CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
CASP9	842	caspase 9, apoptosis-related cysteine peptidase	1	MCH6, ICE-LAP6, APAF-3, PPP1R56

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24592539	2013	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	QRT-PCR Western blotting.	Up-regulation	-	Overexpression of caspase-9 facilitates differentiation of colon cancer.
25031754	2014	Cell line : - Source : Department of Diagnostic Pathology of the Osaka Red Cross Hospital and the Kobe Central Hospital of Social Insurance. Sample Type : Tumor tissue No. of Sample : 75 tumor advanced gastric adenocarcinoma (37 well-to-moderately differentiated and 38 poorly differentiated), 76 tumor advanced colorectal adenocarcinoma (69 well-to-moderately differentiated and 7 poorly differentiated) Stage : -	immunohistochemistry	Up-regulation	-	Levels of p-caspase-9 were significantly higher in colorectal cancer than in gastric cancer, indicating tumor-specific regulation.

Gene Details

NC_000001.10 (15817896..15851407, complement)
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Gene Type	protein coding
Gene Family	Caspases, "Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits"
Description	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	1
Location	1p36.21
Start	15817896
End	15851407
Strand	-
Gene Sequence	>gi\|568815597:c15526529-15491401 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly CAGTTGCTAGGATGGGGACGCACTCTCTGGTCCCTATTCTCTTTAACCCTATTCGTAGAACCTTAGAGCG TCAGATTGGAAGTGACCTTAGGGATTCTTTAACTCTCCAACTCCTGCAATATTGATAGGGAGACCGAGGT CCAGAGAGGGGCAGAGATTTGCCCAAGGCCTAGAATCCAGCATTCCTTTTATTTTTGTTTACTTATCTTT TTTTTTTTTGAGAGAATCCAGGACTTTTAATCCCGTTTACCGAAAACCGAGCTCCACCCAAGAATGTACC AGTCTGTGCCTTAAGCACGGGGAAAGGGCGGTGGGGGTGGAGAGAGGGATAAGGCACAGGTAAGTGAAGG AAACTTTCTTTGAGCCAATGAGATAGATCCCTTGCGGATATAAAGAGCTTTCATATCTCCCTGTCTTGTT TTTATTTTTTTCTCTTTGCATTTATCACTATCTAACATAGTATGTCTTATTTATTGATATAGTTTATCAC CTGATCCTTCCACTGGAATGTAAACTCTAAAAGCAGGGATTTTGTTTTGTTCACCTTCATGTTCTTAGTG TTTGACTACAGGCTCAATAAATATTCGTAGAAGTGAACGAATGGGGCTGAGGTTTTGGTGCTCAAGAGAT TATATTCTAAGGTGGATTCTTAAGAGTGTGGCTTACAGAGTCAGGTTCGGGTTTCAATCCTGCCTGCCTC GGCCACTTAGTACCCAAGTGACCTTAAACATTCGTTTCCCTGAACCCTAGGGTCTACATCTGTAAAACCG GCGGGGGGTGGGAATACTTTCCTGGCAGGATTGTAGTTAAGGATAAGTGAAATAAGCATGAAAAGTGGCT AGCACGATGCCTGGGACTTAGCAAATGCTCAGTAAACAGAAACGATTATTTTTGAAATGTGAAAATGAAC CGTTCAGAACGATGGGAGTTTACAGGACTAGATTTCTGCCGTTTTTTTTTTTTTCTGTGTGGGAGGTGTT AGGGTGGGAGGGAGGGAAGAGGGAATGGAAGACTGTGTAAGGTGGGCTTGGTTGGATCAGACACTCGAGT TTGGAACAGTCAACTGCGATCTGGGCACAAGGGCGGTGAGGGGAGCTTATGGTTTTACTTGGGGTGGAGG AGGGGGCTAAGGGGAAGCCATGCCCCGGAGGAGGTTGAATGGGCGGGACAGATCACGGCTCCACTCATGG TTTCCCTCTTGCTGGAAGTGTGACGACTCCCTCCGGATCTCTGTAAAAGCGGGGCTATAGTGAATTCTGG CGAAGGGCCCGCGGTGGACCAGGAACTGGTGCCAGAATTGCAAAAGGGCACCTGCGCCCGGAGTGGGGAG GTGATGCGGGGGCGGGGCGGGGCCCTGGGGGCGGGGCGAGTCGCGGAGGTGCCGCCTTGGGGCGGGGCGG TGACAGAAGGATGGATCCTGGGGGTGAGGATTGACTTTGGGGGCGGGGCGAGAGTGCGAACTGGAGTCTG AGGCTGAGCGGTGACGCAAGGACGATTCTGAGGGTGGAGCGAGGGGAGGGGATTGGCTCTTGGAGGCGGG GCGGTGGCACGAGGCTAGCCCTTGGGGGCGGGGCGGTGGCGCAAGATTGACCTTGGGGGCGGGGTGGGGG CGTGGGTTGAATCCTGGGGGCGGGGCGGTGGCGCGGAATGGATTCTGGGGTCGGCGCGAGGCGCTGAGGT GCGTCCTGAGGGCGGGGCGATGACGCAGAGCGAATCCTGGGGGCGGGGCGAGACCTTCTAGATGCGTCCC GGGGAGTGGGCGGTGACGCGGTGGCAGGTTCTGGGGACAGGCGGTGACCCCAGAATTGACCCTGGGGACA GGGCGAGGCGCGGAGGCGTCCTGAAGGCGAGGCGGTGACGCAAGAGCGAATCCTTGGGGCGGGGCGAGGC GTTGGAGATGCGTCCTGCGGGCGGGACGGTAACGCGGGGGCGGGGCGGTGACGTGAGGTCAGTGCGGGGA TACGGGGCGGGTTCTGGGGCGGGGACGCAGTGGTGGATTCTGGAGCGGGGCGGTGACGTGGGGCGGGTTC TGGGGCGGGGCGGTGACGCGGAGCGTGTTCTGGGGCGGCGCGGTGATGGGAGGCTTGGCCCTGGGGGCGG GGCGAGGCGCAGAGGTGCGTCCTGAGGGCGGGGCGGTGACGCAAGAGCGACTCCTGGGGGCGGGGCGAGG CCTTGGAGATGCGTCCGGAGGCGGTGGGGAGCGAAGACTGACCCGGGGCCGTGACGCGGGGGCAGGCCCT GGGGCGGGGGCGGGTCCTGGGGACTGGGGCGGGCGGCCGAGGCCCGGAAGCGGACTGAGGCGGCCTGGAG TCTTAGTTGGCTACTCGCCATGGACGAAGCGGATCGGCGGCTCCTGCGGCGGTGCCGGCTGCGGCTGGTG GAAGAGCTGCAGGTGGACCAGCTCTGGGACGCCCTGCTGAGCCGCGAGCTGTTCAGGCCCCATATGATCG AGGACATCCAGGTGCGCCCCCGGCCCCCTGTCCCCGCGCTGCACGGCCGGGTCCCCACGCCCCTCGAGGA GGCGTTGTGCGGGAGCCTAGCCTTCCCTGTGGCTTCAAACCCCTCAGCGGAGCCAAAGAATCCCAAACAC CTCTTAGTCGGGTGTTCGCTAAAGCGATTCCATGCCATACTCAGTCAGCGTACACTGTTAGTGCTTGTGT TTCTTGTGTAAAGGAAAAATGTGAGACACATCTTGAGAACTTTGAATAAGAAACAATTCATGAATTGGAG AACATCAGACTGAAAGAGCTTTAGTGTTGCAATGACAAAACGTCAGAGGCAAGTATTTATTGGGAAAATG TGGAAGCAAAATAAAGAAATTATTTGATTGGTTTGCAGTTACAAAATTGCCTTTTTTTTTTAAGGTCTGT TAATTGACTGCTTTTGGCTGGTCTTAAGTTTTATTTCTCTCTAACATAAGCATTTATCAGATATGACCCA AGTTAAATTTTGCTTATGTTTGCAGTTTAAGCAAGATTTAGGTCACTTAGGATACCTGATTGGTTTTGTC TGCTCAGGAATTCTTCATGGTTGGTCTCCATTTTAATTTACGTTAATACTTGCGAGGAAGGAGGCGTGTG CGTTTTTACTTTTCTAGCATAGAGGTTTCGGGAACCCACTTTGGCATCAGGCTGCCTGGCAGCGTGTTCT TGGGCCAGTCACTTACCCTCTTTGAGCCACAGTTTCTGGGCTGTGAAATGGGAATAAGAATAATACTGTC ATAAGGACTAAATGAAATAACGGATGTGAAACTGTAGTGCTAGGCACAGAGCGGGGGATCAGCGTACCCT GCCCTCTTTGGCCAGCCCCTTCTGTGTTCAGTTTATGTTTTGTTAAGAGGTTTTGGAAATGAGGGGACCT GATGCAGAATGGAGAATAATGAAGTCAAACATTTGAGGTTTTGTTTAAAAGCACTTTCCCATCTTTGTCT CATTTGACCCTCATCACAGGCCTGTGAGGATGCAGGAGATATTTCCTACCATGAGGTGCAGTAGGTGTGA GTGGCTGGCTGGATATCCCTGGCCAGTGCCCTGGCCCAGGGAAAGAGTCTTTAAATAATTGAGTATCATA TGAGTAATTATTCATTAATAATAAAATAAGTTTTGTGCCTTCTGTGTGGCCCCTACTGGGGAACAGTAAT GGTTTGAGGCCACAGTCCTTGCCTTCAGGAATGTTCACGGGGATCACAAACTCAAATGCCCATGGAGGAC CAATGGATGGGCGTCATAGTGGATAGCCTTTGCACTGCCCTCCGTCTCCAGCTGAGTATGGCCATATCAA CAAATGGCCCAGTATTGCCACATCTTACACTTATTTTGAGGCAGGGTCTCACTCTTGCCCAGCCTGGAGT GCAGGGATGAGATCATGGCTCACTGCGACCTTGACCTCCTGGGCTTAAGTGGTCTTCCTGCCTCAGCCTT TAGAGCAGCTGGGACTTTAGGCACATGCCACCATGCCTGGCTAATTAAAAAAAATTTTTTTTTTGTACAG ATAGGAGTCTTGCTATGTTGCCTAGATGAGTCTCAAACTCTTGGCCTCAAGTGATTCTCCTGCCTCAGTG TTGGGATTACAGGTGTGAGCCACTGTACCCGGCCCAGCTTTCACATCTTAAAAAAGAAGCTGAAAATCTT GATTCCTCTGTCAAATTCCCTGGCTTAAAATGTTAGCAACAAATTCAGAAATTTTTTAAGAACCTTGTGG GAACCACAGGTTGCCATTTTGCCATTCAGTATGGCTGAAAAACAGGCAGGTTTTGGAACCAGTTGGATCT GGGCTCTCATCCTGGCCTTGTTACATATTAGCAAGTTGTAAAAAACCACAACCAATGAGCCAAACAAACA GAAAAACCCTATGACTCAGTTTCCCTGAAATTTTTTACCCTAAAAAGTTGGGAAGTTCTAATTTAACTCT ATAAAGTTATTGAGGGAGAAAAAGATGAAACAATGCATTTAACACAGTGTTGACCTCCTGGAGTGTTCAG CAAATGTGGAGAGAAACCTAAACACCACCATCTATTTGCATGTAGCCAACTGTTCTGCTAGTGAGACTTA CCTTCTCAGTGGCACTGTAGGTCTGTGCTGTTCCCAACAGTAGCCATTAGCCACATGTCGTTAAAGGTAA ATTTGAAGTAATTAAAATTAAATAAAACTAAAAATTGGTAGGGTCAAGCCTTACAGGGCCTGTGGGTTTT TCTCCTCGTGTGCGGAGATGAGAGATCGTAGAAATAAAGACACAGGAGAAAGAGATAGAAAAAAAGACAG CTGGGCCCGGGGGACCACTACCACCTAGACGTGGAGACAGGGTAGTGGCCCCGAATGCCTGGCTGCGCTG TTATTGGATATAAGGCAAGGGGACAGGGTAAGGAGGGTGAATCTTCTAAGTGATTGATAAGGTGAAGCAA GTCACGTGATCATAGGACAGGGGGCCCTTCCCTTTTAGGTAGCTGAAGCAGAGAGAGAAGGCAGCATATG TCAGCGTTTTCTTCTATGCACTTATAAGAAAGATCAAAGACTTTAAGACTTTCACTATTTCTTCTACCGC TATCTATGAACTTCAAACAGGAACCAGGAGTACGGGAGGAACATGAAAGTGGGCAAGGAGCGTGACCATG GAAGCACAGCACCACAGGGAGGGGTTTAGGTCTCCGGATGACTGCGGGCAGGCATGGATAATATCCAGCC TCCCACAAGAAGCTGGTGGAGCAGAGTGCTCCCTGACGCCTCCAAGGAAAGGAGACTCCCTTTCTTTTTT TTTTTTTTTTGAGGTGGTGTCCCACTTTTTCGCCCAGGCTGGAGTGCAATGGTACGATCTCAGCTCACTG CAACCTCCACCTTCCGGGTTCAAGCTATTTTCCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTC TGTCGCCCAGGCTGGAGTGCAGTGCCGCAATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCATGCCA TTCTCCTCCCTCAGCCTCCCGAGTAGCTGGGTCTACAGGCACCCGCCACCACGCCCGGCTAATTTTTTGT ATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCC CACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGCGCCCAGCCAGGGTTCAAGCTGTTC TGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCGCACTACCACGCCCAGCTAATTTTTTTGTATTTT TAGTAGAGACGGGTTTCACCGTGTTGGTCAGGCTGGTCTTGAACTCCTAACCTTGTGATCTGCCTGCCTT GGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCAGGAGACTCCCCTTCGCGGTCTG CTAAGTAATGGGTGTCTCCCCAGACACTGGCATTACCGCTTGACCAAGGAGCCCTCAAGCGGCCCTTATG CGGGCCTGACAGAGGGCTCACCTCTTGCCTTCTAGGTCACTTCTCACAATGTCCCTTCAGCACCTGACCC TATACCCGCCGGTTATTCCTAAGTTATATTAGCAATGCAACAAAGAGTAATATTAAAAGCTAATGATTAA TAATGTTTATAATAATGATTGATAATTGTCCATGATCATCTCTATACCTAATTTGTATTATGACTATTCT TATTCTAACTATTTTCTTTATTATACTGAAACAGTTTGTGGCTTCAGTCTCTTGCCTCGGCACCTGGGTA ATCTTTCGCCCACAAAAATTCAGTTCCTCAGTTGTACTACCCAAGTGCTTAATGGTCATGTGATATATGG TTACTAAATAGGACAATACAGACCAAGAATATTTCCATCATCACGGAAGGTTCTCATAGACAGTGCTGCT GTAGGATAGTTGAGGACACGGTGCCATCTTATCCCTGTGGATCCTGAGAACCTGTCCAGTGCTGGGTATC TGAGGACAGGTGGCAGATAACCAGACTCTTCCTTCTTAGTGACTGACCCCACCATCCTGACACCTCTCAA TTTTTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGAAGTGCAGTGGTGCTATCACAGCTCACT GCAGCCTTATCTCCTGGGCTCGAGCCATCCTCTTGGGAGCCTCAGCCTCCTGAGTAGCTGGGACTACAGG TGCGTGACACCATACCTGGCTTTTTTTTTGTTATTTTTTGTAGAGACAGGGTCTCACTGTGTTGTCCAGG CTGGTCTCGAACTGGGCTCAAGCTATCCTCCCACTTCAGCCTCCCAAAGTGCTGGAATTGCAAGCATGAG CCACTGTGCCTGGCCTGCCTGTCAACCTTGACCCTTGCTCTGTCTTCACAGTCCCCCCAGTCAGTGCCCA TGTCCTATGGACCCTCTCTCTTTGTATCTCTGCTTTGTCCTTTCACTTCTCTCTATTCTAGCTGCACCAT CTTTGCTGCCTCCTGATCTGGCTATGGCTCACTCCTTTCCATTTTTCACCCTGACCCCTGGATGACTTTT TGAAAGGCCATATCTGTCTCTGTCACTCCATTCTTAAAACTCTTTGGTGGCCGGGCATGGTAGCTCACGC CTGTAATCCTAGCACTTTGAGAGGCTGAGGTTGGTGGATCGCTTGAGGTCAGGAGTTTTGAGACCAGCCT GGCCAACATGGTGAAACCCTGTCTTAACCAAAAAATACAAACATTAGCCAGGCATGGTGGTGGGTGCCTG TAGTCCCAGCTACCTGGGAGGCTGATGTGGGAGAATCATTTGTACCCAAAAGGTGGAGGTTGCAGTGAGC TGAGATGGTGCCACTGCATTCCAGCCTGGGTGACAGAGCAAGACTCCTCAAAAAACAAACAAAAAAACAA CCGATGGCTGGCCACGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCTGGAGGATCACT TGAGGTCAGTTCAAGACCAGCCTGGGCAACATGGTGAAACCCTGTTTCTACTAAAAATAAAAAAAAAATT AGTCAGGTATGGTGGTGTGTGCCTGTAACCCCAACTACTCCGGAGGCTGAGGCAGGATAATCGCTTGAAC CTTGGAGTTGGAGGTTGCAGTGAGCTGAGATTGCACCAGTACACTCTAGCCTGGGTGACAGAGTGAGACT CCGTCTCAAGAAAAAAAAAAAAAAACAAAAACAAAACCAAAAAACTCTTTGGTGGCACCTGACAGGTCTC AGGATGAATTTCTTGGCCTGGCCACACAAAGGCCTTGTCCCTTGCCACTATCTACCTCCCACCTCATAAG ACTCTGAATTCGCTATTCACTTCATGATATCCTCAGCCCCATGTGCTTCCCTCTGGGCACTTGTCTCTTG TTGTGTCATTGCTGATTTGTCTGATTGCATTCCCCATTAGAAATTTGCTCCTTAAGGACTGAGACTGTCC ATGGCAGCATTTTCAGCACTTAGCATAGTGCTGGGCATCTTTTGCCCTGCAAAATAATGAACAGATCAGC AAAGGCTGGTAAATGGCACACAGTGCACCTGCAGCTCCATTGCTGCCCACGTGCCTGATTGTTTAGACTT ACAGTAGCTGGGAAATGGGGAGACAAGGTGAGAGCCATATAAAAGTACGTGGATAATTAGTATCCTGCCT TTCTTTCCAAACAGCGGGCAGGCTCTGGATCTCGGCGGGATCAGGCCAGGCAGCTGATCATAGATCTGGA GACTCGAGGGAGTCAGGCTCTTCCTTTGTTCATCTCCTGCTTAGAGGACACAGGCCAGGACATGCTGGCT TCGTTTCTGCGAACTAACAGGCAAGCAGCAAAGTTGTCGAAGCCAACCCTAGAAAACCTTACCCCAGTGG TGCTCAGACCAGAGATTCGCAAACCAGAGGTTCTCAGACCGGAAACACCCAGACCAGTGGACATTGGTTC TGGAGGATTTGGTGATGTCGGTAAGTAGCAAGAGAGTGATTGGTGGGTGGGCATGACACGTAGTCATTTG GGACTCACTATGAGTACAGCTGGGTGGGCTGAGATTCAGAATTTAATTTTAGCATTGTCTTTCTGAATGT TCATAGGGATGGCAAAATTCTGGGAGGTTTTCAGGAGGTTGAATCTTGGCAGCCCCTCCTCTGAAAAGCA TGTGTTGAGGTCTGTTTTGGATGTCCCAGGTTTTTTGTTTTTGTTTTTGTTTTTTTTCCTGCCTTTGAGA TAGCAGGCCCCAGGTTTTGATCAATGTTTCCAGAGCCATCTATTGTTTTGGATTTGCCTTTCAGTCTGGG TGGGTAGCCTGGACTACCTCATGTCTGGGGGCAGGAGACAGGCCTCAGTTGTATCTGCCCCATACAAACA GACATCTGCAAAGTATTTACCCTTACCTTCTTCGTTTATAGCAACCTTGCAAGGCAGGTATCATTAGACC CATCCTTGTTGATGGAGAAACTGACTGAAGCTCACGGAAATTAAACACTTTGCCAAAGGTCACACGGCTA CATCCAACAAAATGCATAAATCCCAAGAGTAAGCTGGGTGATTTTTACCTATGCATACCCACAGGTAACT AACACCCATATCATCAAGATGAAAACATTCCGGGGTCCTGTAAGACCGTTGACTCTCTTTCCATTTCTTC CCACTTTCCCTTTCCCAAGGTAATCACCGTTCTCATCTCTATCGCCAGAGATCCCTTTTGCTTGTCCTTA AACTTCAATATAAATCCTATATAGTCTTATATGCTCTTGAGCCTGGCTTCTTTCATTCATCATTGTATCT TTGAAATTCATTCATATTGTTGTACATATCGGTAGTTCATTCTTTTTAATTTCTACATGGCATTCTGAAT AATCCACAGTTTATTTAACCATTTTCCTACTGATGGACATGTGGGTTGTTTTCAGTTGGGGCTTTGTTCC CATGGCAGCGTGTGGAGCTCTAGCACTTCCTGTTTCATGGGTGTCTGGTGGACCATTGCATGGTATCAAA GTTAATAATCATAATAGTAATGGTGAACATTATTGAGTAATTGCTATTTGCCAGGCACCGTTCGGAGTGC TTACATAAATGATCTAATTTAATCTCTCCATCTCTCTTGTAAGGCAGGTGCTTTGCTGTTAGAAAAAGTG AGCCACAGATTGGGAGATGACTTGTGCCAAATCACACAGCTAGTGAGGAGTGGAGACAGGGCTGCAGCCC GGGCTTACCTGTTCTGTCTGCTCTGCAGGGTAGCCCCATGTGTGCTTTGTGGGACACACCTCATTGATCC GACTCATGCTGGTGGACATTGTGTTGTTTCTGCAGTTAGCCTTGCATGTGCGTCTAGTTCTGACTGCAGG ATATTTCTAGAAATGGAATTGTGTGTTAAAGGGTACTTGTTCCTGTCCGATAGATGCTACCAACTTATAC TTCAAAAATATGTCATTTTAGCCAGGTGTGGTGGTGTGAGCCTGTAGGACAAGCTACTTGAGAGGCTGAG GCAGGAGGACTACATGAGCCTAGGAATTCACAGCCAGCCTGGGTAACTTAGTGAGATCCTATCTCTAAGA AAAAAGAAATTGAAAAATTGTGTCTTTTTTTTTTTTTTAATTGAGGCAAGGTCTTCTGTGGCCCAGGCTG GAGTGCAGTGGCATGATCACGGCTCACTGCATCCTTGAACTCCCAGGCTCAAGCGATCCTCCCACTCAGC CTCCCAGGTAGCTGTGTGCGCCACCAGGCCTGGCTAATTTTTTTGTATTTTTTGTAGAGACAGGGTCTCA CCATGTGGCCCAGGCTGGTCTTGATCTCCTGGGCTCAAGCAATCCTCCCATCTCGGCCTCCTGGATAGCT GTGCATGTTATCCCTGGCCATTTTTTTTTTTTTTTTTTAAGAGGGAGTCTCGCTCTGTCACCCAGGCTGG AGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTATCCTGCCTCAGC CTCCTGAGTAGCTGGGACTACAGGCAGCCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATG GGGTTTCACCATGTTGCCTAGGCTGATCTTGAACTCCTGGCCTCAAGTGATCCACCTGCCTCAGCCTCCC AAAGTGCTGGGATTAAAGGTGTGAGCCACCACTCCCAGCCCATGCCTGGCCAATTTTAAAATTTTTTGTA GAGATAGGGTCTTACCGTGTTGCCCAGGCTGCCCTCAAACTCCTGTGCTCCAGTAGTCTGCCCACCTCGG CCTCCCAAAGTGCTGGAATTACAGGTGTGAGCCACTGCACTCGGCCCAAATTGTGTCATTTTATAATCTC ACCAACTGCGAGTGAAGGTGACCACTTTCCCACATTCTTGCCAACAGTGAATATTGACATTTTTTCCTGT GTGATGGGTAAAAAGTGCTGTTTTCTTTCAACAAAAATTCACCAAAACTCATTCATATTGTTGTGCATAT CAGTAGTTCATTCTTTTTAATTTCTAGATGGCAGCAGTTCCTGTTCTGAATAATCCACAATTTATTTAAC CATTTTCCTATTGATGGACATGTGGGTTGTTTTCAGTTGGGGCTTTGTTCCCATGGCAGCGTGTGGAGCT CTAGCACTTCCTGTTTCATGGGTGCCTGGTGGACCATTGCATGGTATCAGAGTTAATATTCATAATAGTA ATGGTGAACATTATTGAGTACTTGCTGCATAATGGTGATTTTTGGGCAATCCACTAAAGCAGAGAAACAG ACAAACATGATAAGGGTAGGAAGCTGCATTTGCTTGAAGTGTAAGGAAGAAGACTGGTTCTGGAATTGGC CATGTGCATTACCATCCTGTAAAGGAGGCAGGCAGAATACAAAGCTCATCTGTTGTTATTTGGTTCTGGG AAATGTCAACGTGAGTCATTTAGGACCAACAGTCAGAATTTGAAACTTCCTGTTTTTTTGGAAGGTGTTT TATTTCCTGTTTCTTGTGAATATTTATTCCTAGTAGGAGCTTAATTCTGAAGGGTAAATAACAACAGCAA TAGTAAGATCACTTAATTTTTTTTACTTTATTATTATTATTTTTTGAGATAGGGTCTTACTCTGTCACCC AGGGTGGAGTGCGGTGGTGTGTTTTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAACAATTCTCTCA CCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCACCACCATGCCTGGCTAGTTTTTGTATTTTTTGATA GAGACAAGGTTTCCCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATAAACCCGCCTCAG CCTCCCAAAGTGCTGGGATTATAGGTATGAGCCAGCACGGCTGGCCCAAGATCACTTTAAATAATGTGAA TATCACTTTGTAGTATACACAGTGTTTTTTCAGGTCATCAAAACCACCCTGTGCCGTGGTAGACATGGCA AGCCCGTCTGTCATTATATGCTACTTACAGGGGAGGAAACTGGGTTCTGAGAGCAACAGTCACAAAGTGA GTTCCAGTACAGAGCTAGGACTTGGGCCTAGGTCTTCTGGCTTAATAGAGCGACTGTCCCATTTTCCATG AGCTGCTGAGAGATGTCCTTTTTAGATGCTGGGCCTTAGACTCCAGAGTACTGCATGGGAATGTTTCCCA AGGTAGGTTTCATGGTGACCCACAAAGGAAGAGCTGTGTATTCATATGTATGGGAAGGTCTGGCTGAGCA AGAATAGGGCCAGCAGCAGAGCCTTTAATAAGTGAATACAGGAAAGGATGCTGTAGGTCAGTGTTTCACA CTGGGGACGATTTTTCCCCGACCTCCAAGGGACATTTGACAATGTCTAGAGACAAATCTGGTTGTTATAG CTGAGGGTGGGTGGGTGCTACTGGCATCTAGTGGGTAGACAGAGATGCTGCCAAAACCCAACAGTGTACA GAGTAGCTCTGCACAATAAAGAAGAATCTGGCCCAAAGGGTTAGTGTGGTGGGGCTGAGTACACACACTG CACTCATACATATTCATTGAGCATGAGTGTCAATGAATAATAATGTGGACACATCAGTTTTATTGAGTTG TCAAGTGTGTCGGGTATTGTTCTATGTGCCTCACATGTATTAATTGTTTGAGGTGTCATCACAATCCTAT GAGGTTGGTAGTTGCTCCTATTATCCTGTAATACAGATGGGGAAATCAGAAGCCCAGAGACTCTGAGCTC CTTGCCCATTGTGACACAGGTGCTAAGTGTTGGAGTTGGGATTTGAACCCAAGTACCTCAGACTCACTCC ATCACTGTCTCATGAAGAACAAATGGCTCATTCTCTTTCTTGTCCCTATATTTGTGCCATTACTCATTAG CTCACACAAATGTTTACTAAGTACCTGTTGGGTTCTAGGTGTTGGGGATGCAGCTTCGAACAAGGATGCC CAGTCCTTGCCTTCAGGTGGAGAGGGGCAGGTACTCAGTTCATGCTTGCCTAATTTGGTCTTTATTCACG GCTGTGGGTAGTGCTATGAAGCTGAACACGGTGCTTTAGAGGTGCATCATTAGGGGACCCACCAGAGAGA GTGGCTTTGTCTTTGTATATTCAAAGGAAAATGCCTTTTCCTTCAGAATGGAAGGAACTTTCTTAGTTTC AGACGTGATGCCTTGTGTGTAACTGCTTGTTCCAGCCAGGGCCTCTTGCCCGGGAGGACTGGGAGAACTG TTGGTGGCTGTGTTCTCATGATTCTCCAGAGAAAGAGAACCAATAGGGGGTGTGTGTATGTGTATAAAAC AGCATCTTTTGTTCAATGCTGCATCCCCAACACCTAGAACTCAGCAGGTACTTAGTAAACATTTGCATGA GCTAATGATTAATGGCACATATACACAGACAAGAAAGAGAATGAGCCGTTCGTTTTTTTTTTTTTTTTTG AGACGGAGTCTTGTTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTCCGCACACTGCAAGCTCTGCC TCCTGGGTTCACGCCATTCTCTCGCCTCAGCCTCCCGAGTATCTGGGACTACAGGCACCTGCCACCATGC CCAGCTAATTTTTTTGTATTTTTTTTAGTAGAGACAGGGTTTCACCATGTTAACCAGTATGGTCTTGATC TCCTGACCTCGTGATCTGTCCGCCTCAGCCTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACTGCACCT GGCCAAGCCATTTGTCCTTTATGAGGCAGTGATGGAGTGAGTCCGAGGTACTTGGTTCAAAGCCCAACTC CAACACTTAGCAGCTGTGTCACAGTGGACAAGTAGTTGAGTCTCTGGGCCTCTGTTTTATATATATACAT ATACACACATACACACACGGATATATATAGAAAGATATATGCATTTTTTTTGTGTGTGTATATATATATA TCTTTATCTAAAAACATATTTATTACAAGGAACAGGCTCATGCAATTATGGACGCTGAGAAGTTCCAAGA TCTGCCATCTGCAAGTTGGAGACCAGGAAAGCTGGTGGTGTAGTTCCAGTCTGAGTCTGAAGGCCTGAGA TCCAGGAGCACCAATGGTAGAAGTCCCATTCCAAAGGCAGGAGAAGACTGATGTCCCAGCTCAAGTAGTG AGACAGAGAGAGATCAAATTCTCCCATTCTCCACTGTTTCGTTCTATTCAGGCCCTTGACGGATTGGACG CGGCCCACCATCCTGGGGAGGGCCATCTGCTTTACTCTGTCTACCTATTCAAATCCCATTCTCATCCCCA AAACACTCTCACAGGCACCCTGAGAAATACTGTTATATTTAACCAAATATTTGGGTACCCTGTGATCTAG TCAAGTTGACCTGTGAACTCAACCATCAGTGGCTTTCTCTGCTCATGCCTTGCCTGGGTTGGAACTTCCT TGAAAGTAGAAGTTGGCTTTTCAGCCCTACCTGGCTTCTTGGTCTCTTTGCTCTGGGGCTGGTGGCTGTG CTCACCTCCCATTACAACTCAGGGTCTCTGAGCCCCCAATTCCCCTCTGGCAAATGGGGATGTGTGCCAG TACTTCTGTGCTGAAGGGCCTGCTCTGAGGAGTAAATGAGGCAGTGTGTGGAGGGACTTCACATGGGGCC TCCTATTGAGTGAGCCTTGGGTCTTGTTGGTCAGCTCTGCTTCCTTCTGTGATTTCTAAATTGCCAAGGG CTGGGGAGGGCCAGTCCTAGGGCATCTTCCCTTCTGTAGGGTCCCCCAGTTCCCCTGTTTCTTTCTGTGT CCTGATTGAAAATCACAGAGTGCTTTGACCACCCTGTGACCCAGCCAGCTACAGGTTTTTCCCAGCAGAC CTGAGCCCAAACCTGGGCCTTAAACATTCTCAGGCATTGATAAAGGTATCTAGGTAGGCTGGGCATGGTG GCTCACGCCTGTGATCCCAGCACTTGGGGAGGCCAAGACGGATGGATCACTTGAGGCCAGTAGTTTGAGA CCAGCCTGGCCAACATGATGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCTGGGCGTGGTGGTGTG TGCTTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGTTTGAACCTGGGAGACAGAGGTTGCA GTGAGCCAAGATTGTGCCATTGTACTCCAGCCTGGGCGACAGAGCGGGACTCTGTCTGAAAAAAAAAAAA AAATTAGGTGTGGTGGTGTAGTCCTAGCTACTTGGATGGCTTAGGAGGGAGGGTCACTTGAGCCCAGCAG GCAAAGTTTGCAATGAGTTGAGATTGTACCACTGCACTCCAGCCTGGACAAGAGAGTGAGACTCCGTCTC CAAAAACAAAACAAAACAAAAAGGTATCTAGGTTATCACCCAAAACAACTGAAAGAAACCAGCCTTGGCC CTGAGCCAAATTCCTTAAACCCTCATATAAACTCCTTACCCTGACCTCTTCACTTTGGACCAAACCTAGG TAGACACCTGTTTTTTTTTCTCGCCTCCGCACCTCGAGGATTGCTTTGGCCAGATCGCCCTGGCATTTAT TGCTTCTTTCTTTGGAATCCCAACTGGCCCCATCTTAGGACAGTTTGGGGCACTCCCTTGTGGGAACTCT TCTGCTGCCACTTCTGGGGTGATTCCAGCATAGGTTCGGAGGGACGAAACCCCTTCTTTCCCTTGGGTGG CAGAGAGGATGTGCTTGCCCTCTTCTGTTTGTGTTGGAGACCTGGGCACATGCCCAGTGACTCAGGCTGG AAGACTGATTCTTTTGCACACACTTAGCCATGTGTGTTTATTGTCCCCATGGGAGTGGCCATTTCAGGAG AAACTGGTCTCATGCACCTTGTATCTGACCATGTCACCCAACTTGAGGGGCCCTGAACATGCCATGCTCC TGCATCCTCCCTGCCTTTGCTCATGCCGGGGCCTCTGCCTGGAGTGTCTCCTCTCCCTCTTTCTTTGGGC ACCCCTTGGTTGATTTGCTCCCTCCATGGGCACCTGTAGCCCTTGGCCTCTTGAGAGCAGTCATTTTGCT TTATCAATAGATATTTCTAATTTGGGGAATGAGTGAATTCCTCAGTAGTGGATAGTAGTTATATTTTTGG GGTACAGCGGAATTTTGGAAATGAGCAAATGTTCTCAGAATGAAGTCTGTGGATGAATAGGAATTTTCAG GGTAGGTAAAACCATTTCTAACTTTAAAAATGGGATGTGAATGGGATGTGAGTGCTTTTCTGCTGTGGCC TTTAAGCTGGCAGAATAGTTCAGACCTGTTCTAAGCAAGGAATGGCACTGTTATTGGAACAGGAGTATGG GCTCCACTGCAACTTGGAGGTGGCCACTGTATTCTCCTTGTTTAAAAAAGAAAAAATGTAGGCCGGGCGT GGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGGTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTC GAGACCAGCCTGGCTAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAAGCGTGATGC AGGTGCCTGTACTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAAGTT GCAGCGAGGCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCTGTCTCAAAAAAAAA GAAAAAACATCTCATAACCTTTTAGGCTGGTGGCCAGTCAACTTCTTGCTAACGGAAATGAAAACTCTTT TGATGTTGATGGAAAATAATCATCTTTATTCATTTATTCATTCTGCAAGTATTTCCTGAGGACCTGCTGT GTGCTGGGCCCCTGTGGACTCGCAGACAGTGAGCATCCGCTCTCCTGAGCTTCTCTCACCTCTTTCTGCT CTGGAATTTCTTCTCAATGAGACCACACTATTTCTATACTCTCTGGTGTCTGGCTTTTTTCACGCAGCAC GTTTTCTTTCTTTTTTTTTTTTTTGAGATGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGACGT GATCTCGACTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCT GGGATTACAGGCGCCTGCCCCCTCGCCTGGCTAATTTTTCTTTTTTTTTTTTTTTTTTTGTATTTTTAGT ACAGATGGGGTTTCACCACGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCTGCCTCCCAAA GTGCCAGGATTATAGGCGTGAGCCACCGCACCTGGCCTTACGCAGCACATTTTCAAGGTTATCCCGCATT GCGTGTATCAGTGAAGCGGTGTCACTCGTCTGGGGTAAATACCCAAGATTCATTGTCTTCACAGCCACGG AAGACTAGGACACGGACATACAGTGAGGTTCAGAGTGGAAGTATAATAGGTGAAAGAAAGAGAAGAGCTC TGTCTGCTGCAGAGAGAGGGGTTCCAGTGAAATGGGTTGCTGTTTCTGCAATGAAATGCAAGGGGTTTTA AAGATGAGCCTGAGGAGATGGTGTCTGATTTACAAAGGGCACAAAGATTGGTCAGACCAGGTGTTTCATT TGCATAGGATGCATAAAACTGGTTAGGGCTAGGTGTGCCATTTGCATGTGGTGCGAAAAGCTGGCCAGCC CCACTCCAATCTTGTGTTATGCAGATGGGTTCTCTACCTGGCCAGTGCCATGTTGCCTACTTCTTTACTG TCTTGTGGTAACAAAAGGGAAGATAGAGCCTCTTTGCTGAGTATATCTGGCCCCCTGGTAGCCCTTTTCT ATTGGCACAGCTGCTGGCATTCACTCCTGTGAGCTTCCAGCTTGCTTATCTATGTCTGCAGCTTGATTTT TCAGGCTGCTCTTTTTTAGAAAAGAAATGATTTGAGGCTGGGTGCAGTGGCTCACACCTGTAATCTCAAC ACTTTGGGAGGCTGAGGTGGGTGGATCAACTGAGGTCAAGAGTTTGAGACTAGCCTGGCCAACATGGTGA AACCCCGTCTCTACTAAAAATACAAAAAAATTAGCCGGGCATGGTGGTGGGTGCCTGTAATTCCAGCTAC TTGGGAGGCTGAGACAGGAGAATTGCTTGAATCTGGGAGGTAGAGTTTGCAGTGAGCCAAGATAGTGCCA TTGCACTCCTGCCTGGGCGACAAGAGTGAAACTCCGTCTCAAAAAAGAAAAAGAAAAAAGAAAAAAAAGA AAAGAAACGATTTGGGGATTTTGTTAAAAGGGAAATTCTGCCGAGGACTGTTTTACCCTCACTATCTGCC TAAATAATTTCTTTCTGTCTCCTGTATCATCAGTAGCTCATTCCTTTTTAGGCTGTGTAATGTTCTCTTG TGTGGCTGTATCACAATTTGTATATCTACCAAACTGTTGTTAGATTGGTTGTTTCCATGTTGGGGCGTGA TGAATAAGGCCTCAGGGAACATTTTGGCCAAGTCTTTTGTGCCCGTTTGCACTCCTTGCTCTTTGATATA TACCTAAGGGTGGACTTGCTGTCAGAGGGTAGGTGTGTGTTTAACTTTGTTAGAAACCTCTAAACAGATC TCCAAGGTGGCTCTCCCACCAGCAGAGTCTGAGGGTCTGAGTTCTCGCTGCTCCGTTCTTGGGGGGCTGT CCTCACAGAGCCCCTTGCCCCTCCTCTGCTGTAACCCAACATTCATGTTTCTCTCTTTCTCTGCCTCTTC AGGTGCTCTTGAGAGTTTGAGGGGAAATGCAGATTTGGTGAGTCTCCATGAAATTTGGGCCAGTAGCTCG GGCTCTGGGCCCTTCCCTCCCCACCCCTCAGGTCCTTCCCTGCAGGTGTGTCAGGAGCCCAGGGAACCCA ACCCTAGGCAGTGCAGTGGGGGTCTGGTCTCAGCCTCCCTGACTCCGGCCCAGCGCCTGCTGGGGCAGAT TGTTCATCTCTGCGCTTCCTCATCTGCAAAGCTGACAGCAGAAGCAGGGCAGACCTGATGAGGGGCAGTC ATCGGGATCCAGACCAAGTCGCCACTCTCTCATTCACAAGTATTTATTGTGTGGCTCCCATGCTCTGTGC TGGGGCCACCTGGGAAGGAGCCATCAGTCAGTTAGGCGAGAGAGAAGTTAGACAAATGAGTATATAAATA GAAATAGTGATAAGTACCATCAACAAAAGAACAGGCTGCCTTGAGAGAATTACAAGGGGACTGAGCCTGG GGAGAGGGCAGCCTTGGGTGCCTCCAGGTGGCCTGGGCATGGTTCTGCTGACAGAGTTCTCAGGTACACC CCGGCCTAGGTGACCCGTGAGGTCCTTTGGGATGAATGCTCATGGCTGTTGGATTTCCAGGTTACCAGCT CCCTTCCCTTAATACCAAGATGGGGGGGTCACCTTCTAGTGCTAGTCTTCCCTGCAGTTGCTTCTCTTTT GCCCTGGAATGCCGGGTGGAGACCCTGCTACTCCTTGTGCGAGAGGGCAGACCCCGTTTTCTTCCCGCCT CTCCAGACTGTCCTCTAGGGAGCGTGGGGAGAGCCCGGGTTTACGTGGGTCCCTGTGCTGGCAGGCTTAC ATCCTGAGCATGGAGCCCTGTGGCCACTGCCTCATTATCAACAATGTGAACTTCTGCCGTGAGTCCGGGC TCCGCACCCGCACTGGCTCCAACATCGACTGTGAGAAGTTGCGGCGTCGCTTCTCCTCGCTGCATTTCAT GGTGGAGGTGAAGGGCGACCTGACTGCCAAGGTACACTCACTATCTGTGGAGGGAGACAGGGTGGGGGGC AGTGGGTGGGGAAGTATCTTTTGAGGGACTCCAAAAGCCAGCTGACTCCCCAGGCGAGCCCTTACATCTG GAGGACCATGGGAGGTAGGACGGCCCAGCGGCTACAGGTTCAAGTTCAGACGCAGAAGTCCGGGTTTGAG GACTGGCTCTCTCGGCCACCTGCTGTGTGACCTCCTGTGCCTCAGTTTCCTTGTCTGGAAAGCAGGAATA GTACCTGCCTCCTTGGGTTGTTTTGGGGGTTAGATGAACAGTGCCCAAGCGTAGCACCTTCTCCCCAAAA ATGGTGGCTATTACGACTGCTGGGACTGTCAGCACTTCGGTACTGGCCCTGGGAAACCGAGAAAGTGCTC TGCCCAGGCGTTTGGGTTGGGCCCTTTGTTGTTTTATTTTTTGGGGGGGGCGGGGGCACAGAGTCCCACT CTGTCATCCAGGCTGGAGTACAGTGGCGCGATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCA ATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGTGCCACCATGCCTGGCTAAATTTTTT TTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCGTGACCTCAAA TGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAACCACCATGCCTGGCCAGGCTGG GCCCTTTTATTGTTAGGAACGGTCCAGTCTGCATCTAGACCTATCCGTGCTTCTGGCTCACCTGCAGCCC TCTCTTGTAGAAAATGGTGCTGGCTTTGCTGGAGCTGGCGCAGCAGGACCACGGTGCTCTGGACTGCTGC GTGGTGGTCATTCTCTCTCACGGCTGTCAGGTAGGAAGCCTCCCACTGTTCCCTGGGCAGGCATTGGGTA CTGGCCGTGCCAAGAGGCTGTGCAGGGGCCATGTCCCTTCTTGTGTCCAAAACACCCTTGGCTTTGTGGA AAAGGGCTGTGGGGCCCTGCCCACCTCCTGTTGTTTTCTTGGGAGCCATGTGGTCCTCTGAGGAGTTGGC TGCACCGTCCTGGGCAGGTCGGTGTTCCTGGGAGAAGCCCTCTGGGAGAGGGAGGGCAGAGACCAGGTCT GCTCACGAAGCTCCTGCACCCAGAGTTTGTTCAGAGGCGGGTACAGCACACATGTTGTCTCAGCTCCTGT CTCTGTCCTGTGAGGCACTGCCCCAGGCCCCTTGCTGCTGGTGGGACTCAGGACACCAGGCCCACTGGGG GCTTGGCCCCTTACGTATTTGTCACTGTGATTAAGCCCTTACCCCTTACTGGGCCTCAGTTTCCTCATCT TTTAAGTTGAGGAGTTGGACAGATCACAGTTATAAGCTGGGGCCTGGAGTCCCCCTGTGGTCTGCACGGT GTTTTGAAAACTGGCAAATTTCACATAAAAATCAGGATTTCTAGTTTCTCTTGACAAACCGCAAAGGTCT GGCCTGACGAGGCCAGCATCTTCAGCCAGTAAAACTCCAGCCTGTGGCTGGGCAGGGCTTTCCCTTTGGT CCTTTCTCTCATAATATGGTCCCTAGAGCTCATGAAGAATGTGGACTCCCAGGCCCTACCCTGGACCTCT TCATTCCAAGTCCGCCCAGCAACAAGGTTTCCAGGTGATTTCCATGCCCTTGAGGTCTGAGCTGAACTGA TTTAAAGCAGCCACTCTCAGCGTTGAGCTGCCTCAGTCAGAGGGGCCTGGAGGACCATACTGCTGATTAG GAGGTCTGGGTGGGGCCCAGGAATCACATTTCTTACAAGTTCCCAAGCGATATTGATGCCGCTGCTGCAG GGGCCAAACTTTGAGAACCACTGGTCTAGAGGCCGCAGCCAGCACTCTCCAGGCACACTGGCCCCTAGAG GCACATGAGTTTGACATGCAACCCCTTGCTGTCAAGGTGTCTTTCCAGATGCTGACCAGGGTCTTTCCAG AACCAACCTGCTCTGTCTCAATCAGCCTCGTGCCCCTGGCTTTGACCTTCCAAATCCTTGGCTCCCACAA AACCTCTGAACAGGCTGTTGGATTCCTACTCCAACTTCTTGGTTTTGTAACCAGGGTTCTTGGTCTTCTA GGCCAGCCACCTGCAGTTCCCAGGGGCTGTCTACGGCACAGATGGATGCCCTGTGTCGGTCGAGAAGATT GTGAACATCTTCAATGGGACCAGCTGCCCCAGCCTGGGAGGGAAGCCCAAGCTCTTTTTCATCCAGGCCT GTGGTGGGGGTAAGCAGCTCCTCAGCCTCCCTCTGGGTGGGTCTGGTGGGGAGGGAGCCGCCACCTGCTT CTTTCTCCAGCCTGCCCCTCACAGGGCCCATGAGGTCTCTCCAGGCAGTCAGAGGGTACCACACATGGTC CCTTTTTGGCAGCACCTCTGTCTGGCTGGAGCAGGCCCTGCTCTGTCTGCTTTGTAGAGGTCAGAGTCTT CTGTTTCATGGCACAGTGGCATCATGGGCTCAAGTAACTTTGGCAGCTTCAATTCCAAAGACTTGGCAAA AAGAAAGCAGAAGAGAGAGGAGAAACCTCTTTTTATTTTTCTTGTCACCATTCTCCTGACCTCCATCAAC TAGACCCCGTTTCCACTATCCCAGAGAAAGGGTGGCCACAGCTAAACTGCATGGAGAAACCAAAGAATTT AAATATTGGAATTTTCAAAAGTGTAGTTGTGGGGGTTCGAGGAACATTTAAAGATTACTTGGGCTGGGTG CAGTGTCTCATGCCCAACACTTTGGGAGGCCGAGGCAGGAGGATTGCTTGAGCCAGGAGTTCGAGACCAG CCTGGGCAACACAGCGAGACCCTGTCTCTATTTTTGTTTTGTTTTTTAAATGTATTACTTGGATTCTTTG TAGTTTTGCTGTATGCTCTAATTTTAAACTTAACTCCTATTACAGTGTTATCTGATTTTCTTATAAAAAA AGAGGGAAGAGAGACAAACATGGGGTTCCTAGTTTGTGGGTCATGACAGGAATATCAGGGAGCGCTAGAA ATTCTGTCCCAGGGAGTCCCCTCTGCCCTAGGCTCTCCACGGACTGGAACATTCAGAAGGTATATCAGTT CCTTGCCTCCAGCCTGATCTGCCAGAGAAGTGAGCACTGTTATACCATAGCGCTGTCCAGCTCGTCCAGC TGTGACATGGGCACCTGTGGTCTATTTCTCCTGTGCACATCCAACTGCCCCATCCCTATTCCACGTTGGT GGAGTTGGGTGGAGGCTACCTAGGAGAGCAGTCTCTGGTCACATCATTCATCCAGTAAGTGTTTATTGAG CACCATCTGTATATACCAGGCTGTGCGTTAGGTGCTGGGGATAGGGGAAAAACAGAGTTTCAGTCTCCTG GAATTTATAATTTGACATGAACTGTATTAAGTCACTGTCATGACCCATGCCCATAACTTGACCACAAGTG ATTGAGAACACTTGATTAACCCTGGATGGGCTACTGACCTATCTATCACACAGCCCTGGGCCAGTTCATC TCTAGACAGCTCAGCAAATGGGGAAAATAACAGAACCCACTCCCAAGCTCAGGTGATCCTCCCACCTCAG CCTCCTGAGTAGCTGGGGCTACAGGTGCACACTACCATGCCCAGCTAATTTTTCTATTTTTTTTTTGTAG AGACAGGGTTTTGCCATGTTGCCCAGGCTGGTCTTGAACTCCTGGGTTCAAGCAATCTGCTCACTTCGGC CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCAGGCAACTTTAATAATATTTAATGCACTA ATTGGTGTGTGTACAGTGATTGGTTCATTTTAATAACTGAAAACCCAGCCTGCCCCCCGCTCCCACCCCG GAGGACCCAGTGTCACATAAGAGTCCCCCACCCCGCTGTCGCCAGCAGAGTTCCCTCAGGACAACAGTAA CAGGAAGTGAGGAAGGCTGCCACTCTCGGGGCTGTAGAAACCCTGCTCTGCCTCACCTCCTGTCTTATCC ACAGTGTGTGGTCCAGCAATGCTCTTCCTTCGGAGCCTCCGGTCCCTCTTTCTCCTATGAATCAAATGAA AGACAGAAAGGGCAGGGGAATTAGGAATGCAGGCTGAGCAGGCATACCTACTTTCTGGACAGTTAGTCAG TCTTGTGCTCCTCCCATGCCCCATCCAGTCTCAGTCTCAACAGCAGGGAGGGCCTTTGTCACGTGAATAT CTGCTGTCACTCTTAGGACTCAGTAGCAGGGCTTCCAAGGCCTTTGGTGACCTGGCCCCTGCCACTTCAC CTTCCCCAGCCTGGCATGCTCCGAGTCCCCAGCACGGCCCAGCCTTCCCAGGATGTCCAGGCTCTTGCTT GCTCTTCTACCTGCTCCCCTGGCTAACTCTTTTTTTAAAATTCATTTTTACTTATTTTGTTTTAGAGATG GGGGTCTCACTATATTGCCCAGGCTAGTCTTGAACTGTTGGGTTCAAGTGATACTCCCACCTCCGCCTCC CAAAGTGCTGGGATAACAGGCATGAGCCACCGTGCCTGGCACCTGGCTGACTCTTAATCATCCATCCTTC TGGTTACAATTTATTGTCACTTCCCTAAACACCCCCTTTCTTGGCCAAAGTCAGGGTTAGCTGGCCTTTG TGCTCCTGCAGCCTCTGTCCCTCCCCTACCATAGCACTGTCTCATTGTATTGAGATGGGCTTATCCCCTG GTCAGCTCTGAGGGGAGGGCCAGGCCTACCCTGCAGCCAGGCCCCCAGCCTGGCACAGAGCCCACAGTCT GGTTGCGTCTCATGTGGATTCTAATTTGAATGTAAAGGAGAACCATACAAAAGCATCTGTGGTGGTTCAC GCCTGTAATCCCAACAGTTTGGGAGGCCAAGGTGGGAGGATCTCTTGAGACGAGGAGTTTGAGACCAGTC TCTATCATAAAATTTAAAACATTAGCCAGGCCTGGTGGTGTGTGCCTATGGTCCCAGCTACTTGGGATGT TTAGGCAGGAAGATCGCTTGAGCCCTGGAGGTCGAGGCTACAGTGAGCCATGTTTACACTATTGCACTCC GGCCTGAGTGACAGAGCCAGTCTGTCACCTGTCTCTAAAAAAATAAAAAATAAAAAAAAAATATGAGCCA AATTTGGCATAATGTAGATTTCCATCATTAAAACAAAACTCACAGAAAACAGCAAGATTTCAAAGCCAGC ATGCAGTGATTAAGATATCCCTTTGGAGTCGGGTCCTTGCTTTGCCTCCGCAGGCTGCGTGACCTGGTGC TTAACGCAGTTACCACATGGTGGCGCCACGTCAGCTGAGAGCAGAAATAGAAAGGTCCCCGTTCTTCACT AGTGCCTGGCGAGGGGTCTGTTTACATGCATCAGAACACCTGTCCTGGGTTTTGAGGACTCTTGTATTGC TATTTTATAACTCACTATAATACTTTAAAAATATTTAATTTAAAAATCATTTAATAATTAATTTAAATAT AATAATAAATAATTTAAAAATCATTTTTAAATAATAATTTTAAAACCCTCCAACATGTCATCCACCCATT CATTAGGAGGTAACAGCACCAGGGCTGAAAAATGTGCATTAAAGTCGATAACTTTGGTGTGCAACGTCAG CGTGATAGGCAACCAAGTAGCCACCTCTCTGAGGCTGAGCCGTCAATTTTGGGGTGACCCCTCTTTGGGA TTTGAGAGATCGGGCTGAGAAGACAGAAAGCAATGACAATATGCTGCAGTGGTCGTGGATTTTCTGTGCG GAGGGAACATCTCCTCCTACTGTATATTTATTCTTGTGGGGAATGAGTCCTGCCCTACGGGGAGTTTTGC ATTAATGAGGCTCTCTAAGAACCGAGGCTCTCCAAGAACCAAGCCATGCATACAGTGCAGAACACCCTAG GCAAGGCCTTCACATCAGATTTGTGGGCTGAGGCTGACACGTGAACGGAGCTGCCTTAGCGCCCCGCCTG ACCCCCTCTTTCCTTTCCCCCACACCCCCTGCTCTGATCTGCTGTCTCTTCTCAGCCTCTCTGCTCACCC TGTCTCTTCTGGCCATTCTTAACGGCATCCCCCACTTAGGCATCCCTCCGCCCCCACAGGCTGCCAGGCA GACCCAGCACCATCACATTCACGCCTCAGGCCTCCTTGCTGTGCTGTTTCACGTCATTCCCAGACACCTG GGGCAGATTCCGGAGTCTCTACCAAGAAAACAACCAGAAGCAATGAACCACAAAATCTGGAGAAAAACAT GGCTGTCACAGATCAAAGAGGCCCCCCTTTGGAGGCTGGGGGCCTCCGTGAGAAGCAGTGGGATAGTTGA GAGGCAAAAAACATGGGGCAGAATTCCGCGCCCCTCATATCAGCTGGGAGAATGCCAATGACCAGTGGTT TCTGAGCTTTAGCTGTGTGGGGTAAGAGGTCAATAGATTTTGGTGTTACTATTATGGGGTTGCCAGAGCC ACCTCTGTTCCTGCCAGATGGGCCCCCAGCTCCTCTGGGTGAACTGTGACTTCCCTCAGTCACATAGATC CAGCCATGCAAACCTGCCTGCGTTGCGGCCACAGCACTTGCTGTCTCTCTCACCAGGACCGTTCTCCCTG ATGGCATCAGGGCCTGGATCACAGTCACATTCTCCAGGAGTGTTTTTGCAGGGGACCCTCTGGATCACTC CTACTCCAACTTCAGCCTATTTTTAAAAAAATTTCTCTTTTTTTTTCTGCAGTATGTATACATAGTTAAA TATATATTTATATTTTTTAACCAAAGCTCTTGTTAGATGCCTTCTTTCCTGAGTAGCCCTCTGTGCTCCG CCTTACCCCACCCACCATGAGCCCTACTGCAGAAGACCTCATCCCGGAAGACCTCCGTCAGTGTCTCCAC TTCAGTAGCTCTGTAGCTGAGCCATGTGGGGCACAAGTCCTGCCAGGACCTCTCTGTTTTCCAAGCTTGG CACTGCCTTTGGGGAGTCTAGATTTTAAAATGGAAAAGACAAAAAATATGGCAACCTAAAAAAGAAAATA ATTCAGAATGTTATAAGCTAATACAGCCATCTCATTTTTGCATCTTCCTTTTGGATTCCAGCCCATGAGC ACAGTCTGCTTTTCTCAGCTAACGTTATCCCTTAAGCAGTTCCCCAGATCTCCATGGCCTTCATCATCAC TAGCTCAAATGGCTTTATAATGGGCCATTTTCATGACATGCACTAATTTACTAAACCATTTTCCTAATGT CGGCCATTTAGGTGATATCTAATTTTTGGCTCACACAACCACAGGTGTCTTCATATAGAAAGCTTTTGAC TGCATTTGAATTATTTTCTTAGGAAATTACTGGATTAGAAGGTGTAAACATCTCCATGGATTTCATTATC CATGACTTGGTGTCTATTTGGTATTTTTCTGATGGCTTCTTTGATTCTAGAAAAGGATTTGCCATAGTGC AAGAAGTACAAATGATAACACTAGGACAAAATAGAGAGGGAACACAAGGAGAGAAGAAAAGTAAAAGTTT GGATTCCAAAAATACATCCTAGGATGTCCTGCAGCTTTCTACAGTTCTCTAATGTACAAGTGAATTAAAA ATTTAAGGTATACAACGACTGATTTTAGAGATAAAATCACTTTGCAGATGTAAAGAAACATGGAAAAATC CCAGCCATTGGTAATAGTAGACTCAAAAATGAGGTAGGTCAAAGTCCCAGTCAGCCTCTGTCTGGGGGGA AACCCCTTAACTTATCTCAGTCTCAGTTGCCTAATTACATAAAATGGAATACTGATAGCTACTTGCTAGA GGTGGCCTGCGCATTTTTTACGCTTTCCAGCCGCCATTGGAAATAAGATCATTGGCCAGGGGCGGTGGCT CACGCCTGTCATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACGAGGTCAGGAGATCAAGACCATC CTGGCTAACACAGTGAAGCCCCATCTCTACAAATAATTAGCCAGGTGTGGTGGCACACGCCTGTAGTCCC AGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCCAGGAGGCGAAGCTTGCAGTGAGCCATCGCG CCACTGCATTCCAGCCTGGATGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGAT CACTTTCAAGATCCATGGAATCTGGTGTTCTATAGTTCTATATCTGGTATTTGCAAGACAGAAGTCAGGA ATAGAGACTCCAGACACATTTCTTCCCTTGGTTGTCTTAAAGGGGACACTGTGATCTTGACAGCCTGAGT AAAGGGTTTGAGTGAGTGCCTATGATATAGTGGACAGTTTCCTCAACTATATTTCTAAAAAAAGACAAGT TTTATGTCTTTTTAAAAATTGTGGCAAAATACATATAACATAAAATTTACTATCTTAACCATTTTTTTGG GGTGATTGCTTGAGCTCAGGAGTTTGAGGCTGGAGCGAGTTAAGATCATGCCACTTCAATCTGGGCAACA GAGCAAAAGTGTGTCTCTTAAAAAAAAAAATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAG ATTGCTTGAGCCCAGGAGTTTGAGACCAGCCCGGGCAACATGGCAAGATCCTGTCTCTACAAAAAATACA AAAATTAACTGGGTGTGGTGGCACCTGTAGTCCCAGCTACTTGAGAGGCTGAGGTGGGGGATCACTTGAG CCTGGCAGGTCAAGGCTGCAGTGAGCTGTGATTGCACCACTGCACTCCAGCCTGGGTGACAGAATGAGAC TCTCTCAAAAAACAAAAACAAAAACAAAAAACAATCCCCCAAAACAAAACAAAAAACCACTGCCCTCTCC CCACTGAATGGTCCTGCCACCCTTTTCAAAATTCATTTGACCACGCATGTGAGGGTGTATGTCTGGGCTC TATTCAATGACATTGACCTATGTCTGTCTTTATGCCAGTACCATACTGTTTTGATTACTGTAGCTTTGTA GTAAGTTTTGAAATCAGGAAGTGTGAGTCCTCCAATTTTGCTCTTTTTCCAGATTGTTTTGTCTATTTGG GGTCCCTTGAGATTCTCGTGTGAATTTTAGGATAGATTTTCTATTTCTGCAAAAAACATCATTGGGGTTT TGATAGGGATTACATTTAATCTATGGATTGCTTTGGGTAGTATTGAGATCTTTAAGTTTTCTAATCCATG AACATAGGATATATTTCCATTTATTTATATCTTTTTTTTTTTTTTCTTGAGACAGAGTCTCGCTCTGTTG TCAGACTGGAGGACTGTGGCGCCATCTCGGCTCACTGCAACCTCTGACTCCCTGGTTCAAGCAATTCTCC TGCTTCAGCCTCCTGAGTAGCTGGGATTACAGGCACACGCCACCACGCCCAGCTAATTTTTATATTTTTA GTAGAGACGGGGTTTCACCATGTTGGCTAGGATGGTCTCAATCTCCTGACCTAGTGATCCACCAGCCTCG GTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCTGGCCTATGTCTTCTTTATTTTTCTTTC TTTCTTTCTTTCTTTTTTTTTTTTTTTTTTAGATGGAGTCCTGCTCTGTTGCCCAGGCTGGAGTGCAATG GCACGATCTTGACTCACTGCAACCTCCGCCTCCTGGATTCAAGTGATTTTCCTGCCTCAGCCTCCCAAGT AGCTGGGATTACAGGTGCCCACCACCACGCCTGGGTAATTTTTGTATTTTTTAATAGAGACGGGGTTTTA CCATGTTGGCCAGGCTTGTTTCAAACTCCTGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCT GGGATTACAGGTGTGAGCCACTGTGCCCGGCTCTTTTTCTTTTTTGAGACTGGGTCTTGCTTTGTCACCC AGGCTGAAGTGCAGTGGCGCGATCACTGCACACTGCAGCCTCAACTGCTTGGACTCAAGTGGTTCTCCCA CCTCAGCCTCACGAGTAGCTGGGACCACAGGCACATGCCACCACACCTGGCTAAATTTTTTATTATGTGT AGAGATGAGGTTTTGCTGGTCTGGAACTCCTGGGCTCAAGGGATCCTCCTGCCTCAGCCTCCCAAAGTGT TGAGATTACAGGCGTGAGCCATGGCATCCAGCCTTCTTTCTTTCAGCAATGTTTTGTAGTTTTCATTTTA CAAGTCTTTCATCTTGGTTAAGTTAATTTCTAACTATTTTATTATTTTTGATGCTATTGTCAATGGAACC ATTTTTGTAATTTCTTTTTCTGATTGTTCATTGTTAGTGTATAGAAATGGAAGTATTTTTTGTGGTTGGC TTCGTATCCTGCTAATATGCTAATTTTATTTGTTCTAATAGTGTTTCATCTTTAGGGTTTTCTGCATATA AAATCATACCATTTGTGAGTAGAGATAATTTTACTCCTTCTTTCCAATTTGAATGTCTTTTATTTCTTTT TCTTGCCTCCTTGCTCTATTAACTTCTAGTAATGTGTTGAATAGAAGTGGCAAAAGCAGAAATTCTTGCC TTCTTCCTGATCTTATAGAAAAAGGTTTCAGTCTTTCACCATTGAGTATAATGTTTGCTGTGGGTTTTTC ATATATGGCTTTTACTATGTTGAGGTAGTTTCCTTCTATTCTGAGTTTGTTGACTGTTTTTATCATGAAA GCTTGTTGAATTTTGTCATGTGCTTTTTTCTGCATCAATTGAGATGATGATGTAGGGTTTTTTTCATTCT CTTATGAACCCCAAAAATCTGAGACAGGTCTCAGTCAATTTAAGAAGTTTCTTTTGCCAAAGTTAAGGAT GCACGCCCAGGAGACAGGTCTATGCCTTTCTCTGAACATGAATTTTAGGGTTCCAAATTTAAAGGGGAAA GGGCAGGATATTGAGAAGTACACAGTTTTCAGGTAAGAGCAGGGTAGGGGGAAATAGTCATTCAAGCATT TGTCTGGCTCAGTGAATTTGCATTTTTACGTAAGGTAACATAGGGCAGGGGAAAATGCAGGGAACCTGCA TTTTTACGTAAGATAACAAAGACAAATGGGGCAGGGGAATAATCAGATATGCATTTGTGCCAGGTGGGCA GAGGGGTGATGCCTCTGTAAAGATAAGCTATCCATTTACATTGCCGTGGTGAATTTTATCAGACAACTAT CTTGGAGCTCACCAGGAATTTCCTTGTGGGCAAAATATGGGAGAGGTGTGTAGCTTTTCATCTTGTAGCC ATCTTATTTAGGAACCAAAACGGGGAGGCAGGTTTGCGTGACCCAGTTCCCAGCTTGACTTTTCCGTTTG GCTTAATGAGTTTGGGGTCCCAAGATTTATTTTCCTTTCACACTGTTAATGTAGTATATTGCACCGACTT TCATATGTTGAACCATCCTTGTCTGTGTATTTCAATGACAAGAGGTGTTTGTTTCTGCTTCCTGCAGAGC AGAAAGACCATGGGTTTGAGGTGGCCTCCACTTCCCCTGAAGACGAGTCCCCTGGCAGTAACCCCGAGCC AGATGCCACCCCGTTCCAGGAAGGTTTGAGGACCTTCGACCAGCTGGACGCCATATCTAGTTTGCCCACA CCCAGTGACATCTTTGTGTCCTACTCTACTTTCCCAGGTGAGCACATCAGAAGGGCTCGTCCTCGCAGCC AGTGGGTCTTCCCGTCTGCCCTAGAGGCAGCTGTGTGGTGAGAGAAAAGACCAGGGTATGAGTCCTGGTT CTGTCTTTTGCCCCTCTGTGACCCTGAGCAAGTTACTTCTCTCTGAGCCTCGGCTCAGGCTGAGCGGGCA AGGATGCGCGCTGCAAGGAGGCCTGCGCCCTTGGGTTCCTATGCCTCACTTGCCTCTCCTCTGCCTGACC CTGCCTCTGCCTTCGCATCTTTAGCAGGGGAATAGGAATCGTGCCTCAGGGGTTTCCATGGGAATTAAAC AAGGTGGCTGGCACGTCACTGAGCACAGTGCGGGGCACGTAGTAGTTGCAGCAAGCGGTAGTTTCCTTCC TTCTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAATCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGC GCGATCTTGGGTCACTGCAAGCTCTGCATCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCAAGTAG CTGGGACTACAAGCACCTGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACC GTGTTAGCCACGATGGTCTCGATCTCCTGACCTCGTGATCCACCTGCCTCGGCTTCCCAAAGTGCTGGGA TTACAGGCGTGAGCCACCGCGCCCAGCCTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTTTGTCGCCC AGGCTGGAGTTCAGTAGCATGATCTCAGCTCACTGCAACCTCCACCTCCCGGGTTGAAGTAATTCTCCTG CCTTAGCCTCCTAAGTAGCTGGGATTACAGGCATGCATCACCACACCCAGCTAATTTTTGTATTTTTAGT AGACACAGGGTTTCACCATGTTGGCCAGGCTGGTCAAGAATTCCTGACCTCAAGTGATTTGCCCACCTCG GCCTTCCAAAATGCTGGGATTACAGGTGTGAGCCACTGTGCCTGGCAGTTTCCTTCCTTTCTTATGTCTT GGATGAGTCACTTGACTTTTCCAAGCCTTGGTTTCCTTGCTGGGAAAACAGGAATTATAGCCGGAATCAG GGGATGGTCATGAGGGTGAAATAAGATCATGATTAGGGCAGAGCCTCAGGGGCCAGGCTGCTCCTGTTGG ATGTATGTATGAGTCAAGGTCTGGAGGGCGCCCGAGCCAGCGTGCATGGCCAGAGGGGTGGTGGGGAGCC GGCGGAGGGGTGGCTCTCCAGCAGTGTTCAGCCCTCCTCCCTCCAAAGGTTTTGTTTCCTGGAGGGACCC CAAGAGTGGCTCCTGGTACGTTGAGACCCTGGACGACATCTTTGAGCAGTGGGCTCACTCTGAAGACCTG CAGTCCCTCCTGCTTAGGGTGAGTGCTGCCTTCCTCTGCAAAGGAGAGGGGAGGCTGCTGAGGGGCAGCG TGTCCTCCTGGGGCTGGGGATTTGGGGTGAGCAGGGCAGGCCCAAACCAAGGGTAAAAGGTAGTAGACTC CTGCCTCTGAGCCTTGGAGTCGGCACTTTTGTGTCTCTTTATGAGAGGCATCCTGCCTGTGGTGACGTTT GCCCTTTATTCAAAGAGTTGCCTTCCCTGTCTCCTCCAAGGTCCCCAGGTTGACACCTCCCGCTCCTCCA CTGATGGAGCTGGTCCTCAGTGCCAGCGCAGGATGGCTCTGTCCAGACCCTGAAGGCGGGTCATGGGCCC CTCCCTATATCCTGTGGGCATCATGTAGTCTTCTACTCTTGACCCTCAAGAATTGTGAACCCCTCCTTGT ACATCGCCTTCTCAGGAGGCCCCAGTGAGGAAACAGATAGGGAAGGGTGGCCTGATAGGCCCAGTCCTAC TCCATAGAAACCCGACTCAGAGCAGTTGCTTCCTCTGAGGGTCCTGTGGCCTTGTGGCTGCCTTGGGAGG CAGCATGTATGGGCCCCAGCTGCTCTGCTCAGGTATTCATGCCACGAGAAGGGGCTGCGAGGCTGGGGCC ACTCCTGGCTCCTTGCAAATATTTCAGTCTGATTTGAACTTTATGAATTTGGAAATTTTGAATTTTGAGT TTTTTAAAGGTAAAGTTGAGGTGCGTATTCTTTAAGCCCTCCTGCTCAAAGAGGCTGCAGTTTGAGCTGT TTTTAAGGTGCGGGTTGAGTGGACATTCCCCCCAGCCCCTCTTGAATTCTTCCTTCAGTCCAGAGAACTG AACTCACAGAGCTCTCCATGGTCATGTCTTACAGGTCGCTAATGCTGTTTCGGTGAAAGGGATTTATAAA CAGATGCCTGGTTGCTTTAATTTCCTCCGGAAAAAACTTTTCTTTAAAACATCATAAGGCCAGGGCCCCT CACCCTGCCTTATCTTGCACCCCAAAGCTTTCCTGCCCCAGGCCTGAAAGAGGCTGAGGCCTGGACTTTC CTGCAACTCAAGGACTTTGCAGCCGGCACAGGGTCTGCTCTTTCTCTGCCAGTGACAGACAGGCTCTTAG CAGCTTCCAGATTGACGACAAGTGCTGAACAGTGGAGGAAGAGGGACAGATGAATGCCGTGGATTGCACG TGGCCTCTTGAGCAGTGGCTGGTCCAGGGCTAGTGACTTGTGTCCCATGATCCCTGTGTTGTCTCTAGAG CAGGGATTAACCTCTGCACTACTGACATGTGGGGCCAGGTCACCCTTTGCTGTGAGGCTGTCCTGTACAT TGTGGGATGTTCAGCACTGTCCCTTGCCTCAATGCCAGTAACGCGTCTTCCTGAGTGGTGCCAAACAAAA AGGTTCTCAGGTGTTGCCAAATATGTCCTGGGGTATAAAACTTTCCTCGCCTGACAACCACTGGTCTGTA GGGATTTTTGGCTACACACAAACCAGTATCGCTCATAGATCAGCAAACCGGGGCCTACTAGAGTCTGAAC AGCTGTAATCTATGAATTCTAAGTGAAATTTTAAAAATTGTTAATTTTTCCTATATTGCATTAATTTTAA AAAATAAATCTGAGGCAAATATGGACTCTCTTTTGCCTATTTCTTCCCTCATTTTGCTCCAACTCTTTCT TCTTCCTTACAAAAGAGACTTTTGCTTTTTTCGAAACATTTCCCCATGTTTTTCTGGGGTCTCGCTATGT TGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTGACCCTCCCAAGTAGCTCTTACTACAGGCGTGCACC ATTGCACCCAGCCCCATTTATTCATGTCTTATTTCACTTGATCCTTATCCCATCCCAGGAAGGCAACAAG GGTGAGAACCCTGTGCTCAGGGAGGTTAGGTCTCTTGTCCAAGGGAAAACGATTATCCAGAGAAGAGACC TGGCCAGAACCTGGGTCCCCTGAGTCCTAGCCATGCTTCCCATGTGCCTTACTTGCTGAAGCACCCCCGG ACTGCAGTGTGAACGTGCTGTGCAATAGTGACACGCTGGGCTTCCCCACAAGGCTCCACCCTGAGGTCTT TTAAGCTGTCCTTATGCCAGCCTATTTCTTGTTTTTTGGGCCTTTTTTTTTGGAGATAGGGTCTCACTCT GTCGCCCAGGCTGGAGTGCAATGACGCAATCTTGGCTTATTGCAGTCTCGACCTCCTGGGCTCAAGAGAT CCTTCCACCTCAGCCACCTGAGTAGCTTGGACTACAGGTGTGCACCACCTCTCCCAGTTAATTTTTGTAT TTTTAGTAGAGACAGAGTTATGCCATGTTACTCAGGCTGGTCTTGAACTCCTGGACTCAAGCGATCAGCC TGCCTTAGCCTCCCAAAGTGCAGGGGTTACAGGCTTGAGCCATTGCGCCTGACCTATTTCTGGTTCTTAG GGCCCTGGATGTTAGGATGGATTTCTGAATTAATAATAATAATAAAACCCTCATCAAGA Download Select all
Length	33512
OMIM ID	602234
HGNC ID	HGNC:1511
Unigene ID	Hs.329502
Ensembl ID	ENSG00000132906
PharmGKB ID	PA26094

mRNA Information

mRNA ID	NM_032996.3
Exon	join(1740..1947,8135..8420,18623..18657,19455..19631, 20451..20540,21772..21919,31078..31257,32529..32638, 33495..35129)
mRNA Sequence	Download Select all
Length	2869

CDS Information

Location	326..1327
CDS Sequence	Download Select all
CCDS ID	CCDS158.1

Protein Information

Protein ID	NP_127463.2
Protein Name	caspase 9, apoptosis-related cysteine peptidase
Molecular Wt. (Da)	36433
Protein Sequence	>lcl\|NM_032996.3_prot_NP_127463.2_1 [gene=CASP9] [protein=caspase-9 isoform 3] [protein_id=NP_127463.2] [location=326..1327] MLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAY ILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQD HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWY VETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS Download Select all
Length	333
Uniprot ID	O75293
Ensembl Protein ID	ENSP00000215631

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
D	Proteolytic Cleavage	180
T	Phosphorylation	125
T	Phosphorylation	125
T	Phosphorylation	125
T	Phosphorylation	125
Y	Phosphorylation	153
D	Proteolytic Cleavage	330
T	Phosphorylation	125
T	Phosphorylation	125
T	Phosphorylation	125
T	Phosphorylation	125
D	Proteolytic Cleavage	315
D	Proteolytic Cleavage	165
D	Proteolytic Cleavage	315
I	Proteolytic Cleavage	115
D	Proteolytic Cleavage	315
D	Proteolytic Cleavage	165
S	Phosphorylation	183
S	Phosphorylation	196
S	Phosphorylation	144
S	Phosphorylation	302
S	Phosphorylation	310
S	Phosphorylation	152
S	Phosphorylation	160
S	Phosphorylation	307
S	Phosphorylation	157

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
317	APAF1	3755	NP_863651.1	in vitro;in vivo	9 488 720 939 055 790 000 000 000 000 000 000 000 000 000
330	BIRC3	3426	NP_001156.1	in vivo	9545235
331	XIAP	2094	NP_001158.2	in vitro;in vivo	119 276 049 545 235 000 000 000 000 000 000 000 000
598	BCL2L1	2497	NP_612815.1	in vivo	9539746
824	CAPN2	254	NP_001739.2	in vitro	10671558
836	CASP3	2799	NP_004337.2	in vitro	1 067 155 890 020 110 000 000
843	CASP10	3458	NP_116759.2	in vitro	8962078
1630	DCC	391	NP_005206.2	in vitro;in vivo;yeast 2-hybrid	11248093
1832	DSP	513	NP_004406.2	in vitro	15500642
3329	HSPD1	318	NP_002147.2	in vitro	11230124
4671	NAIP	9049	NP_004527.2	in vivo	15280366
5925	RB1	1574	NP_000312.2	in vitro	15735701
7431	VIM	1899	NP_003371.2	in vitro;in vivo	115 145 631 142 390 000 000 000
54205	CYCS	479	NP_061820.1	in vivo	12147322
56616	DIABLO	5560	NP_063940.1	in vitro	11242052
112401	BIRC8	12525	NP_203127.3	in vivo	11390657

Pathway Information

Pathway Name	Pathway ID
Alzheimer's disease	hsa05010
Amyotrophic lateral sclerosis (ALS)	hsa05014
Apoptosis	hsa04210
Colorectal cancer	hsa05210
Endometrial cancer	hsa05213
Hepatitis B	hsa05161
Huntington's disease	hsa05016
Influenza A	hsa05164
Legionellosis	hsa05134
Non-small cell lung cancer	hsa05223
p53 signaling pathway	hsa04115
Pancreatic cancer	hsa05212
Parkinson's disease	hsa05012
Pathways in cancer	hsa05200
PI3K-Akt signaling pathway	hsa04151
Prostate cancer	hsa05215
Small cell lung cancer	hsa05222
Thyroid hormone signaling pathway	hsa04919
Toxoplasmosis	hsa05145
Tuberculosis	hsa05152
VEGF signaling pathway	hsa04370
Viral myocarditis	hsa05416

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00032	152-414	CASc
cl00042	152-414	CASc superfamily
cd08326	17-90	CARD_CASP9
cl14633	17-90	DD superfamily
smart00115	153-413	CASc
pfam00656	161-413	Peptidase_C14
smart00114	Jan-91	CARD
cd08304	17-89	DD
cd01671	17-89	CARD
pfam00619	17-90	CARD

Ontology Information

HPRD ID	1174
Molecular Class	Cysteine protease
Molecular Function	Structural molecule activity (GO:0005198)
Biological Process	Cell growth and/or maintenance (GO:0008151)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO