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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TP63 | 8626 | tumor protein p63 | 3 | p51, SHFM4, EEC3, p63, p73L, OFC8, KET, p73H, NBP, p53CP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23015401 | 2012 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 66 Stage : - | Immunohistochemistry | Down-regulation | - | p63 was negatively correlated with peritumoral deposits and positively associated with OS and PFS in CRC. The data suggest that p63 is a potential prognostic factor for CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008] |
| Chromosome | 3 |
| Location | 3q27-q29 |
| Start | 189348942 |
| End | 189615068 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 266127 |
| OMIM ID | 603273 |
| HGNC ID | HGNC:15979 |
| Unigene ID | Hs.137569 |
| Ensembl ID | ENSG00000073282 |
| PharmGKB ID | PA162406776 |
mRNA Information
| mRNA ID | ?NM_001114978.1 |
|---|---|
| Exon | join(1..35,170880..171008,171782..171914,241412..241666, 297372..297558,299822..299937,300973..301082, 301720..301856,302464..302546,305999..306135, 319534..319691,322480..322624,323929..324022, 327346..330419) | mRNA Sequence | Download Select all |
| Length | 4793 |
Protein Information
| Protein ID | NP_001108450.1 |
|---|---|
| Protein Name | tumor protein p63 |
| Molecular Wt. (Da) | 99262 |
| Protein Sequence | Download Select all |
| Length | 680 |
| Uniprot ID | Q9Y230 |
| Ensembl Protein ID | ENSP00000473172 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 326 |
| T | Phosphorylation | 329 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1616 | DAXX | 4424 | NP_001135442.1 | yeast 2-hybrid | 12954772 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro | 8695800 |
| 3182 | HNRNPAB | 4067 | NP_112556.2 | in vitro;yeast 2-hybrid | 12692135 |
| 5525 | PPP2R5A | 3384 | NP_006234.1 | in vitro | 12086851 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vivo | 11238924 |
| 7161 | TP73 | 3587 | NP_005418.1 | in vitro;in vivo | 1 123 892 410 373 480 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08367 | 177-358 | P53 |
| cl14608 | 177-358 | P53 superfamily |
| cd09572 | 543-607 | SAM_tumor-p63 |
| cl15755 | 543-607 | SAM_superfamily superfamily |
| pfam00870 | 163-358 | P53 |
| cd09503 | 543-607 | SAM_tumor-p63,p73 |
| cd09571 | 543-606 | SAM_tumor-p73 |
| pfam07710 | 397-432 | P53_tetramer |
| cl06653 | 397-432 | P53_tetramer superfamily |
| pfam07647 | 541-605 | SAM_2 |
| cd09487 | 548-601 | SAM_superfamily |
| pfam08430 | 455-534 | Fork_head_N |
| cl22540 | 455-534 | Fork_head_N superfamily |
| smart00454 | 541-606 | SAM |
Ontology Information
| HPRD ID | 9013 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.