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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25289111 | 2014 | Cell line : - Source : Medical Institute of Bioregulation at Kyushu University (Beppu, Ohita, Japan) and the Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine (Suita, Osaka, Japan) Sample Type : CRC tumor and normal tissues No. of Sample : 100 Stage : UICC Stage I-IV | real time RT-PCR | Up-regulation | - | Patients with high ANXA9 expression were statistically susceptible to a relatively worse prognosis, and those with low ANXA9 expression showed improved overall survival compared with those with high expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Annexins |
| Description | The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q21.2 |
| Start | 150954499 |
| End | 150968114 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 13616 |
| OMIM ID | 603319 |
| HGNC ID | HGNC:547 |
| Unigene ID | Hs.3346 |
| Ensembl ID | ENSG00000143412 |
| PharmGKB ID | PA24837 |
mRNA Information
| mRNA ID | ?NM_003568.2 |
|---|---|
| Exon | join(1..357,465..561,1068..1158,1316..1412,1953..2047, 2259..2372,2564..2654,4314..4393,4580..4639,5850..5934, 6069..6164,6261..6319,12555..12677,13238..13616) | mRNA Sequence | Download Select all |
| Length | 1843 |
Protein Information
| Protein ID | NP_003559.2 |
|---|---|
| Protein Name | annexin A9 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 345 |
| Uniprot ID | O00187 |
| Ensembl Protein ID | ENSP00000383690 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 69 |
| T | Phosphorylation | 69 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 55160 | ARHGEF10L | 7679 | NP_060595.3 | yeast 2-hybrid | 16169070 |
| 56901 | NDUFA4L2 | 14249 | NP_064527.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00191 | 117-182 | Annexin |
| cl02574 | 117-182 | Annexin superfamily |
| pfam00191 | 274-339 | Annexin |
| cl02574 | 274-339 | Annexin superfamily |
| pfam00191 | 45-110 | Annexin |
| cl02574 | 45-110 | Annexin superfamily |
| smart00335 | 134-182 | ANX |
| smart00335 | 289-339 | ANX |
| smart00335 | 58-110 | ANX |
| pfam00191 | 201-264 | Annexin |
| cl02574 | 201-264 | Annexin superfamily |
| smart00335 | 214-264 | ANX |
| pfam10337 | 37-184 | DUF2422 |
| cl20397 | 37-184 | DUF2422 superfamily |
Ontology Information
| HPRD ID | 9251 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.