Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RUNX1 | 861 | runt-related transcription factor 1 | 21 | PEBP2A2, AMLCR1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21088106 | 2011 | Cell line : - Source : Twin Cities Metropolitan Area or a seven-county area of Utah, enrolled in the Kaiser Permanente Medical Care Program of Northern California (KPMCP) Sample Type : Population basded Case control study. No. of Sample : 5 1555 CRC and 5 1956 control Stage : - | Meta-analysis | Polymorhpism | - | For rectal cancer, the strongest association was detected for the combined genotype of RUNX1 and RUNX3 (odds ratio 1.87 95% CI 1.22, 2.87). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 21 |
| Location | 21q22.3 |
| Start | 36160098 |
| End | 36421595 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 261498 |
| OMIM ID | 151385 |
| HGNC ID | HGNC:10471 |
| Unigene ID | Hs.149261 |
| Ensembl ID | ENSG00000159216 |
| PharmGKB ID | PA34884 |
mRNA Information
| mRNA ID | XM_011529768.1 |
|---|---|
| Exon | join(1..143,353..469,162215..162468,168598..168754, 189733..189837,249849..250010,256701..261510) | mRNA Sequence | Download Select all |
| Length | 5748 |
Protein Information
| Protein ID | XP_011528070.1 |
|---|---|
| Protein Name | runt-related transcription factor 1 |
| Molecular Wt. (Da) | 42924 |
| Protein Sequence | Download Select all |
| Length | 403 |
| Uniprot ID | P60660 |
| Ensembl Protein ID | ENSP00000446714 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 41 |
| S | Phosphorylation | 48 |
| T | Phosphorylation | 14 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 249 |
| S | Phosphorylation | 276 |
| S | Phosphorylation | 44 |
| T | Phosphorylation | 45 |
| S | Phosphorylation | 17 |
| T | Phosphorylation | 18 |
| S | Phosphorylation | 256 |
| S | Phosphorylation | 229 |
| T | Phosphorylation | 257 |
| T | Phosphorylation | 230 |
| K | Acetylation | 51 |
| K | Acetylation | 70 |
| K | Acetylation | 24 |
| K | Acetylation | 43 |
| T | Phosphorylation | 311 |
| T | Phosphorylation | 312 |
| S | Phosphorylation | 318 |
| S | Phosphorylation | 319 |
| T | Phosphorylation | 284 |
| T | Phosphorylation | 285 |
| S | Phosphorylation | 291 |
| S | Phosphorylation | 292 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 367 | AR | 2437 | NP_000035.2 | in vitro | 10521447 |
| 595 | CCND1 | 1346 | NP_444284.1 | in vivo | 16287839 |
| 865 | CBFB | 418 | NP_074036.1 | in vitro;in vivo | 108 562 441 127 626 000 000 000 |
| 894 | CCND2 | 451 | NP_001750.1 | in vivo | 16287839 |
| 896 | CCND3 | 452 | NP_001751.1 | in vitro;in vivo;yeast 2-hybrid | 16287839 |
| 1021 | CDK6 | 4533 | NP_001250.1 | in vivo | 17431401 |
| 1050 | CEBPA | 296 | NP_004355.2 | in vivo | 17431401 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro;in vivo | 14752096 |
| 9612 | NCOR2 | 2910 | NP_006303.3 | yeast 2-hybrid | 16042694 |
| 25937 | WWTR1 | 9580 | NP_056287.1 | in vitro | 11118213 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| Chronic myeloid leukemia | hsa05220 |
| Pathways in cancer | hsa05200 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00853 | 48-182 | Runt |
| cl02989 | 48-182 | Runt superfamily |
| pfam08504 | 359-453 | RunxI |
| cl07214 | 359-453 | RunxI superfamily |
| PHA03247 | 172-399 | PHA03247 |
| pfam03867 | 217-299 | FTZ |
Ontology Information
| HPRD ID | 1248 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.