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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21339732 | 2011 | Cell line : - Source : - Sample Type : CRC tissue and blood sample No. of Sample : 62 Stage : - | Immunohistochemistry | Up-regulation | - | Cten expression is of prognostic significance in CRC, and Cten-ILK pathway controlling cell motility and possibly promoting metastasis. High expression of Cten was associated with advanced Dukes' stage, poor prognosis and distant metastasis. |
| 21698197 | 2011 | Cell line : SW 620, DLD 1 Source : - Sample Type : - No. of Sample : - Stage : - | Transfection of cell lines and proteasomal inhibition, real time RT-PCR, Western blotting, Flow cytometry | Up-regulation | - | Found an association between high Cten expression and KRAS/BRAF mutation in a series of CRC cell lines (p?=?0.03) and hypothesised that Kras may regulate Cten. In the colon and pancreas, Cten is a downstream target of Kras and may be a mechanism through which Kras regulates of cell motility. |
| 22968445 | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : 8 Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | 7.2 | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | SH2 domain containing |
| Description | - |
| Chromosome | 17 |
| Location | 17q21.2 |
| Start | 40475828 |
| End | 40501681 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 25854 |
| OMIM ID | 608385 |
| HGNC ID | HGNC:24352 |
| Unigene ID | Hs.438292 |
| Ensembl ID | ENSG00000131746 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005257744.1 |
|---|---|
| Exon | join(1..148,5162..5695,12713..13136,14225..14646, 16675..16761,17073..17198,19266..19358,19476..19553, 20914..20982,21840..22008,23034..23102,23349..23375, 23953..25854) | mRNA Sequence | Download Select all |
| Length | 4148 |
CDS Information
| Location | join(5257..5695,12713..13136,14225..14646,16675..16761, 17073..17198,19266..19358,19476..19553,20914..20982, 21840..22008,23034..23102,23349..23375,23953..24094) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_116254.4 |
|---|---|
| Protein Name | Tensin 4 |
| Molecular Wt. (Da) | 74997 |
| Protein Sequence | Download Select all |
| Length | 715 |
| Uniprot ID | P35916 |
| Ensembl Protein ID | ENSP00000261937 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 242 |
| S | Phosphorylation | 248 |
| S | Phosphorylation | 82 |
| S | Phosphorylation | 571 |
| S | Phosphorylation | 404 |
| S | Phosphorylation | 350 |
| S | Phosphorylation | 241 |
| S | Phosphorylation | 253 |
| S | Phosphorylation | 136 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01213 | 580-710 | PTB_tensin |
| cl17171 | 580-710 | PH-like superfamily |
| cd09927 | 445-558 | SH2_Tensin_like |
| cl15255 | 445-558 | SH2 superfamily |
| pfam08416 | 582-701 | PTB |
| cd00173 | 449-538 | SH2 |
| smart00252 | 449-546 | SH2 |
| smart00462 | 582-689 | PTB |
| cd00934 | 585-689 | PTB |
| pfam00017 | 449-538 | SH2 |
| cd10398 | 449-557 | SH2_Tec_Txk |
| cd09937 | 449-560 | SH2_csk_like |
| cd09932 | 446-489 | SH2_C-SH2_PLC_gamma_like |
| cd10397 | 449-555 | SH2_Tec_Btk |
| cd09930 | 449-538 | SH2_cSH2_p85_like |
| cd10347 | 449-503 | SH2_Nterm_shark_like |
| cd09941 | 449-491 | SH2_Grb2_like |
| cd10354 | 449-538 | SH2_Cterm_RasGAP |
| cd09934 | 447-519 | SH2_Tec_family |
| cd09931 | 449-523 | SH2_C-SH2_SHP_like |
| cd09944 | 446-553 | SH2_Grb7_family |
| cd10364 | 449-519 | SH2_Src_Lyn |
| cd09923 | 448-496 | SH2_SOCS_family |
| cd09926 | 444-499 | SH2_CRK_like |
| cd10360 | 449-490 | SH2_Srm |
| pfam15087 | 155-277 | DUF4551 |
| cl20957 | 155-277 | DUF4551 superfamily |
| cd09918 | 450-541 | SH2_Nterm_SPT6_like |
| cd10396 | 449-513 | SH2_Tec_Itk |
| cd10348 | 449-541 | SH2_Cterm_shark_like |
| cd10371 | 449-555 | SH2_Src_Blk |
| cd10344 | 449-513 | SH2_SLAP |
| cd10349 | 449-522 | SH2_SH2D2A_SH2D7 |
| cd10343 | 449-556 | SH2_SHIP |
| cd10350 | 444-527 | SH2_SH2D4A |
| cd10388 | 438-490 | SH2_SOCS7 |
| cd10384 | 448-490 | SH2_SOCS3 |
| cd09942 | 449-488 | SH2_nSH2_p85_like |
| cd10399 | 449-517 | SH2_Tec_Bmx |
| cd09943 | 449-491 | SH2_Nck_family |
| cd10340 | 449-538 | SH2_N-SH2_SHP_like |
| cd09940 | 449-534 | SH2_Vav_family |
| cd10417 | 449-514 | SH2_SH2D7 |
| cd10414 | 446-552 | SH2_Grb14 |
| cd10352 | 454-488 | SH2_a2chimerin_b2chimerin |
| cd10357 | 445-478 | SH2_ShkD_ShkE |
| cd09945 | 449-511 | SH2_SHB_SHD_SHE_SHF_like |
| PHA03247 | 191-438 | PHA03247 |
| PTZ00449 | 212-447 | PTZ00449 |
Ontology Information
| HPRD ID | 3134 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Kinase activity (GO:0016301) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.