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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ANTXR1 | 84168 | anthrax toxin receptor 1 | 2 | TEM8, FLJ21776, FLJ10601, ATR |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22340594 | 2012 | Cell line : - Source : Cooperative Human Tissue Network (CHTN). Sample Type : CRC tumor No. of Sample : - Stage : - | Western Blotting,Immunofluorescence | Up-regulation | - | Anthrax toxin receptor 1 (ANTXR1), is a highly conserved cell-surface protein overexpressed on tumor-infiltrating vasculature. |
| 23372686 | 2013 | Cell line : HCT116 and SW620 cells Source : Two colon cancer patient datasets, GSE14333 [37] and GSE17538 [38], available in the Gene Expression Omnibus (GEO) Database (http://www.ncbi.nlm.nih.gov/gds) were included in this study. Cells were obtained from American Type Culture Collection. Sample Type : - No. of Sample : - Stage : Stage A, B, C and D | Western blot analysis,Anchorage-independent soft agar and clonogenic assays, | Up-regulation | - | Genes that are associated with colon cancer progression (ANTXR1, EFEMP2, SULF1, TAGLN, VCAN, ZEB1 and ZEB2) were upregulated in patients co-overexpressing TAZ-AXL-CTGF. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008] |
| Chromosome | 2 |
| Location | 2p13.1 |
| Start | 69240276 |
| End | 69476459 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 236184 |
| OMIM ID | 606410 |
| HGNC ID | HGNC:21014 |
| Unigene ID | Hs.165859 |
| Ensembl ID | ENSG00000169604 |
| PharmGKB ID | PA134956382 |
Protein Information
| Protein ID | NP_060623.2 |
|---|---|
| Protein Name | anthrax toxin receptor 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 564 |
| Uniprot ID | Q8IWW6 |
| Ensembl Protein ID | ENSP00000310984 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 425;- |
| S | Phosphorylation | 362;- |
| N | Glycosylation | 184 |
| N | Glycosylation | 184 |
| N | Glycosylation | 184 |
| N | Glycosylation | 262 |
| N | Glycosylation | 262 |
| N | Glycosylation | 262 |
| S | Phosphorylation | 81 |
| S | Phosphorylation | 86 |
| T | Phosphorylation | 87 |
| T | Phosphorylation | 90 |
| S | Phosphorylation | 81 |
| S | Phosphorylation | 86 |
| T | Phosphorylation | 87 |
| T | Phosphorylation | 90 |
| S | Phosphorylation | 81 |
| S | Phosphorylation | 86 |
| T | Phosphorylation | 87 |
| T | Phosphorylation | 90 |
| S | Phosphorylation | 441 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 598 | BCL2L1 | 2497 | NP_612815.1 | in vitro;in vivo | 11574549 |
| 672 | BRCA1 | 218 | NP_009231.2 | in vivo | 20566643 |
| 3066 | HDAC2 | 5521 | NP_001518.2 | in vivo | 10545197 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01474 | 39-223 | vWA_ATR |
| cl00057 | 39-223 | vWFA superfamily |
| pfam05587 | 216-320 | Anth_Ig |
| cl05254 | 216-320 | Anth_Ig superfamily |
| pfam05586 | 396-489 | Ant_C |
| cl05253 | 396-489 | Ant_C superfamily |
| cd01450 | 43-199 | vWFA_subfamily_ECM |
| pfam00092 | 44-215 | VWA |
| smart00327 | 44-212 | VWA |
| cd00198 | 44-199 | vWFA |
| cd01471 | 44-180 | vWA_micronemal_protein |
| pfam13519 | 44-215 | VWA_2 |
| cd01472 | 44-203 | vWA_collagen |
| cd01476 | 44-199 | VWA_integrin_invertebrates |
| cd01482 | 44-203 | vWA_collagen_alphaI-XII-like |
| cd01469 | 44-211 | vWA_integrins_alpha_subunit |
| cd01480 | 44-192 | vWA_collagen_alpha_1-VI-type |
| cd01467 | 42-180 | vWA_BatA_type |
| cd01465 | 45-199 | vWA_subgroup |
| COG1240 | 79-151 | ChlD |
| COG0153 | 66-155 | GalK |
Ontology Information
| HPRD ID | 10095 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.