Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ENC1 | 8507 | ectodermal-neural cortex 1 (with BTB domain) | 5 | PIG10, ENC-1, TP53I10, KLHL37 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11691783 | 2001 | Cell line : SW480, LoVo, HT29, HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR,cDNA Microarray,Western Blotting,ELISA | Up-regulation | - | ENC1 is regulated by the beta-catenin/Tcf pathway and that its altered expression may contribute to colorectal carcinogenesis by suppressing differentiation of colonic cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kelch-like, "BTB/POZ domain containing" |
| Description | This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] |
| Chromosome | 5 |
| Location | 5q13 |
| Start | 73923231 |
| End | 73937249 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 14019 |
| OMIM ID | 605173 |
| HGNC ID | HGNC:3345 |
| Unigene ID | Hs.104925 |
| Ensembl ID | ENSG00000171617 |
| PharmGKB ID | PA27782 |
mRNA Information
| mRNA ID | ?NM_001256574.1 |
|---|---|
| Exon | join(1..1118,5063..6741,11433..14019) | mRNA Sequence | Download Select all |
| Length | 5384 |
Protein Information
| Protein ID | NP_001243503.1 |
|---|---|
| Protein Name | ectodermal-neural cortex 1 (with BTB domain) |
| Molecular Wt. (Da) | 54240 |
| Protein Sequence | Download Select all |
| Length | 589 |
| Uniprot ID | Q9UHD8 |
| Ensembl Protein ID | ENSP00000329161 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 435 |
| S | Phosphorylation | 441 |
| T | Phosphorylation | 569 |
| T | Phosphorylation | 570 |
| Y | Phosphorylation | 573 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo | 9566959 |
| 7046 | TGFBR1 | 1822 | NP_004603.1 | in vivo | 15761153 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14735 | 144-202 | BACK_Kelch |
| cl06652 | 144-202 | BACK_like superfamily |
| pfam07707 | 149-251 | BACK |
| pfam00651 | 36-144 | BTB |
| cl02518 | 36-144 | BTB superfamily |
| smart00875 | 149-249 | BACK |
| smart00225 | 47-144 | BTB |
| smart00612 | 389-441 | Kelch |
| cl02701 | 389-441 | Kelch_1 superfamily |
| pfam01344 | 329-374 | Kelch_1 |
| cl02701 | 329-374 | Kelch_1 superfamily |
| smart00612 | 539-585 | Kelch |
| cl02701 | 539-585 | Kelch_1 superfamily |
| pfam01344 | 527-572 | Kelch_1 |
| smart00612 | 341-384 | Kelch |
| pfam13415 | 339-386 | Kelch_3 |
| pfam13854 | 326-363 | Kelch_5 |
| pfam13418 | 329-374 | Kelch_4 |
| pfam01344 | 377-431 | Kelch_1 |
| pfam13964 | 329-378 | Kelch_6 |
| cd14733 | 144-199 | BACK_like |
| pfam01344 | 481-523 | Kelch_1 |
| cl02701 | 481-523 | Kelch_1 superfamily |
| pfam13964 | 481-528 | Kelch_6 |
| pfam13415 | 491-536 | Kelch_3 |
| pfam07646 | 329-374 | Kelch_2 |
| pfam13964 | 528-575 | Kelch_6 |
| pfam07646 | 481-524 | Kelch_2 |
| pfam07646 | 528-572 | Kelch_2 |
| PHA03098 | 48-566 | PHA03098 |
| PHA02790 | 63-566 | PHA02790 |
| PLN02153 | 337-529 | PLN02153 |
| PHA02713 | 32-568 | PHA02713 |
| PLN02193 | 337-521 | PLN02193 |
| PLN02153 | 327-545 | PLN02153 |
| PLN02193 | 342-570 | PLN02193 |
| PRK14131 | 466-579 | PRK14131 |
| TIGR03548 | 486-574 | mutarot_permut |
| PLN02193 | 283-462 | PLN02193 |
| COG3055 | 325-549 | NanM |
Ontology Information
| HPRD ID | 17828 |
|---|---|
| Molecular Class | Structural protein |
| Molecular Function | Phosphoric diester hydrolase activity (GO:0008081) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.