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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
EIF3B 8662 eukaryotic translation initiation factor 3, subunit B  7PRT1, eIF3b 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22734884   2012Cell line : SW1116

Source : Shanghai Institute of Digestive Disease.

Sample Type : CRC tumor

No. of Sample : -

Stage : -

Gene Knockdown, Transfection,Real time RT-PCR, western blotting,Fluorescence-activated cell sortingMethylation-The silencing of EIF3B gene expression inhibits the proliferation of colon cancer cells.


Gene Details



NC_000007.13 (2394474..2420380)

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Gene Type protein coding
Gene Family RNA binding motif (RRM) containing
Description -  
Chromosome 7
Location 7p22
Start 2394474  
End 2420380  
Strand +  
Gene Sequence

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Length 25907  
OMIM ID 603917   
HGNC ID HGNC:3280   
Unigene ID Hs.371001   
Ensembl ID ENSG00000106263   
PharmGKB ID PA162384603   

mRNA Information


mRNA ID ?NM_001037283.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS5332.1



Protein Information


      
Protein IDNP_001032360.1
Protein Nameeukaryotic translation initiation factor 3, subunit B
Molecular Wt. (Da)0
Protein Sequence

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Length 814  
Uniprot IDO95800
Ensembl Protein ID ENSP00000378195  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation125
SPhosphorylation83
SPhosphorylation85
YPhosphorylation525;-
YPhosphorylation486;-
YPhosphorylation525;-
SPhosphorylation119;-
SPhosphorylation80;-
SPhosphorylation119;-
SPhosphorylation154;-
SPhosphorylation115;-
SPhosphorylation154;-
SPhosphorylation152;-
SPhosphorylation113;-
SPhosphorylation152;-
SPhosphorylation164;-
SPhosphorylation125;-
SPhosphorylation164;-
SPhosphorylation78
SPhosphorylation81
SPhosphorylation78
SPhosphorylation81
SPhosphorylation83
SPhosphorylation85
SPhosphorylation95
SPhosphorylation95
SPhosphorylation117
SPhosphorylation78
SPhosphorylation117
SPhosphorylation86
SPhosphorylation125
SPhosphorylation239
SPhosphorylation200
SPhosphorylation239
KAcetylation209
KAcetylation170
KAcetylation209
KAcetylation288
KAcetylation249
KAcetylation288
KAcetylation436
KAcetylation397
KAcetylation436
KAcetylation364
KAcetylation325
KAcetylation364
KAcetylation213
KAcetylation174
KAcetylation213
TPhosphorylation500
TPhosphorylation461
TPhosphorylation500
SPhosphorylation738
SPhosphorylation699
SPhosphorylation738
SPhosphorylation728
SPhosphorylation689
SPhosphorylation728

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1981EIF4G16774NP_886553.2in vivo16541103   
3560IL2RB896NP_000869.1in vivo7693677   
8661EIF3A3618NP_003741.1in vitro;in vivo89   954   109   822   659   
8666EIF3G4886NP_003746.2in vivo14688252   
8668EIF3I4884NP_003748.1in vivo14688252   
8669EIF3J4883NP_003749.2in vivo14688252   


Pathway Information


      
Pathway Name Pathway ID
RNA transport hsa03013


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12278184-264  RRM_eIF3B
cl17169184-264  RRM_SF superfamily
cd00590187-258  RRM_SF
pfam00076207-256  RRM_1
cd12390189-263  RRM3_RAVER
cd12365199-258  RRM_RNPS1
cd12384187-255  RRM_RBM24_RBM38_like
cd12380201-256  RRM3_I_PABPs
cd12671187-264  RRM_CSTF2_CSTF2T
pfam13893207-258  RRM_5
cd12567207-252  RRM3_RBM19
cd12371207-264  RRM2_PUF60
cd12414187-257  RRM2_RBM28_like
cd12398207-255  RRM_CSTF2_RNA15_like
cd12236207-256  RRM_snRNP70
cd12411210-263  RRM_ist3_like
cd12311189-259  RRM_SRSF2_SRSF8
cd12316209-252  RRM3_RBM19_RRM2_MRD1
cd12379207-261  RRM2_I_PABPs
cd12599207-265  RRM1_SF2_plant_like
cd12324207-255  RRM_RBM8
cd12566209-254  RRM2_MRD1
pfam0576011-166  IER
cl1568111-166  IER superfamily
cd12355209-252  RRM_RBM18
cd12389198-269  RRM2_RAVER
cd12341210-256  RRM_hnRNPC_like
cd00200340-480  WD40
cl02567340-480  WD40 superfamily
cd12347206-264  RRM_PPIE
cd12382209-256  RRM_RBMX_like
cd12381201-256  RRM4_I_PABPs
COG5354305-805  COG5354
pfam14259187-259  RRM_6
pfam08662507-702  eIF2A
COG2319340-743  WD40
COG2319304-535  WD40
smart00360207-259  RRM
PRK077644-161  PRK07764
PRK077646-141  PRK07764
PRK124953-141  PRK12495
PHA0316916-184  PHA03169
PRK077642-145  PRK07764
PRK070037-156  PRK07003
TIGR01628189-256  PABP-1234
pfam07926713-797  TPR_MLP1_2
pfam08662315-392  eIF2A
pfam054664-157  BASP1
PRK077648-179  PRK07764
PRK077648-184  PRK07764
PHA0330710-166  PHA03307
PRK149512-128  PRK14951
pfam0354619-157  Treacle
PHA032478-108  PHA03247


Ontology Information


   
HPRD ID4995
Molecular ClassTranslation regulatory protein
Molecular FunctionCytokine activity (GO:0005125)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO