Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CASP10 | 843 | caspase 10, apoptosis-related cysteine peptidase | 2 | MCH4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21559821 | 2011 | Cell line : - Source : West China Hopital Chengdu China Sample Type : CRC tumor and normal tissues No. of Sample : 120 Stage : TNM Stage II | real time RT-PCR | Down-regulation | - | Caspase-10 expression, measured by quantitative real-time RT-PCR, is a possible prognostic factor in patients with stage II colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Caspases |
| Description | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] |
| Chromosome | 2 |
| Location | 2q33-q34 |
| Start | 202047621 |
| End | 202094129 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 46509 |
| OMIM ID | 601762 |
| HGNC ID | HGNC:1500 |
| Unigene ID | Hs.5353 |
| Ensembl ID | ENSG00000003400 |
| PharmGKB ID | PA26084 |
mRNA Information
| mRNA ID | NM_032974.4 |
|---|---|
| Exon | join(1..411,2874..3227,4809..4902,10087..10222, 12945..13051,20833..20869,22985..23076,25178..25286, 26173..26665,46036..46509) | mRNA Sequence | Download Select all |
| Length | 2307 |
Protein Information
| Protein ID | NP_116756.2 |
|---|---|
| Protein Name | caspase 10, apoptosis-related cysteine peptidase |
| Molecular Wt. (Da) | 58820 |
| Protein Sequence | Download Select all |
| Length | 521 |
| Uniprot ID | P35579 |
| Ensembl Protein ID | ENSP00000216181 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 219 |
| D | Proteolytic Cleavage | 219 |
| D | Proteolytic Cleavage | 219 |
| S | Phosphorylation | 216;- |
| S | Phosphorylation | 216;- |
| S | Phosphorylation | 216;- |
| S | Phosphorylation | 216;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 637 | BID | 3590 | NP_932070.1 | in vitro | 15772077 |
| 835 | CASP2 | 2800 | NP_116764.2 | in vitro | 8962078 |
| 836 | CASP3 | 2799 | NP_004337.2 | in vitro | 8755496 |
| 839 | CASP6 | 3321 | NP_001217.2 | in vitro | 8962078 |
| 840 | CASP7 | 3457 | NP_203124.1 | in vitro | 8962078 |
| 841 | CASP8 | 3459 | NP_001073594.1 | in vitro;in vivo | 117 174 453 031 469 000 000 000 000 000 000 000 000 000 000 |
| 1832 | DSP | 513 | NP_004406.2 | in vitro | 15500642 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro | 15735701 |
| 7132 | TNFRSF1A | 1861 | NP_001056.1 | in vitro | 11098060 |
| 7185 | TRAF1 | 3418 | NP_005649.1 | in vivo | 11098060 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Apoptosis | hsa04210 |
| Hepatitis B | hsa05161 |
| RIG-I-like receptor signaling pathway | hsa04622 |
| TNF signaling pathway | hsa04668 |
| Tuberculosis | hsa05152 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00032 | 275-497 | CASc |
| cl00042 | 275-497 | CASc superfamily |
| cd08814 | 112-190 | DED_Caspase_10_r2 |
| cl14633 | 112-190 | DD superfamily |
| cd08341 | 18-99 | DED_Caspase_10_r1 |
| cl14633 | 18-99 | DD superfamily |
| smart00115 | 276-517 | CASc |
| pfam00656 | 284-496 | Peptidase_C14 |
| cd08334 | 112-190 | DED_Caspase_8_10_r2 |
| cd08792 | 20-96 | DED_Caspase_8_10_r1 |
| pfam01335 | 20-102 | DED |
| smart00031 | 19-97 | DED |
| pfam01335 | 115-191 | DED |
| smart00031 | 113-188 | DED |
| cd08333 | 20-100 | DED_Caspase_8_r1 |
| cd00045 | 20-93 | DED |
| cd00045 | 115-177 | DED |
| cd08813 | 112-188 | DED_Caspase_8_r2 |
| cd08336 | 19-96 | DED_FADD |
| cd08336 | 115-189 | DED_FADD |
| cd08333 | 115-173 | DED_Caspase_8_r1 |
| cd08792 | 115-173 | DED_Caspase_8_10_r1 |
| cd08340 | 113-188 | DED_c-FLIP_r2 |
| cd08775 | 113-188 | DED_Caspase-like_r2 |
| cd08338 | 115-171 | DED_PEA15 |
| cd08338 | 30-92 | DED_PEA15 |
| cd08776 | 20-95 | DED_Caspase-like_r1 |
Ontology Information
| HPRD ID | 17618 |
|---|---|
| Molecular Class | Cysteine protease |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.