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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
GAS7 8522 growth arrest-specific 7  17KIAA0394, MGC1348 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21298349   2011Cell line : -

Source : Samsung Medical Center (Seoul, Korea)

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : 22

Stage : TNM Stage I-IV

 Pyrosequencing,beadchip array-based technique.Hypermethylation-CpG sites that were hypermethylated (ADHFE1, BOLL, SLC6A15, ADAMTS5, TFPI2, EYA4, NPY, TWIST1, LAMA1, GAS7) and 2 CpG sites showing hypomethylation (MAEL, SFT2D3) in CRC compared to the normal mucosa.

24441198   2014Cell line : -

Source : Department of Pathology, Howard University Hospital.

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : 42

Stage : -

EpiQuest library construction,Bisulfite conversion and multiplex amplification,Barcoding adapterization PCRHypermethylation- GAS7 (1), GPR75 (24), and TNFAIP2 (1)-were significantly hypermethylated in tumor vs. normal tissues.


Gene Details



NC_000017.10 (9813926..10101868, complement)

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Gene Type protein coding
Gene Family -
Description Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17p13.1
Start 9813926  
End 10101868  
Strand -  
Gene Sequence

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Length 287943  
OMIM ID 603127   
HGNC ID HGNC:4169   
Unigene ID Hs.462214   
Ensembl ID -   
PharmGKB ID PA28583   

mRNA Information


mRNA ID ?NM_001130831.1
Exon join(1..344,178655..178775,216668..216748,228790..228875, 239297..239350,251569..251658,255316..255431, 258352..258426,264308..264386,271783..271911, 272953..273076,278847..278926,280453..280551, 281211..287943)  
mRNA Sequence

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Length 8211  



CDS Information


   
Location162..1592
CDS Sequence

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CCDS ID CCDS11152.1



Protein Information


      
Protein IDNP_001124303.1
Protein Namegrowth arrest-specific 7
Molecular Wt. (Da)61578
Protein Sequence

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Length 476  
Uniprot IDO95452
Ensembl Protein ID ENSP00000241124  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vitro;in vivo11795944   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd07649214-446  F-BAR_GAS7
cl12013214-446  BAR superfamily
cd11829May-57  SH3_GAS7
cl17036May-57  SH3 superfamily
cd07610219-446  FCH_F-BAR
cd07647216-429  F-BAR_PSTPIP
cd07648218-475  F-BAR_FCHO
pfam00611202-296  FCH
cd07671219-423  F-BAR_PSTPIP1
cd07673200-475  F-BAR_FCHO2
cd07651218-420  F-BAR_PombeCdc15_like
smart00055210-292  FCH
cd07658219-438  F-BAR_NOSTRIN
smart00326May-58  SH3
cd00174May-56  SH3
cd07672216-428  F-BAR_PSTPIP2
cd07674218-433  F-BAR_FCHO1
cd07653240-428  F-BAR_CIP4-like
cd07655235-401  F-BAR_PACSIN
cd11837May-59  SH3_Intersectin_2
cd11877Jul-59  SH3_PIX
cd11763May-58  SH3_SNX9_like
pfam14604Sep-58  SH3_9
cd07652235-430  F-BAR_Rgd1
cd11771Jun-59  SH3_Pex13p_fungal
cd11805May-58  SH3_GRB2_like_C
cd07650231-472  F-BAR_Syp1p_like
cd11779May-58  SH3_Irsp53_BAIAP2L
cd11823May-58  SH3_Nostrin
cd11960May-59  SH3_Abp1_eu
cd11839Jul-59  SH3_Intersectin_4
cd11875May-59  SH3_CD2AP-like_3
cd11825Jun-58  SH3_PLCgamma
cd11803Jun-60  SH3_Endophilin_A
cd11889May-57  SH3_Cyk3p-like
cd1182821-59  SH3_ARHGEF9_like
cd11883Jun-56  SH3_Sdc25
pfam00018Jul-54  SH3_1
cd07307235-440  BAR
cd11819May-59  SH3_Cortactin_like
cd1206121-58  SH3_betaPIX
cd11928Jul-59  SH3_SH3RF3_1
cd1206021-58  SH3_alphaPIX
cd11963May-57  SH3_STAM2
cd11781Jun-59  SH3_Sorbs_1
cd11999Mar-58  SH3_PACSIN_like
pfam0765319-58  SH3_2
cd11820May-58  SH3_STAM
cd11786Jul-58  SH3_SH3RF_1
cd11770May-59  SH3_Nephrocystin
cd11964May-57  SH3_STAM1
cd11767Jul-59  SH3_Nck_3
cd11897May-59  SH3_SNX18
cd1191421-60  SH3_BAIAP2L2
cd1197419-59  SH3_ASEF2
cd11821May-56  SH3_ASAP
cd11913May-59  SH3_BAIAP2L1
cd11840Jul-59  SH3_Intersectin_5
cd11838Sep-59  SH3_Intersectin_3
cd11841Aug-58  SH3_SH3YL1_like
cd1205216-58  SH3_CIN85_1
cd12057Jun-60  SH3_CIN85_3
cd12073Sep-60  SH3_HS1
cd11849Jul-58  SH3_SPIN90
cd07680230-423  F-BAR_PACSIN1
cd11826Jul-58  SH3_Abi
cd11827May-58  SH3_MyoIe_If_like
cd11915Apr-60  SH3_Irsp53
cd11858May-59  SH3_Myosin-I_fungi
cd1199321-60  SH3_Intersectin1_4
cd12142Jun-59  SH3_D21-like
cd11997Mar-58  SH3_PACSIN3
cd1179621-57  SH3_DNMBP_N3
cd12072Jun-59  SH3_FNBP1L
cd11874May-59  SH3_CD2AP-like_2
cd11994Apr-60  SH3_Intersectin2_4
cd07676230-429  F-BAR_FBP17
cd11836May-58  SH3_Intersectin_1
cd11833Sep-58  SH3_Stac_1
cd1196121-59  SH3_Abp1_fungi_C2
cd11769Mar-58  SH3_CSK
cd11992Sep-58  SH3_Intersectin2_3
cd07679230-428  F-BAR_PACSIN2
cd11856Jul-62  SH3_p47phox_like
cd11882May-59  SH3_GRAF-like
cd1179326-58  SH3_ephexin1_like
cd11904Jul-59  SH3_Nck1_3
cd11998May-58  SH3_PACSIN1-2
cd07656236-400  F-BAR_srGAP
cd11951Oct-58  SH3_GRAP_C
cd11989May-59  SH3_Intersectin1_2
cd11911May-59  SH3_CIP4-like
cd11962Jul-59  SH3_Abp1_fungi_C1
cd1176621-58  SH3_Nck_2
cd11927Jul-59  SH3_SH3RF1_1
cd11929May-59  SH3_SH3RF2_1
cd11813May-59  SH3_SGSM3
cd1197319-59  SH3_ASEF
cd1199621-59  SH3_Intersectin2_5
cd11982Nov-57  SH3_Shank1
cd1197521-59  SH3_ARHGEF9
cd11898May-60  SH3_SNX9
cd11758Jul-58  SH3_CRK_N
cd11782Jul-58  SH3_Sorbs_2
cd11903Jul-61  SH3_Nck2_3
cd11896May-59  SH3_SNX33
cd11873Sep-57  SH3_CD2AP-like_1
cd11970Jul-58  SH3_PLCgamma1
cd1177824-56  SH3_Bzz1_2
cd12071Jun-59  SH3_FBP17
cd11924Oct-59  SH3_Vinexin_2
cd11812Aug-57  SH3_AHI-1
cd07675220-375  F-BAR_FNBP1L
cd11988Jul-58  SH3_Intersectin2_1
cd1199521-59  SH3_Intersectin1_5
cd1199021-59  SH3_Intersectin2_2
cd11843May-58  SH3_PACSIN
cd11969Jul-58  SH3_PLCgamma2
cd11818May-56  SH3_Eve1_5
cd11987Jul-58  SH3_Intersectin1_1
cd1188421-58  SH3_MYO15
cd11901Oct-57  SH3_Nck1_2
cd11855May-59  SH3_Sho1p
cd11762Jun-58  SH3_FCHSD_2
cd11984Nov-57  SH3_Shank3
cd11887May-58  SH3_Bbc1
cd1195921-59  SH3_Cortactin
cd11772Jul-57  SH3_OSTF1
cd1183221-54  SH3_Shank
cd11830Oct-58  SH3_VAV_2
cd12056Jun-59  SH3_CD2AP_3
cd11978Oct-58  SH3_VAV3_2
cd11950Jul-57  SH3_GRAP2_C
cd11972Sep-63  SH3_Abi2
cd11816May-57  SH3_Eve1_3
cd1201718-58  SH3_Tks_3
cd07596249-400  BAR_SNX
cd1193827-55  SH3_ARHGEF16_26
cd11824Jul-59  SH3_PSTPIP1
cd11920Jul-60  SH3_Sorbs2_1
cd11902Oct-57  SH3_Nck2_2
cd11976Apr-58  SH3_VAV1_2
cd1202322-59  SH3_NoxO1_1
cd1197736-58  SH3_VAV2_2
pfam09325239-435  Vps5
pfam04012267-409  PspA_IM30
pfam01540250-450  Lipoprotein_7
PRK12704268-421  PRK12704
pfam10186277-400  Atg14
COG1196221-421  Smc
COG0419224-414  SbcC
COG0419221-476  SbcC
pfam05667231-395  DUF812
pfam01576223-410  Myosin_tail_1
COG4942224-376  EnvC
COG0419224-425  SbcC


Ontology Information


   
HPRD ID9195
Molecular ClassUnclassified
Molecular FunctionTranslation regulator activity (GO:0045182)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO