Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PIAS1 8554 protein inhibitor of activated STAT, 1  15GBP, GU/RH-II, ZMIZ3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19288270   2009Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Tissue microarraysDown-regulation-The PIAS1 results in particular may represent a basis for new approaches for efficiently distinguishing adenomas from colon cancer.


Gene Details



NC_000015.9 (68346572..68483797)

View Larger Image
   
Gene Type protein coding
Gene Family Zinc fingers, MIZ-type
Description This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q
Start 68346572  
End 68483797  
Strand +  
Gene Sequence

   Download   Select all

Length 137226  
OMIM ID 603566   
HGNC ID HGNC:2752   
Unigene ID Hs.162458   
Ensembl ID -   
PharmGKB ID PA33285   

mRNA Information


mRNA ID ?NM_016166.1
Exon join(1..117,32073..32517,87713..87797,88057..88104, 91583..91673,92333..92467,99357..99462,110498..110571, 119499..119659,121404..121534,122241..122421, 126979..127121,129397..129434,133309..133842)  
mRNA Sequence

   Download   Select all

Length 5743  



CDS Information


   
Location 149..2104
CDS Sequence

   Download   Select all

CCDS ID CCDS45290.1



Protein Information


      
Protein IDNP_057250.1
Protein Nameprotein inhibitor of activated STAT, 1
Molecular Wt. (Da)100673
Protein Sequence

   Download   Select all

Length 651  
Uniprot IDQ8WUF5
Ensembl Protein ID ENSP00000354218  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation90
SPhosphorylation466;-
SPhosphorylation467;-
SPhosphorylation468;-
SPhosphorylation488;-
SPhosphorylation485;-
TPhosphorylation487;-
SPhosphorylation503
SPhosphorylation506
SPhosphorylation522
TPhosphorylation635

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
367AR2437NP_000035.2in vitro;in vivo1   187   741   812   177   000   
1053CEBPE2852NP_001796.2in vitro;yeast 2-hybrid15588942   
1466CSRP23523NP_001312.1in vitro;in vivo;yeast 2-hybrid11672422   
1759DNM13851NP_004399.2in vitro;yeast 2-hybrid15123615   
1788DNMT3A4141NP_072046.2in vitro;in vivo;yeast 2-hybrid14752048   
2004ELK32593NP_005221.2in vitro;in vivo;yeast 2-hybrid15580297   
2099ESR1589NP_000116.2yeast 2-hybrid15666801   
2516NR5A11702NP_004950.2in vitro;in vivo;yeast 2-hybrid15192080   
2626GATA48994NP_002043.2in vitro15337742   
3725JUN1302NP_002219.1in vitro11867732   
4086SMAD13356NP_005891.1yeast 2-hybrid15231748   
4089SMAD42995NP_005350.1in vitro;yeast 2-hybrid1   502   871   415   231   740   
4092SMAD74241NP_005895.1yeast 2-hybrid15231748   
4193MDM21272NP_002383.2in vitro12393906   
4306NR3C22991NP_000892.2in vitro;in vivo;yeast 2-hybrid14500761   
5747PTK22859NP_005598.3in vitro;in vivo;yeast 2-hybrid14500712   
5770PTPN11477NP_002818.1in vivo17159996   
5970RELA1241NP_068810.3in vitro;in vivo1   565   743   717   540   170   
6498SKIL1319NP_005405.2yeast 2-hybrid15231748   
6670SP33483NP_003102.1in vitro;yeast 2-hybrid12356736   
6772STAT12777NP_009330.1in vitro;in vivo;yeast 2-hybrid10   805   787   972   475   400   000   000   
7026NR2F2139NP_066285.1in vitro;yeast 2-hybrid1   566   682   715   611   120   
7157TP531859NP_000537.3in vitro;yeast 2-hybrid15   133   049   118   677   300   000   000   000   000   000   
7161TP733587NP_005418.1in vitro15572666   
7329UBE2I9045NP_003336.1yeast 2-hybrid12177000   
7341SUMO13554NP_003343.1in vitro;yeast 2-hybrid11583632   
7629ZNF761929NP_003418.2in vitro;yeast 2-hybrid15280358   
8312AXIN14819NP_003493.1yeast 2-hybrid12223491   
9063PIAS26944NP_004662.2in vitro;yeast 2-hybrid11877418   
9188DDX215895NP_004719.2in vitro;in vivo9177271   
9937DCLRE1A8519NP_055696.2in vitro;yeast 2-hybrid15572677   
23314SATB212178NP_056080.1in vitro;in vivo14701874   
51588PIAS46910NP_056981.2in vitro11877418   
51684SUFU6124NP_057253.2yeast 2-hybrid14611647   
55660PRPF40A10995NP_060362.3yeast 2-hybrid15231748   
79753SNIP16999NP_078976.2yeast 2-hybrid15231748   


Pathway Information


                  
Pathway Name Pathway ID
Hepatitis C hsa05160
Jak-STAT signaling pathway hsa04630
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam14324137-286  PINIT
cl16800137-286  PINIT superfamily
pfam02891331-379  zf-MIZ
cl17238331-379  RING superfamily
smart00513Nov-45  SAP
cl02640Nov-45  SAP superfamily
COG5222313-397  COG5222


Ontology Information


   
HPRD ID16098
Molecular ClassCell cycle control protein
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO