Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PPM1D | 8493 | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 17 | Wip1, PP2C-DELTA |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25009596 | 2014 | Cell line : - Source : Second and First Affiliated Hospitals of Hunan University of Chinese Medicine (Changsha, China) Sample Type : CRC tumor and normal tissue No. of Sample : 368 patients with CRC. Stage : - | real time RT-PCR, western blotting, MTT ,immunohistochemistry | Up-regulation | - | PPM1D as a prognostic marker and potential therapeutic target in CRC. multivariate analyses demonstrated that high PPM1D expression was an independent prognostic factor for overall survival. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent |
| Description | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. |
| Chromosome | 17 |
| Location | 17q23.3 |
| Start | 60600183 |
| End | 60666280 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 66098 |
| OMIM ID | 605100 |
| HGNC ID | HGNC:9277 |
| Unigene ID | Hs.286073 |
| Ensembl ID | ENSG00000170836 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_003620.3 |
|---|---|
| Exon | join(1..704,23339..23567,33671..33795,47710..47900, 56417..56659,62813..66098) | mRNA Sequence | Download Select all |
| Length | 4790 |
CDS Information
| Location | join(233..704,23339..23567,33671..33795,47710..47900, 56417..56659,62813..63370) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11625.1 |
Protein Information
| Protein ID | NP_003611.1 |
|---|---|
| Protein Name | protein phosphatase, Mg2+/Mn2+ dependent, 1D |
| Molecular Wt. (Da) | 66544 |
| Protein Sequence | Download Select all |
| Length | 605 |
| Uniprot ID | Q16552 |
| Ensembl Protein ID | ENSP00000344192 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 85 |
Enzyme Information
| EC | 3.1.3.16 |
|---|---|
| Name | phosphoprotein phosphatase protein phosphatase-1 protein phosphatase-2A protein phosphatase-2B protein phosphatase-2C protein D phosphatase phosphospectrin phosphatase casein phosphatase Aspergillus awamori acid protein phosphatase calcineurin phosphatase 2A phosphatase 2B phosphatase II phosphatase IB phosphatase C-II polycation modulated (PCM-) phosphatase phosphopyruvate dehydrogenase phosphatase phosphatase SP branched-chain alpha-keto acid dehydrogenase phosphatase BCKDH phosphatase 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase HMG-CoA reductase phosphatase phosphatase H-II phosphatase III phosphatase I protein phosphatase phosphatase IV |
| Class | Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases |
| Sysname | phosphoprotein phosphohydrolase |
| Substrate | |
| Product | protein [CPD:C00017]; phosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4193 | MDM2 | 1272 | NP_002383.2 | in vitro;in vivo | 17936559 |
| 4691 | NCL | 1245 | NP_005372.2 | in vitro;in vivo | 12185196 |
| 6125 | RPL5 | 4699 | NP_000960.2 | in vitro;yeast 2-hybrid | 7649987 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vivo | 17936559 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| p53 signaling pathway | hsa04115 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00143 | 91-375 | PP2Cc |
| cl00120 | 91-375 | PP2Cc superfamily |
| pfam00481 | 71-368 | PP2C |
| smart00332 | 93-373 | PP2Cc |
| COG0631 | 99-373 | PTC1 |
| pfam13672 | 96-201 | PP2C_2 |
| PLN03145 | 99-378 | PLN03145 |
| PTZ00224 | 96-317 | PTZ00224 |
Ontology Information
| HPRD ID | 4419 |
|---|---|
| Molecular Class | Serine/threonine phosphatase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.