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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PIK3R3 8503 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)  1p55 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24837077   2014Cell line : SW480, SW48, HT 29, HCT 116, LoVo, SW620

Source : Type Culture Collection cell bank (Chinese Academy of Sciences, Beijing, PR China)

Sample Type : -

No. of Sample : -

Stage : -

Transfection,Colony formation assay,Cell motility and migration assays,real time RT-PCR, Western blottingUp-regulation-PIK3R3 plays an important role in colorectal cancer metastasis and might be a potential and specific target for therapies against metastatic colorectal cancer. Overexpression of PIK3R3 increases tumor migration and invasion in vitro and promotes metastasis of colorectal cancers in vivo.


Gene Details



NC_000001.10 (46505812..46642167, complement)

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Gene Type protein coding
Gene Family SH2 domain containing
Description -  
Chromosome 1
Location 1p34.1
Start 46505812  
End 46642167  
Strand -  
Gene Sequence

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Length 136356  
OMIM ID 606076   
HGNC ID HGNC:8981   
Unigene ID Hs.655387   
Ensembl ID ENSG00000117461   
PharmGKB ID PA33314   

mRNA Information


mRNA ID ?NM_001114172.1
Exon join(1..268,95746..95854,98883..98981,109405..109585, 110317..110442,114425..114567,120525..120701, 129871..129945,130408..130578,132625..136356)  
mRNA Sequence

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Length 5098  



CDS Information


   
Location25..1548
CDS Sequence

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CCDS ID CCDS529.1



Protein Information


      
Protein IDNP_001107644.1
Protein Namephosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Molecular Wt. (Da)57724
Protein Sequence

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Length 461  
Uniprot IDQ9HC98
Ensembl Protein ID ENSP00000319734  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation341

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3480IGF1R932NP_000866.1in vitro;in vivo;yeast 2-hybrid95   242   599   415   396   
3643INSR975NP_000199.2in vitro;yeast 2-hybrid9524259   
3667IRS1943NP_005535.1in vitro;in vivo7   542   745   104   173   500   000   000   
5290PIK3CA1382NP_006209.2yeast 2-hybrid9415396   
5925RB11574NP_000312.2in vitro;in vivo12588990   
7006TEC2786NP_003206.2yeast 2-hybrid9178903   


Pathway Information


                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Adrenergic signaling in cardiomyocytes hsa04261
AGE-RAGE signaling pathway in diabetic complications hsa04933
Aldosterone-regulated sodium reabsorption hsa04960
Amoebiasis hsa05146
AMPK signaling pathway hsa04152
Apoptosis hsa04210
B cell receptor signaling pathway hsa04662
Bacterial invasion of epithelial cells hsa05100
cAMP signaling pathway hsa04024
Carbohydrate digestion and absorption hsa04973
Central carbon metabolism in cancer hsa05230
cGMP-PKG signaling pathway hsa04022
Chagas disease (American trypanosomiasis) hsa05142
Chemokine signaling pathway hsa04062
Choline metabolism in cancer hsa05231
Cholinergic synapse hsa04725
Chronic myeloid leukemia hsa05220
Colorectal cancer hsa05210
Endometrial cancer hsa05213
Epstein-Barr virus infection hsa05169
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Fc epsilon RI signaling pathway hsa04664
Fc gamma R-mediated phagocytosis hsa04666
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Glioma hsa05214
Hepatitis B hsa05161
Hepatitis C hsa05160
HIF-1 signaling pathway hsa04066
HTLV-I infection hsa05166
Inflammatory mediator regulation of TRP channels hsa04750
Influenza A hsa05164
Insulin resistance hsa04931
Insulin signaling pathway hsa04910
Jak-STAT signaling pathway hsa04630
Leukocyte transendothelial migration hsa04670
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
Measles hsa05162
Melanoma hsa05218
mTOR signaling pathway hsa04150
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Non-small cell lung cancer hsa05223
Osteoclast differentiation hsa04380
Oxytocin signaling pathway hsa04921
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phosphatidylinositol signaling system hsa04070
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Platelet activation hsa04611
Progesterone-mediated oocyte maturation hsa04914
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Regulation of lipolysis in adipocytes hsa04923
Renal cell carcinoma hsa05211
Signaling pathways regulating pluripotency of stem cells hsa04550
Small cell lung cancer hsa05222
Sphingolipid signaling pathway hsa04071
T cell receptor signaling pathway hsa04660
Thyroid hormone signaling pathway hsa04919
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Type II diabetes mellitus hsa04930
VEGF signaling pathway hsa04370
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0994259-167  SH2_nSH2_p85_like
cl1525559-167  SH2 superfamily
cd09930351-454  SH2_cSH2_p85_like
cl15255351-454  SH2 superfamily
cd12925172-332  iSH2_PIK3R3
cl17108172-332  iSH2_PI3K_IA_R superfamily
cd12926172-332  iSH2_PIK3R2
cd12924172-332  iSH2_PIK3R1
cd12923172-331  iSH2_PI3K_IA_R
smart0025264-145  SH2
pfam00017358-432  SH2
smart00252358-438  SH2
pfam0001765-140  SH2
cd0993065-160  SH2_cSH2_p85_like
cd0017364-140  SH2
cd00173358-432  SH2
cd09942355-452  SH2_nSH2_p85_like
cd0992364-140  SH2_SOCS_family
cd0994064-160  SH2_Vav_family
cd09934348-452  SH2_Tec_family
cd09932353-456  SH2_C-SH2_PLC_gamma_like
cd1038765-139  SH2_SOCS6
cd09940353-452  SH2_Vav_family
cd1038359-140  SH2_SOCS2
cd0993765-144  SH2_csk_like
cd09933358-451  SH2_Src_family
cd10397350-452  SH2_Tec_Btk
cd0993459-162  SH2_Tec_family
cd1071860-140  SH2_CIS
cd1038854-137  SH2_SOCS7
cd1040765-159  SH2_Vav3
cd10369358-451  SH2_Src_Frk
cd1038254-140  SH2_SOCS1
cd0993364-140  SH2_Src_family
cd0994364-140  SH2_Nck_family
cd10363358-451  SH2_Src_HCK
cd0992959-160  SH2_BLNK_SLP-76
cd10344358-436  SH2_SLAP
cd09935354-451  SH2_ABL
cd10355358-432  SH2_DAPP1_BAM32_like
cd1034164-145  SH2_N-SH2_PLC_gamma_like
cd10356355-429  SH2_ShkA_ShkC
cd10399354-436  SH2_Tec_Bmx
cd1036159-141  SH2_Fps_family
cd09941354-436  SH2_Grb2_like
cd0993165-160  SH2_C-SH2_SHP_like
cd10360358-432  SH2_Srm
cd0992665-105  SH2_CRK_like
cd09937358-452  SH2_csk_like
cd10405357-451  SH2_Vav1
cd10341352-437  SH2_N-SH2_PLC_gamma_like
cd09931358-454  SH2_C-SH2_SHP_like
cd0993865-144  SH2_N-SH2_Zap70_Syk_like
cd0993565-159  SH2_ABL
cd10407353-451  SH2_Vav3
cd1040964-140  SH2_Nck2
cd1038460-140  SH2_SOCS3
cd1037065-144  SH2_Src_Src42
cd1040665-161  SH2_Vav2
cd1039265-160  SH2_SHF
cd10371358-451  SH2_Src_Blk
cd0993264-162  SH2_C-SH2_PLC_gamma_like
cd1036761-140  SH2_Src_Fgr
cd1035655-137  SH2_ShkA_ShkC
cd1035464-140  SH2_Cterm_RasGAP
cd10364358-436  SH2_Src_Lyn
cd10406353-451  SH2_Vav2
cd1040565-159  SH2_Vav1
cd10398349-452  SH2_Tec_Txk
cd1034765-140  SH2_Nterm_shark_like
cd0994565-160  SH2_SHB_SHD_SHE_SHF_like
cd10417358-444  SH2_SH2D7
cd1036561-144  SH2_Src_Src
cd10362357-451  SH2_Src_Lck
cd1036464-144  SH2_Src_Lyn
cd10370354-451  SH2_Src_Src42
cd10340358-452  SH2_N-SH2_SHP_like
cd1036861-140  SH2_Src_Fyn
cd1041861-140  SH2_Src_Fyn_isoform_a_like
cd1035266-137  SH2_a2chimerin_b2chimerin
cd0994165-144  SH2_Grb2_like
cd09938358-453  SH2_N-SH2_Zap70_Syk_like
cd1034864-140  SH2_Cterm_shark_like
cd1039759-162  SH2_Tec_Btk
cd1035765-128  SH2_ShkD_ShkE
cd1040864-140  SH2_Nck1
cd0992765-105  SH2_Tensin_like
cd10343358-453  SH2_SHIP
cd10365358-449  SH2_Src_Src
cd0992565-141  SH2_SHC
cd1039165-160  SH2_SHE
cd1034465-140  SH2_SLAP
cd1039660-161  SH2_Tec_Itk
cd1036364-140  SH2_Src_HCK
cd09929345-452  SH2_BLNK_SLP-76
cd09946358-446  SH2_HSH2_like
cd1039959-144  SH2_Tec_Bmx
cd09927355-451  SH2_Tensin_like
cd10352363-407  SH2_a2chimerin_b2chimerin
cd10396348-452  SH2_Tec_Itk
cd1040265-139  SH2_C-SH2_Zap70
cd10347358-432  SH2_Nterm_shark_like
cd10368356-436  SH2_Src_Fyn
cd10402358-426  SH2_C-SH2_Zap70
cd10349358-432  SH2_SH2D2A_SH2D7
cd1034065-160  SH2_N-SH2_SHP_like
cd1033760-140  SH2_BCAR3
cd10350358-437  SH2_SH2D4A
cd1035865-147  SH2_PTK6_Brk
cd1035163-145  SH2_SH2D4B
cd10367356-444  SH2_Src_Fgr
cd1036965-144  SH2_Src_Frk
cd09923358-386  SH2_SOCS_family
cd1041965-144  SH2_Src_Fyn_isoform_b_like
cd10351358-429  SH2_SH2D4B
cd09926353-436  SH2_CRK_like
cd1036261-144  SH2_Src_Lck
cd10418356-451  SH2_Src_Fyn_isoform_a_like
cd1034361-162  SH2_SHIP
cd1039859-160  SH2_Tec_Txk
cd10348358-436  SH2_Cterm_shark_like
cd09943356-433  SH2_Nck_family
cd10357356-386  SH2_ShkD_ShkE
cd10419356-436  SH2_Src_Fyn_isoform_b_like
cd10359367-451  SH2_SH3BP2
cd10387358-436  SH2_SOCS6
cd1038965-160  SH2_SHB
cd10401358-432  SH2_C-SH2_Syk_like
cd10361365-437  SH2_Fps_family
cd09944358-406  SH2_Grb7_family
cd1036661-140  SH2_Src_Yes
cd10354358-432  SH2_Cterm_RasGAP
cd1035976-141  SH2_SH3BP2
cd1038566-148  SH2_SOCS4
cd1038666-140  SH2_SOCS5
cd0994465-162  SH2_Grb7_family
cd10358361-437  SH2_PTK6_Brk
cd0994664-105  SH2_HSH2_like
cd09925356-403  SH2_SHC
cd10391356-452  SH2_SHE
cd10408356-437  SH2_Nck1
cd09945358-432  SH2_SHB_SHD_SHE_SHF_like
COG1196163-348  Smc
TIGR02168141-307  SMC_prok_B
COG1196189-326  Smc
PRK03918179-278  PRK03918
pfam10174155-302  Cast
COG1196163-369  Smc
COG1196179-312  Smc
COG1196170-283  Smc
COG0419189-312  SbcC
TIGR02169164-339  SMC_prok_A
pfam13166143-370  AAA_13
TIGR02168164-349  SMC_prok_B
pfam06160171-295  EzrA


Ontology Information


   
HPRD ID5215
Molecular ClassAdapter molecule
Molecular FunctionHydrolase activity (GO:0016787)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q92569DB01064IsoprenalineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO