Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RECK | 8434 | reversion-inducing-cysteine-rich protein with kazal motifs | 9 | hRECK |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22158033 | 2012 | Cell line : - Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : - Stage : TNM Stage I-IV. | - | Down-regulation | - | In patients with lung, colorectal and bladder cancers, the RECK/SKP2 ratio is high in normal tissues and lower in the cancer tissues. |
| 22397871 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Down-regulation | - | Decreased RECK expression was an independent prognostic factor of poor survival. |
| 20878580 | 2010 | Cell line : - Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : 283 Stage : - | S-P immunohistochemistry | Unknown | - | RECK expression is low in colorectal cancer, while MMP-9 and VEGF-C expressions are high. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] |
| Chromosome | 9 |
| Location | 9p13.3 |
| Start | 36036910 |
| End | 36124452 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 87543 |
| OMIM ID | 605227 |
| HGNC ID | HGNC:11345 |
| Unigene ID | Hs.388918 |
| Ensembl ID | ENSG00000122707 |
| PharmGKB ID | PA34314 |
mRNA Information
| mRNA ID | ?NM_021111.2 |
|---|---|
| Exon | join(1..186,15353..15411,21915..21989,23207..23243, 26883..26968,28665..28712,43693..43726,46453..46650, 50782..51049,54252..54431,63419..63631,65182..65318, 68231..68371,71064..71252,73045..73167,75393..75564, 80073..80265,81845..82055,83751..83824,84621..84776, 85912..87543) | mRNA Sequence | Download Select all |
| Length | 4427 |
Protein Information
| Protein ID | NP_066934.1 |
|---|---|
| Protein Name | reversion-inducing-cysteine-rich protein with kazal motifs |
| Molecular Wt. (Da) | 90143 |
| Protein Sequence | Download Select all |
| Length | 971 |
| Uniprot ID | Q9HBJ0 |
| Ensembl Protein ID | ENSP00000352173 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4318 | MMP9 | 387 | NP_004985.2 | in vitro | 9789069 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam14828 | 776-868 | Amnionless |
| cl17735 | 776-868 | VWC superfamily |
| pfam07648 | 635-671 | Kazal_2 |
| cl00097 | 635-671 | KAZAL_FS superfamily |
Ontology Information
| HPRD ID | 5348 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.