Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FBXL20 | 84961 | F-box and leucine-rich repeat protein 20 | 17 | Fbl2; Fbl20 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23023584 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | real time RT-PCR, Western Blotting | Up-regulation | - | FBXL20 plays an essential role in the carcinogenesis of human colorectal adenocarcinoma. Moreover, our data suggest that FBXL20 promotes carcinogenesis through the regulation of the Wnt signaling pathway and caspase activation. FBXL20 mRNA expression was upregulated in 76.7% of the tumor samples. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | F-boxes / Leucine-rich repeats |
| Description | Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] |
| Chromosome | 17 |
| Location | 17q12 |
| Start | 39252644 |
| End | 39402661 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 150018 |
| OMIM ID | 609086 |
| HGNC ID | HGNC:24679 |
| Unigene ID | Hs.462946 |
| Ensembl ID | ENSG00000108306 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001184906.1 |
|---|---|
| Exon | join(1006..1301,59421..59482,99023..99077,101587..101661, 103578..103672,105467..105535,119807..119933, 121199..121273,127562..127692,131806..131866, 133791..133835,137209..137265,138275..138487, 141095..150018) | mRNA Sequence | Download Select all |
| Length | 10285 |
CDS Information
| Location | join(337..489,59421..59482,99023..99077,101587..101661, 103578..103672,105467..105535,119807..119933, 121199..121273,127562..127692,131806..131866, 133791..133835,137209..137265,138275..138487, 141095..141202) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001171835.1 |
|---|---|
| Protein Name | F-box and leucine-rich repeat protein 20 |
| Molecular Wt. (Da) | 44849 |
| Protein Sequence | Download Select all |
| Length | 404 |
| Uniprot ID | P02751 |
| Ensembl Protein ID | ENSP00000323534 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 417 |
| S | Phosphorylation | 425 |
| S | Phosphorylation | 421 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd09293 | 220-394 | AMN1 |
| cl23706 | 220-394 | AMN1 superfamily |
| cd09293 | 181-371 | AMN1 |
| cd09293 | 93-289 | AMN1 |
| cl23706 | 93-289 | AMN1 superfamily |
| cd09293 | 89-236 | AMN1 |
| pfam12937 | 27-70 | F-box-like |
| cl02535 | 27-70 | F-box superfamily |
| cd00116 | 75-332 | LRR_RI |
| cl23707 | 75-332 | LRR_RI superfamily |
| smart00256 | 28-68 | FBOX |
| cd09293 | 25-160 | AMN1 |
| pfam00646 | 27-70 | F-box |
| cd00116 | 197-405 | LRR_RI |
| cl23707 | 197-405 | LRR_RI superfamily |
| smart00367 | 324-349 | LRR_CC |
| cl23352 | 324-349 | LRR_CC superfamily |
Ontology Information
| HPRD ID | 1974 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Hydrolase activity (GO:0016787) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.