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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
UNC5C 8633 unc-5 homolog C (C. elegans)  4- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19331160   2009Cell line : -

Source : Showa University Fujigaoka Hospital from colorectal cancer patients during colorectal surgery.

Sample Type : CRC Tumor and normal tissue

No. of Sample : 49

Stage : Duke Stage A,B,C.

 methylation-specific PCR,Sodium bisulfite modification,Methylation-UNC5C might act as a tumor suppressor and UNC5C methylation might present a malignant potential in colorectal cancer.

21893118   2011Cell line : -

Source : France, United States, and Finland.

Sample Type : CRC Blood samples

No. of Sample : 1801 CRC and 4152 controls

Stage : -

Haplotype analysis,Immunohistochemistry and immunoblottingPolymorhpism-Inherited mutations in UNC5C prevent apoptosis and increase risk of CRC.


Gene Details



NC_000004.11 (96083655..96470361, complement)

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Gene Type protein coding
Gene Family Immunoglobulin superfamily / I-set domain containing
Description This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]  
Chromosome 4
Location 4q21-q23
Start 96083655  
End 96470361  
Strand -  
Gene Sequence

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Length 386707  
OMIM ID 603610   
HGNC ID HGNC:12569   
Unigene ID Hs.388565   
Ensembl ID ENSG00000182168   
PharmGKB ID PA37206   

mRNA Information


mRNA ID ?NM_003728.3
Exon join(1..477,213580..213801,247462..247605,270849..270952, 298544..298724,304067..304234,306618..306782, 329035..329226,329898..330242,333000..333087, 342415..342583,346247..346480,364015..364164, 366150..366314,378879..379057,379812..386707)  
mRNA Sequence

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Length 9879  



CDS Information


   
Location354..3149
CDS Sequence

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CCDS ID CCDS3643.1



Protein Information


      
Protein IDNP_003719.3
Protein Nameunc-5 homolog C (C. elegans)
Molecular Wt. (Da)36736
Protein Sequence

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Length 931  
Uniprot IDQ14314
Ensembl Protein ID ENSP00000248598  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
9423NTN13368NP_004813.2in vitro12810718   


Pathway Information


      
Pathway Name Pathway ID
Axon guidance hsa04360


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd08799844-926  Death_UNC5C
cl14633844-926  DD superfamily
pfam00791528-630  ZU5
cl02517528-630  ZU5 superfamily
smart00218528-631  ZU5
cd08781844-925  Death_UNC5-like
cd08802844-926  Death_UNC5B
cd08800844-927  Death_UNC5A
cd08801844-930  Death_UNC5D
cd05724171-257  Ig2_Robo
cl11960171-257  Ig superfamily
smart00005845-928  DEATH
smart00209263-314  TSP1
cl15278263-314  TSP_1 superfamily
pfam00531850-928  Death
cd08310848-922  Death_NFkB-like
cd08312849-919  Death_MyD88
smart00209319-367  TSP1
cl15278319-367  TSP_1 superfamily
cd00096184-252  Ig
cd04967169-254  Ig1_Contactin
cd08782847-918  Death_DAPK1
pfam00090264-310  TSP_1
cd04969183-257  Ig5_Contactin_like
cd05849169-255  Ig1_Contactin-1
cd05736186-245  Ig2_Follistatin_like
cd08798850-922  Death_NFkB2_p100
cd05725184-257  Ig3_Robo
pfam13895177-257  Ig_2
cd04976193-257  Ig2_VEGFR
cd08311846-925  Death_p75NR
pfam13927172-243  Ig_3
cd05730180-243  Ig3_NCAM-1_like
cd05748193-257  Ig_Titin_like
cd05729172-243  Ig2_FGFR_like
cd05848169-255  Ig1_Contactin-5
cd05723183-256  Ig4_Neogenin
cd05727184-245  Ig2_Contactin-2-like
cd05845172-247  Ig2_L1-CAM_like
cd08797848-922  Death_NFkB1_p105
cd01670848-925  Death
cd05750186-255  Ig_Pro_neuregulin
cd05864193-257  Ig2_VEGFR-2
cd05857184-243  Ig2_FGFR
cd04979184-259  Ig_Semaphorin_C
pfam07686168-243  V-set
pfam07679169-257  I-set
smart00410173-257  IG_like
smart00409173-257  IG
smart00408182-243  IGc2


Ontology Information


   
HPRD ID5305
Molecular ClassCell surface receptor
Molecular FunctionPeroxidase activity (GO:0004601)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO