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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19956716 | 2009 | Cell line : Co115, LS174, Lovo,
TC71, HCT15, HCT116, TC7, SW48, RKO, HCT8, LS411 Source : - Sample Type : - No. of Sample : - Stage : - | TOPflash assay,Cell proliferation assay,Immunofluorescence staining and microscopy, immunoprecipitations | Mutation | - | NKD1 mutations promote Wnt-dependent tumorigenesis in a subset of DNA mismatch-repair-deficient colorectal adenocarcinomas . |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | EF-hand domain containing |
| Description | In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003] |
| Chromosome | 16 |
| Location | 16q12.1 |
| Start | 50582241 |
| End | 50674771 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 92531 |
| OMIM ID | 607851 |
| HGNC ID | HGNC:17045 |
| Unigene ID | Hs.187578 |
| Ensembl ID | ENSG00000140807 |
| PharmGKB ID | PA31637 |
Protein Information
| Protein ID | NP_149110.1 |
|---|---|
| Protein Name | naked cuticle homolog 1 (Drosophila) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 470 |
| Uniprot ID | Q96PY5 |
| Ensembl Protein ID | ENSP00000288670 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 18257 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.