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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HVCN1 | 84329 | hydrogen voltage-gated channel 1 | 12 | MGC15619, Hv1, VSOP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23940591 | 2013 | Cell line : - Source : Department of Surgery, Tonghua Center Hospital Sample Type : - No. of Sample : - Stage : - | Western blotting, Immunohistochemistry, real time RT-PCR | Up-regulation | - | Hv1 may be used as a potential biomarker for diagnosis and prognosis of colorectal carcinoma, and a potential target for anticancer drugs in colorectal cancer therapy. Hv1 is strongly expressed in adenocarcinomas but not or lowly expressed in normal colorectal or hyperplastic polyps. Hv1 expression in colorectal cancer is significantly associated with the tumor size, tumor classification, lymph node status, clinical stage and p53 status. Sample size: 139 colorectal cancer tissues and paired adjacent non-tumor colorectal tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Voltage-gated ion channels / Hydrogen voltage-gated channel |
| Description | This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Chromosome | 12 |
| Location | 12q24.11 |
| Start | 110648686 |
| End | 110704950 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 56265 |
| OMIM ID | 611227 |
| HGNC ID | HGNC:28240 |
| Unigene ID | Hs.211511 |
| Ensembl ID | ENSG00000122986 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001173976.1 |
|---|---|
| Exon | complement(<55821..55908) | mRNA Sequence | Download Select all |
| Length | 1736 |
CDS Information
| Location | join(21706..21726,43503..43787,49613..49717,53503..53734, 54671..54783,55476..55541) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001035196.1 |
|---|---|
| Protein Name | hydrogen voltage-gated channel 1 |
| Molecular Wt. (Da) | 31552 |
| Protein Sequence | Download Select all |
| Length | 273 |
| Uniprot ID | P53671 |
| Ensembl Protein ID | ENSP00000332687 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 35 |
| Y | Phosphorylation | 35 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 3A2A |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A, B, |
| Molecule | Voltage-gated hydrogen channel 1 |
| Model | View |
Ontology Information
| HPRD ID | 3978 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.