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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ING5 84289 inhibitor of growth family, member 5  2FLJ23842, p28ING5 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21193223   2011Cell line : DLD 1, HCT 15, SW480,WiDr

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : CRC 306 , adenomas 69, and nonneoplastic mucosa 288

Stage : -

 Immunohistochemistry,Western blotting ,real time RT-PCRUp-regulation-Among 18 frozen samples of colorectal carcinoma, significantly increased expression of inhibitor of growth 5 protein was observed in the carcinoma in comparison with adjacent mucosa in 14 cases


Gene Details



NC_000002.11 (242641456..242668896)

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Gene Type protein coding
Gene Family Zinc fingers, PHD-type
Description The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q37.3
Start 242641456  
End 242668896  
Strand +  
Gene Sequence

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Length 27441  
OMIM ID 608525   
HGNC ID HGNC:19421   
Unigene ID Hs.529172   
Ensembl ID ENSG00000168395   
PharmGKB ID PA134935441   

mRNA Information


mRNA ID ?NM_032329.4
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS33425.1



Protein Information


      
Protein IDNP_115705.2
Protein Nameinhibitor of growth family, member 5
Molecular Wt. (Da)0
Protein Sequence

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Length 240  
Uniprot IDO14950
Ensembl Protein ID ENSP00000237500  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation118;-
KAcetylation114
SPhosphorylation148
SPhosphorylation122

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
580BARD13354NP_000456.2yeast 2-hybrid15383276   
2033EP3004078NP_001420.2in vivo12750254   
7157TP531859NP_000537.3in vivo12750254   
7431VIM1899NP_003371.2yeast 2-hybrid15383276   
10474TADA34252NP_006345.1yeast 2-hybrid15383276   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd15685187-235  PHD_ING5
cl22851187-235  PHD_SF superfamily
pfam129985-107  ING
cl152295-107  ING superfamily
cd15586188-232  PHD_ING4_5
cd15684187-234  PHD_ING4
cd15505188-232  PHD_ING
cd15585188-232  PHD_ING3
cd15584188-232  PHD_ING1_2
cd15587188-232  PHD_Yng1p_like
cd15683187-232  PHD_ING2
cd15682187-235  PHD_ING1
pfam00628188-235  PHD
cd15522191-232  PHD_TAF3
cd15568197-231  PHD5_NSD
cd15661188-230  PHD5_NSD3
smart00249188-232  PHD
cd15659197-230  PHD5_NSD1
cd15553188-232  PHD_Cfp1
cd15560188-232  PHD2_3_BPTF
cd16039188-232  PHD_SPP1
cd15489189-232  PHD_SF
cd15660197-230  PHD5_NSD2
cd15539197-232  PHD1_AIRE
cd15519197-232  PHD1_Lid2p_like
cd15531188-232  PHD1_CHD_II
cd15518188-232  PHD_Ecm5p_Lid2p_like
cd15529197-232  PHD2_PHF10
cd15567197-232  PHD4_NSD
cd15535188-232  PHD1_Rco1
cd15532188-232  PHD2_CHD_II
cd15606188-232  PHD2_KDM5A
cd15533197-232  PHD1_PHF12
cd15538188-232  PHD_PRKCBP1
cd15516188-232  PHD2_KDM5A_like
cd15543189-232  PHD_RSF1
cd15524207-232  PHD_PHF21B
cd15574199-232  PHD_AF10_AF17
cd15552188-232  PHD_PHF3_like
COG50341-236  TNG2
COG04977-121  RecN


Ontology Information


   
HPRD ID17908
Molecular ClassTranscription regulatory protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO