Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HOPX | 84525 | HOP homeobox | 4 | LAGY, HOP, OB1, NECC1, SMAP31 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22904674 | 2012 | Cell line : - Source : Kitasato University School of Medicine. Sample Type : CRC tissue and blood sample No. of Sample : 99 Stage : TNM Stage I-IV | Methylation-Specific PCR, RT-PCR, Western Blotting, Immunohistochemistry, Immunofluorescence and DNA microarray | Methylation | - | HOPX promoter methylation is a frequent and cancer-specific event in CRC progression. This epigenetic alteration may have clinical ramifications in the diagnosis and treatment of CRC patients. |
| 20617406 | 2010 | Cell line : - Source : Department of Gastroenterological Surgery, Akita University Graduate School of Medicine. Sample Type : CRC Tumor and adjescent tissue No. of Sample : 19 colon cancer patients (11 males and 8 females in age from 57 to 84) Stage : - | Immunoprecipitation,Western blotting,Cell culture and viability test,Immunohistochemistry | Up-regulation | - | Expression level of HOP was significantly increased in the tumor tissues . |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / PRD class |
| Description | The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. |
| Chromosome | 4 |
| Location | 4q12 |
| Start | 56647988 |
| End | 56681706 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 33719 |
| OMIM ID | 607275 |
| HGNC ID | HGNC:24961 |
| Unigene ID | Hs.619396 |
| Ensembl ID | ENSG00000171476 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_139212.3 |
|---|---|
| Exon | join(1..452,25695..25850,32910..33719) | mRNA Sequence | Download Select all |
| Length | 1198 |
CDS Information
| Location | join(23891..23932,25695..25850,32910..32987) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS47062.1 |
Protein Information
| Protein ID | NP_001138931.1 |
|---|---|
| Protein Name | HOP homeobox |
| Molecular Wt. (Da) | 8129 |
| Protein Sequence | Download Select all |
| Length | 73 |
| Uniprot ID | P48059 |
| Ensembl Protein ID | ENSP00000331775 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3066 | HDAC2 | 5521 | NP_001518.2 | in vivo | 12975471 |
| 6722 | SRF | 2788 | NP_003122.1 | in vitro;in vivo | 12297045 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | Oct-62 | homeodomain |
| cl00084 | Oct-62 | homeodomain superfamily |
| pfam00046 | Sep-60 | Homeobox |
| smart00389 | Oct-59 | HOX |
| COG5576 | Oct-61 | COG5576 |
Ontology Information
| HPRD ID | 3338 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Chaperone activity (GO:0003754) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.