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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25331005 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 620 Stage : - | Immunohistochemistry | Up-regulation | - | The expression of PROK1 protein was identified for the first time as a new prognostic factor in colorectal cancer. |
| 26318037 | 2015 | Cell line : - Source : First Department of Surgery, University of Fukui, Japan. Sample Type : CRC tumor and normal tissue No. of Sample : 620 Stage : TNM Stage I-IV. | Immunohistochemistry | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011] |
| Chromosome | 1 |
| Location | 1p21 |
| Start | 110993788 |
| End | 110999976 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6189 |
| OMIM ID | 606233 |
| HGNC ID | HGNC:18454 |
| Unigene ID | Hs.514793 |
| Ensembl ID | ENSG00000143125 |
| PharmGKB ID | PA38539 |
Protein Information
| Protein ID | NP_115790.1 |
|---|---|
| Protein Name | prokineticin 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 105 |
| Uniprot ID | Q9H6Z9 |
| Ensembl Protein ID | ENSP00000250457 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam06607 | Jan-97 | Prokineticin |
| cl05897 | Jan-97 | Prokineticin superfamily |
Ontology Information
| HPRD ID | 12276 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.