
| cd15719 | 1349-1409  | FYVE_WDFY3 |
| cd15758 | 1349-1409  | FYVE_RUFY1 |
| cd15720 | 1349-1409  | FYVE_Hrs |
| cd15728 | 1349-1409  | FYVE_ANFY1 |
| cd15760 | 1348-1406  | FYVE_scVPS27p_like |
| cd15729 | 1349-1409  | FYVE_endofin |
| cd15733 | 1349-1406  | FYVE_MTMR4 |
| cd15755 | 1349-1409  | FYVE_PKHF2 |
| cd15732 | 1348-1406  | FYVE_MTMR3 |
| cd15727 | 1349-1405  | FYVE_ZF21 |
| cd15743 | 1349-1406  | FYVE_FGD6 |
| cd15739 | 1348-1406  | FYVE_RABE_unchar |
| cd15726 | 1349-1406  | FYVE_FYCO1 |
| cd15741 | 1348-1409  | FYVE_FGD1_2_4 |
| cd15716 | 1349-1409  | FYVE_RBNS5 |
| cd15724 | 1349-1407  | FYVE_ZFY26 |
| cd15754 | 1349-1409  | FYVE_PKHF1 |
| cd15735 | 1352-1406  | FYVE_spVPS27p_like |
| cd15734 | 1349-1406  | FYVE_ZFYV1 |
| cd15759 | 1349-1405  | FYVE_RUFY2 |
| cd15725 | 1349-1406  | FYVE_PIKfyve_Fab1 |
| cd15738 | 1348-1406  | FYVE_MTMR_unchar |
| cd15742 | 1355-1410  | FYVE_FGD5 |
| cd15737 | 1348-1405  | FYVE2_Vac1p_like |
| cd15736 | 1358-1406  | FYVE_scVPS27p_Vac1p_like |
| cd15718 | 1349-1406  | FYVE_WDFY1_like |
| cd15745 | 1358-1406  | FYVE_RUFY4 |
| cd15740 | 1352-1406  | FYVE_FGD3 |
| cd15723 | 1357-1405  | FYVE_protrudin |
| cd15749 | 1357-1406  | FYVE_ZFY19 |
| cd15744 | 1358-1406  | FYVE_RUFY3 |
| cd15756 | 1348-1410  | FYVE_WDFY1 |
| cd15750 | 1357-1405  | FYVE_CARP |
| cd15757 | 1367-1405  | FYVE_WDFY2 |
| cd15761 | 1349-1406  | FYVE1_Vac1p_like |
| cd15769 | 1358-1405  | FYVE_CARP1 |
| cd15770 | 1356-1394  | FYVE_CARP2 |
| cd15590 | 1358-1405  | PHD2_KMT2A |
| pfam01576 | 170-993  | Myosin_tail_1 |
| COG1196 | 367-1190  | Smc |
| COG1196 | 436-1299  | Smc |
| TIGR02168 | 609-1340  | SMC_prok_B |
| TIGR02168 | 375-1153  | SMC_prok_B |
| COG1196 | 288-1158  | Smc |
| TIGR02168 | 500-1334  | SMC_prok_B |
| TIGR02168 | 243-964  | SMC_prok_B |
| COG1196 | 242-995  | Smc |
| COG1196 | 108-869  | Smc |
| COG1196 | 177-949  | Smc |
| COG1196 | 609-1338  | Smc |
| TIGR02168 | 137-864  | SMC_prok_B |
| COG1196 | 625-1357  | Smc |
| TIGR02169 | 221-1023  | SMC_prok_A |
| TIGR02169 | 446-1293  | SMC_prok_A |
| COG1196 | 82-775  | Smc |
| TIGR02168 | 79-911  | SMC_prok_B |
| TIGR02169 | 267-983  | SMC_prok_A |
| TIGR02169 | 161-939  | SMC_prok_A |
| pfam12128 | 80-823  | DUF3584 |
| TIGR02169 | 511-1298  | SMC_prok_A |
| TIGR02168 | 696-1355  | SMC_prok_B |
| COG1196 | 695-1358  | Smc |
| TIGR02169 | 74-851  | SMC_prok_A |
| TIGR02169 | 629-1340  | SMC_prok_A |
| pfam02463 | 460-1254  | SMC_N |
| TIGR02169 | 369-1162  | SMC_prok_A |
| TIGR02168 | 77-737  | SMC_prok_B |
| COG0419 | 74-650  | SbcC |
| TIGR02169 | 376-727  | SMC_prok_A |
| TIGR04523 | 380-995  | Mplasa_alph_rch |
| COG0419 | 288-864  | SbcC |
| PTZ00121 | 713-1270  | PTZ00121 |
| pfam02463 | 312-1139  | SMC_N |
| TIGR02169 | 847-1153  | SMC_prok_A |
| PRK02224 | 226-709  | PRK02224 |
| PRK02224 | 435-1043  | PRK02224 |
| pfam05483 | 465-1151  | SCP-1 |
| PRK03918 | 696-1274  | PRK03918 |
| PTZ00121 | 764-1357  | PTZ00121 |
| COG0419 | 763-1318  | SbcC |
| COG0419 | 626-1168  | SbcC |
| pfam02463 | 176-976  | SMC_N |
| pfam12128 | 793-1339  | DUF3584 |
| TIGR04523 | 771-1333  | Mplasa_alph_rch |
| pfam01576 | 136-822  | Myosin_tail_1 |
| COG1196 | 70-426  | Smc |
| TIGR00606 | 251-1128  | rad50 |
| TIGR04523 | 247-737  | Mplasa_alph_rch |
| PRK11281 | 265-692  | PRK11281 |
| PRK03918 | 348-851  | PRK03918 |
| pfam02463 | 107-954  | SMC_N |
| TIGR04523 | 564-1149  | Mplasa_alph_rch |
| COG4372 | 876-1099  | COG4372 |
| TIGR04523 | 664-1291  | Mplasa_alph_rch |
| pfam12128 | 245-915  | DUF3584 |
| pfam12128 | 582-1170  | DUF3584 |
| PRK02224 | 630-1157  | PRK02224 |
| PRK02224 | 81-625  | PRK02224 |
| PRK01156 | 381-978  | PRK01156 |
| pfam05483 | 503-1240  | SCP-1 |
| TIGR02169 | 107-471  | SMC_prok_A |
| TIGR00618 | 394-1110  | sbcc |
| pfam13166 | 771-1161  | AAA_13 |
| PLN02939 | 785-1094  | PLN02939 |
| PRK03918 | 156-686  | PRK03918 |
| TIGR02169 | 1079-1355  | SMC_prok_A |
| TIGR00606 | 129-982  | rad50 |
| COG0419 | 904-1319  | SbcC |
| pfam01576 | 244-980  | Myosin_tail_1 |
| pfam09726 | 913-1129  | Macoilin |
| COG4372 | 1067-1292  | COG4372 |
| COG1511 | 619-970  | YhgE |
| PRK11281 | 366-645  | PRK11281 |
| TIGR03185 | 375-712  | DNA_S_dndD |
| PRK04863 | 240-644  | mukB |
| TIGR02169 | 788-1340  | SMC_prok_A |
| TIGR00606 | 422-1270  | rad50 |
| TIGR02168 | 1076-1357  | SMC_prok_B |
| PTZ00121 | 145-972  | PTZ00121 |
| pfam13166 | 789-992  | AAA_13 |
| PRK03918 | 860-1343  | PRK03918 |
| pfam01576 | 347-1202  | Myosin_tail_1 |
| pfam05483 | 840-1342  | SCP-1 |
| pfam12128 | 359-1201  | DUF3584 |
| COG1511 | 284-699  | YhgE |
| pfam02463 | 692-1354  | SMC_N |
| pfam13514 | 226-987  | AAA_27 |
| COG4372 | 334-598  | COG4372 |
| COG1511 | 187-597  | YhgE |
| COG4942 | 453-663  | EnvC |
| TIGR00618 | 366-989  | sbcc |
| pfam13514 | 89-822  | AAA_27 |
| TIGR00606 | 91-843  | rad50 |
| pfam05483 | 418-972  | SCP-1 |
| TIGR01843 | 383-514  | type_I_hlyD |
| pfam07888 | 339-613  | CALCOCO1 |
| PTZ00303 | 1325-1410  | PTZ00303 |
| COG0419 | 47-549  | SbcC |
| PHA02562 | 619-872  | 46 |
| PRK03918 | 90-487  | PRK03918 |
| PRK11281 | 784-1111  | PRK11281 |
| COG4372 | 822-1026  | COG4372 |
| PRK11281 | 386-661  | PRK11281 |
| COG4942 | 885-1149  | EnvC |
| pfam13166 | 377-738  | AAA_13 |
| PRK11281 | 893-1118  | PRK11281 |
| PRK04863 | 88-702  | mukB |
| PHA02562 | 892-1112  | 46 |
| pfam09726 | 529-964  | Macoilin |
| TIGR00618 | 375-1031  | sbcc |
| PRK05771 | 689-949  | PRK05771 |
| PRK03918 | 248-747  | PRK03918 |
| COG4372 | 969-1146  | COG4372 |
| pfam07888 | 140-472  | CALCOCO1 |
| pfam04111 | 894-1027  | APG6 |
| PRK10929 | 333-719  | PRK10929 |
| pfam07888 | 673-932  | CALCOCO1 |
| COG5185 | 867-1195  | HEC1 |
| pfam05622 | 88-543  | HOOK |
| COG3264 | 531-699  | MscK |
| pfam05478 | 515-707  | Prominin |
| TIGR04320 | 584-702  | Surf_Exclu_PgrA |
| TIGR00618 | 88-736  | sbcc |
| COG4372 | 447-695  | COG4372 |
| TIGR03007 | 511-819  | pepcterm_ChnLen |
| PRK00448 | 786-989  | polC |
| pfam05622 | 371-817  | HOOK |
| PRK09039 | 537-702  | PRK09039 |
| PRK02224 | 1074-1297  | PRK02224 |
| pfam01496 | 55-306  | V_ATPase_I |
| PRK12704 | 882-994  | PRK12704 |
| COG4372 | 223-459  | COG4372 |
| pfam09726 | 462-697  | Macoilin |
| TIGR03007 | 427-669  | pepcterm_ChnLen |
| pfam01576 | 686-1189  | Myosin_tail_1 |
| pfam12128 | 907-1345  | DUF3584 |
| PRK01156 | 87-646  | PRK01156 |
| TIGR04211 | 375-468  | SH3_and_anchor |
| PRK02224 | 61-397  | PRK02224 |
| COG4942 | 263-483  | EnvC |
| pfam13166 | 579-783  | AAA_13 |
| pfam04156 | 346-472  | IncA |
| PTZ00108 | 766-1157  | PTZ00108 |
| PRK04863 | 463-737  | mukB |
| pfam09726 | 1019-1190  | Macoilin |
| COG3096 | 450-698  | MukB |
| PLN02939 | 244-636  | PLN02939 |
| TIGR02302 | 399-600  | aProt_lowcomp |
| TIGR00618 | 108-733  | sbcc |
| PRK04863 | 372-565  | mukB |
| PRK12704 | 840-983  | PRK12704 |
| TIGR00606 | 542-1333  | rad50 |
| COG4942 | 840-1101  | EnvC |
| PTZ00440 | 85-979  | PTZ00440 |
| PRK03918 | 75-588  | PRK03918 |
| pfam10174 | 54-613  | Cast |
| pfam01496 | 688-938  | V_ATPase_I |
| pfam02463 | 75-824  | SMC_N |
| PHA02562 | 136-392  | 46 |
| TIGR03346 | 355-473  | chaperone_ClpB |
| PRK11281 | 924-1175  | PRK11281 |
| pfam01576 | 75-717  | Myosin_tail_1 |
| PRK11637 | 574-747  | PRK11637 |
| COG3096 | 390-804  | MukB |
| TIGR00618 | 617-1235  | sbcc |
| TIGR00414 | 376-481  | serS |
| COG4717 | 154-739  | YhaN |
| PRK01156 | 787-1310  | PRK01156 |
| pfam10174 | 140-878  | Cast |
| COG4372 | 539-751  | COG4372 |
| pfam12252 | 895-1175  | SidE |
| pfam09726 | 264-465  | Macoilin |
| pfam01496 | 420-634  | V_ATPase_I |
| PRK00409 | 689-869  | PRK00409 |
| PRK10929 | 117-471  | PRK10929 |
| TIGR04211 | 901-994  | SH3_and_anchor |
| PRK09039 | 349-469  | PRK09039 |
| pfam06785 | 913-1020  | UPF0242 |
| pfam13166 | 173-566  | AAA_13 |
| COG3264 | 272-483  | MscK |
| pfam04156 | 521-640  | IncA |
| COG5283 | 446-983  | COG5283 |
| TIGR04211 | 231-322  | SH3_and_anchor |
| TIGR03319 | 501-665  | RNase_Y |
| COG4372 | 596-808  | COG4372 |
| COG1269 | 358-634  | NtpI |
| COG3096 | 175-865  | MukB |
| PRK02224 | 858-1322  | PRK02224 |
| pfam09730 | 167-483  | BicD |
| COG3883 | 668-854  | CwlO1 |
| COG5185 | 318-734  | HEC1 |
| TIGR04211 | 593-703  | SH3_and_anchor |
| COG2176 | 640-934  | PolC |
| pfam06160 | 680-983  | EzrA |
| COG4372 | 650-833  | COG4372 |
| PRK01156 | 159-736  | PRK01156 |
| pfam12004 | 260-377  | DUF3498 |
| TIGR03794 | 256-367  | NHLM_micro_HlyD |
| COG4372 | 437-661  | COG4372 |
| TIGR03545 | 576-686  | TIGR03545 |
| TIGR03185 | 502-808  | DNA_S_dndD |
| PRK01156 | 1006-1285  | PRK01156 |
| COG4913 | 499-721  | COG4913 |
| COG1511 | 91-475  | YhgE |
Ontology Information
| HPRD ID | 7173 |    
|---|---|
| Molecular Class | Membrane transport protein |
| Molecular Function | Hormone activity (GO:0005179) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
